Standard name
Human Ortholog
Description Stress-inducible dual-specificity MAP kinase phosphatase; negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock; SDP1 has a paralog, MSG5, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0.09 0.09 0 0 0 0 – 0 0 0 0 0.05 0 0 0.07 0.05 0 0 0 0 0 0.05 0.06
Bud 0 0 0 0.05 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.06 0.06 0.05 0 0 0 – 0 0 0 0 0.06 0.08 0 0.15 0.09 0.09 0 0 0 0 0 0
Cytoplasm 0 0.1 0.06 0.08 0.07 0.05 0 – 0 0 0 0 0.05 0.09 0.09 0.22 0.21 0.26 0 0 0 0 0 0
Endoplasmic Reticulum 0 0.07 0 0 0 0 0 – 0 0 0 0 0.05 0.06 0.07 0.06 0.07 0.08 0 0 0 0 0 0
Endosome 0.14 0 0.21 0.16 0.27 0 0.2 – 0 0.08 0 0 0.12 0.14 0.12 0.15 0.17 0.24 0.11 0.12 0.07 0.11 0.08 0.08
Golgi 0.22 0.06 0.15 0.13 0.12 0 0 – 0 0 0 0 0.33 0.25 0.35 0.15 0.16 0.09 0.12 0.07 0 0.09 0.14 0.13
Mitochondria 0.66 0.79 0.37 0.67 0.35 0.87 0.59 – 0.87 0.84 0.9 0.91 0.6 0.52 0.36 0.13 0.14 0.12 0.64 0.59 0.76 0.64 0.55 0.55
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0.05 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0.06 0.05 0 0 – 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0.05 0.08 0.07
SpindlePole 0 0 0.12 0 0.09 0 0.07 – 0 0 0 0 0 0 0 0.05 0.1 0.05 0 0 0 0 0 0
Vac/Vac Membrane 0.2 0.11 0.23 0.08 0.26 0.13 0.27 – 0.11 0.08 0.06 0.06 0.1 0.15 0.15 0.22 0.22 0.2 0 0.08 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 5 11 11 10 10 1 0 – 0 1 1 2 16 10 14 16 6 5 6 3 2 8 27 30
Bud 2 4 1 14 5 5 7 – 14 16 7 3 5 5 2 4 2 3 0 0 0 0 3 3
Bud Neck 0 0 1 0 0 0 0 – 0 0 0 0 0 0 0 0 2 0 1 1 1 0 4 3
Bud Site 0 0 0 1 0 4 2 – 6 3 2 3 0 0 0 0 0 0 – – – – – –
Cell Periphery 6 7 8 13 7 5 7 – 3 6 2 2 17 26 16 34 11 12 0 0 0 0 2 2
Cytoplasm 5 12 8 23 21 15 16 – 12 8 6 3 14 30 38 50 26 34 1 1 0 0 1 1
Endoplasmic Reticulum 11 8 5 3 2 8 0 – 11 6 6 0 15 19 27 14 9 10 1 4 1 1 5 8
Endosome 36 2 27 43 81 5 95 – 6 35 3 10 36 46 50 33 21 31 33 17 14 36 43 45
Golgi 56 7 19 36 35 3 7 – 7 10 4 1 96 84 145 34 20 12 36 9 5 29 77 70
Mitochondria 172 97 47 181 105 287 283 – 349 377 258 328 176 173 147 30 18 16 198 87 146 206 295 295
Nucleus 0 0 1 4 2 6 15 – 9 5 5 5 0 0 2 3 0 1 0 0 0 0 0 1
Nuclear Periphery 9 1 1 0 1 3 13 – 18 21 8 21 4 2 0 1 0 0 8 0 2 5 7 8
Nucleolus 4 0 1 1 5 6 5 – 15 14 14 9 6 1 2 0 0 0 0 0 0 0 0 4
Peroxisomes 3 1 5 15 14 0 17 – 2 2 1 1 8 11 6 4 1 6 6 3 7 17 42 37
SpindlePole 6 0 16 6 28 4 35 – 15 14 6 12 7 3 2 12 12 7 3 1 5 1 5 7
Vac/Vac Membrane 51 14 29 22 78 44 129 – 45 38 16 21 29 51 63 49 28 26 8 11 1 8 15 13
Unique Cell Count 259 123 128 272 303 331 479 402 449 288 360 292 332 411 227 125 131 312 148 192 323 539 540
