Standard name
Human Ortholog
Description Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0.05 0 – 0.05 – 0 0.07 0.11 0.1 0.15 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.06 0 0.06 – 0 – 0 0.06 0.1 0.13 0.17 0.1 0.08 0.1 0.13 0.08 0.11 0 0 0 0 0 0
Cytoplasm 0.94 0.94 0.9 0.88 – 0.81 – 0.74 0.75 0.64 0.55 0.53 0.92 0.95 0.96 0.94 1.0 0.98 0.92 0.94 0.91 0.81 0.83 0.75
Endoplasmic Reticulum 0 0.07 0 0.06 – 0.06 – 0.08 0.07 0.14 0.1 0.16 0.06 0 0 0 0 0.05 0 0 0 0.07 0.07 0.11
Endosome 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 – 0.14 – 0.18 0.29 0.26 0.43 0.31 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 – 0 – 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 5 4 2 0 – 3 – 3 6 9 10 18 2 2 0 0 0 1 5 1 1 3 2 5
Bud 1 1 1 0 – 0 – 1 1 0 0 2 2 1 1 0 0 0 6 1 0 1 3 6
Bud Neck 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0 4 0 0 1 0 2
Bud Site 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 11 13 1 1 – 1 – 0 5 8 13 20 21 12 22 19 7 12 0 1 0 0 0 1
Cytoplasm 521 216 35 15 – 52 – 54 63 51 54 62 196 146 215 139 89 103 537 218 65 103 165 168
Endoplasmic Reticulum 25 15 0 1 – 4 – 6 6 11 10 19 12 5 8 5 2 5 12 4 0 9 13 23
Endosome 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0 1 1 0 1 1 2
Golgi 6 0 0 0 – 1 – 0 0 1 4 3 3 1 2 0 0 0 0 0 0 1 1 2
Mitochondria 3 0 0 0 – 9 – 13 24 21 42 36 1 0 0 1 2 1 0 0 0 0 2 1
Nucleus 0 0 0 0 – 0 – 1 1 1 0 0 0 0 0 0 1 0 0 0 0 1 1 0
Nuclear Periphery 0 0 0 0 – 0 – 0 0 0 0 1 0 0 0 0 0 0 2 0 0 0 1 1
Nucleolus 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Peroxisomes 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 9 1 0 0 – 0 – 1 0 2 1 6 0 1 0 3 0 0 3 1 1 1 2 2
Unique Cell Count 556 230 39 17 64 73 84 80 98 117 214 153 224 148 89 105 581 232 72 128 200 223
Labelled Cell Count 581 250 39 17 70 79 106 104 134 167 237 168 248 167 101 122 581 232 72 128 200 223


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 18.8 22.1 11.7 14.3 – 13.5 – 12.9 11.8 12.1 11.9 12.5 18.3 18.7 18.8 23.5 21.9 22.0 18.5 19.7 19.3
Std Deviation (1e-4) 3.3 4.1 2.1 2.3 – 2.6 – 2.4 2.9 2.4 2.4 2.3 3.1 3.3 3.8 5.9 5.1 5.0 4.4 4.0 3.7
Intensity Change (Log2) – – – 0.28 – 0.2 – 0.13 0.01 0.04 0.02 0.09 0.64 0.67 0.68 1.0 0.9 0.91 0.65 0.75 0.72


