Standard name
Human Ortholog
Description 6-phosphofructo-2-kinase; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Cytoplasm 0.97 0.97 1.0 0.99 0.99 0.96 0.93 0.94 0.88 – 0.77 0.79 0.99 1.0 0.99 0.83 0.92 – 0.91 0.87 0.83 0.8 0.82 0.76
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.12 0.1 – 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.08 0 – 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.08 0.12 0.08 0.26 – 0.36 0.3 0 0 0 0 0 – 0 0 0 0.07 0.08 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – 0 0 0 0.05 0 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 0 0 0 0 0 0 0 – 0 0 0 0 0 1 0 – 0 2 2 2 1 4
Bud 0 2 0 1 0 4 3 2 7 – 8 9 1 0 1 0 0 – 1 2 1 1 1 13
Bud Neck 0 0 5 1 0 1 2 0 0 – 0 2 0 0 0 0 0 – 0 0 0 1 2 6
Bud Site 0 0 0 0 0 0 0 0 0 – 0 2 0 0 0 0 0 – – – – – – –
Cell Periphery 3 1 5 1 1 3 1 9 4 – 5 6 0 0 3 0 1 – 0 1 3 2 1 1
Cytoplasm 195 439 253 129 299 354 418 398 313 – 228 249 241 176 304 43 47 – 184 400 195 141 230 245
Endoplasmic Reticulum 4 5 0 0 1 0 0 0 0 – 0 1 2 1 0 6 5 – 0 2 1 0 3 6
Endosome 0 0 1 0 0 1 0 1 2 – 3 0 0 0 0 1 0 – 1 9 0 0 1 2
Golgi 0 1 0 0 0 0 0 0 0 – 0 0 0 0 0 4 2 – 1 2 1 1 1 2
Mitochondria 3 10 0 1 4 29 55 32 94 – 108 96 2 0 0 1 1 – 5 15 9 12 22 13
Nucleus 1 0 1 2 4 4 8 11 4 – 10 7 0 0 0 2 2 – 0 2 3 0 0 0
Nuclear Periphery 1 1 0 0 0 0 0 0 1 – 0 0 0 0 0 0 0 – 0 2 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 1 – 1 2 0 0 0 1 1 – 0 0 1 0 0 2
Peroxisomes 0 0 0 0 0 0 0 0 1 – 0 0 0 0 1 0 0 – 0 0 0 0 1 0
SpindlePole 0 0 1 0 1 1 1 4 2 – 2 3 0 0 0 0 0 – 0 6 2 0 1 2
Vac/Vac Membrane 0 1 0 1 0 2 4 5 2 – 1 5 0 1 1 1 1 – 0 6 5 8 9 15
Unique Cell Count 201 452 254 130 303 367 449 422 355 296 316 243 176 306 52 51 204 462 236 176 282 324
Labelled Cell Count 207 461 266 136 310 399 492 462 431 366 382 246 178 310 60 60 204 462 236 176 282 324


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.8 4.1 4.8 5.1 5.4 4.3 4.6 5.2 4.4 – 4.2 4.3 4.1 4.6 4.8 7.1 7.3 – 3.9 4.1 4.8
Std Deviation (1e-4) 0.5 0.9 1.5 2.5 1.9 1.5 1.4 1.6 1.7 – 1.6 1.2 1.3 1.1 1.6 1.8 2.2 – 1.2 1.6 2.2
Intensity Change (Log2) – – – 0.08 0.17 -0.14 -0.05 0.11 -0.13 – -0.2 -0.14 -0.21 -0.07 0.0 0.56 0.6 – -0.31 -0.22 0.02


