ORF
Human Ortholog
Description Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.06 0.07 0.06 0 0 0 0 0 0
Cytoplasm 0.89 0.97 0.97 0.97 0.94 0.9 0.92 0.89 0.82 – 0.71 0.82 0.99 0.99 1.0 0.92 0.86 0.83 0.84 0.86 0.89 0.9 0.85 0.81
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.06 0 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.11 0.07 0.05 0.22 – 0.32 0.11 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0.05 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.05 0 – 0 0.06 0 0 0 0.05 0.06 0.07 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 9 0 2 1 9 1 3 1 0 – 0 3 1 0 0 0 1 1 4 3 0 0 3 5
Bud 3 4 3 5 7 8 5 2 5 – 10 10 1 2 0 0 1 2 5 7 0 1 8 8
Bud Neck 0 0 0 0 3 1 1 1 0 – 0 0 0 0 0 0 0 0 2 2 0 0 2 3
Bud Site 2 0 0 0 1 0 2 0 0 – 0 1 0 0 0 0 0 1 – – – – – –
Cell Periphery 0 2 4 4 7 8 8 9 5 – 14 14 3 4 0 16 14 11 0 0 0 0 2 3
Cytoplasm 226 254 276 311 412 404 612 413 340 – 253 383 406 622 683 241 173 156 223 230 268 163 387 378
Endoplasmic Reticulum 0 1 0 0 6 0 0 5 3 – 2 11 0 1 1 15 6 11 0 0 0 2 11 5
Endosome 4 2 2 3 1 6 3 3 0 – 0 0 0 1 1 6 6 4 4 5 4 0 6 14
Golgi 0 0 0 0 0 1 0 0 0 – 0 0 0 0 1 1 2 3 4 0 0 0 0 1
Mitochondria 4 1 0 10 6 47 50 22 92 – 114 51 2 0 1 0 1 4 0 1 4 5 14 19
Nucleus 0 1 1 2 0 3 5 8 4 – 4 5 1 0 0 5 6 4 0 0 0 0 0 0
Nuclear Periphery 0 1 0 0 0 1 0 0 0 – 1 0 2 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 1 1 0 0 0 3 0 0 0 – 1 0 1 0 0 1 1 0 0 1 0 0 0 0
Peroxisomes 2 1 2 0 0 0 0 0 0 – 0 0 0 1 0 0 1 0 0 0 0 0 0 1
SpindlePole 12 1 2 2 9 8 4 4 0 – 1 1 0 1 0 2 2 3 15 4 4 0 1 6
Vac/Vac Membrane 3 1 0 2 3 14 13 22 15 – 15 28 0 4 0 12 13 14 0 8 11 3 11 15
Unique Cell Count 255 263 284 322 439 447 667 465 415 355 465 411 629 686 261 202 187 266 269 302 182 457 469
Labelled Cell Count 266 270 292 340 464 505 706 490 464 415 507 417 636 687 299 227 214 266 269 302 182 457 469


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.8 5.8 6.4 5.6 6.3 5.4 5.6 6.0 5.0 – 4.8 5.6 6.2 6.2 6.3 10.4 10.6 9.7 5.3 5.6 5.7
Std Deviation (1e-4) 1.1 1.3 1.1 0.9 1.3 1.2 1.2 1.0 1.0 – 0.9 1.0 1.3 1.2 1.3 2.9 2.8 2.5 1.2 1.1 1.3
Intensity Change (Log2) – – – -0.2 -0.03 -0.23 -0.2 -0.09 -0.37 – -0.42 -0.2 -0.05 -0.05 -0.01 0.7 0.72 0.6 -0.27 -0.2 -0.16