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 – 0 – 0 0 0 0 1.7 0 0 0 0 0 0
Bud 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 – 0 – 0 0 0 0 2.3 0 0 0 0 0 0
Cytoplasm -0.2 – -1.2 – -2.0 -1.9 -3.0 -3.8 -4.1 0.4 1.4 1.7 0.9 3.1 2.2
Endoplasmic Reticulum 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 – 0 – 0 3.7 3.5 4.9 3.9 0 0 0 0 0 0
Nucleus 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 – 0 – 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 14.153 16.7509 15.0495 14.9417 16.0844 16.5229 11.6762 15.5947 14.4036 15.261 13.4358 14.6869 15.7996 17.9503 16.9363 16.4887 16.2982 17.7254
Actin 0.0346 0.0125 0.0352 0.05 0.0017 0.0065 0.0387 0.0152 0.0363 0.0257 0.0029 0.011 0.0376 0.0056 0.0212 0.0044 0.0133 0.0106
Bud 0.0073 0.0089 0.0288 0.0064 0.0009 0.0016 0.0115 0.0064 0.0234 0.0029 0.0008 0.0019 0.0085 0.0035 0.0208 0.0069 0.0042 0.0021
Bud Neck 0.0026 0.0018 0.0082 0.0052 0.0021 0.0443 0.005 0.0052 0.0059 0.0031 0.0009 0.0439 0.0038 0.0019 0.006 0.0047 0.0029 0.039
Bud Periphery 0.0051 0.0025 0.0146 0.0054 0.0002 0.0017 0.0079 0.0025 0.0243 0.0042 0.0004 0.0022 0.012 0.0013 0.0219 0.01 0.0025 0.0027
Bud Site 0.0174 0.0487 0.0157 0.0008 0.0004 0.0005 0.0213 0.0813 0.0335 0.0003 0.0012 0.0008 0.0306 0.0447 0.0198 0.0008 0.0007 0.0005
Cell Periphery 0.004 0.002 0.0011 0.0025 0.0002 0.0011 0.0026 0.0029 0.0026 0.0005 0.0005 0.0012 0.003 0.0016 0.0024 0.0014 0.0004 0.0011
Cytoplasm 0.7036 0.8511 0.7672 0.7487 0.8832 0.7671 0.638 0.8085 0.7737 0.8902 0.8326 0.7659 0.7165 0.871 0.802 0.8081 0.8401 0.7633
Cytoplasmic Foci 0.0212 0.0324 0.0157 0.0087 0.0317 0.0211 0.0454 0.0171 0.0126 0.0091 0.0273 0.0253 0.0211 0.0166 0.0119 0.0108 0.0129 0.0295
Eisosomes 0.0003 0 0.0002 0.0003 0 0 0.0003 0.0001 0.0001 0 0 0 0.0003 0 0.0001 0 0 0.0001
Endoplasmic Reticulum 0.0702 0.0069 0.017 0.0418 0.0074 0.0568 0.0519 0.0136 0.0107 0.0101 0.0188 0.0386 0.0683 0.0178 0.0289 0.0548 0.028 0.0396
Endosome 0.0492 0.014 0.0338 0.0508 0.0494 0.0518 0.0726 0.0177 0.0288 0.0277 0.0717 0.0509 0.0391 0.0158 0.0275 0.0529 0.0507 0.0574
Golgi 0.0225 0.0062 0.0174 0.0053 0.0056 0.0213 0.0278 0.009 0.011 0.0075 0.0157 0.0308 0.0227 0.0049 0.0129 0.0095 0.0205 0.0294
Lipid Particles 0.0036 0.0005 0.0046 0.0004 0.0002 0.0001 0.0091 0.0009 0.0044 0.0001 0.0015 0.0006 0.0038 0.0007 0.0004 0.0003 0.0001 0.0004
Mitochondria 0.0135 0.0009 0.0114 0.0078 0.0017 0.015 0.01 0.0015 0.0063 0.0021 0.0065 0.0113 0.0067 0.0012 0.0058 0.0041 0.0083 0.0133
None 0.0076 0.0005 0.0039 0.0005 0.0003 0.0005 0.0077 0.0006 0.0008 0.0003 0.0074 0.0009 0.0032 0.0005 0.0005 0.0006 0.0005 0.0009
Nuclear Periphery 0.0115 0.0009 0.0019 0.0048 0.0009 0.0015 0.0144 0.0009 0.0025 0.001 0.0019 0.0024 0.0044 0.0011 0.0015 0.0045 0.0027 0.0019
Nucleolus 0.0005 0.0001 0.0002 0 0.0001 0.0001 0.0004 0.0002 0.0001 0 0.0005 0.0001 0.0004 0.0011 0.0001 0 0 0.0001
Nucleus 0.0049 0.0015 0.0015 0.0019 0.0009 0.0009 0.0059 0.0017 0.0016 0.001 0.0014 0.0018 0.0022 0.0029 0.0013 0.0013 0.0015 0.0012
Peroxisomes 0.0014 0.0009 0.0085 0.0002 0.0002 0.0002 0.003 0.004 0.0029 0.0001 0.0002 0.0004 0.0021 0.0003 0.0003 0.0001 0.0002 0.0006
Punctate Nuclear 0.0049 0.0005 0.0019 0.0001 0.0002 0.0001 0.012 0.0004 0.0004 0.0001 0.0011 0.0005 0.0025 0.0011 0.0001 0.0001 0.0001 0.001
Vacuole 0.0114 0.0063 0.0082 0.0469 0.0095 0.0051 0.0112 0.0091 0.0136 0.0114 0.005 0.0071 0.0085 0.0055 0.0118 0.0169 0.0066 0.0037
Vacuole Periphery 0.0028 0.0008 0.0029 0.0114 0.0034 0.0027 0.0032 0.0011 0.0044 0.0027 0.0018 0.0025 0.0024 0.0009 0.0031 0.0079 0.0037 0.0017

