Standard name
Human Ortholog
Description Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion; protein abundance increases in response to DNA replication stress
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0.05 0 0 – 0 0 0.05 0.08 0.05 0 0 0 0 0 0 0 0 0 0 0.05 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.86 0.85 0.91 0.92 0.9 0.94 – 0.93 0.94 0.91 0.88 0.88 0.91 0.95 0.98 0.73 0.72 0.69 0.27 0.26 0.25 0.23 0.29 0.23
Endoplasmic Reticulum 0.06 0.08 0.05 0.05 0.05 0 – 0 0 0 0 0 0.07 0.05 0 0 0 0 0.15 0.14 0.16 0.26 0.15 0.14
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 – 0 0.07 0.09 0.17 0.18 0 0 0 0 0 0 0 0 0.05 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.08 0.08 0 0 0 0 – 0 0 0 0 0 0 0 0 0.31 0.33 0.35 0.45 0.46 0.47 0.41 0.44 0.51
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 3 0 3 2 10 2 – 3 0 3 2 0 2 1 0 1 0 0 10 4 4 2 5 5
Bud 1 2 7 18 16 18 – 11 25 36 46 35 4 1 0 0 0 0 25 4 6 5 21 7
Bud Neck 0 0 1 0 0 0 – 0 0 0 1 0 0 0 1 0 0 0 12 4 3 0 3 3
Bud Site 0 0 0 0 0 0 – 0 1 1 1 7 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 1 1 10 15 18 – 6 2 4 6 5 4 5 4 1 2 2 1 0 1 0 1 1
Cytoplasm 557 169 268 347 374 575 – 890 702 684 512 617 425 504 628 137 145 141 185 56 79 39 134 125
Endoplasmic Reticulum 37 16 14 17 19 18 – 2 1 5 2 2 32 28 4 5 7 9 106 31 51 44 67 75
Endosome 3 0 0 1 6 5 – 13 6 10 4 3 5 0 1 7 4 9 9 3 2 2 6 9
Golgi 2 1 0 0 1 0 – 0 0 0 0 0 0 0 1 1 0 2 4 2 0 0 2 4
Mitochondria 11 1 7 8 1 5 – 24 55 70 99 129 0 2 1 4 1 4 13 5 14 6 12 16
Nucleus 0 1 1 0 0 3 – 2 1 0 0 1 2 1 1 3 0 1 0 0 0 0 1 1
Nuclear Periphery 1 1 0 0 0 1 – 13 1 0 0 1 0 1 0 0 0 0 0 1 0 0 0 1
Nucleolus 1 0 0 1 1 0 – 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 1 0 1 0 0 0 – 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0
SpindlePole 1 0 0 0 0 0 – 7 1 6 1 3 0 0 0 0 0 0 2 0 0 0 1 3
Vac/Vac Membrane 53 15 2 3 10 20 – 37 18 18 11 18 10 1 4 58 67 71 314 100 152 70 202 276
Unique Cell Count 646 198 294 376 414 614 962 750 752 582 703 467 531 639 187 201 203 692 220 322 173 465 538
Labelled Cell Count 672 207 305 407 453 665 1012 813 837 685 821 484 544 645 217 226 240 692 220 322 173 465 538


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.2 6.4 4.9 5.5 6.9 5.4 – 4.7 3.9 4.2 3.9 4.0 6.2 5.6 5.0 8.0 7.8 7.9 6.7 6.6 6.0
Std Deviation (1e-4) 2.9 2.5 2.6 2.8 2.2 1.7 – 1.3 0.8 0.6 0.6 1.3 2.6 1.6 1.3 2.6 3.2 3.0 3.6 3.1 1.9
Intensity Change (Log2) – – – 0.18 0.5 0.14 – -0.04 -0.33 -0.23 -0.32 -0.3 0.35 0.21 0.04 0.71 0.67 0.7 0.46 0.43 0.3