Labelled Cell Count 366 164 180 372 394 396 631 512 556 339 421 429 461 514 284 156 163 312 148 192 323 539 540


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.0 6.1 6.9 6.9 7.2 5.0 6.4 – 5.5 5.8 5.3 5.5 7.6 7.3 7.7 7.1 7.6 7.3 6.9 7.1 7.5
Std Deviation (1e-4) 1.0 0.9 1.0 1.4 1.4 1.1 1.5 – 1.1 1.2 1.0 1.0 1.3 1.7 1.3 1.2 1.2 1.2 1.2 1.4 2.3
Intensity Change (Log2) – – – 0.0 0.07 -0.45 -0.11 – -0.33 -0.24 -0.39 -0.31 0.15 0.09 0.17 0.05 0.13 0.08 0.01 0.05 0.13


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -2.1 -2.3 0 0 – 0 0 0 0 -1.2 -2.6 -2.4 -0.5 -1.2 -1.6
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery -0.6 0 0 0 – 0 0 0 0 -0.2 0.6 -1.1 2.4 0.8 0.9
Cytoplasm 0.8 0.3 -0.8 -1.5 – 0 0 0 0 -0.6 1.0 1.1 3.9 3.4 4.3
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0.5 0.8 1.1 0.9 1.1 1.3
Endosome -1.3 1.2 -7.4 -0.3 – -8.0 -4.3 -7.3 -6.7 -2.3 -1.9 -2.5 -1.6 -0.9 0.5
Golgi -0.4 -0.9 -6.3 -6.6 – -6.0 -5.8 -5.5 -7.1 3.8 2.4 4.4 0 0.3 -1.4
Mitochondria 5.6 -0.4 10.8 4.5 – 11.4 10.7 11.3 12.5 4.5 3.0 -0.2 -5.2 -4.1 -4.6
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 2.4 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.7 0.3 0 0 – 0 0 0 0 0 0 0 0 0 0.3
SpindlePole -4.2 -1.0 -5.3 -1.9 – -3.7 -4.2 -4.4 -3.8 -4.2 -5.6 0 -2.4 -0.7 -2.0
Vacuole -4.1 0.7 -2.5 1.0 – -3.3 -4.4 -5.2 -5.4 -3.5 -1.8 -1.9 -0.2 0 -0.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.5864 1.8734 1.5876 1.2787 0.9918 1.442 4.1523 4.4157 3.6438 3.8745 3.2498 3.6734 4.7445 5.0157 4.9198 5.4361 4.3038 4.8811
Actin 0.0171 0.0161 0.0099 0.0091 0.0058 0.0051 0.0563 0.0729 0.0295 0.0046 0.0148 0.0259 0.0471 0.0205 0.0212 0.0179 0.016 0.0142
Bud 0.0018 0.0013 0.0016 0.0016 0.0052 0.0019 0.0009 0.0056 0.0014 0.0009 0.0013 0.0006 0.0008 0.0016 0.0007 0.0008 0.0018 0.0013
Bud Neck 0.0004 0.0004 0.0007 0.0004 0.0008 0.0012 0.0009 0.001 0.0007 0.0003 0.0007 0.001 0.0022 0.0006 0.0007 0.0004 0.0005 0.0009
Bud Periphery 0.0023 0.0018 0.0025 0.0045 0.006 0.0017 0.0016 0.0065 0.0026 0.003 0.0028 0.0014 0.0016 0.002 0.0013 0.0019 0.0064 0.0065
Bud Site 0.0026 0.0064 0.0046 0.0011 0.0062 0.0009 0.002 0.0294 0.0073 0.0008 0.0019 0.001 0.0044 0.0083 0.0023 0.0008 0.0025 0.0009
Cell Periphery 0.0006 0.0004 0.0005 0.0003 0.0007 0.0004 0.0005 0.0019 0.0013 0.0002 0.0003 0.0007 0.0007 0.0006 0.0005 0.0003 0.0009 0.0006
Cytoplasm 0.002 0.0086 0.0031 0.0022 0.0102 0.0035 0.0056 0.0096 0.0105 0.0003 0.0086 0.0014 0.0077 0.0212 0.0033 0.0009 0.0106 0.0037
Cytoplasmic Foci 0.0269 0.0313 0.0249 0.0245 0.0366 0.0283 0.0267 0.0431 0.0263 0.0037 0.0404 0.0145 0.0301 0.0384 0.0251 0.0074 0.0437 0.0244
