Standard name
Human Ortholog
Description Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 – 0 0 0 0.13 0 0 – – 0.06 0 0 0 0 0 0
Bud 0 0 0 0.05 0.06 0.06 0.05 0 – 0 0 0 0.06 0 0 – – 0.06 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0.06 – – – – – –
Cell Periphery 0 0.05 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0.25 0 0 0 0 0 0
Cytoplasm 0 0.05 0.05 0.07 0 0 0.05 0 – 0 0 0 0.18 0.17 0.21 – – 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0.06 0 0 0 0 0 0 – 0 0 0 0.09 0 0 – – 0.12 0 0 0 0 0 0
Endosome 0.05 0 0 0 0 0 0 0 – 0 0 0 0 0.11 0.2 – – 0 0.09 0.06 0.11 0.11 0.07 0.06
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0.11 0.07 0.07 – – 0.25 0 0 0 0 0 0
Mitochondria 0.83 0.84 0.96 0.92 0.94 0.93 0.92 0.92 – 0.95 0.95 0.97 0.45 0.43 0.31 – – 0.06 0.76 0.76 0.77 0.58 0.61 0.65
Nucleus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0.07 0 – 0.07 0.06 0.09 0 0 0 – – 0.06 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0.06 0.05 – 0.05 0.05 0 0 0 0 – – 0.06 0 0 0 0 0 0
Peroxisomes 0 0 0 0.05 0 0 0 0 – 0 0 0 0 0.07 0.11 – – 0 0.05 0 0.05 0 0 0.05
SpindlePole 0 0 0 0.05 0 0 0 0 – 0 0 0 0 0.06 0 – – 0 0 0 0 0 0 0
Vac/Vac Membrane 0.16 0.16 0 0 0.07 0.06 0 0.06 – 0 0.05 0 0.12 0.26 0.24 – – 0.12 0 0 0 0.06 0.07 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 5 1 1 0 1 0 0 – 0 0 0 13 3 3 – – 1 1 5 1 5 6 14
Bud 2 5 4 12 18 24 27 20 – 17 11 17 6 5 4 – – 1 0 0 0 2 4 4
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 3 0 0 – – 0 1 2 0 3 4 5
Bud Site 0 2 0 2 3 6 7 7 – 11 8 6 0 0 1 – – 1 – – – – – –
Cell Periphery 7 13 2 7 3 5 2 2 – 3 2 10 2 2 4 – – 4 0 1 0 0 0 1
Cytoplasm 9 13 6 16 13 15 28 21 – 10 15 5 18 40 59 – – 0 1 0 0 3 4 4
Endoplasmic Reticulum 11 16 4 0 0 4 3 0 – 0 2 6 9 9 3 – – 2 0 2 0 3 7 4
Endosome 13 8 1 4 6 0 0 0 – 2 1 0 2 25 56 – – 0 24 19 13 15 20 19
Golgi 6 8 0 0 0 0 0 0 – 0 0 1 11 16 18 – – 4 6 13 1 4 13 11
Mitochondria 203 226 121 219 288 387 497 528 – 526 460 570 46 99 85 – – 1 214 245 101 83 181 204
Nucleus 7 1 0 0 3 12 7 11 – 2 5 4 1 1 3 – – 0 0 0 0 0 2 1
Nuclear Periphery 6 6 4 2 3 17 40 22 – 39 31 55 0 0 1 – – 1 3 1 1 1 1 2
Nucleolus 0 0 1 1 8 10 30 29 – 30 26 26 0 1 1 – – 1 1 0 0 1 0 1
Peroxisomes 4 1 1 13 3 3 2 1 – 4 1 3 0 17 30 – – 0 13 8 6 2 11 16
SpindlePole 11 1 2 11 11 3 15 12 – 11 14 6 4 13 6 – – 0 3 5 0 3 8 3
Vac/Vac Membrane 38 43 2 6 22 27 18 36 – 24 24 19 12 59 65 – – 2 7 11 1 7 20 13
Unique Cell Count 245 269 126 237 308 416 538 574 556 486 586 102 231 276 16 282 323 131 145 296 316
Labelled Cell Count 318 348 149 294 381 514 676 689 679 600 728 127 290 339 18 282 323 131 145 296 316


