Standard name
Human Ortholog
Description Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; role in anaphase progression; required for recovery after DSB repair; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.67 0.8 0.89 0.82 0.98 0.94 0.88 0.94 0.8 0.74 0.65 0.72 0.78 0.87 0.91 0.78 0.65 0.69 0.65 0.67 0.68 0.65 0.69 0.66
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.07 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.05 0 0 0 0.06 0.17 0.07 0.37 0.37 0.54 0.43 0 0 0 0 0 0 0 0 0.05 0 0 0
Nucleus 0.09 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.05 0.05 0.18 0.09 0.07 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.33 0.17 0.13 0.13 0.05 0 0 0 0 0 0 0 0.25 0.17 0.12 0.25 0.37 0.35 0.07 0.11 0.14 0.17 0.16 0.16
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 3 0 2 4 7
Bud 1 2 0 1 0 2 5 0 2 10 6 4 2 1 2 0 0 0 0 1 0 6 9 21
Bud Neck 0 1 1 0 0 0 0 9 1 0 1 2 0 0 0 0 0 0 1 2 1 2 6 15
Bud Site 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 1 1 0 1 1 1 1 0 1 0 0 0 0 0 1 0 0 1 0
Cytoplasm 51 326 113 65 103 234 246 289 239 181 147 124 352 419 475 142 132 134 75 343 127 164 364 384
Endoplasmic Reticulum 2 7 1 1 0 0 0 1 0 0 0 0 2 1 1 5 12 14 0 1 0 3 7 6
Endosome 1 5 0 0 1 0 0 0 0 0 0 1 7 14 12 2 10 10 1 7 0 1 3 4
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 2 1 0 0 2 0 0 1 1
Mitochondria 1 19 0 2 0 15 47 20 111 92 123 74 6 1 2 4 4 4 1 17 9 10 15 9
Nucleus 7 22 5 3 0 4 3 4 6 7 6 5 4 2 1 12 10 10 20 48 13 8 16 17
Nuclear Periphery 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 2
Nucleolus 0 1 0 0 0 0 0 0 0 0 0 0 1 0 1 0 1 0 0 1 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 1 0 0 0 0 1 1 1 0 1 2 0 0 0 0 0 0 1 12 3 4 5 6
Vac/Vac Membrane 25 68 16 10 5 5 5 8 4 10 7 5 113 83 65 46 75 67 8 58 26 43 83 92
Unique Cell Count 76 410 127 79 105 249 278 306 299 246 227 173 451 479 524 181 204 193 115 516 187 253 529 586
Labelled Cell Count 88 453 136 82 109 261 308 332 367 302 292 218 489 522 560 214 246 239 115 516 187 253 529 586


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.2 4.4 5.4 5.0 5.8 4.3 4.4 4.7 3.6 3.6 3.7 4.2 5.4 5.4 5.4 7.1 7.0 6.6 5.0 5.2 5.3
Std Deviation (1e-4) 0.9 0.5 0.9 1.5 2.0 1.5 1.3 1.5 0.8 0.8 1.0 1.2 1.1 1.0 1.1 1.1 1.4 1.4 1.2 2.2 1.5
Intensity Change (Log2) – – – -0.1 0.1 -0.31 -0.28 -0.2 -0.57 -0.58 -0.55 -0.37 -0.01 0.01 0.01 0.4 0.38 0.29 -0.11 -0.06 -0.03

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 2.8 4.8 4.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.5245 2.6096 2.54 2.2704 2.6191 2.3215 1.3959 1.2141 1.2637 0.8816 1.6407 1.2932 0.2873 0.6229 0.3925 0.7181 0.1985 0.4603