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 89.68 125.834 125.001 96.0715 104.4994 113.4561 133.9 99.0299 128.3283 95.9602
Translational Efficiency 3.1207 2.5505 1.9693 3.4175 2.66 2.1997 1.8509 3.3025 2.0824 2.4085

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1627 1621 341 1219 2063 2015 2560 1681 3690 3636 2901 2900

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1266.95 1578.87 2108.55 2168.27 1323.40 1577.37 1930.28 2126.53 1298.51 1578.04 1951.23 2144.08
Standard Deviation 259.40 286.69 279.01 426.96 273.02 259.61 268.05 392.57 268.57 272.02 275.41 407.90
Intensity Change Log 2 — 0.317533 0.734892 0.775185 — 0.253272 0.544561 0.684252 — 0.285060 0.640790 0.729444

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001269 0.001198 0.006355 0.001309 0.000346 0.001139 0.001222 0.000727 0.000753 0.001165 0.001825 0.000972
Bud Neck 0.001515 0.001328 0.013950 0.002534 0.000880 0.001067 0.002442 0.001553 0.001160 0.001183 0.003795 0.001965
Bud Site 0.127965* 0.112814* 0.141694* 0.038770 0.066733 0.116802* 0.080825 0.035615 0.093732 0.115024* 0.087980 0.036941
Cell Periphery 0.001921 0.003608 0.033822 0.017707 0.002028 0.001880 0.002865 0.014333 0.001981 0.002650 0.006504 0.015751
Cytoplasm 0.560247* 0.623347* 0.471138* 0.799862* 0.693285* 0.653200* 0.825845* 0.832081* 0.634626* 0.639891* 0.784151* 0.818538*
Cytoplasmic Foci 0.199031* 0.130930 0.055914 0.008789 0.115433 0.130227 0.018783 0.009626 0.152293 0.130540 0.023148 0.009274
Eisosomes 0.000016 0.000012 0.000036 0.000009 0.000008 0.000012 0.000007 0.000006 0.000012 0.000012 0.000010 0.000007
Endoplasmic Reticulum 0.006767 0.005608 0.007748 0.000794 0.004455 0.004270 0.000690 0.000605 0.005475 0.004867 0.001520 0.000685
Endosome 0.010926 0.010289 0.019651 0.001923 0.008657 0.008844 0.003088 0.001764 0.009657 0.009488 0.005035 0.001831
Golgi 0.047917 0.062539 0.063208 0.010541 0.035152 0.038968 0.007787 0.010573 0.040780 0.049476 0.014301 0.010560
Lipid Particles 0.001650 0.003609 0.063179 0.023683 0.001915 0.002135 0.008260 0.019621 0.001798 0.002792 0.014716 0.021329
Mitochondria 0.001835 0.001518 0.000080 0.000800 0.001793 0.002071 0.000244 0.000142 0.001811 0.001825 0.000225 0.000419
Mitotic Spindle 0.001937 0.003949 0.006972 0.002595 0.001700 0.003856 0.002137 0.000759 0.001804 0.003897 0.002705 0.001530
None 0.000860 0.000341 0.000290 0.000644 0.000736 0.000187 0.000128 0.000283 0.000790 0.000256 0.000147 0.000435
Nuclear Periphery 0.000041 0.000032 0.000227 0.000116 0.000040 0.000024 0.000024 0.000055 0.000040 0.000028 0.000048 0.000080
Nuclear Periphery Foci 0.001115 0.002046 0.012955 0.003538 0.001509 0.000948 0.001058 0.001796 0.001335 0.001438 0.002456 0.002528
Nucleolus 0.000121 0.000029 0.000050 0.000090 0.000088 0.000047 0.000052 0.000082 0.000103 0.000039 0.000052 0.000086
Nucleus 0.001346 0.000696 0.004313 0.004605 0.001630 0.000628 0.002231 0.002692 0.001505 0.000658 0.002476 0.003496
Peroxisomes 0.000688 0.000987 0.000779 0.000348 0.000548 0.000878 0.000852 0.000489 0.000610 0.000927 0.000843 0.000430
Vacuole 0.009799 0.011413 0.085938 0.074257 0.023006 0.011752 0.035892 0.060721 0.017182 0.011601 0.041775 0.066411
Vacuole Periphery 0.023034 0.023706 0.011699 0.007085 0.040057 0.021063 0.005567 0.006477 0.032551 0.022241 0.006288 0.006733