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 1.4 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 1.6 1.1 0.5 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 2.9 2.6 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.5 -0.4 1.4 – 0.8 1.4 -0.1 -1.4 -1.5 -0.1 2.1 5.2 -5.2 -5.6 -6.2
Endoplasmic Reticulum -0.1 -0.1 -1.4 – 0 0 0 0 0 1.2 0.3 -4.3 -1.1 -0.7 -0.2
Endosome 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria -0.2 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 2.4 – 2.7 1.8 1.8 0 1.9 0 0 0 9.8 10.3 10.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.381 1.0255 0.7976 0.5954 0.6488 0.6621 -0.3034 -0.021 -0.0193 0.4305 0.2038 -0.121 1.9721 2.543 2.3301 2.9566 2.1808 1.9677
Actin 0.0102 0.0004 0.01 0.0001 0.0108 0.0059 0.0266 0.0002 0.0072 0.0436 0.0605 0.0018 0.0161 0.0007 0.0121 0.0018 0.0288 0.004
Bud 0.0005 0.0003 0.0027 0.0002 0.0046 0.0019 0.0005 0.0038 0.0048 0.001 0.0013 0.0002 0.0002 0.0005 0.0007 0.0009 0.001 0.0007
Bud Neck 0.0151 0.0089 0.0012 0.0004 0.0026 0.0035 0.0093 0.0003 0.0018 0.0012 0.0015 0.0031 0.0003 0.001 0.0066 0.0017 0.0036 0.003
Bud Periphery 0.0005 0.0004 0.004 0.0004 0.0028 0.0041 0.0009 0.001 0.0036 0.0014 0.0028 0.0003 0.0002 0.0008 0.0017 0.0012 0.0019 0.0014
Bud Site 0.0029 0.0121 0.0063 0.0002 0.0029 0.0023 0.0105 0.0027 0.009 0.0025 0.0021 0.0004 0.0009 0.0107 0.0126 0.0491 0.0048 0.0011
Cell Periphery 0.0005 0.001 0.0007 0.0002 0.0012 0.0004 0.0011 0.0015 0.0008 0.0005 0.0005 0.0002 0.0004 0.0024 0.0018 0.0009 0.0005 0.0006
Cytoplasm 0.3119 0.4282 0.3684 0.3357 0.3421 0.4842 0.2614 0.3953 0.4698 0.3451 0.277 0.5061 0.2993 0.4431 0.4654 0.3645 0.4254 0.5443
Cytoplasmic Foci 0.0507 0.0252 0.052 0.0369 0.0883 0.048 0.0619 0.0205 0.0381 0.0302 0.0467 0.0515 0.0402 0.0272 0.027 0.0353 0.0357 0.0177
Eisosomes 0.0002 0.0001 0.0005 0 0.0002 0.0001 0.0003 0.0001 0.0001 0.0007 0.0005 0 0.0002 0 0.0003 0.0001 0.0002 0
Endoplasmic Reticulum 0.017 0.0237 0.0163 0.0104 0.0179 0.0129 0.0299 0.0429 0.0215 0.0239 0.0169 0.0181 0.0403 0.0693 0.0444 0.088 0.017 0.0336
Endosome 0.0623 0.0254 0.0781 0.0885 0.1038 0.0391 0.0799 0.0475 0.0753 0.0996 0.149 0.0675 0.0541 0.0489 0.0606 0.0835 0.0704 0.0432
Golgi 0.0045 0.0008 0.0029 0.0008 0.01 0.0015 0.0089 0.0008 0.004 0.0084 0.0185 0.0019 0.0092 0.001 0.0014 0.0012 0.0071 0.0008
Lipid Particles 0.0093 0.004 0.0083 0.0035 0.0483 0.0041 0.0286 0.0086 0.0103 0.0111 0.011 0.0048 0.0263 0.0032 0.0075 0.01 0.0178 0.0015
Mitochondria 0.0035 0.0011 0.0017 0.0023 0.0087 0.002 0.0054 0.0005 0.0045 0.0042 0.0171 0.0013 0.008 0.0006 0.0046 0.0009 0.0074 0.001
None 0.4392 0.4201 0.3719 0.4283 0.1862 0.329 0.3927 0.4011 0.2676 0.2778 0.2585 0.2629 0.4482 0.3127 0.3109 0.2816 0.2244 0.2807
Nuclear Periphery 0.0112 0.0028 0.0078 0.0115 0.0213 0.0121 0.0101 0.0099 0.0075 0.0306 0.023 0.0079 0.0103 0.0087 0.0047 0.0067 0.0051 0.0045
Nucleolus 0.0021 0.0015 0.0016 0.001 0.0064 0.0011 0.0011 0.0006 0.0009 0.0031 0.0007 0.0003 0.0003 0.0004 0.0007 0.0008 0.0016 0.0002
Nucleus 0.0087 0.0059 0.0085 0.0053 0.0137 0.0078 0.0037 0.005 0.0123 0.0173 0.038 0.0115 0.0072 0.0041 0.0046 0.0047 0.0074 0.0058
Peroxisomes 0.0058 0.0005 0.0013 0.0005 0.0261 0.0024 0.0081 0.0001 0.0053 0.0051 0.0087 0.0012 0.0167 0.0004 0.001 0.0007 0.0619 0.0003
Punctate Nuclear 0.0091 0.004 0.0065 0.0187 0.0273 0.0047 0.0074 0.0017 0.003 0.014 0.0056 0.0023 0.0034 0.0021 0.0013 0.0023 0.0106 0.001
Vacuole 0.0322 0.0323 0.0459 0.0471 0.0704 0.0303 0.0482 0.054 0.0472 0.0725 0.0518 0.0529 0.017 0.0594 0.028 0.0605 0.0632 0.0519
Vacuole Periphery 0.0027 0.001 0.0036 0.0079 0.0046 0.0026 0.0035 0.0019 0.0054 0.0062 0.0083 0.0037 0.0014 0.0029 0.0021 0.0036 0.0042 0.0024