Actin 0.0347 0.0003 0.0096 0.0025 0.0343 0.0034 0.0068 0.0008 0.0068 0.0302 0.0358 0.0144 0.0136 0.0006 0.0011 0.0002 0.0029 0.0007
Bud 0.0014 0.002 0.0012 0.0004 0.001 0.0013 0.0037 0.0044 0.0022 0.0008 0.0032 0.0024 0.0003 0.0002 0.0006 0.0002 0.0106 0.0002
Bud Neck 0.008 0.0005 0.0034 0.0074 0.003 0.0028 0.0021 0.0008 0.0033 0.0031 0.0021 0.0066 0.002 0.0003 0.0008 0.0009 0.001 0.0027
Bud Periphery 0.0031 0.0015 0.0023 0.0003 0.0021 0.0053 0.0023 0.003 0.0046 0.0007 0.0078 0.0044 0.0003 0.0001 0.0004 0.0001 0.0064 0.0001
Bud Site 0.0059 0.0052 0.017 0.0041 0.0052 0.0007 0.0053 0.0057 0.0025 0.0032 0.0063 0.0022 0.0037 0.0013 0.0011 0.0003 0.0025 0.0002
Cell Periphery 0.001 0.0001 0.0007 0.0001 0.0007 0.0002 0.0004 0.0002 0.0002 0.0001 0.0008 0.0001 0.0002 0.0001 0.0001 0 0.0001 0
Cytoplasm 0.3355 0.5026 0.3578 0.3499 0.3717 0.4522 0.5442 0.6171 0.4967 0.5467 0.5508 0.5695 0.4929 0.6142 0.4896 0.4739 0.5006 0.5178
Cytoplasmic Foci 0.0308 0.0048 0.0186 0.019 0.0433 0.0242 0.0231 0.0121 0.0118 0.043 0.0357 0.0159 0.0172 0.0062 0.0063 0.0047 0.0122 0.0165
Eisosomes 0.0007 0.0001 0.0003 0.0001 0.0004 0.0001 0.0001 0 0.0001 0.0005 0.0003 0.0001 0.0002 0 0 0 0.0001 0
Endoplasmic Reticulum 0.0088 0.0029 0.0049 0.0038 0.0063 0.0047 0.0173 0.0044 0.0104 0.0041 0.0059 0.0048 0.0071 0.004 0.0046 0.0037 0.0028 0.003
Endosome 0.0254 0.0019 0.0177 0.0079 0.0393 0.0093 0.0371 0.0084 0.0127 0.0181 0.0422 0.0118 0.0122 0.0042 0.0049 0.008 0.0125 0.0066
Golgi 0.0081 0.0001 0.0097 0.0055 0.0161 0.001 0.0043 0.0005 0.004 0.0044 0.0169 0.0032 0.002 0.0002 0.0002 0.0001 0.0021 0.0006
Lipid Particles 0.0161 0.0001 0.0072 0.0163 0.0141 0.001 0.0143 0.0002 0.0081 0.0031 0.0108 0.0031 0.0022 0.0002 0.0002 0.0001 0.0057 0.0012
Mitochondria 0.0139 0.0005 0.0267 0.0039 0.038 0.009 0.0072 0.0009 0.0124 0.0016 0.0472 0.0038 0.0012 0.0006 0.0008 0.001 0.0017 0.0007
None 0.3514 0.3727 0.3659 0.3819 0.2611 0.3568 0.179 0.2303 0.2305 0.142 0.1529 0.1836 0.2937 0.2738 0.3049 0.2742 0.3313 0.2086
Nuclear Periphery 0.0158 0.0033 0.0121 0.0049 0.006 0.0064 0.0374 0.0072 0.0109 0.0084 0.0076 0.0174 0.015 0.0055 0.0094 0.0135 0.0109 0.009
Nucleolus 0.0041 0.0005 0.0026 0.0009 0.0027 0.0011 0.0013 0.0007 0.006 0.0011 0.0008 0.0011 0.0024 0.0006 0.001 0.0014 0.0013 0.001
Nucleus 0.0701 0.094 0.0974 0.1597 0.0875 0.0848 0.0878 0.0898 0.147 0.1338 0.0478 0.1334 0.1018 0.0777 0.1597 0.2028 0.0709 0.2007
Peroxisomes 0.0257 0.0001 0.0125 0.0125 0.043 0.0034 0.0025 0.0003 0.0043 0.0149 0.0064 0.0027 0.006 0.0002 0.0003 0.0001 0.0009 0.0007
