Standard name
Human Ortholog
Description Protein required for localizing proteasomes to the nucleus; involved in cotranslational protein degradation; mediates interaction between nuclear import factor Srp1p and the proteasome; Sts1p and Srp1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation; involved in ubiquitin-mediated protein degradation
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.18 0.24 0.41 0.45 0.87 0.85 0.56 0.58 0.37 0.47 0.29 0.29 0.51 0.86 0.96 0.37 0.41 0.32 0.13 0.15 0.17 0.25 0.64 0.68
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0.08 0 0 0 0 0 0 0 0 0 0 0 0.09 0.07 0.09 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.4 0.05 0 0 0 0.09 0.45 0.46 0.64 0.52 0.76 0.71 0 0 0 0 0 0.05 0.05 0 0.13 0 0.06 0
Nucleus 0.29 0.18 0.15 0.18 0 0 0.08 0.06 0.14 0.09 0.17 0.19 0.24 0 0 0.1 0.06 0.11 0.37 0.41 0.22 0.26 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0.07 0.06 0.05 0.07
Vac/Vac Membrane 0.31 0.66 0.59 0.3 0.13 0.12 0.11 0.06 0.08 0.06 0.06 0.12 0.36 0.17 0.05 0.56 0.59 0.52 0.26 0.25 0.26 0.27 0.09 0.07
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 2
Bud 2 1 0 0 0 0 7 0 3 0 0 0 0 0 0 0 0 0 4 4 1 3 6 6
Bud Neck 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 2 2 0 1 3 4
Bud Site 0 0 0 0 0 0 1 0 0 2 0 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 0 1 1 0 0 0 0 0 0
Cytoplasm 60 33 11 49 135 111 144 65 66 102 34 12 73 195 206 84 96 89 57 24 10 44 117 159
Endoplasmic Reticulum 1 1 0 0 0 0 1 0 0 0 0 0 1 0 1 5 7 10 2 0 0 0 1 1
Endosome 0 1 0 9 3 2 0 0 0 1 0 0 2 3 0 21 16 26 14 6 2 3 3 2
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 5 4 2 1 0 0 0 0
Mitochondria 131 7 0 4 0 12 116 51 116 114 88 30 0 0 0 6 2 15 23 4 8 7 11 8
Nucleus 96 24 4 20 3 4 22 7 25 19 20 8 35 0 1 22 13 29 161 66 14 47 5 7
Nuclear Periphery 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1 12 1 1 0 0 0
Nucleolus 1 1 0 0 0 0 0 0 1 1 0 0 0 0 0 1 1 2 3 0 0 1 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 1 0 2 1 1 2 2 0 2 0 0 0 1 0 2 1 2 22 5 4 11 8 17
Vac/Vac Membrane 101 90 16 33 21 16 28 7 14 14 7 5 52 39 10 128 137 143 114 39 16 48 15 16
Unique Cell Count 326 137 27 109 156 130 259 112 180 218 116 42 143 226 215 227 234 275 437 162 66 178 183 234
Labelled Cell Count 394 159 31 117 163 148 321 132 225 256 149 56 164 238 218 271 281 322 437 162 66 178 183 234


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.7 5.0 5.6 5.2 5.1 4.0 3.7 4.1 3.4 3.9 3.6 3.7 6.1 5.8 5.5 7.4 6.9 6.8 5.7 6.0 6.3
Std Deviation (1e-4) 0.5 0.7 0.8 1.5 1.4 1.5 1.2 1.0 1.2 1.6 1.8 1.3 1.1 1.3 1.0 1.8 1.9 1.9 1.7 2.3 2.1
Intensity Change (Log2) – – – -0.09 -0.14 -0.47 -0.6 -0.45 -0.7 -0.52 -0.63 -0.58 0.12 0.05 -0.02 0.41 0.31 0.28 0.03 0.11 0.18

