Standard name
Human Ortholog
Description DNA-binding transcriptional activator; involved in cell cycle regulation; overexpression promotes recovery from pheromone induced arrest via CLN1/2 transcription, induction of of IME1 during sporulation, and suppression of stress sensitivity resulting from mutation of the E3 ubiquitin ligase Rsp5p; binds upstream of BAR1 and cell cycle-related genes; phosphorylated form may be ubiquitinated by Dma2p; potential Cdc28p substrate; regulated by Swi4/6 cell-cycle box binding factor (SBF)
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.12 0.11 0.21 0.24 0.3 0.24 0.22 0.16 0.13 0.14 0.1 0.09 0.16 0.21 0.27 0.1 0.08 0.16 0 0 0.08 0.06 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.1 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.07 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.4 0.07 0.08 0.14 0.12 0.43 0.59 0.49 0.69 0.6 0.78 0.52 0 0 0 0.06 0.08 0.1 0 0 0.05 0 0 0
Nucleus 0.63 0.69 0.68 0.6 0.54 0.44 0.43 0.46 0.47 0.46 0.49 0.61 0.8 0.76 0.66 0.74 0.64 0.53 0.61 0.62 0.52 0.5 0.53 0.49
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0.11 0.08 0.08
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0.09 0 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0.11 0.05 0.07 0.08 0.07 0.1
Vac/Vac Membrane 0.06 0.15 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0.16 0.18 0.29 0.13 0.15 0.17 0.12 0.12 0.16
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0
Bud 0 1 0 0 1 0 5 13 4 9 2 4 0 0 0 1 0 0 5 9 2 5 13 9
Bud Neck 0 0 3 1 1 0 1 6 1 4 0 2 0 0 0 0 0 0 0 0 0 1 1 2
Bud Site 0 0 0 1 0 4 10 9 9 12 11 6 0 0 0 0 2 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 31 20 19 25 61 43 66 43 37 37 22 23 12 28 42 11 11 9 3 7 10 8 10 9
Endoplasmic Reticulum 0 3 0 1 0 1 0 0 1 0 0 0 0 0 1 4 3 6 0 0 0 0 1 2
Endosome 1 7 1 2 8 1 3 3 0 0 0 0 0 1 6 4 8 4 3 3 1 2 5 9
Golgi 0 0 1 0 0 1 1 0 0 0 0 0 0 0 0 0 1 0 3 1 0 1 1 1
Mitochondria 99 13 7 14 24 77 174 133 194 163 165 138 3 0 1 6 11 6 2 2 6 2 6 4
Nucleus 158 131 61 62 109 79 127 125 132 124 104 161 59 104 101 80 87 31 172 140 69 70 130 122
Nuclear Periphery 0 3 0 0 0 0 1 0 2 0 1 0 0 0 0 0 0 0 4 0 2 0 1 2
Nucleolus 0 4 0 1 0 0 3 1 5 6 6 5 0 0 0 0 3 1 10 11 2 16 18 20
Peroxisomes 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 3 3 4 9 6 7 10 18 7 9 2 10 1 3 3 2 1 0 30 11 9 11 16 24
Vac/Vac Membrane 15 28 2 3 13 8 10 8 11 9 2 8 0 6 3 17 24 17 37 34 22 17 30 39
Unique Cell Count 250 189 90 103 201 180 295 270 282 270 211 265 74 136 153 108 135 58 285 226 134 142 246 252
Labelled Cell Count 307 214 98 119 223 221 411 359 403 373 315 357 75 142 158 125 151 74 285 226 134 142 246 252


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.9 5.4 5.2 4.8 4.7 4.2 3.9 4.3 3.5 3.7 3.2 3.9 5.0 5.4 5.5 7.4 6.5 6.1 5.5 5.8 6.3
Std Deviation (1e-4) 0.7 1.4 1.1 1.6 1.3 1.8 2.0 1.7 1.2 1.0 0.6 0.9 0.9 1.3 1.5 1.6 1.5 1.3 2.0 1.9 1.8
Intensity Change (Log2) – – – -0.11 -0.12 -0.3 -0.4 -0.26 -0.56 -0.46 -0.68 -0.4 -0.06 0.07 0.09 0.51 0.34 0.23 0.11 0.17 0.28