Eisosomes 0.0005 0.0003 0.0011 0.0002 0.0002 0.0003 0.0006 0.0008 0.0004 0.0002 0.0002 0.0003 0.0005 0.0004 0.0014 0.0013 0.0005 0.0005
Endoplasmic Reticulum 0.0055 0.0011 0.0008 0.0006 0.001 0.0015 0.0047 0.0015 0.004 0.0007 0.0024 0.0011 0.0083 0.0012 0.0016 0.0003 0.0023 0.0007
Endosome 0.1026 0.0704 0.0681 0.0777 0.0714 0.0592 0.1058 0.0819 0.0806 0.0472 0.0872 0.0444 0.0957 0.0921 0.0567 0.0258 0.0457 0.0481
Golgi 0.074 0.081 0.0754 0.0609 0.0502 0.0663 0.0997 0.1473 0.1222 0.0631 0.1398 0.108 0.1043 0.1065 0.0731 0.0603 0.1255 0.0904
Lipid Particles 0.0339 0.0058 0.0061 0.0065 0.0174 0.0139 0.032 0.0037 0.017 0.0016 0.0102 0.0057 0.0187 0.0112 0.0044 0.0024 0.0136 0.0109
Mitochondria 0.6642 0.7443 0.7594 0.772 0.7254 0.7723 0.5666 0.5615 0.6618 0.8622 0.6169 0.7775 0.6018 0.6388 0.7575 0.8718 0.68 0.7447
None 0.0021 0.0025 0.0079 0.0035 0.0087 0.0014 0.0018 0.0006 0.0013 0.0003 0.0025 0.0002 0.0102 0.0017 0.007 0.0007 0.0068 0.0007
Nuclear Periphery 0.0065 0.0003 0.0003 0.0003 0.0055 0.0005 0.0257 0.0003 0.0039 0.0004 0.0123 0.0004 0.0091 0.0006 0.0059 0.0001 0.0034 0.0045
Nucleolus 0.0026 0.0003 0.0003 0.0003 0.0033 0.0003 0.0011 0.0003 0.0003 0.0002 0.0007 0.0002 0.0013 0.0003 0.0004 0.0001 0.0005 0.0001
Nucleus 0.0011 0.0004 0.0004 0.0004 0.0069 0.0004 0.0299 0.0004 0.0015 0.0004 0.0062 0.0002 0.0024 0.0004 0.0017 0.0001 0.0008 0.0003
Peroxisomes 0.0261 0.0198 0.0221 0.0162 0.0196 0.0286 0.0129 0.0204 0.0173 0.0022 0.0194 0.009 0.0366 0.0333 0.0265 0.0044 0.0288 0.0426
Punctate Nuclear 0.0008 0.0002 0.0002 0.0004 0.0056 0.0003 0.0047 0.0002 0.0006 0.0001 0.0249 0.0001 0.0023 0.0002 0.0015 0 0.0007 0.0002
Vacuole 0.0135 0.0045 0.0056 0.008 0.0072 0.0059 0.0093 0.0068 0.0047 0.0039 0.0027 0.0037 0.008 0.0137 0.0037 0.0009 0.0036 0.0014
Vacuole Periphery 0.0127 0.0028 0.0044 0.0093 0.006 0.0062 0.0107 0.0044 0.0051 0.0037 0.0038 0.0026 0.0062 0.0066 0.0036 0.0014 0.0054 0.0026

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 2.6272 3.1314 2.3236 5.586 2.2708 8.7523 5.1449 5.8765 4.7407 3.3521
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
340 1350 844 2256 1707 2347 152 1496 2047 3697 996 3752

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 742.80 908.77 1042.40 981.44 760.65 881.01 1108.57 1056.61 757.69 891.15 1052.50 1011.41
Standard Deviation 94.63 139.25 146.67 141.34 103.45 122.52 123.19 148.59 102.25 129.57 145.30 148.90
Intensity Change Log 2 — 0.290941 0.488863 0.401926 — 0.211926 0.543395 0.474138 — 0.251505 0.516711 0.438913