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.4 5.5 5.1 1.5 1.6 -0.4 0.6 -1.2 -1.0 1.0 5.8 8.9 -0.4 0 -0.9
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 1.1 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -2.8 -5.5 -5.5 0 0 0 0 0 -4.2 -2.2 -5.0 0 -0.3 -0.1 -0.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.0379 0.1043 0.2276 -0.1079 -0.2279 0.1474 0.2235 0.6301 0.5586 0.944 0.4485 0.3915 0.1808 0.0448 -0.1631 0.0695 0.5108 -0.037
Actin 0.0066 0.0008 0.0047 0.003 0.0118 0.0007 0.0304 0.0005 0.0216 0.0035 0.0058 0.0005 0.0427 0.0017 0.0005 0.0108 0.0048 0.0003
Bud 0.0001 0.0018 0.0002 0.0003 0.0002 0 0.0006 0.0002 0.0017 0.0001 0.0007 0.0126 0.0009 0.0033 0.0001 0.0029 0.0015 0.0001
Bud Neck 0.0016 0.0008 0.0098 0.0014 0.0014 0.0017 0.0061 0.0007 0.0044 0.0012 0.0033 0.0023 0.0043 0.0007 0.0006 0.0309 0.0013 0.0022
Bud Periphery 0.0001 0.0005 0.0003 0.0003 0.0002 0 0.0007 0.0002 0.001 0.0001 0.0007 0.0029 0.0011 0.0004 0.0001 0.0031 0.0028 0.0001
Bud Site 0.0008 0.0051 0.0004 0.0006 0.0008 0.0001 0.0027 0.0027 0.0104 0.0003 0.0009 0.0006 0.0147 0.005 0.0007 0.0282 0.0053 0.0002
Cell Periphery 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0003 0.0001 0.0002 0 0.0001 0.0001 0.0003 0.0002 0 0.0014 0.0003 0
Cytoplasm 0.2115 0.2402 0.1457 0.1835 0.1342 0.1188 0.1733 0.2594 0.2204 0.1813 0.164 0.141 0.3363 0.3066 0.2787 0.341 0.4569 0.2676
Cytoplasmic Foci 0.0053 0.0054 0.0058 0.0062 0.0129 0.0064 0.011 0.0038 0.0134 0.015 0.0217 0.007 0.0142 0.0164 0.0078 0.0075 0.0113 0.0059
Eisosomes 0.0001 0.0001 0.0004 0 0.0002 0.0002 0.0003 0 0.0001 0 0.0001 0 0.0004 0.0001 0 0.0001 0.0001 0
Endoplasmic Reticulum 0.0139 0.0063 0.0045 0.0063 0.0031 0.0027 0.0194 0.0064 0.005 0.0061 0.0092 0.0028 0.0129 0.0133 0.0129 0.0082 0.013 0.0052
Endosome 0.0134 0.0075 0.0047 0.0122 0.0165 0.0053 0.0251 0.0063 0.0068 0.0037 0.0122 0.0056 0.0173 0.0077 0.0075 0.0059 0.0308 0.0084
Golgi 0.0011 0.0002 0.0004 0.0006 0.0058 0.0001 0.0033 0.0005 0.0037 0.0014 0.0044 0.0003 0.0069 0.0008 0.0002 0.0002 0.0128 0.0001
Lipid Particles 0.0019 0.0005 0.0015 0.0008 0.0136 0.0007 0.0037 0.0006 0.0028 0.0062 0.0166 0.0009 0.0095 0.0006 0.0005 0.0002 0.0236 0.0003
Mitochondria 0.0014 0.0012 0.0013 0.0023 0.0014 0.0006 0.0017 0.0008 0.0038 0.0011 0.0037 0.0008 0.009 0.0024 0.0006 0.0008 0.0385 0.0006
None 0.3361 0.2491 0.3944 0.1776 0.5428 0.2209 0.1307 0.1829 0.1616 0.1566 0.1334 0.1488 0.0663 0.2048 0.0964 0.1176 0.0509 0.1399
Nuclear Periphery 0.0505 0.0313 0.033 0.0509 0.017 0.0164 0.0418 0.0261 0.0318 0.0251 0.0381 0.0139 0.0419 0.0465 0.0274 0.0276 0.0512 0.0219
Nucleolus 0.0038 0.0049 0.0029 0.0033 0.006 0.0062 0.0037 0.003 0.0034 0.0021 0.0053 0.0056 0.0017 0.0042 0.0021 0.0012 0.0022 0.0023
Nucleus 0.312 0.3921 0.3251 0.4832 0.1698 0.5423 0.4997 0.4798 0.4534 0.5318 0.4336 0.5902 0.3734 0.3424 0.5397 0.3974 0.26 0.5226
Peroxisomes 0.0004 0.0003 0.001 0.0005 0.0033 0.0011 0.0008 0.0003 0.0039 0.0184 0.0581 0.0005 0.0148 0.0008 0.0002 0.0001 0.0064 0.0001
Punctate Nuclear 0.0336 0.046 0.0619 0.0633 0.0571 0.0737 0.0334 0.0211 0.0485 0.044 0.0838 0.0595 0.025 0.0374 0.0213 0.0125 0.0142 0.0186
Vacuole 0.0045 0.0049 0.0015 0.0022 0.0013 0.0017 0.0092 0.0039 0.0017 0.0013 0.0032 0.0036 0.005 0.0039 0.0023 0.0019 0.0082 0.0029
Vacuole Periphery 0.001 0.0008 0.0006 0.0014 0.0005 0.0004 0.002 0.0005 0.0005 0.0005 0.0012 0.0005 0.0014 0.0009 0.0005 0.0005 0.004 0.0006

