Standard name
Human Ortholog
Description Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.21 0.33 0.41 0.36 0.37 0.34 0.25 0.16 – 0.15 0.16 0.09 0.15 0.15 0.09 0.12 0.08 0.1 0 0 0 0 0 0
Bud 0 0 0.07 0.07 0.07 0.11 0.1 0.14 – 0.15 0.17 0.11 0 0 0 0.05 0.05 0.08 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.93 0.84 0.85 0.83 0.78 0.62 0.51 0.29 – 0.33 0.32 0.23 0.91 0.91 0.92 0.86 0.81 0.74 0.94 0.86 0.89 0.93 0.89 0.9
Cytoplasm 0.05 0.15 0.1 0.17 0.16 0.34 0.48 0.54 – 0.64 0.68 0.73 0.05 0.05 0 0.18 0.22 0.18 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0.06 0.06 0.07 – 0.07 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.06 0 0.08 0 0 0 0.05 – 0.05 0.07 0.05 0 0 0 0.05 0.07 0.12 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0.05 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 45 32 120 92 124 106 89 82 – 75 67 43 138 137 74 19 10 9 5 2 7 3 16 15
Bud 4 4 19 17 23 33 35 72 – 76 72 53 14 14 8 8 6 7 0 0 1 1 2 6
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 1 1 3 9 7
Bud Site 0 0 0 0 1 2 0 1 – 4 1 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 198 81 248 213 257 195 184 147 – 163 137 110 814 814 743 138 105 65 225 100 301 374 530 560
Cytoplasm 10 15 30 43 53 106 175 275 – 320 292 344 47 47 30 29 28 16 0 4 3 1 5 6
Endoplasmic Reticulum 2 0 3 6 11 20 20 37 – 33 16 17 18 20 22 2 2 5 1 1 11 4 10 10
Endosome 0 0 0 0 0 1 1 0 – 3 0 1 0 0 0 0 0 0 1 0 0 0 1 0
Golgi 1 0 0 0 0 0 0 0 – 0 0 0 1 2 1 0 0 0 1 0 0 0 0 1
Mitochondria 3 6 12 20 1 5 9 27 – 24 29 25 3 3 2 8 9 11 2 0 5 5 9 5
Nucleus 2 0 0 1 0 0 3 4 – 5 2 2 2 2 5 2 0 1 0 0 0 0 0 0
Nuclear Periphery 0 0 0 1 0 0 0 24 – 1 1 0 0 0 0 0 0 0 0 1 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 1 0 0 0 0 1 2 0 – 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 1 0 0 2 2 4 3 3 – 1 2 5 5 4 4 0 0 0 0 0 0 0 0 1
Vac/Vac Membrane 0 0 0 0 0 0 1 17 – 6 5 20 1 1 1 0 0 0 0 2 0 5 5 5
Unique Cell Count 214 97 292 257 331 312 362 506 500 431 470 896 891 804 160 129 88 240 117 337 404 595 625
Labelled Cell Count 267 138 432 395 472 473 522 689 711 624 622 1043 1044 890 206 160 114 240 117 337 404 595 625


Cell Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 12.8 14.2 11.4 11.1 11.9 9.5 8.6 7.6 – 6.4 6.5 6.0 13.8 13.8 15.9 16.0 19.2 23.0 13.1 12.6 13.1
Std Deviation (1e-4) 2.4 3.1 2.5 2.2 2.5 2.3 2.4 2.1 – 1.8 1.8 1.5 1.9 1.9 2.5 3.6 5.4 5.7 2.4 2.5 2.6
Intensity Change (Log2) – – – -0.04 0.06 -0.27 -0.42 -0.58 – -0.84 -0.81 -0.93 0.27 0.27 0.48 0.49 0.75 1.01 0.2 0.15 0.19