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.2879 1.9773 1.5699 1.7293 1.3183 1.8572 0.8775 0.3306 0.0145 0.1535 0.2769 -0.1733 -0.9379 -0.4665 -0.8777 -0.4697 0.8217 -0.5409
Actin 0.0266 0.0001 0.005 0.0115 0.0165 0.0081 0.0711 0.0084 0.014 0.0095 0.0179 0.0064 0.0331 0 0.0009 0 0.1243 0.0082
Bud 0.0004 0.0008 0.0002 0.0001 0.0004 0.0005 0.0067 0.0021 0.0045 0.0015 0.0024 0.0034 0.0074 0 0.0034 0 0.0006 0.0006
Bud Neck 0.0006 0.0001 0.0003 0.0002 0.0005 0.0005 0.0083 0.0004 0.0031 0.0006 0.0015 0.0022 0.0024 0 0.0004 0 0.0004 0.0006
Bud Periphery 0.0006 0.0032 0.0003 0.0001 0.0007 0.0027 0.0224 0.0041 0.0067 0.002 0.0035 0.0088 0.0025 0 0.0088 0 0.0007 0.0036
Bud Site 0.005 0.0009 0.0007 0.0002 0.0008 0.0001 0.0217 0.0088 0.012 0.0021 0.007 0.0004 0.0043 0.0001 0.0027 0 0.0013 0.0001
Cell Periphery 0.0004 0.0005 0.0001 0.0001 0.0001 0.0001 0.0011 0.0007 0.0005 0.0001 0.0004 0.0002 0.0004 0.0001 0.0002 0 0.0001 0.0001
Cytoplasm 0.1193 0.1954 0.1571 0.259 0.0648 0.2266 0.1998 0.3403 0.3005 0.2735 0.3517 0.3889 0.0675 0.1647 0.1987 0.2394 0.1553 0.2029
Cytoplasmic Foci 0.0081 0.0024 0.0143 0.0223 0.0167 0.0048 0.0423 0.0094 0.0262 0.025 0.0399 0.0285 0.0317 0.0014 0.0031 0.0047 0.0067 0.0022
Eisosomes 0.0011 0.0001 0.0002 0.0001 0.0003 0.0001 0.0006 0.0002 0.0003 0.0003 0.0002 0 0.0004 0 0.0001 0 0.0005 0.0001
Endoplasmic Reticulum 0.0016 0.0007 0.0012 0.001 0.0008 0.001 0.0159 0.0018 0.0049 0.0013 0.0058 0.0019 0.0019 0.0005 0.0007 0.0013 0.0008 0.0006
Endosome 0.0051 0.0004 0.004 0.0023 0.0143 0.0027 0.0483 0.0048 0.0159 0.0237 0.0338 0.0063 0.0179 0.0002 0.0011 0.002 0.0088 0.0007
Golgi 0.0037 0.0001 0.0013 0.0013 0.0064 0.0013 0.0124 0.0006 0.0046 0.0228 0.0229 0.0009 0.0101 0 0.0001 0.0001 0.0261 0.0001
Lipid Particles 0.0057 0.0001 0.0035 0.0051 0.0097 0.0033 0.0177 0.0002 0.0025 0.0256 0.0065 0.0008 0.0213 0.0001 0.0002 0.0002 0.0059 0
Mitochondria 0.0083 0.0002 0.0021 0.001 0.0091 0.0082 0.0106 0.0005 0.0075 0.014 0.0265 0.0012 0.0048 0 0.0003 0.0001 0.0213 0.0001
None 0.793 0.7928 0.7934 0.6684 0.822 0.7366 0.4491 0.6117 0.5811 0.5533 0.4254 0.5372 0.7427 0.8321 0.7742 0.7485 0.6422 0.7792
Nuclear Periphery 0.0007 0.0001 0.0037 0.0004 0.003 0.0003 0.0164 0.0005 0.0041 0.0011 0.0092 0.0034 0.0018 0.0001 0.0003 0.0007 0.0006 0.0002
Nucleolus 0.0006 0.0001 0.0002 0.0001 0.0004 0.0001 0.0015 0.0002 0.0005 0.0003 0.0005 0.0002 0.0018 0 0.0009 0 0.0001 0
Nucleus 0.0008 0.0006 0.0009 0.0007 0.0007 0.0004 0.0037 0.0012 0.0022 0.0009 0.009 0.0023 0.0026 0.0002 0.0007 0.0006 0.0002 0.0003
Peroxisomes 0.0105 0 0.0083 0.0248 0.0269 0.0017 0.0214 0.0001 0.0019 0.0385 0.0172 0.0025 0.0342 0 0.0002 0 0.0029 0
Punctate Nuclear 0.0069 0.0002 0.0021 0.0008 0.0052 0.0004 0.0082 0.0007 0.0028 0.0013 0.0111 0.0024 0.0093 0.0001 0.0022 0.0005 0.0005 0.0001
Vacuole 0.0007 0.0011 0.0005 0.0005 0.0004 0.0003 0.0143 0.003 0.0032 0.0017 0.0052 0.0016 0.0014 0.0002 0.0007 0.0015 0.0004 0.0003
Vacuole Periphery 0.0002 0.0001 0.0004 0.0001 0.0004 0.0001 0.0065 0.0003 0.001 0.001 0.0025 0.0006 0.0005 0 0.0001 0.0002 0.0004 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 9.3283 7.9418 8.2505 8.9992 6.0473 11.9869 12.1453 15.8526 14.4988 13.414
Translational Efficiency 0.9324 0.906 0.6458 0.7909 0.9903 1.2182 0.8521 0.6697 0.8704 0.706