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001450 0.003821 0.003926 0.016167 0.001010 0.004797 0.012537 0.019233 0.001083 0.004440 0.005240 0.017390
Bud Neck 0.001777 0.003398 0.006766 0.001457 0.002946 0.003017 0.010333 0.002394 0.002752 0.003156 0.007310 0.001831
Bud Site 0.007322 0.028517 0.042559 0.048576 0.013875 0.017712 0.065458 0.083951 0.012787 0.021658 0.046053 0.062681
Cell Periphery 0.001697 0.000431 0.000232 0.001269 0.000471 0.000433 0.001586 0.001298 0.000675 0.000432 0.000439 0.001281
Cytoplasm 0.001950 0.008412 0.015655 0.018657 0.004356 0.006046 0.013595 0.022167 0.003956 0.006910 0.015341 0.020057
Cytoplasmic Foci 0.016363 0.064085 0.147268 0.039570 0.038267 0.042823 0.131790 0.069518 0.034629 0.050587 0.144906 0.051511
Eisosomes 0.000057 0.000088 0.000061 0.000150 0.000071 0.000098 0.000110 0.000155 0.000069 0.000095 0.000068 0.000152
Endoplasmic Reticulum 0.000763 0.000661 0.002951 0.000878 0.000378 0.000276 0.003232 0.001280 0.000442 0.000416 0.002994 0.001038
Endosome 0.032811 0.090264 0.158581 0.053676 0.077721 0.079346 0.168236 0.078052 0.070261 0.083333 0.160055 0.063395
Golgi 0.036318 0.138692* 0.182875* 0.149121* 0.099985 0.131383* 0.129596* 0.189674* 0.089410 0.134052* 0.174744* 0.165290*
Lipid Particles 0.002255 0.001351 0.002665 0.000220 0.001850 0.000807 0.002142 0.000248 0.001917 0.001006 0.002586 0.000231
Mitochondria 0.851953* 0.573357* 0.116117* 0.592918* 0.691511* 0.647872* 0.179184* 0.409368* 0.718160* 0.620662* 0.125742* 0.519733*
Mitotic Spindle 0.003520 0.017161 0.098973 0.020769 0.006568 0.011378 0.090180 0.037673 0.006062 0.013490 0.097631 0.027509
None 0.000237 0.000246 0.000349 0.000266 0.000260 0.000184 0.000182 0.000308 0.000256 0.000206 0.000323 0.000283
Nuclear Periphery 0.000117 0.000163 0.000983 0.000051 0.000058 0.000032 0.000258 0.000118 0.000068 0.000080 0.000873 0.000078
Nuclear Periphery Foci 0.000075 0.000305 0.002501 0.000212 0.000150 0.000074 0.000982 0.000217 0.000137 0.000158 0.002269 0.000214
Nucleolus 0.000172 0.000179 0.000906 0.000016 0.000164 0.000087 0.000455 0.000065 0.000166 0.000121 0.000837 0.000036
Nucleus 0.002278 0.000277 0.003344 0.000288 0.000414 0.000436 0.001553 0.000146 0.000724 0.000378 0.003070 0.000231
Peroxisomes 0.020933 0.037074 0.021739 0.027043 0.033435 0.036752 0.073005 0.032414 0.031358 0.036869 0.029562 0.029184
Vacuole 0.004279 0.015472 0.124283 0.013735 0.011498 0.008800 0.071457 0.024815 0.010299 0.011236 0.116222 0.018153
Vacuole Periphery 0.013675 0.016046 0.067266 0.014959 0.015012 0.007649 0.044129 0.026905 0.014790 0.010715 0.063735 0.019722