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 263.625 251.3756 262.9014 319.476 226.8768 212.8198 313.7933 323.3555 336.1179 363.3228
Translational Efficiency 0.9999 1.2446 1.1748 1.0747 1.1275 1.1779 1.1551 0.9179 0.9588 0.9712

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
27 1258 208 834 1918 1401 1772 1415 1945 2659 1980 2249

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1702.63 812.50 987.18 1134.50 1256.22 822.50 886.05 1119.86 1262.42 817.77 896.67 1125.29
Standard Deviation 2307.62 131.89 120.68 167.86 298.30 131.72 115.51 187.34 405.46 131.89 120.13 180.50
Intensity Change Log 2 — -1.067325 -0.786380 -0.585708 — -0.611002 -0.503629 -0.165771 — -0.855746 -0.659509 -0.392319

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.017678 0.000627 0.001073 0.007612 0.000727 0.000604 0.000855 0.005170 0.000962 0.000615 0.000878 0.006076
Bud Neck 0.007283 0.019680 0.006424 0.007938 0.001302 0.022745 0.013744 0.008364 0.001385 0.021295 0.012975 0.008206
Bud Site 0.087672 0.023110 0.007597 0.026912 0.012122 0.017119 0.024209 0.028050 0.013171 0.019953 0.022464 0.027628
Cell Periphery 0.038792 0.001805 0.000621 0.002319 0.078714 0.003972 0.000833 0.004158 0.078160 0.002947 0.000810 0.003476
Cytoplasm 0.257881 0.352559 0.215675 0.099897 0.037995 0.326807 0.420956 0.141372 0.041047 0.338991 0.399391 0.125992
Cytoplasmic Foci 0.067851 0.191381 0.025408 0.028703 0.014027 0.165731 0.060385 0.024055 0.014775 0.177867 0.056711 0.025779
Eisosomes 0.002111 0.000226 0.000163 0.000583 0.000427 0.000441 0.000305 0.000885 0.000450 0.000340 0.000290 0.000773
Endoplasmic Reticulum 0.252087 0.012292 0.027282 0.432723 0.766360 0.030372 0.076011 0.548320 0.759221 0.021818 0.070892 0.505453
Endosome 0.021417 0.043638 0.010239 0.037141 0.011248 0.043515 0.012212 0.024704 0.011390 0.043573 0.012005 0.029316
Golgi 0.010959 0.003795 0.000187 0.006375 0.003607 0.005597 0.001553 0.009845 0.003709 0.004744 0.001410 0.008558
Lipid Particles 0.034476 0.013099 0.008229 0.053631 0.009825 0.022473 0.024492 0.049686 0.010167 0.018038 0.022784 0.051149
Mitochondria 0.001276 0.003315 0.000410 0.001150 0.001213 0.006121 0.001438 0.002601 0.001214 0.004794 0.001330 0.002063
Mitotic Spindle 0.000440 0.008226 0.000678 0.004480 0.000080 0.003932 0.007052 0.003589 0.000085 0.005964 0.006383 0.003919
None 0.007121 0.001427 0.001925 0.000683 0.001605 0.001006 0.001669 0.001998 0.001682 0.001205 0.001696 0.001511
Nuclear Periphery 0.000506 0.000804 0.003531 0.004038 0.000908 0.001078 0.009270 0.001263 0.000902 0.000949 0.008667 0.002292
Nuclear Periphery Foci 0.011733 0.001889 0.017579 0.055187 0.002254 0.001284 0.023188 0.030695 0.002386 0.001570 0.022599 0.039777
Nucleolus 0.000861 0.001551 0.000587 0.000535 0.000106 0.001420 0.000717 0.000297 0.000117 0.001482 0.000703 0.000385
Nucleus 0.108475 0.054730 0.444101 0.019870 0.001026 0.060845 0.190704 0.019224 0.002518 0.057952 0.217323 0.019463
Peroxisomes 0.002959 0.008081 0.000680 0.001097 0.006084 0.005903 0.002244 0.001408 0.006041 0.006934 0.002080 0.001293
Vacuole 0.065408 0.254811 0.227321 0.205257 0.045679 0.275926 0.127377 0.092379 0.045953 0.265936 0.137876 0.134238
Vacuole Periphery 0.003013 0.002954 0.000288 0.003868 0.004690 0.003107 0.000788 0.001935 0.004666 0.003035 0.000735 0.002652