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.5 1.6 0.5 0.3 -1.1 -1.8 -1.7 -2.5 -3.2 -0.8 -0.1 1.1 -2.1 -2.8 -0.8
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 -0.6 0.1 0.5
Nucleus -1.1 -2.2 -3.7 -4.1 -3.5 -3.5 -3.6 -3.0 -1.2 1.7 1.4 -0.3 1.0 -0.5 -1.8
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 3.2 3.6 4.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.8374 1.398 1.2226 0.8 0.6637 1.1725 -0.4545 0.9482 0.1559 0.1153 -0.0395 0.5079 -0.3125 0.4774 0.2654 0.0595 -0.3542 0.0306
Actin 0.0179 0.0001 0.0087 0.0004 0.0318 0.0008 0.0038 0 0 0.0001 0.0015 0.0019 0.0097 0.0004 0.0067 0.027 0.0064 0.0026
Bud 0.0004 0.0001 0.0002 0.0002 0.0002 0 0.0001 0 0 0 0 0 0.0005 0 0.0007 0.0003 0.0001 0.0001
Bud Neck 0.009 0.0003 0.0003 0.0034 0.0023 0.0032 0.0008 0.0002 0.0002 0.0004 0.001 0.002 0.0019 0.0003 0.003 0.0007 0.0005 0.0023
Bud Periphery 0.0007 0.0001 0.0002 0.0006 0.0003 0.0001 0.0001 0 0 0 0 0.0001 0.0009 0 0.0013 0.0006 0.0004 0.0002
Bud Site 0.006 0.0005 0.001 0.0007 0.003 0.0001 0.0004 0.0001 0 0 0.0001 0.0001 0.0019 0.0003 0.0025 0.0009 0.0003 0.0001
Cell Periphery 0.0005 0 0.0001 0.0002 0.0001 0 0 0 0 0 0 0 0.0004 0 0.0006 0.0002 0 0
Cytoplasm 0.0214 0.0151 0.0062 0.0082 0.0083 0.0039 0.0131 0.0028 0.0041 0.0048 0.0039 0.0017 0.02 0.0139 0.0141 0.0148 0.0032 0.0029
Cytoplasmic Foci 0.0163 0.0015 0.0081 0.0012 0.0055 0.0012 0.0046 0.0003 0.0004 0.0001 0.0039 0.0001 0.0097 0.0009 0.0045 0.0033 0.018 0.0011
Eisosomes 0.0003 0 0.0001 0 0.0001 0 0.0001 0 0 0 0.0002 0 0.0002 0 0.0001 0.0002 0.0001 0
Endoplasmic Reticulum 0.0029 0.0009 0.0028 0.0008 0.0009 0.0006 0.0008 0.0002 0.0001 0.0001 0.0001 0.0003 0.0034 0.0004 0.0007 0.0012 0.0006 0.0005
Endosome 0.0191 0.0016 0.0143 0.0049 0.0114 0.0016 0.0024 0.0003 0.0002 0.0001 0.0003 0.0003 0.0141 0.0004 0.016 0.0111 0.0059 0.0027
Golgi 0.0054 0.0001 0.0042 0.0016 0.006 0.0002 0.0004 0 0 0 0.0001 0.0001 0.0047 0 0.0081 0.0114 0.0073 0.001
Lipid Particles 0.0115 0.0005 0.0058 0.0153 0.025 0.001 0.0011 0.0001 0 0 0.0001 0.0001 0.0229 0.0001 0.0034 0.0114 0.0276 0.0068
Mitochondria 0.0089 0.0003 0.0105 0.0041 0.002 0.0053 0.0005 0.0001 0.0001 0.0003 0.0003 0.0002 0.0058 0.0002 0.0078 0.045 0.0046 0.0012
None 0.029 0.0431 0.012 0.0048 0.0332 0.0079 0.0332 0.014 0.003 0.0485 0.0376 0.0072 0.0242 0.0074 0.0211 0.0391 0.0015 0.0119
Nuclear Periphery 0.0266 0.0136 0.0161 0.0172 0.0198 0.0078 0.0126 0.0111 0.0063 0.0068 0.0103 0.0061 0.0252 0.0099 0.0119 0.0053 0.0275 0.0071
Nucleolus 0.0164 0.0116 0.0087 0.0134 0.0287 0.0538 0.0275 0.0184 0.012 0.0105 0.0411 0.0428 0.0202 0.0125 0.0146 0.0081 0.0168 0.043
Nucleus 0.738 0.8883 0.8703 0.8687 0.7556 0.8783 0.8493 0.9106 0.9363 0.8836 0.7191 0.9112 0.7618 0.9345 0.8511 0.7933 0.8536 0.8997
Peroxisomes 0.0104 0.0001 0.0079 0.0011 0.0037 0.0027 0.0007 0 0 0 0 0 0.0129 0.0001 0.0019 0.0022 0.0085 0.0013
Punctate Nuclear 0.0531 0.021 0.0197 0.0486 0.0595 0.0308 0.0469 0.0414 0.0371 0.0445 0.1802 0.0258 0.0528 0.0182 0.0263 0.0225 0.015 0.0143
Vacuole 0.0037 0.0011 0.0013 0.0035 0.0018 0.0003 0.0012 0.0002 0.0001 0.0001 0.0001 0.0001 0.0051 0.0003 0.0023 0.0007 0.0006 0.0006
Vacuole Periphery 0.0022 0.0003 0.0016 0.0011 0.0005 0.0002 0.0003 0.0001 0 0.0001 0.0001 0.0001 0.0018 0.0001 0.0013 0.0006 0.0013 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 3.6571 2.8022 4.8518 10.0915 4.7416 3.1329 3.7777 11.4737 7.4865 4.5552
Translational Efficiency 0.6886 1.7976 2.1476 0.591 0.4909 0.7608 1.4733 0.7565 0.9801 0.7385