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 – 0 1.4 0 0 0 2.9 3.2 2.7
Cytoplasm -0.4 -2.0 -3.5 -3.1 -4.1 -6.1 – -8.6 -6.1 1.5 1.9 3.2 -2.6 -4.7 -5.3
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 4.1 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0 5.6 4.7 3.7 8.5 – 0 5.8 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 3.0 0 3.7 3.2 – 3.5 4.2 0 0 0 3.7 4.3 4.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.9631 3.3805 2.3796 2.4351 3.1098 3.1215 3.2853 4.64 4.018 3.7805 3.2153 4.0204 3.1504 5.5095 4.1383 4.6438 2.797 4.2193
Actin 0.0415 0.0035 0.0243 0.0994 0.0024 0.0208 0.0384 0.0032 0.0104 0.008 0.0103 0.0098 0.0518 0.0087 0.0155 0.0086 0.0039 0.0067
Bud 0.0006 0.0012 0.0005 0.0007 0.0004 0.0004 0.0029 0.002 0.0074 0.0009 0.0011 0.0041 0.002 0.0027 0.0069 0.0022 0.0001 0.0005
Bud Neck 0.0015 0.0004 0.0007 0.0084 0.0379 0.0528 0.0054 0.0007 0.0026 0.0017 0.0013 0.0093 0.0091 0.0011 0.0057 0.007 0.0006 0.0415
Bud Periphery 0.0008 0.0004 0.0005 0.0005 0.0002 0.0006 0.006 0.0007 0.0043 0.0005 0.0011 0.005 0.0015 0.0015 0.0048 0.0013 0.0001 0.0003
Bud Site 0.0056 0.0075 0.0046 0.0019 0.0189 0.0014 0.0139 0.0323 0.0094 0.0011 0.002 0.001 0.0103 0.0418 0.0124 0.0036 0.0003 0.001
Cell Periphery 0.0006 0.0005 0.0004 0.0002 0.0003 0.0008 0.0006 0.0002 0.0002 0.0002 0.0002 0.0001 0.0004 0.0002 0.0004 0.0004 0 0.0001
Cytoplasm 0.5938 0.8738 0.7388 0.7109 0.5631 0.7268 0.6465 0.8342 0.7615 0.7752 0.7483 0.8002 0.6112 0.7011 0.6474 0.5599 0.6888 0.7072
Cytoplasmic Foci 0.1303 0.0504 0.1052 0.058 0.2876 0.0901 0.1407 0.0812 0.1025 0.1052 0.0734 0.0945 0.1599 0.1712 0.2035 0.2829 0.2006 0.1968
Eisosomes 0.0006 0 0.0001 0.0002 0.0001 0.0001 0.0002 0 0 0 0.0001 0.0002 0.0005 0 0 0 0 0
Endoplasmic Reticulum 0.0131 0.0028 0.0058 0.0057 0.0056 0.0027 0.0064 0.0015 0.0024 0.0046 0.0027 0.0029 0.0068 0.0016 0.0023 0.0049 0.0034 0.002
Endosome 0.0373 0.004 0.0127 0.0115 0.0151 0.0047 0.0331 0.0042 0.0153 0.0381 0.0299 0.0129 0.0296 0.0063 0.0128 0.0242 0.0153 0.0093
Golgi 0.0178 0.0007 0.0029 0.0143 0.0044 0.0031 0.0087 0.0011 0.0065 0.0049 0.0136 0.0025 0.0083 0.0079 0.0039 0.0045 0.0018 0.002
Lipid Particles 0.0273 0.0006 0.0036 0.0044 0.0059 0.0078 0.007 0.0006 0.0024 0.0046 0.0229 0.0016 0.0129 0.0029 0.0067 0.019 0.0006 0.0016
Mitochondria 0.017 0.0002 0.0006 0.0077 0.0003 0.0008 0.0127 0.0002 0.0029 0.0013 0.0085 0.0006 0.0045 0.0013 0.0005 0.0006 0.0003 0.0003
None 0.0749 0.0394 0.0653 0.0581 0.0136 0.0428 0.0362 0.0211 0.0267 0.0338 0.0503 0.0301 0.0364 0.0163 0.0291 0.0068 0.0288 0.0101
Nuclear Periphery 0.0059 0.0009 0.0031 0.0013 0.0007 0.0011 0.0066 0.0005 0.0009 0.0016 0.0018 0.0012 0.006 0.0004 0.0007 0.0021 0.0007 0.0005
Nucleolus 0.0006 0.0001 0.0002 0.0001 0.0016 0.0156 0.0006 0.0001 0.0047 0.0003 0.0003 0.0006 0.0071 0.0004 0.0002 0.0091 0.0001 0.0002
Nucleus 0.0022 0.0013 0.0017 0.0013 0.0025 0.0061 0.0056 0.002 0.0028 0.005 0.0041 0.0041 0.0038 0.0021 0.0013 0.0045 0.001 0.0017
Peroxisomes 0.0197 0.0029 0.0079 0.0052 0.0033 0.0101 0.0189 0.0067 0.0323 0.0067 0.0209 0.0088 0.0223 0.0231 0.0326 0.0154 0.0125 0.0108
Punctate Nuclear 0.0055 0.0039 0.0186 0.0091 0.0346 0.0082 0.0064 0.0055 0.0028 0.0031 0.0042 0.0088 0.0118 0.0071 0.0104 0.0213 0.0399 0.0068
Vacuole 0.0026 0.0051 0.002 0.0009 0.0013 0.0031 0.0026 0.0019 0.0017 0.0023 0.0023 0.0015 0.0029 0.002 0.0026 0.0206 0.0009 0.0007
Vacuole Periphery 0.001 0.0005 0.0003 0.0003 0.0002 0.0002 0.0006 0.0002 0.0003 0.0005 0.0005 0.0002 0.0009 0.0001 0.0002 0.0009 0.0002 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 20.3162 22.6428 22.4026 32.9015 20.1832 40.0824 28.9753 33.1574 36.3801 31.8141
Translational Efficiency 1.2986 1.0336 1.0419 0.9513 1.2439 0.8072 0.911 0.9083 0.8514 0.8089