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 31.0332 20.5495 22.1105 28.0355 18.6278 13.7849 24.4137 31.9034 24.1564 30.6756
Translational Efficiency 1.0471 1.4648 1.3173 0.9975 1.8804 2.9053 1.4363 1.0527 1.4902 1.3753

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1384 1080 180 1594 1505 2358 211 1096 2889 3438 391 2690

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 722.00 700.15 961.92 988.23 670.21 758.96 988.12 994.31 695.02 740.49 976.06 990.71
Standard Deviation 84.81 124.29 101.42 138.01 78.15 94.42 109.02 133.73 85.42 108.22 106.39 136.31
Intensity Change Log 2 — -0.044335 0.413918 0.452848 — 0.179411 0.560073 0.569083 — 0.067712 0.486127 0.509973

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000061 0.000406 0.001167 0.001332 0.000053 0.000262 0.000848 0.000685 0.000057 0.000307 0.000995 0.001069
Bud Neck 0.003625 0.010231 0.003482 0.013028 0.004006 0.014702 0.005367 0.010879 0.003823 0.013297 0.004499 0.012153
Bud Site 0.000831 0.005590 0.002143 0.006807 0.002540 0.007954 0.015035 0.005824 0.001721 0.007212 0.009100 0.006406
Cell Periphery 0.000126 0.000172 0.000249 0.000153 0.000135 0.000376 0.000208 0.000132 0.000130 0.000312 0.000227 0.000144
Cytoplasm 0.275880 0.318102 0.086334 0.081029 0.318813 0.243030 0.122271 0.102103 0.298246 0.266613 0.105727 0.089616
Cytoplasmic Foci 0.078579 0.061680 0.004581 0.002454 0.073067 0.051584 0.010915 0.004539 0.075708 0.054756 0.007999 0.003304
Eisosomes 0.000066 0.000056 0.000098 0.000025 0.000045 0.000168 0.000090 0.000022 0.000055 0.000133 0.000094 0.000024
Endoplasmic Reticulum 0.003112 0.005729 0.017456 0.012226 0.002296 0.003174 0.011553 0.010445 0.002687 0.003977 0.014271 0.011500
Endosome 0.003810 0.006848 0.003908 0.003191 0.002472 0.005970 0.004281 0.002167 0.003113 0.006246 0.004109 0.002774
Golgi 0.000405 0.001553 0.000156 0.001747 0.000701 0.001472 0.000105 0.000733 0.000559 0.001497 0.000129 0.001334
Lipid Particles 0.019234 0.009452 0.003706 0.000617 0.012140 0.010584 0.002837 0.000990 0.015538 0.010229 0.003237 0.000769
Mitochondria 0.003546 0.006277 0.000839 0.003841 0.005240 0.009373 0.000928 0.002023 0.004428 0.008401 0.000887 0.003100
Mitotic Spindle 0.000487 0.011772 0.000821 0.028156 0.001903 0.009511 0.000689 0.022286 0.001225 0.010221 0.000750 0.025765
None 0.010757 0.031329 0.003735 0.007325 0.008052 0.011692 0.011114 0.006324 0.009348 0.017860 0.007717 0.006917
Nuclear Periphery 0.007487 0.005547 0.003749 0.009819 0.004264 0.008353 0.003270 0.006093 0.005808 0.007471 0.003490 0.008301
Nuclear Periphery Foci 0.003152 0.005540 0.010930 0.002800 0.001412 0.001897 0.003171 0.004685 0.002246 0.003041 0.006743 0.003568
Nucleolus 0.005480 0.013785 0.003924 0.001477 0.003155 0.009089 0.003254 0.002658 0.004269 0.010564 0.003562 0.001958
Nucleus 0.569505 0.476041 0.802714 0.795291 0.549914 0.587360 0.739459 0.800205 0.559299 0.552391 0.768579 0.797293
Peroxisomes 0.002911 0.005413 0.000510 0.000332 0.001938 0.004657 0.000468 0.001004 0.002404 0.004894 0.000487 0.000606
Vacuole 0.010446 0.023298 0.049210 0.026322 0.007510 0.017631 0.063881 0.015743 0.008916 0.019411 0.057127 0.022012
Vacuole Periphery 0.000501 0.001179 0.000286 0.002028 0.000344 0.001163 0.000256 0.000458 0.000419 0.001168 0.000270 0.001389