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2608 1445 163 94 1753 1383 2341 2748 4361 2828 2504 2842

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 641.05 725.41 962.32 873.93 617.71 708.42 875.25 807.26 631.67 717.10 880.92 809.47
Standard Deviation 62.64 91.24 118.90 90.52 72.77 91.55 100.99 104.38 67.87 91.79 104.49 104.63
Intensity Change Log 2 — 0.178360 0.586080 0.447081 — 0.197675 0.502765 0.386104 — 0.187871 0.545796 0.417480

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000335 0.000276 0.001414 0.000895 0.000110 0.000545 0.000090 0.000379 0.000244 0.000407 0.000176 0.000396
Bud Neck 0.032483 0.032456 0.003367 0.002287 0.012783 0.057896 0.003984 0.011178 0.024564 0.044897 0.003944 0.010883
Bud Site 0.009062 0.016002 0.035456 0.008954 0.003138 0.027877 0.008023 0.021072 0.006681 0.021809 0.009809 0.020671
Cell Periphery 0.000159 0.000110 0.000278 0.000240 0.000112 0.000186 0.000067 0.000093 0.000140 0.000147 0.000081 0.000097
Cytoplasm 0.485467* 0.464586* 0.250463* 0.379548* 0.499984* 0.358206* 0.620732* 0.646479* 0.491302* 0.412562* 0.596629* 0.637650*
Cytoplasmic Foci 0.228704* 0.227546* 0.016055 0.046553 0.241195* 0.309200* 0.010277 0.014037 0.233725* 0.267478* 0.010654 0.015112
Eisosomes 0.000378 0.000103 0.000110 0.000110 0.000149 0.000268 0.000019 0.000026 0.000286 0.000183 0.000024 0.000028
Endoplasmic Reticulum 0.001425 0.000433 0.010427 0.003968 0.000759 0.000385 0.000749 0.000396 0.001157 0.000410 0.001379 0.000514
Endosome 0.012706 0.028761 0.006145 0.007983 0.011854 0.036764 0.001034 0.004814 0.012364 0.032675 0.001367 0.004918
Golgi 0.006034 0.004534 0.000191 0.000144 0.001762 0.012008 0.000070 0.000895 0.004317 0.008189 0.000077 0.000870
Lipid Particles 0.009631 0.004665 0.004286 0.004377 0.010139 0.007295 0.000412 0.000540 0.009835 0.005951 0.000664 0.000667
Mitochondria 0.006606 0.011313 0.000493 0.001941 0.003488 0.020380 0.000374 0.002377 0.005353 0.015747 0.000381 0.002362
Mitotic Spindle 0.001092 0.007374 0.003467 0.005785 0.001573 0.010253 0.004429 0.036689 0.001285 0.008782 0.004367 0.035667
None 0.003599 0.003591 0.002186 0.002894 0.004938 0.001648 0.005084 0.003854 0.004137 0.002641 0.004895 0.003823
Nuclear Periphery 0.000199 0.000314 0.002176 0.001224 0.000471 0.000217 0.000840 0.000958 0.000308 0.000266 0.000927 0.000967
Nuclear Periphery Foci 0.000230 0.000342 0.005114 0.003057 0.000350 0.000226 0.000521 0.000258 0.000278 0.000285 0.000820 0.000351
Nucleolus 0.001085 0.002024 0.000565 0.000596 0.001715 0.001251 0.000165 0.000865 0.001339 0.001646 0.000191 0.000857
Nucleus 0.127302 0.103839 0.486078* 0.254210* 0.152473* 0.059497 0.291641* 0.164334* 0.137420* 0.082154 0.304298* 0.167306*
Peroxisomes 0.006894 0.014183 0.001596 0.002271 0.005553 0.030015 0.000111 0.000648 0.006355 0.021925 0.000208 0.000701
Vacuole 0.065401 0.075503 0.169892 0.272570* 0.046455 0.063534 0.051275 0.088148 0.057785 0.069650 0.058996 0.094248
Vacuole Periphery 0.001207 0.002046 0.000242 0.000392 0.000998 0.002349 0.000104 0.001960 0.001123 0.002194 0.000113 0.001908