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1815 732 1552 898 1330 1765 630 1121 3145 2497 2182 2019

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 685.79 762.73 1156.29 1129.01 716.89 838.51 1033.42 1085.44 698.94 816.29 1120.81 1104.82
Standard Deviation 224.69 120.08 223.75 252.11 102.93 115.74 163.83 272.93 183.99 122.01 215.54 264.76
Intensity Change Log 2 — 0.153406 0.753665 0.719219 — 0.226076 0.527603 0.598456 — 0.191004 0.642554 0.658763

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000349 0.000649 0.037191 0.010344 0.000548 0.002206 0.000255 0.024671 0.000433 0.001750 0.026527 0.018299
Bud Neck 0.018054 0.016585 0.010787 0.011073 0.005905 0.030642 0.002217 0.008320 0.012916 0.026521 0.008313 0.009544
Bud Site 0.014031 0.033283 0.148459* 0.144379* 0.007706 0.062594 0.005907 0.154742* 0.011356 0.054001 0.107300* 0.150133*
Cell Periphery 0.000176 0.000118 0.000261 0.000212 0.000141 0.000186 0.000231 0.000275 0.000161 0.000166 0.000252 0.000247
Cytoplasm 0.565740* 0.538519* 0.245197* 0.315535* 0.631446* 0.443455* 0.529919* 0.379544* 0.593527* 0.471323* 0.327403* 0.351074*
Cytoplasmic Foci 0.223400* 0.235433* 0.258246* 0.151490 0.182712* 0.254306* 0.038244 0.177917 0.206193* 0.248773* 0.194726* 0.166163
Eisosomes 0.000198 0.000092 0.000055 0.000052 0.000087 0.000170 0.000122 0.000075 0.000151 0.000147 0.000074 0.000065
Endoplasmic Reticulum 0.000994 0.000411 0.001491 0.002714 0.001683 0.000593 0.002418 0.000507 0.001285 0.000539 0.001758 0.001488
Endosome 0.012986 0.023514 0.011250 0.023442 0.010709 0.031649 0.003813 0.009183 0.012023 0.029264 0.009103 0.015525
Golgi 0.003541 0.004290 0.003496 0.009582 0.002108 0.008959 0.000624 0.006188 0.002935 0.007590 0.002666 0.007698
Lipid Particles 0.004710 0.003174 0.008811 0.002268 0.004288 0.003090 0.002668 0.004430 0.004531 0.003114 0.007037 0.003468
Mitochondria 0.002447 0.003334 0.000458 0.002624 0.002364 0.005396 0.000467 0.000433 0.002412 0.004791 0.000461 0.001408
Mitotic Spindle 0.000410 0.008821 0.107789* 0.115715* 0.000862 0.012191 0.006760 0.059361 0.000601 0.011203 0.078619 0.084426
None 0.008201 0.004160 0.001253 0.000851 0.004916 0.001557 0.009819 0.002220 0.006812 0.002320 0.003726 0.001611
Nuclear Periphery 0.000149 0.000140 0.000314 0.000500 0.000496 0.000177 0.000904 0.000148 0.000296 0.000167 0.000485 0.000304
Nuclear Periphery Foci 0.000573 0.001206 0.005862 0.002175 0.001930 0.000510 0.002691 0.002363 0.001147 0.000714 0.004946 0.002279
Nucleolus 0.001312 0.000751 0.000382 0.000426 0.001630 0.000818 0.000568 0.000164 0.001446 0.000799 0.000435 0.000280
Nucleus 0.080269 0.040107 0.033649 0.015206 0.080364 0.029522 0.246550* 0.022215 0.080309 0.032625 0.095119 0.019097
Peroxisomes 0.005832 0.013220 0.091606 0.058799 0.004293 0.035014 0.002059 0.074412 0.005181 0.028625 0.065751 0.067468
Vacuole 0.055731 0.071048 0.033164 0.126010 0.054976 0.074926 0.143433 0.072515 0.055412 0.073789 0.065001 0.096308
Vacuole Periphery 0.000899 0.001144 0.000281 0.006604 0.000835 0.002040 0.000334 0.000319 0.000872 0.001777 0.000296 0.003114