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -8.15 -9.25 -6.11 -3.94 0.64 -3.43 -5.48 -17.38 -9.35 1.23 -6.14 -9.34 -9.21 -6.60 1.02
Bud Neck -6.57 -1.33 -13.53 -6.25 -13.36 -8.71 -1.23 -10.04 -0.43 -6.15 -10.69 -1.66 -16.83 -4.01 -12.63
Bud Site -6.56 -5.06 -6.95 0.15 -3.74 -3.62 -1.86 -2.33 1.41 1.15 -5.84 -2.29 -5.35 1.51 0.64
Cell Periphery -2.73 -5.27 -1.68 1.58 4.63 -4.71 -3.05 -0.09 4.99 4.00 -5.27 -5.79 -1.10 5.08 5.98
Cytoplasm -3.30 18.52 30.16 28.32 1.58 9.49 17.69 32.55 27.08 2.11 5.52 25.08 44.99 40.56 2.85
Cytoplasmic Foci 3.40 21.63 22.80 16.80 4.07 5.29 16.57 20.98 21.41 2.79 6.82 26.31 31.07 27.89 3.90
Eisosomes 1.08 -4.50 8.44 7.39 7.64 -1.79 -8.29 4.26 1.96 9.71 -1.68 -8.89 9.10 2.11 12.20
Endoplasmic Reticulum -5.81 -9.97 -19.07 -11.74 3.19 -3.10 -9.13 -17.41 -15.74 2.67 -5.46 -13.41 -26.42 -22.17 3.94
Endosome -3.85 -0.86 3.13 7.14 4.50 -5.46 -2.18 1.58 7.68 3.42 -6.20 -2.22 3.26 10.04 5.17
Golgi -4.47 3.94 -0.88 2.92 -1.96 -1.89 2.97 1.70 3.29 -1.90 -3.54 3.88 0.47 3.69 -2.54
Lipid Particles 4.77 8.67 10.69 8.24 6.29 1.08 7.58 9.58 12.01 6.24 4.30 11.48 14.30 14.67 9.01
Mitochondria -3.18 4.70 -0.38 3.72 -13.01 -2.99 3.57 2.33 8.66 -8.54 -4.53 5.16 1.72 8.69 -14.85
Mitotic Spindle -5.56 -1.52 -9.28 -4.24 -9.01 -4.28 1.02 -5.76 -3.39 -6.14 -7.00 0.33 -10.70 -5.96 -10.86
None -6.25 5.75 3.64 8.44 -3.36 -3.12 0.52 2.93 6.19 0.88 -6.20 3.60 4.51 10.11 -0.56
Nuclear Periphery 1.67 4.28 -4.82 -6.57 -9.27 -5.12 -1.31 -6.14 0.10 -3.36 -2.77 1.81 -7.50 -4.48 -8.90
Nuclear Periphery Foci -3.28 -1.52 0.49 4.17 1.59 -1.86 -3.18 -2.83 -1.87 1.42 -2.60 -2.51 -2.05 0.36 2.07
Nucleolus -5.60 1.38 5.24 8.06 1.03 -7.26 1.54 1.25 7.38 -0.06 -8.44 1.96 4.72 11.58 0.87
Nucleus 7.44 -11.34 -21.67 -27.14 -0.62 -3.68 -7.41 -24.67 -22.81 -4.87 0.96 -12.62 -32.77 -33.95 -4.11
Peroxisomes -2.92 4.32 4.84 7.59 4.05 -4.95 6.97 5.09 7.94 -0.22 -5.05 6.79 7.00 11.26 1.43
Vacuole -6.65 -7.52 -13.47 -5.96 3.38 -8.71 -8.55 -10.28 -6.33 6.12 -10.43 -11.14 -17.15 -10.23 6.79
Vacuole Periphery -5.10 3.17 -1.00 1.43 -1.79 -7.19 2.06 0.90 6.81 -0.22 -8.37 3.78 -0.89 3.55 -1.85
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein required for localizing proteasomes to the nucleus; involved in cotranslational protein degradation; mediates interaction between nuclear import factor Srp1p and the proteasome; Sts1p and Srp1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation; involved in ubiquitin-mediated protein degradation
Localization
Cell Percentages nucleus (46%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Sts1

Sts1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sts1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available