Punctate Nuclear 0.0329 0.0056 0.0288 0.0175 0.016 0.0296 0.0126 0.0103 0.021 0.0365 0.0082 0.0158 0.0221 0.0078 0.0118 0.0103 0.0211 0.0278
Vacuole 0.005 0.001 0.0025 0.0011 0.0071 0.002 0.0069 0.0027 0.0038 0.003 0.0062 0.0023 0.0031 0.002 0.002 0.0037 0.0015 0.0014
Vacuole Periphery 0.0016 0.0001 0.0012 0.0003 0.001 0.0005 0.0043 0.0004 0.0008 0.0006 0.0042 0.0013 0.0007 0.0003 0.0004 0.0008 0.0008 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 10.0349 5.0703 5.4989 11.0342 7.071 7.8491 9.3659 9.9811 8.8918 12.6186
Translational Efficiency 0.4883 0.8838 0.9357 0.5055 0.6688 0.6521 0.6292 0.4583 0.7024 0.4962

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1107 644 191 1168 1597 2197 1929 1711 2704 2841 2120 2879

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 652.78 776.79 948.72 895.70 696.46 760.89 868.22 880.17 678.58 764.49 875.47 886.47
Standard Deviation 76.19 122.52 95.40 126.91 83.78 95.51 103.31 137.99 83.56 102.48 105.18 133.82
Intensity Change Log 2 — 0.250928 0.539386 0.456419 — 0.127647 0.318020 0.337742 — 0.188608 0.429364 0.396379

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000083 0.000704 0.001233 0.008262 0.000072 0.000247 0.000593 0.001514 0.000077 0.000350 0.000650 0.004252
Bud Neck 0.004105 0.006455 0.004164 0.020944 0.004171 0.017568 0.007939 0.029233 0.004144 0.015049 0.007599 0.025870
Bud Site 0.002393 0.006495 0.002294 0.053089 0.001966 0.009916 0.005530 0.045876 0.002141 0.009141 0.005238 0.048802
Cell Periphery 0.000109 0.000261 0.000155 0.000310 0.000087 0.000106 0.000136 0.000199 0.000096 0.000141 0.000138 0.000244
Cytoplasm 0.393942 0.412035 0.050177 0.193899 0.457819 0.436318 0.164158 0.282815 0.431668 0.430813 0.153889 0.246742
Cytoplasmic Foci 0.073506 0.106594 0.001329 0.005199 0.080276 0.078741 0.001956 0.013785 0.077504 0.085055 0.001899 0.010302
Eisosomes 0.000061 0.000068 0.000080 0.000042 0.000044 0.000049 0.000022 0.000033 0.000051 0.000053 0.000028 0.000037
Endoplasmic Reticulum 0.000935 0.003178 0.016991 0.006036 0.000955 0.000917 0.002589 0.002984 0.000947 0.001430 0.003887 0.004222
Endosome 0.002327 0.007542 0.001994 0.007464 0.002183 0.003810 0.000963 0.015889 0.002242 0.004656 0.001056 0.012471
Golgi 0.000846 0.001966 0.000105 0.005642 0.000488 0.001271 0.000298 0.010990 0.000634 0.001428 0.000281 0.008820
Lipid Particles 0.004419 0.005974 0.001974 0.001040 0.003449 0.002968 0.000462 0.002198 0.003846 0.003649 0.000599 0.001728
Mitochondria 0.003058 0.002307 0.001021 0.010514 0.001996 0.007353 0.001234 0.008038 0.002431 0.006209 0.001215 0.009043