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.63 -12.03 -3.71 -3.46 9.00 -2.70 0.91 -7.22 -6.17 -7.35 -3.12 -11.82 -8.12 -6.74 5.15
Bud Neck 0.79 3.36 4.99 2.99 2.65 -11.44 3.18 -1.93 11.09 -7.88 -7.65 2.82 4.13 11.06 1.82
Bud Site -4.59 -24.50* -13.90 -8.88 5.87 -15.71 -0.61 -18.28 -6.88 -17.83 -15.20 -23.46 -22.59 -9.92 -0.13
Cell Periphery 5.22 -5.74 1.14 -1.74 5.38 -2.46 -2.76 -5.74 -3.83 -3.26 -0.23 -6.72 -3.85 -3.41 1.81
Cytoplasm 2.31 30.91 17.95 12.11 -6.61 18.08 12.38 18.55 2.94 3.62 15.66 33.44 24.88 9.32 -6.15
Cytoplasmic Foci -1.11 0.43 14.86 12.16 12.48 -9.85 25.21 5.85 14.73 -15.53 -7.54 6.60 14.72 19.99 6.12
Eisosomes 5.16 6.89 7.82 8.00 4.16 -4.14 -0.16 2.10 5.07 0.98 0.33 5.99 7.61 6.52 1.55
Endoplasmic Reticulum 2.46 -3.41 -0.34 -1.41 1.38 3.06 -2.50 3.01 -0.47 5.80 3.55 -3.81 1.26 -1.36 4.65
Endosome -4.60 2.18 0.20 4.43 -1.58 -11.10 8.01 4.46 13.60 -2.33 -11.38 4.20 3.11 13.15 -0.59
Golgi -0.82 1.65 0.09 0.56 -0.65 -7.31 4.07 -0.62 4.30 -2.12 -6.40 2.55 -0.18 4.25 -1.32
Lipid Particles 3.56 -7.10 2.97 -0.73 8.87 3.03 3.57 -2.65 -4.35 -4.75 4.91 -5.87 -1.29 -4.30 3.78
Mitochondria -0.55 4.64 2.66 1.62 -1.39 -2.13 2.04 2.08 5.00 0.28 -2.45 4.08 3.55 4.97 -1.00
Mitotic Spindle -3.55 -19.79* -14.96 -13.25 -0.30 -6.15 -4.31 -11.26 -8.31 -5.86 -7.21 -19.73 -18.54 -15.19 0.36
None 2.94 7.14 7.00 2.62 -0.52 4.63 -0.74 3.86 -1.06 2.62 6.21 5.42 7.72 1.27 1.87
Nuclear Periphery 0.01 -5.63 -10.27 -10.28 -0.94 1.49 -3.66 0.51 -3.40 13.47 1.29 -4.90 -2.78 -7.51 3.94
Nuclear Periphery Foci -3.46 -9.12 -6.46 -4.48 5.20 5.80 -4.02 -4.93 -8.17 0.11 2.61 -9.56 -8.46 -9.60 4.73
Nucleolus 2.00 2.48 2.21 0.62 -0.54 2.07 2.33 3.43 3.14 1.96 2.67 3.51 4.13 2.65 1.41
Nucleus 11.51 9.81 17.42 3.88 5.63 16.37 -14.65 11.97 -3.24 19.67 22.15 -3.67 20.23 -0.29 16.01
Peroxisomes -4.11 -17.19 -7.96 -5.00 7.93 -12.68 2.56 -10.01 -1.25 -10.79 -13.17 -16.38 -12.68 -2.47 3.46
Vacuole -4.47 -4.09 -18.75 -15.19 -16.05 -5.07 -16.81 -15.43 -12.50 5.19 -6.99 -14.05 -24.13 -19.65 -10.86
Vacuole Periphery -1.21 8.75 -1.85 -1.50 -2.75 -2.73 3.12 3.80 4.54 0.61 -2.95 7.07 -0.68 1.53 -2.62
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
ORF
Human Ortholog
Description Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress
Localization
Cell Percentages cytoplasm (85%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

YIL108W

YIL108W


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Yil108w-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available