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.69 -2.50 -9.92 -8.19 -7.22 -5.73 -2.22 -9.43 -7.10 -1.26 -7.17 -3.74 -14.07 -10.48 -7.63
Bud Neck -2.02 -4.95 0.71 3.57 6.02 -0.13 -1.90 1.07 1.33 2.04 -0.79 -4.67 2.28 3.86 5.85
Bud Site -5.64 -8.91 -11.42 -5.94 -1.34 -1.91 -4.74 -15.99 -15.06 -1.65 -4.88 -10.44 -19.75 -16.17 -4.27
Cell Periphery 2.07 2.40 0.65 -3.00 -3.72 0.42 -1.30 -3.84 -4.04 0.31 1.97 1.39 -2.75 -4.46 -3.74
Cytoplasm -4.14 -6.80 -10.42 -6.71 -0.84 -1.90 -2.92 -11.41 -10.12 -1.81 -3.81 -7.21 -15.54 -12.44 -1.83
Cytoplasmic Foci -12.91 -22.78 -8.09 7.78 19.87 -1.90 -8.14 -10.06 -9.04 5.34 -7.53 -22.06 -8.06 -0.45 18.88
Eisosomes -4.06 -0.61 -9.81 -8.08 -11.60 -5.66 -2.52 -10.86 -7.15 -2.63 -6.63 -0.00 -14.70 -10.27 -13.22
Endoplasmic Reticulum 0.47 -5.15 -0.51 -1.38 5.19 1.49 -1.59 -5.58 -6.53 1.09 0.36 -6.05 -5.20 -5.83 4.63
Endosome -11.01 -18.94 -4.83 9.29 18.48 -0.41 -6.77 -0.08 0.38 6.81 -3.79 -15.72 2.18 7.70 18.60
Golgi -14.88 -16.49 -17.59 -1.56 3.57 -5.88 -2.06 -13.13 -8.58 -4.50 -10.00 -11.27 -15.85 -6.82 0.81
Lipid Particles 0.83 -0.45 1.90 4.41 5.06 3.26 -0.67 5.44 3.92 3.75 2.83 -1.46 5.55 5.85 5.68
Mitochondria 16.92 50.32* 17.28 -1.48 -47.04* 4.06 22.21 23.01 20.53 -9.83 10.52 60.53* 21.25 12.17 -43.87*
Mitotic Spindle -6.71 -13.88 -10.58 -1.75 11.26 -4.33 -5.27 -11.88 -9.77 3.23 -7.13 -14.58 -15.14 -9.03 10.99
None -0.04 -0.93 -0.57 -0.88 0.79 2.16 1.70 -1.21 -5.02 -3.13 1.74 -0.68 -0.77 -4.81 0.47
Nuclear Periphery -0.44 -3.97 0.86 1.62 4.51 2.46 -4.03 -2.40 -3.60 2.61 -0.42 -4.59 -0.61 0.03 4.53
Nuclear Periphery Foci -2.24 -4.82 -1.22 0.58 4.48 2.47 -3.73 -1.15 -3.83 3.50 -0.21 -4.98 -0.94 -0.77 4.79
Nucleolus 0.12 -2.48 1.55 1.95 3.08 1.06 -0.75 1.21 0.48 1.30 0.90 -2.42 1.62 2.14 3.22
Nucleus 1.32 -0.98 1.12 -0.67 3.93 0.09 -2.06 1.53 0.80 2.50 1.09 -3.90 1.01 -0.05 4.56
Peroxisomes -2.98 -0.23 -1.23 2.88 -1.66 -0.95 -3.29 0.34 1.31 3.39 -1.91 0.49 0.86 3.30 0.20
Vacuole -6.67 -21.29 -6.81 0.93 19.77 2.41 -6.55 -7.62 -9.62 5.16 -1.01 -21.37 -7.36 -7.10 19.73
Vacuole Periphery -1.06 -11.75 -0.59 0.71 12.28 7.21 -3.87 -5.79 -10.19 2.20 4.16 -12.91 -3.92 -8.31 11.49
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Stress-inducible dual-specificity MAP kinase phosphatase; negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock; SDP1 has a paralog, MSG5, that arose from the whole genome duplication
Localization
Cell Percentages mitochondrion (99%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Sdp1

Sdp1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sdp1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available