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.91 -4.01 -0.74 -0.98 2.12 -5.36 -0.08 -1.23 2.27 -1.24 -3.02 1.56 -0.08 1.38 -0.66
Bud Neck 0.17 20.25 22.65 14.41 4.54 -14.00 8.74 3.18 15.42 -6.68 -9.71 20.69 14.33 18.16 -6.64
Bud Site -4.74 -1.38 1.27 3.93 1.65 -12.12 -3.49 -9.00 5.78 -5.19 -12.01 -0.63 -5.94 4.61 -4.28
Cell Periphery 5.30 -5.20 0.04 -2.01 3.89 -4.42 7.86 6.26 7.08 -1.11 -0.67 10.55 10.75 7.87 1.07
Cytoplasm 2.68 15.67 5.99 4.94 -3.66 14.09 -5.36 -9.23 -23.21 -4.23 11.85 -4.65 -11.50 -20.30 -5.95
Cytoplasmic Foci 0.19 49.65 32.75 27.18 -3.55 -8.08 45.22 44.79 45.68 -2.33 -6.20 70.92 69.82 58.31 -2.90
Eisosomes 12.84 10.55 11.92 0.25 2.08 -6.12 12.15 11.98 14.77 -1.54 6.55 19.01 19.25 18.41 1.70
Endoplasmic Reticulum 2.74 -8.88 -3.55 -6.09 6.86 2.32 -2.69 1.43 -3.06 11.24 3.30 -3.27 2.29 -5.66 11.32
Endosome -8.48 6.81 6.13 11.26 1.09 -11.61 13.81 9.77 16.59 -4.08 -14.27 22.91 14.21 21.00 -3.57
Golgi 2.40 13.14 13.30 8.49 2.46 -10.53 12.75 6.47 11.83 -3.10 -6.22 15.55 12.52 13.67 -3.06
Lipid Particles 7.44 6.59 7.97 2.30 1.83 3.29 13.89 13.83 12.01 -0.95 7.17 20.88 21.23 15.86 2.29
Mitochondria -2.80 11.24 6.77 6.28 -0.50 -8.11 9.04 4.49 9.06 -6.69 -7.81 14.11 9.18 10.93 -6.68
Mitotic Spindle -3.73 -1.24 -1.27 0.87 -0.80 -4.04 -2.79 -11.30 -6.04 -9.61 -5.54 -3.42 -11.69 -7.39 -9.70
None 0.12 3.94 3.73 2.68 0.46 4.10 0.63 1.28 -6.01 0.87 3.28 -0.19 0.62 -3.50 0.74
Nuclear Periphery -3.71 -13.78 -8.58 -7.58 6.10 3.10 -9.89 -9.19 -14.27 -2.19 0.81 -22.20 -13.89 -14.87 -1.02
Nuclear Periphery Foci -3.07 -8.07 -7.47 -7.09 3.25 2.25 -6.24 3.07 0.00 9.13 -0.55 -11.04 -1.35 -0.63 9.62
Nucleolus -4.60 5.50 9.21 7.95 1.88 1.82 5.53 3.71 3.69 -5.85 -1.62 9.36 4.68 6.60 -5.63
Nucleus 4.96 -14.15 -2.88 -3.92 8.82 19.72 -28.64 -10.09 -30.83 19.65 17.04 -37.70 -15.81 -27.54 21.33
Peroxisomes -5.95 9.96 7.45 10.06 -0.25 -12.80 10.59 9.95 16.23 -4.72 -13.75 18.29 17.27 20.00 -3.87
Vacuole -4.08 -9.15 -11.89 -11.40 -4.94 -5.49 -12.18 -22.16 -16.35 -9.68 -5.96 -12.15 -22.10 -17.64 -9.20
Vacuole Periphery -4.83 9.41 7.53 11.38 0.34 -5.28 7.59 -0.40 3.14 -3.32 -6.98 13.24 0.08 3.26 -3.30
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description 6-phosphofructo-2-kinase; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
Localization
Cell Percentages cytoplasm (46%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Pfk26

Pfk26


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pfk26-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available