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.14 2.09 1.26 -3.94 -3.68 0.61 -0.81 -6.37 -6.52 -6.20 1.73 0.31 -6.51 -7.07 -6.70
Bud Neck -3.59 -0.06 -0.62 5.89 -1.33 -13.69 -10.55 -9.53 7.99 3.47 -17.79 -10.99 -12.81 9.86 3.41
Bud Site 1.75 2.18 1.61 -1.27 -6.36 -2.09 -4.44 -6.03 -4.06 -1.85 -3.07 -3.61 -6.49 -3.78 -2.53
Cell Periphery 2.06 2.14 2.04 -0.60 -5.93 23.49 25.75 24.47 -0.27 -9.66 24.63 25.83 24.86 -0.85 -10.86
Cytoplasm -1.54 1.38 2.87 25.88 6.16 -41.24 -55.40 -19.08 21.88 32.86 -53.27 -53.36 -19.33 33.03 36.07
Cytoplasmic Foci -5.64 2.13 1.72 30.77 -3.09 -33.75 -18.66 -5.12 31.06 13.95 -46.27 -17.69 -6.36 43.85 13.34
Eisosomes 2.09 2.17 1.70 -2.38 -2.89 -0.15 1.95 -4.05 -4.47 -6.21 1.68 2.51 -3.05 -5.30 -6.03
Endoplasmic Reticulum 3.40 3.19 -2.17 -28.89 -27.64 101.71 94.63 20.68 -47.28 -43.00 108.33 95.02 27.87 -55.09 -47.24
Endosome -3.49 1.84 -2.30 2.38 -10.53 -16.49 -0.93 -8.21 8.25 -8.09 -20.01 -0.52 -11.72 7.83 -12.37
Golgi 2.46 3.81 1.66 -1.57 -4.95 -2.13 4.68 -4.72 -2.67 -6.59 -1.60 5.41 -4.69 -3.37 -7.59
Lipid Particles 1.67 2.15 -1.51 -10.32 -11.94 -7.97 -9.92 -13.56 -8.78 -8.51 -6.46 -8.96 -16.91 -13.70 -11.57
Mitochondria -1.99 1.90 0.28 2.22 -2.06 -4.06 -0.87 -2.22 2.69 -1.88 -4.56 -0.39 -1.93 3.22 -1.69
Mitotic Spindle -4.20 -1.09 -3.24 1.23 0.06 -3.46 -5.23 -3.26 -0.16 1.47 -5.57 -5.26 -4.67 0.94 1.33
None 0.99 0.96 1.14 1.68 2.31 0.79 0.00 -0.32 -1.21 -0.42 0.59 0.10 0.27 -0.40 0.29
Nuclear Periphery -1.37 -9.38 -5.93 -5.68 -0.56 -0.83 -12.30 -2.48 -1.07 11.50 -0.32 -12.73 -5.84 -5.48 9.78
Nuclear Periphery Foci 2.16 -0.69 -7.40 -15.58 -9.74 2.41 -14.36 -15.08 -15.87 -3.28 2.01 -14.96 -21.06 -22.00 -7.89
Nucleolus -1.75 0.72 0.01 1.43 -0.48 -2.64 -9.10 -2.62 2.22 4.20 -4.47 -9.53 -1.89 2.86 1.07
Nucleus 1.24 -5.58 1.82 9.01 21.23 -26.67 -41.36 -13.61 15.09 35.39 -29.62 -42.85 -11.84 17.25 38.34
Peroxisomes -5.03 3.25 2.38 8.34 -3.53 0.21 7.02 10.58 6.77 2.14 -1.55 7.65 11.15 10.67 2.20
Vacuole -7.97 -6.46 -7.12 1.19 0.34 -33.93 -20.71 -11.70 20.94 5.66 -43.68 -22.98 -21.17 16.39 -0.44
Vacuole Periphery 0.01 1.75 -0.32 -0.55 -3.25 2.73 7.93 4.82 2.37 -2.94 3.09 8.16 3.51 0.98 -3.94
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages ER (90%)
Cell Cycle Regulation No
Subcompartmental Group ER-5

Vtc4

Vtc4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Vtc4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available