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1839 1466 2397 1527 1011 2006 1601 1829 2850 3472 3998 3356

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 726.98 666.09 816.01 884.96 700.12 756.11 872.93 923.30 717.45 718.10 838.80 905.86
Standard Deviation 84.39 110.04 102.14 131.99 81.16 94.59 103.87 135.62 84.24 110.72 106.56 135.33
Intensity Change Log 2 — -0.126199 0.166671 0.283697 — 0.110994 0.318264 0.399197 — -0.004962 0.243032 0.341516

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000103 0.000603 0.000484 0.001215 0.000108 0.000327 0.000460 0.000908 0.000104 0.000444 0.000474 0.001048
Bud Neck 0.003096 0.010754 0.024151 0.026689 0.002064 0.009967 0.007339 0.027930 0.002730 0.010299 0.017418 0.027365
Bud Site 0.000906 0.004961 0.008658 0.010355 0.000351 0.004224 0.001129 0.013160 0.000709 0.004535 0.005643 0.011884
Cell Periphery 0.000136 0.000396 0.000169 0.000169 0.000120 0.000184 0.000107 0.000198 0.000130 0.000273 0.000144 0.000185
Cytoplasm 0.067388 0.081806 0.044426 0.013697 0.050942 0.041712 0.012739 0.026020 0.061554 0.058641 0.031737 0.020413
Cytoplasmic Foci 0.011462 0.015610 0.000742 0.003347 0.007732 0.007346 0.000890 0.005464 0.010138 0.010836 0.000801 0.004501
Eisosomes 0.000027 0.000041 0.000024 0.000030 0.000028 0.000029 0.000023 0.000030 0.000027 0.000034 0.000024 0.000030
Endoplasmic Reticulum 0.001564 0.004715 0.004123 0.009618 0.001525 0.003498 0.003841 0.007085 0.001550 0.004012 0.004010 0.008238
Endosome 0.000810 0.002320 0.001132 0.006866 0.000611 0.002137 0.000634 0.007159 0.000739 0.002214 0.000933 0.007025
Golgi 0.000414 0.001589 0.000183 0.003630 0.000644 0.001010 0.000101 0.004508 0.000496 0.001254 0.000150 0.004109
Lipid Particles 0.003159 0.002979 0.000343 0.000567 0.002496 0.001947 0.000397 0.000588 0.002924 0.002383 0.000365 0.000578
Mitochondria 0.003076 0.004412 0.003081 0.012174 0.001259 0.007553 0.001108 0.009072 0.002431 0.006227 0.002291 0.010483
Mitotic Spindle 0.003373 0.004705 0.011413 0.044805 0.001256 0.006531 0.002370 0.060456 0.002622 0.005760 0.007792 0.053335
None 0.013159 0.046124 0.007003 0.004958 0.011027 0.011373 0.009283 0.013628 0.012403 0.026046 0.007916 0.009683
Nuclear Periphery 0.001936 0.001798 0.002222 0.006053 0.001288 0.002317 0.000974 0.004161 0.001706 0.002098 0.001723 0.005022
Nuclear Periphery Foci 0.000716 0.001871 0.000433 0.002675 0.000683 0.001137 0.000222 0.001009 0.000704 0.001447 0.000348 0.001767
Nucleolus 0.010428 0.023511 0.007210 0.005697 0.011910 0.015085 0.005983 0.007396 0.010954 0.018643 0.006719 0.006623
Nucleus 0.875630* 0.783952* 0.878271* 0.823642* 0.903792* 0.876389* 0.949697* 0.793373* 0.885620* 0.837359* 0.906873* 0.807146*
Peroxisomes 0.001009 0.003014 0.000272 0.000354 0.000824 0.001988 0.000194 0.000873 0.000943 0.002422 0.000241 0.000637
Vacuole 0.001432 0.004088 0.005149 0.016217 0.001193 0.004468 0.002378 0.013756 0.001347 0.004308 0.004039 0.014876
Vacuole Periphery 0.000178 0.000749 0.000512 0.007240 0.000147 0.000778 0.000130 0.003227 0.000167 0.000766 0.000359 0.005053