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.8 5.2 3.7 4.0 4.2 4.4 4.0 4.3 – 4.1 4.2 4.2 6.2 6.2 6.5 – – 7.7 7.3 6.7 7.1
Std Deviation (1e-4) 0.8 0.8 0.7 1.7 1.2 1.4 1.4 1.3 – 1.3 1.3 1.1 1.0 1.1 1.5 – – 1.1 3.1 2.1 2.5
Intensity Change (Log2) – – – 0.11 0.18 0.24 0.09 0.2 – 0.14 0.17 0.17 0.74 0.73 0.8 – – 1.06 0.98 0.85 0.92


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud 0 0 0 0 0 – – 0 – 0 0 0 – – 0
Bud Neck 0 0 0 0 0 – – 0 – 0 0 0 – – 0
Bud Site 0 0 0 0 0 – – 0 – 0 0 0 – – 0
Cell Periphery 0 0 0 0 0 – – 0 – 0 0 0 – – 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum 0 0 0 0 0 – – 0 – 1.8 0 0 – – 0
Endosome 0 0 0 0 0 – – 0 – 0 3.5 5.2 – – 0
Golgi 0 0 0 0 0 – – 0 – 0 3.0 2.9 – – 0
Mitochondria 0 0 0 0 0 – – 0 – -8.6 -9.9 -12.1 – – -9.7
Nuclear Periphery 0 0 0 0 0 – – 0 – 0 0 0 – – 0
Nuc – – – – – – – – – – – – – – –
Nucleolus 0 0 0 0 0 – – 0 – 0 0 0 – – 0
Peroxisomes 0 0 0 0 0 – – 0 – 0 2.7 3.5 – – 0
SpindlePole 0 0 0 0 0 – – 0 – 0 1.8 0 – – 0
Vac – – – – – – – – – – – – – – –
Cortical Patches 0 0 0 0 0 – – 0 – 3.7 0 0 – – 0
Cytoplasm 0.8 -0.3 0 0.2 0 – – 0 – 3.2 3.4 4.2 – – 0
Nucleus 0 0 0 0 0 – – 0 – 0 0 0 – – 0
Vacuole 0 2.3 2.1 0 2.1 – – 1.7 – 3.2 5.7 5.5 – – 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.417 2.8796 2.6202 2.0557 2.4575 3.0177 2.3416 2.348 2.4691 1.7218 2.1487 2.2055 3.1154 2.6151 2.3093 1.7193 2.2175 2.0965
Actin 0.0058 0.0028 0.0057 0.0032 0.0038 0.0016 0.0336 0.0139 0.0283 0.0029 0.0067 0.0153 0.0037 0.0037 0.0068 0.0016 0.0016 0.0037
Bud 0.0004 0.0011 0.0007 0.0004 0.0002 0.0002 0.0006 0.0008 0.0028 0.0002 0.0013 0.0007 0.0006 0.0011 0.001 0.0003 0.0003 0.0002
Bud Neck 0.0012 0.0004 0.0005 0.0083 0.0001 0.0003 0.0007 0.0015 0.0039 0.0002 0.0005 0.0082 0.0001 0.0002 0.0004 0.0006 0.0011 0.0003
Bud Periphery 0.0015 0.0021 0.0013 0.0009 0.0004 0.0005 0.0014 0.0033 0.01 0.0007 0.0055 0.002 0.0029 0.0014 0.0016 0.0006 0.0007 0.0004
Bud Site 0.0027 0.0054 0.0022 0.0014 0.0003 0.0002 0.0017 0.0185 0.0113 0.0003 0.0016 0.0011 0.0004 0.0148 0.0032 0.0009 0.0005 0.0003
Cell Periphery 0.0061 0.0004 0.0002 0.0003 0.0002 0.0001 0.0009 0.0043 0.007 0.0023 0.0045 0.0013 0.0002 0.0002 0.0002 0.0002 0.0001 0.0001
Cytoplasm 0.0018 0.0015 0.0007 0.0004 0.0002 0.0011 0.0077 0.0035 0.0108 0.0006 0.0053 0.0093 0.0001 0.0023 0.0034 0.0004 0.0043 0.0013