WT3RAP60RAP140RAP220RAP300RAP380RAP540RAP620RAP70001020WT3HU80HU120HU16001020WT3rpd3Δ_1rpd3Δ_2rpd3Δ_301020WT1AF100AF140AF18001020
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.3 -0.9 -1.8 -4.5 -7.8 – -8.2 -7.7 -10.5 -9.2 -9.2 -12.2 -6.4 -6.8 -5.4
Bud 0.1 0.2 1.8 1.5 3.3 – 3.6 4.1 2.2 -4.5 -4.4 -5.2 -0.6 -0.7 0.5
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cell Periphery -0.7 -2.3 -6.2 -9.2 -15.2 – -14.2 -14.1 -16.5 2.9 3.1 3.7 0.4 -0.9 -2.4
Cytoplasm 2.2 2.1 7.0 10.4 12.3 – 14.7 15.3 16.9 -3.0 -3.0 -4.2 2.4 3.1 2.0
Endoplasmic Reticulum 0 1.9 3.5 3.1 3.9 – 3.6 2.2 2.2 1.1 1.3 1.7 0 0 0
Endosome 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Mitochondria 1.8 -3.3 -1.9 -1.2 0.8 – 0.5 1.5 0.8 0 0 0 0.4 1.2 2.9
Nucleus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 3.8 – 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 3.2 – 0 0 3.6 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 7.6583 11.5 10.2461 9.8148 8.8692 9.754 5.5894 10.8194 7.6014 7.3124 6.6703 8.0125 8.6482 11.5492 10.2527 10.4903 8.5877 11.1204
Actin 0.0719 0.0005 0.0251 0.0333 0.0189 0.0104 0.0271 0.0037 0.0113 0.0002 0.0015 0.0006 0.0004 0.0009 0.0004 0.0005 0.0286 0
Bud 0.0015 0.0004 0.0065 0.0005 0.0114 0.0003 0.0012 0.0007 0.0007 0.0003 0.001 0.0008 0.0001 0.0002 0.0002 0.001 0.0003 0.0001
Bud Neck 0.0045 0.0023 0.0029 0.0032 0.0044 0.0029 0.0048 0.0006 0.0026 0.0012 0.0029 0.0011 0.0009 0.0007 0.0016 0.0011 0.0023 0.0007
Bud Periphery 0.0088 0.0029 0.0052 0.007 0.0479 0.0063 0.0082 0.0046 0.0059 0.0082 0.0186 0.015 0.002 0.0018 0.0027 0.0116 0.0031 0.0047
Bud Site 0.0211 0.0312 0.0178 0.0017 0.0051 0.0005 0.0252 0.0282 0.0076 0.0011 0.0025 0.0006 0.0031 0.0204 0.0116 0.0019 0.0013 0.0002
Cell Periphery 0.6455 0.7707 0.7987 0.7423 0.7215 0.8741 0.6649 0.8802 0.8326 0.9041 0.848 0.9174 0.8804 0.8912 0.8991 0.9122 0.8248 0.9348
Cytoplasm 0.0701 0.1517 0.0924 0.0691 0.0682 0.0375 0.0803 0.0521 0.0475 0.0476 0.0485 0.0269 0.045 0.0472 0.0347 0.0121 0.0207 0.0194
Cytoplasmic Foci 0.012 0.0001 0.0012 0.0041 0.0028 0.0007 0.0374 0.0003 0.0078 0 0.0002 0.0001 0.0027 0.0001 0.0002 0 0.0026 0
Eisosomes 0.0046 0.0005 0.0009 0.0002 0.0003 0.001 0.0031 0.0003 0.0009 0.0008 0.001 0.0004 0.0017 0.0004 0.0008 0.0008 0.0029 0.0001
Endoplasmic Reticulum 0.0335 0.0179 0.0099 0.0373 0.006 0.0206 0.02 0.0115 0.0186 0.0148 0.0337 0.0074 0.0234 0.0131 0.0193 0.0281 0.0252 0.0121
Endosome 0.0136 0.0001 0.0014 0.0017 0.0137 0.0061 0.0212 0.0003 0.0076 0 0.0009 0.0001 0.0021 0 0 0 0.0036 0
Golgi 0.0084 0.0001 0.0014 0.0029 0.0088 0.003 0.0074 0.0007 0.0034 0.0001 0.0005 0.0003 0.0004 0 0.0001 0 0.0035 0
Lipid Particles 0.0144 0.0039 0.003 0.0136 0.0104 0.0024 0.024 0.0006 0.0065 0.0011 0.0038 0.001 0.0024 0.0009 0.0007 0.001 0.0121 0.0009
Mitochondria 0.0148 0 0.0022 0.0009 0.0137 0.0012 0.0017 0.0001 0.0134 0 0.0016 0.0003 0.0001 0 0 0 0.0013 0
None 0.0107 0.0001 0.0005 0.0005 0.0009 0.0003 0.0022 0.0001 0.0036 0.0001 0.0004 0.0001 0.0006 0.0001 0.0051 0.0001 0.0137 0.0001
Nuclear Periphery 0.009 0.0013 0.001 0.0013 0.0038 0.0073 0.0197 0.0007 0.0013 0.0008 0.0013 0.0004 0.003 0.0018 0.0015 0.0014 0.006 0.0008
Nucleolus 0.0062 0.0001 0.0014 0.0001 0.0005 0.0001 0.001 0 0.0002 0 0.0003 0.0001 0.0004 0 0.0001 0 0.0063 0
Nucleus 0.0079 0.0003 0.0038 0.0003 0.0016 0.0008 0.004 0.0002 0.0004 0.0001 0.0007 0.0001 0.0008 0.0001 0.0002 0.0001 0.0084 0.0001
Peroxisomes 0.0074 0 0.0063 0.034 0.0053 0.0003 0.0059 0 0.0008 0 0 0 0.0001 0 0 0 0.001 0
Punctate Nuclear 0.0039 0 0.0003 0.0003 0.0019 0.0008 0.003 0 0.0003 0 0 0 0.0052 0 0.0001 0 0.0238 0
Vacuole 0.0282 0.0159 0.018 0.0454 0.0515 0.0228 0.0357 0.0149 0.0267 0.0195 0.0316 0.027 0.0251 0.0212 0.0216 0.0279 0.0081 0.0258
Vacuole Periphery 0.002 0 0.0002 0.0002 0.0015 0.0004 0.0019 0.0001 0.0005 0.0001 0.0009 0.0002 0.0001 0.0001 0.0001 0.0001 0.0005 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 18.2885 21.1929 32.8 32.8003 30.2984 34.5258 32.1421 31.6109 38.2858 33.0224
Translational Efficiency 0.4994 0.6685 0.4724 0.581 0.45 0.3697 0.5526 0.5838 0.5269 0.5055