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.34 -7.57 -0.18 -0.41 7.00 -4.29 -10.71 -6.41 2.01 5.09 -3.00 -8.24 -1.56 0.97 5.05
Bud Neck 0.77 -9.81 -4.36 -5.79 8.80 -1.70 -9.73 -5.25 -4.15 4.97 -0.17 -11.83 -6.34 -7.01 7.57
Bud Site 2.43 -1.36 16.54 14.62 10.76 -10.07 -3.80 8.93 17.73* 13.03 -5.42 1.18 18.27 23.05* 15.87
Cell Periphery -4.54 -9.30 -10.66 -9.24 4.34 0.60 -2.44 -10.77 -10.99 -9.99 -3.11 -8.72 -15.15 -14.26 -9.07
Cytoplasm -5.73 4.91 -22.31 -16.24 -17.85 4.33 -16.61 -16.39 -20.29 -1.17 -0.74 -20.78 -27.13 -26.03 -5.37
Cytoplasmic Foci 10.71 22.77 36.91 30.59 12.73 -3.04 28.61 31.63 32.81 9.22 5.48 41.77 47.34 44.85 14.05
Eisosomes 2.47 -6.75 4.34 2.21 9.28 -3.82 1.91 3.20 6.50 1.72 -0.71 1.70 5.49 6.18 4.32
Endoplasmic Reticulum 1.24 -0.50 8.58 7.38 5.33 0.26 7.35 7.42 6.99 0.70 1.05 8.98 11.34 10.18 4.34
Endosome 0.78 -5.01 13.51 13.09 10.70 -0.29 11.18 14.15 14.10 4.66 0.34 9.82 19.55 19.26 9.74
Golgi -4.74 -3.07 17.68 19.66 12.49 -1.89 19.31 14.14 15.42 -2.35 -4.88 20.36 22.32 24.71 3.52
Lipid Particles -4.62 -12.48 -13.64 -12.15 7.47 -0.73 -9.31 -12.81 -12.54 -7.42 -3.93 -14.48 -18.60 -17.38 -4.97
Mitochondria 1.22 10.65 2.47 1.68 -1.66 -0.79 10.34 11.11 6.00 2.69 -0.06 14.11 6.95 5.43 -1.03
Mitotic Spindle -2.92 -5.05 -0.83 1.17 3.52 -2.56 -1.57 2.36 4.07 4.35 -3.76 -3.00 0.51 3.77 3.03
None 2.08 2.29 0.74 -1.65 -1.95 4.93 5.47 3.72 -1.73 -2.84 4.24 5.15 2.45 -2.14 -3.55
Nuclear Periphery 0.72 -9.87 -2.53 -3.01 3.56 2.08 2.25 -1.36 -2.62 -2.58 1.83 -1.80 -2.86 -3.91 -2.22
Nuclear Periphery Foci -2.65 -10.25 -7.17 -4.25 7.83 1.51 1.81 -1.28 -2.60 -4.68 -0.31 -5.24 -6.06 -4.64 -0.67
Nucleolus 2.10 1.61 0.67 -7.63 -5.81 1.32 1.41 0.21 -1.83 -6.47 2.45 2.09 0.68 -4.22 -8.26
Nucleus 1.91 -6.18 -7.88 -12.13 -1.12 5.65 -4.05 -4.15 -7.85 -1.81 4.74 -5.85 -8.47 -13.81 -4.65
Peroxisomes -1.43 -0.78 7.19 3.10 4.14 -2.92 -4.83 1.11 3.37 5.35 -2.83 -4.26 4.81 4.43 7.53
Vacuole -1.40 -11.47 -18.68 -18.44 1.25 7.26 -7.32 -13.41 -18.21 -7.90 5.53 -14.37 -22.51 -25.87 -9.26
Vacuole Periphery -0.35 6.89 10.65 9.91 3.03 9.03 18.76 17.79 11.90 -1.29 7.10 21.80 20.65 15.39 -0.63
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-5

Tpm2

Tpm2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Tpm2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available