Cytoplasmic Foci 0.0162 0.0218 0.0192 0.0167 0.0116 0.0201 0.0331 0.0521 0.0271 0.0505 0.014 0.0377 0.011 0.0107 0.015 0.0056 0.0232 0.0152
Eisosomes 0.001 0.0005 0.0002 0.0002 0.0002 0.0002 0.0022 0.002 0.0023 0.0005 0.0002 0.0004 0.0002 0.0001 0.0003 0.0002 0.0001 0.0001
Endoplasmic Reticulum 0.0014 0.0005 0.0002 0.0002 0.0002 0.0002 0.0034 0.0003 0.0009 0.0001 0.0004 0.0007 0.0001 0.0003 0.0006 0.0001 0.0001 0.0003
Endosome 0.0433 0.038 0.0417 0.0301 0.0254 0.0268 0.0646 0.0498 0.0388 0.02 0.0311 0.0467 0.0283 0.0417 0.0272 0.0265 0.0315 0.028
Golgi 0.0509 0.0307 0.0427 0.046 0.0494 0.0314 0.044 0.0849 0.0275 0.0418 0.0367 0.0393 0.0278 0.0292 0.0336 0.017 0.0498 0.039
Lipid Particles 0.0248 0.0114 0.0162 0.0443 0.023 0.0132 0.0318 0.0109 0.0117 0.0032 0.0047 0.0232 0.0235 0.0134 0.0086 0.001 0.0037 0.0095
Mitochondria 0.796 0.8498 0.8285 0.8041 0.8142 0.8724 0.6569 0.6188 0.7354 0.8031 0.8573 0.733 0.8692 0.8361 0.8637 0.9352 0.8707 0.8639
None 0.0025 0.0006 0.0003 0.0021 0.0002 0.0017 0.0112 0.0535 0.0293 0.0025 0.0004 0.0204 0.0001 0.0081 0.0037 0.0001 0.0001 0.0004
Nuclear Periphery 0.0013 0.0002 0.0002 0.0001 0.0002 0.0004 0.0082 0.0001 0.0012 0 0.0001 0.0003 0.0002 0.0002 0.0004 0 0 0.0004
Nucleolus 0.0005 0.0004 0.001 0.0053 0.0001 0.0002 0.002 0.0012 0.0013 0.0001 0.0003 0.0005 0.0003 0.0002 0.0004 0.0001 0.0001 0.0002
Nucleus 0.0008 0.0003 0.0005 0.001 0.0001 0.0002 0.0012 0.0004 0.0014 0.0001 0.0004 0.0004 0.0001 0.0002 0.0002 0.0001 0.0001 0.0003
Peroxisomes 0.0326 0.0228 0.0267 0.0299 0.0662 0.0219 0.0836 0.0734 0.0366 0.0686 0.0213 0.0533 0.0241 0.0262 0.0249 0.0062 0.0098 0.0292
Punctate Nuclear 0.001 0.0023 0.0001 0.0008 0.0007 0.0039 0.0018 0.0006 0.0007 0.0012 0 0.0003 0.0001 0.0001 0.0002 0 0 0.0001
Vacuole 0.0035 0.0039 0.0057 0.0023 0.0011 0.0015 0.0065 0.0034 0.0091 0.0004 0.0042 0.0031 0.0026 0.0055 0.0026 0.0016 0.0011 0.0035
Vacuole Periphery 0.0048 0.0032 0.0054 0.0022 0.0022 0.002 0.003 0.0027 0.0028 0.0008 0.0036 0.0029 0.0042 0.0043 0.0021 0.0018 0.0012 0.0034

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 33.8765 30.2835 41.7331 40.0003 29.8044 50.7865 39.368 56.8319 66.2665 43.0963
Translational Efficiency 1.8294 1.1751 0.772 1.2569 1.6494 1.9128 1.6129 1.4329 1.4439 1.4665