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
63 259 1340 246 122 1525 2340 1829 185 1784 3680 2075

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1111.26 1285.63 1568.07 1576.22 1266.81 1164.24 1393.60 1421.12 1213.84 1181.86 1457.13 1439.51
Standard Deviation 156.41 218.14 248.53 273.69 187.02 182.67 341.39 209.46 191.91 193.03 321.94 223.75
Intensity Change Log 2 — 0.210279 0.496794 0.504273 — -0.121812 0.137616 0.165828 — 0.042914 0.316620 0.333892

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.013399 0.001946 0.001660 0.003201 0.000433 0.003256 0.001263 0.009217 0.004848 0.003066 0.001408 0.008504
Bud Neck 0.015367 0.004894 0.002079 0.002858 0.003558 0.003057 0.003476 0.003930 0.007580 0.003323 0.002967 0.003803
Bud Site 0.053299 0.038017 0.021595 0.036049 0.012149 0.032343 0.021758 0.053376 0.026163 0.033166 0.021699 0.051322
Cell Periphery 0.356271 0.922410 0.936827 0.932798 0.943322 0.873161 0.864926 0.595832 0.743407 0.880311 0.891107 0.635781
Cytoplasm 0.147676 0.023086 0.019245 0.016602 0.016786 0.065373 0.093653 0.314547 0.061360 0.059234 0.066559 0.279224
Cytoplasmic Foci 0.024634 0.000777 0.000288 0.000079 0.000175 0.004176 0.001168 0.002715 0.008504 0.003683 0.000847 0.002402
Eisosomes 0.020321 0.000313 0.000880 0.001191 0.000224 0.000862 0.000298 0.000813 0.007068 0.000782 0.000510 0.000858
Endoplasmic Reticulum 0.005969 0.002834 0.002761 0.000802 0.008901 0.005701 0.001189 0.001577 0.007902 0.005285 0.001761 0.001485
Endosome 0.017046 0.000570 0.000448 0.000117 0.000227 0.002039 0.000511 0.001321 0.005954 0.001826 0.000488 0.001178
Golgi 0.000734 0.000380 0.000729 0.000134 0.000281 0.001847 0.000753 0.002730 0.000435 0.001634 0.000744 0.002423
Lipid Particles 0.003872 0.001096 0.001633 0.000634 0.000045 0.001544 0.001939 0.002697 0.001348 0.001479 0.001827 0.002452
Mitochondria 0.000072 0.000498 0.000213 0.000189 0.000047 0.001957 0.000305 0.001511 0.000055 0.001745 0.000272 0.001354
Mitotic Spindle 0.013645 0.000239 0.000492 0.000251 0.000337 0.000325 0.000184 0.000475 0.004869 0.000312 0.000296 0.000449
None 0.000013 0.000012 0.000020 0.000014 0.000003 0.000026 0.000624 0.000047 0.000006 0.000024 0.000404 0.000043
Nuclear Periphery 0.000272 0.000062 0.000814 0.000129 0.000315 0.000222 0.000212 0.000148 0.000300 0.000199 0.000431 0.000146
Nuclear Periphery Foci 0.002136 0.000103 0.000329 0.000158 0.000481 0.000206 0.000190 0.000294 0.001045 0.000191 0.000240 0.000278
Nucleolus 0.000792 0.000014 0.000035 0.000010 0.000008 0.000018 0.000044 0.000024 0.000275 0.000017 0.000040 0.000022
Nucleus 0.006594 0.000084 0.000258 0.000157 0.000056 0.000198 0.000893 0.000817 0.002283 0.000182 0.000662 0.000739
Peroxisomes 0.001497 0.000486 0.000147 0.000043 0.000105 0.001530 0.000500 0.001013 0.000579 0.001379 0.000372 0.000898
Vacuole 0.315685 0.001404 0.008304 0.004245 0.012208 0.001377 0.004981 0.005482 0.115554 0.001381 0.006191 0.005336
Vacuole Periphery 0.000706 0.000775 0.001242 0.000337 0.000339 0.000784 0.001135 0.001433 0.000464 0.000783 0.001174 0.001303