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -8.71 -15.85 -14.51 -6.54 -8.31 -7.13 -11.01 -19.37 -13.74 -8.64 -11.22 -19.06 -23.39 -13.63 -12.19
Bud Neck -7.39 -18.62 -16.70 -10.13 -0.56 -7.98 -10.85 -20.31 -12.32 -13.88 -10.27 -20.67 -25.80 -15.94 -7.22
Bud Site -5.49 -7.19 -6.53 -2.38 0.27 -5.61 -5.53 -8.60 -3.83 -7.23 -7.37 -7.78 -10.48 -4.46 -2.91
Cell Periphery -6.27 -0.91 -0.08 6.38 1.04 -2.83 1.59 -1.38 2.05 -3.62 -6.58 0.14 -0.85 6.45 -1.23
Cytoplasm -2.77 7.74 17.03 16.98 12.22 2.40 10.98 8.16 8.03 -5.69 1.10 12.68 17.93 18.06 7.16
Cytoplasmic Foci -2.11 10.50 9.19 8.71 -1.35 0.83 7.44 5.81 5.94 -2.36 -0.34 12.78 10.70 10.54 -2.78
Eisosomes -6.03 0.09 -4.63 2.60 -4.97 0.20 1.44 -2.93 -3.89 -5.59 -4.07 1.01 -5.68 -0.87 -7.48
Endoplasmic Reticulum -11.42 -14.41 -16.72 -10.09 -10.00 -8.74 -14.22 -16.76 -11.06 -8.74 -13.76 -19.59 -23.49 -15.03 -13.08
Endosome -4.14 -1.10 -3.56 -1.16 -3.20 -3.29 0.03 -4.37 -1.13 -4.12 -4.73 -0.80 -5.44 -1.62 -5.06
Golgi -2.83 1.60 -2.43 0.21 -3.17 -0.69 1.14 -1.30 -0.90 -2.85 -2.54 1.82 -2.65 -0.61 -4.12
Lipid Particles 0.28 6.81 6.55 6.90 -1.77 1.65 4.99 4.82 6.76 -1.08 1.74 8.42 8.09 9.60 -2.08
Mitochondria -1.78 -0.05 -3.98 -3.10 -4.87 -5.31 0.12 -5.71 1.36 -6.55 -4.70 0.16 -5.76 -0.37 -7.48
Mitotic Spindle -1.23 -5.95 -8.91 -8.39 -5.85 -3.47 -1.91 -11.94 -10.27 -11.14 -3.08 -6.01 -14.68 -13.21 -11.62
None -9.36 5.55 6.55 12.54 2.04 0.08 2.36 1.56 1.59 -1.04 -7.45 5.73 5.21 11.54 -0.69
Nuclear Periphery 0.58 -3.93 -6.95 -7.51 -5.60 -2.55 -0.04 -11.06 -5.80 -11.03 -1.39 -3.37 -11.32 -9.18 -10.34
Nuclear Periphery Foci -2.49 1.69 -1.84 0.39 -3.64 -1.67 1.65 -1.92 0.34 -3.95 -2.44 2.20 -2.13 0.43 -5.19
Nucleolus -6.66 1.58 2.80 8.79 1.44 -1.58 4.43 1.67 3.79 -3.47 -6.00 3.97 2.75 8.89 -1.20
Nucleus 10.55 0.17 3.47 -6.74 3.54 3.43 -7.66 9.44 6.56 18.69 8.49 -4.29 8.66 0.17 13.43
Peroxisomes -4.22 3.82 3.92 6.21 0.24 -2.94 3.67 2.53 5.39 -2.29 -5.03 5.17 4.39 8.25 -1.67
Vacuole -5.47 -9.67 -10.07 -7.81 -5.81 -5.05 -3.47 -11.43 -8.09 -9.21 -6.95 -9.92 -15.18 -11.17 -10.19
Vacuole Periphery -5.67 -2.87 -4.17 -3.29 -3.79 -4.02 0.56 -3.43 -1.24 -3.48 -6.00 -2.64 -5.29 -3.45 -4.85
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description DNA-binding transcriptional activator; involved in cell cycle regulation; overexpression promotes recovery from pheromone induced arrest via CLN1/2 transcription, induction of of IME1 during sporulation, and suppression of stress sensitivity resulting from mutation of the E3 ubiquitin ligase Rsp5p; binds upstream of BAR1 and cell cycle-related genes; phosphorylated form may be ubiquitinated by Dma2p; potential Cdc28p substrate; regulated by Swi4/6 cell-cycle box binding factor (SBF)
Localization
Cell Percentages nucleus (95%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Pog1

Pog1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pog1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available