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
715 918 150 83 1704 2015 462 2217 2419 2933 612 2300

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 594.46 729.38 1116.02 1089.13 684.86 755.83 1045.88 910.62 658.14 747.55 1063.07 917.06
Standard Deviation 76.90 112.33 156.04 121.13 97.37 98.49 127.99 119.80 100.64 103.75 138.73 124.39
Intensity Change Log 2 — 0.295091 0.908711 0.873525 — 0.142253 0.610836 0.411040 — 0.215290 0.756923 0.644442

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000888 0.002680 0.004390 0.004607 0.001102 0.000744 0.005259 0.000923 0.001039 0.001350 0.005046 0.001056
Bud Neck 0.016117 0.017887 0.019525 0.008717 0.009318 0.007341 0.007900 0.007489 0.011328 0.010642 0.010749 0.007533
Bud Site 0.006656 0.026733 0.016192 0.028051 0.016214 0.010817 0.035528 0.028168 0.013389 0.015799 0.030789 0.028164
Cell Periphery 0.001265 0.000922 0.000460 0.001020 0.000712 0.000278 0.000386 0.000392 0.000875 0.000479 0.000404 0.000415
Cytoplasm 0.009094 0.013591 0.002927 0.003895 0.013619 0.011688 0.009011 0.006064 0.012281 0.012284 0.007520 0.005986
Cytoplasmic Foci 0.058202 0.065081 0.085854 0.121388 0.052438 0.068341 0.050162 0.029201 0.054141 0.067321 0.058910 0.032528
Eisosomes 0.000226 0.000142 0.000100 0.000126 0.000104 0.000102 0.000087 0.000059 0.000140 0.000114 0.000090 0.000061
Endoplasmic Reticulum 0.000668 0.000631 0.001657 0.001927 0.000690 0.000312 0.000880 0.000385 0.000683 0.000412 0.001071 0.000441
Endosome 0.029190 0.082774 0.108561 0.105605 0.090795 0.094544 0.096845 0.120879 0.072586 0.090860 0.099717 0.120328
Golgi 0.077704 0.104943 0.074401 0.113325* 0.087540 0.142255* 0.085378 0.060298 0.084633 0.130577* 0.082688 0.062211
Lipid Particles 0.017302 0.007684 0.011037 0.005435 0.009939 0.004421 0.001497 0.001059 0.012116 0.005442 0.003835 0.001217
Mitochondria 0.715993* 0.563727* 0.429611* 0.403323* 0.638206* 0.578678* 0.527961* 0.617976* 0.661198* 0.573999* 0.503855* 0.610230*
Mitotic Spindle 0.002346 0.014946 0.059486 0.059155 0.005827 0.010264 0.082554 0.030705 0.004798 0.011730 0.076900 0.031732
None 0.001438 0.001505 0.000495 0.000243 0.001160 0.000413 0.000295 0.000525 0.001242 0.000755 0.000344 0.000514
Nuclear Periphery 0.000093 0.000081 0.003611 0.000618 0.000150 0.000084 0.000335 0.000171 0.000133 0.000083 0.001138 0.000188
Nuclear Periphery Foci 0.000128 0.000288 0.006748 0.001348 0.000335 0.000121 0.001103 0.000352 0.000273 0.000173 0.002486 0.000388
Nucleolus 0.000978 0.002651 0.005378 0.001156 0.000856 0.000332 0.000481 0.000926 0.000892 0.001058 0.001682 0.000934
Nucleus 0.002739 0.003584 0.003891 0.002898 0.001817 0.001775 0.000939 0.001245 0.002090 0.002341 0.001663 0.001305
Peroxisomes 0.048376 0.064101 0.050320 0.086962 0.039183 0.032150 0.038426 0.026691 0.041900 0.042150 0.041341 0.028866
Vacuole 0.003258 0.014591 0.051603 0.023683 0.014184 0.018666 0.029975 0.036544 0.010955 0.017391 0.035276 0.036080
Vacuole Periphery 0.007338 0.011457 0.063751 0.026517 0.015810 0.016674 0.024997 0.029947 0.013306 0.015041 0.034496 0.029823