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 3.05 3.18 2.54 -0.81 -1.07 -6.57 -4.10 -11.20 -6.87 -10.16 1.19 2.54 -2.73 -6.93 -10.00
Bud Neck 2.20 3.02 2.79 1.30 -1.13 0.37 0.06 -0.28 -2.08 -0.92 2.30 2.52 2.02 -1.14 -2.23
Bud Site 0.97 2.45 1.06 0.19 -1.73 -3.96 -2.11 -7.93 -5.24 -9.51 -1.36 0.71 -4.49 -4.86 -9.68
Cell Periphery -11.70 -12.24 -11.92 -0.67 0.35 5.38 6.22 23.73 25.33 25.73 -5.08 -5.50 3.34 24.28 27.75
Cytoplasm 5.13 5.39 5.46 1.01 0.60 -7.05 -10.93 -30.23 -28.10 -24.58 0.04 -0.69 -18.07 -27.13 -26.97
Cytoplasmic Foci 3.75 3.83 3.86 2.50 6.61 -4.56 -4.13 -5.98 1.49 -3.09 2.11 3.31 2.68 1.51 -3.79
Eisosomes 2.29 2.22 2.18 -5.11 -1.73 -6.21 -1.26 -8.26 0.45 -7.74 2.05 2.15 2.03 -0.79 -5.52
Endoplasmic Reticulum 1.63 1.81 2.97 2.55 5.72 0.49 1.19 1.13 4.96 -1.26 0.59 1.42 1.48 5.26 1.00
Endosome 3.45 3.48 3.55 2.31 7.71 -4.68 -2.58 -3.81 1.46 -2.70 2.30 3.17 2.71 1.52 -2.68
Golgi 1.49 -0.24 3.14 2.28 7.74 -3.65 -1.71 -3.62 -1.11 -2.71 -3.27 -1.74 -3.34 -1.13 -2.70
Lipid Particles 1.94 1.74 2.59 0.48 1.35 -2.43 -4.19 -4.73 -1.39 -1.06 -0.24 -0.96 -1.79 -1.33 -1.04
Mitochondria -2.29 -3.65 -1.35 1.53 0.30 -3.15 -5.48 -3.15 0.57 -2.58 -3.26 -6.58 -3.17 0.58 -2.63
Mitotic Spindle 0.99 0.97 0.99 -0.23 6.76 0.22 2.98 -1.05 -1.18 -2.19 0.99 0.99 0.95 -1.20 -1.34
None 0.24 -1.53 -0.27 -0.69 1.43 -7.20 -1.63 -8.09 -3.37 1.52 -5.57 -1.65 -7.27 -3.50 1.50
Nuclear Periphery 1.14 -2.73 0.77 -3.22 9.55 1.56 1.73 2.83 5.17 4.91 1.37 -1.66 2.08 4.17 10.46
Nuclear Periphery Foci 4.65 4.17 4.52 -1.46 3.91 3.03 3.44 1.70 -1.20 -1.55 4.95 4.74 4.30 -1.34 -0.68
Nucleolus 1.02 0.99 1.03 1.83 12.88 -5.26 -8.26 -5.39 -2.48 4.26 0.99 0.90 0.97 -2.29 5.40
Nucleus 3.60 3.51 3.56 -2.37 2.78 -9.80 -2.19 -10.17 -8.27 0.25 3.23 2.38 2.42 -8.41 -0.24
Peroxisomes 2.70 4.25 4.59 2.41 4.37 -4.88 -5.93 -10.61 1.73 -5.43 -2.97 1.56 -2.50 1.86 -6.85
Vacuole 7.77 7.62 7.71 -2.62 3.49 3.49 2.32 2.12 -8.15 -0.94 6.50 6.26 6.30 -8.55 1.50
Vacuole Periphery -0.30 -1.56 0.86 3.44 13.61 -3.19 -3.57 -2.91 -1.65 -0.70 -1.94 -3.80 -2.42 -1.51 -0.38
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper
Localization
Cell Percentages cell periphery (75%)
Cell Cycle Regulation No
Subcompartmental Group cell periphery-1

Qdr2

Qdr2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Qdr2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available