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.31 -2.38 -3.17 -1.59 -0.11 1.17 -3.19 0.50 -0.84 3.37 -1.23 -3.83 -0.07 1.23 3.82
Bud Neck -0.46 -0.48 1.70 2.27 1.48 1.36 0.50 1.44 -0.13 0.55 0.42 0.08 2.85 2.63 1.73
Bud Site -7.29 -2.39 -2.71 -0.17 -1.34 3.10 -4.66 -5.33 -8.76 1.86 -1.63 -5.29 -7.43 -6.23 0.91
Cell Periphery 1.15 2.80 0.45 -0.20 -1.16 5.20 3.39 3.83 -3.42 -0.10 3.69 4.34 4.52 1.25 -0.19
Cytoplasm -1.90 3.32 2.31 3.87 -0.50 1.03 1.55 4.93 4.25 1.36 -0.04 2.13 5.09 5.44 0.95
Cytoplasmic Foci -1.41 -2.72 -4.00 -3.55 -1.99 -4.68 0.64 8.95 14.55 5.21 -4.66 -1.01 8.99 14.64 6.66
Eisosomes 2.30 3.41 2.53 0.89 -1.28 0.36 2.02 8.25 8.64 4.30 2.16 4.00 7.01 12.22 5.04
Endoplasmic Reticulum 0.15 -2.81 -1.57 -1.68 -0.33 2.43 -0.93 1.95 -1.53 2.76 2.08 -2.07 1.79 -0.62 4.04
Endosome -10.93 -7.57 -6.79 -1.95 0.20 -0.81 -0.81 -5.82 -5.48 -3.40 -4.95 -4.53 -10.62 -6.76 -3.28
Golgi -3.56 0.30 -2.21 -0.53 -2.16 -10.07 0.34 6.59 17.25 3.54 -10.35 0.36 6.06 17.06 3.38
Lipid Particles 3.35 1.23 3.89 1.02 1.17 3.79 5.93 6.61 4.90 0.81 4.99 4.98 8.95 6.41 2.21
Mitochondria 9.05 9.01 7.47 3.80 0.52 5.17 5.88 1.70 -3.73 -4.98 9.16 9.67 4.92 -3.76 -6.54
Mitotic Spindle -7.51 -5.78 -3.41 -2.64 0.03 -4.14 -9.97 -12.63 -9.55 6.54 -7.59 -11.44 -13.67 -9.50 6.85
None -0.10 1.34 1.71 2.83 2.40 2.81 3.38 2.12 -0.82 -1.81 1.54 3.27 2.33 1.15 -1.42
Nuclear Periphery 0.63 -4.30 -2.14 -2.19 3.51 2.48 -3.20 -0.61 -3.05 2.81 2.57 -4.73 -1.75 -3.80 4.46
Nuclear Periphery Foci -3.37 -2.61 -2.02 -1.75 2.07 3.39 -1.27 -0.16 -3.53 1.24 2.15 -2.85 -1.41 -3.16 2.70
Nucleolus -1.93 -2.24 -0.23 1.44 2.06 1.71 1.31 0.27 -2.23 -1.49 -0.02 -1.05 0.24 0.29 1.28
Nucleus -0.77 -0.83 -0.07 0.42 0.49 0.07 0.75 1.13 0.93 0.12 -0.47 0.27 1.60 1.87 1.01
Peroxisomes -2.57 -0.19 -1.80 -1.05 -1.61 2.10 0.17 3.92 2.08 2.63 -0.11 0.14 4.46 4.94 2.96
Vacuole -6.98 -6.88 -4.17 -1.77 3.27 -2.87 -4.93 -11.93 -9.33 -1.24 -5.36 -8.02 -14.93 -10.62 0.19
Vacuole Periphery -3.62 -5.78 -2.10 -1.65 2.79 -0.61 -2.80 -8.16 -8.34 -1.52 -1.63 -6.08 -10.66 -10.00 1.26
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
Localization
Cell Percentages mitochondrion (89%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Cox5b

Cox5b


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cox5b-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available