Mitotic Spindle 0.002646 0.005781 0.002840 0.061943 0.003630 0.006392 0.007279 0.100117 0.003227 0.006254 0.006879 0.084630
None 0.006900 0.005852 0.002399 0.012870 0.004890 0.005512 0.008587 0.012957 0.005713 0.005589 0.008030 0.012922
Nuclear Periphery 0.001037 0.001230 0.002793 0.002861 0.000948 0.000934 0.001868 0.003978 0.000984 0.001001 0.001952 0.003525
Nuclear Periphery Foci 0.000629 0.002184 0.001359 0.001683 0.000484 0.000344 0.000241 0.002380 0.000544 0.000761 0.000342 0.002097
Nucleolus 0.001568 0.003336 0.001508 0.000549 0.001088 0.002160 0.000803 0.001487 0.001285 0.002426 0.000866 0.001106
Nucleus 0.484415 0.372304 0.864310 0.562351 0.415958 0.392097 0.779937 0.374959 0.443984 0.387610 0.787538 0.450983
Peroxisomes 0.001738 0.003219 0.000319 0.001110 0.001832 0.005582 0.001202 0.002696 0.001794 0.005046 0.001122 0.002053
Vacuole 0.014864 0.051391 0.042740 0.041983 0.017367 0.027078 0.014028 0.076004 0.016342 0.032589 0.016615 0.062202
Vacuole Periphery 0.000418 0.001124 0.000218 0.002207 0.000297 0.000640 0.000174 0.011869 0.000347 0.000749 0.000178 0.007949

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.84 -11.68 -3.07 -2.08 -0.88 -4.31 -4.32 -4.07 -2.96 -1.36 -3.33 -5.89 -4.17 -3.24 -2.45
Bud Neck -2.26 -2.62 -8.60 -7.31 -6.95 -9.70 -4.48 -9.43 0.25 -5.41 -9.84 -4.74 -12.75 -1.84 -7.28
Bud Site -2.42 -2.07 -6.83 -4.75 -6.16 -6.40 -3.00 -8.55 -3.94 -7.02 -6.70 -3.05 -10.90 -5.72 -9.04
Cell Periphery -1.49 -5.03 -4.83 0.66 0.41 -2.17 -2.59 -4.68 -2.20 -1.43 -1.83 -2.73 -6.62 -0.53 -3.18
Cytoplasm -0.53 31.23 27.23 22.13 -9.92 2.56 42.44 27.06 26.36 -13.78 0.54 48.45 37.47 37.06 -12.38
Cytoplasmic Foci -4.40 19.27 19.12 17.55 -1.38 0.40 25.03 23.52 25.77 -5.87 -1.91 31.55 30.30 31.42 -5.85
Eisosomes -1.37 -4.37 0.90 3.75 6.16 -1.30 4.94 0.12 1.60 -6.24 -0.74 3.39 0.87 2.37 -4.63
Endoplasmic Reticulum -5.30 -14.60 -19.35 -9.48 8.42 0.22 -17.39 -17.16 -17.20 0.77 -4.13 -20.56 -25.25 -20.79 -0.43
Endosome -6.11 -0.78 -0.07 5.28 0.52 -4.22 5.06 -3.19 -0.81 -5.27 -6.75 5.19 -2.66 2.01 -5.30
Golgi -1.09 1.76 -0.55 0.69 -2.13 -2.36 1.53 -2.92 -1.75 -3.44 -2.23 2.14 -2.79 -1.12 -3.94
Lipid Particles -1.72 3.12 5.45 6.71 3.31 1.12 8.54 5.62 5.79 -3.44 0.47 10.03 7.81 9.05 -4.22
Mitochondria 0.70 1.65 -0.79 -1.85 -3.15 -5.54 1.31 -3.12 3.58 -5.95 -4.49 2.05 -2.40 2.70 -5.93
Mitotic Spindle -1.44 -0.85 -8.41 -7.33 -7.78 -1.71 -3.91 -12.41 -11.78 -10.14 -2.36 -4.44 -14.97 -13.82 -11.54
None 1.01 6.65 -2.42 -3.32 -8.64 -0.94 -2.11 -5.90 -5.78 -3.60 0.22 -0.75 -6.10 -6.81 -4.49
Nuclear Periphery -1.70 -9.73 -17.04 -16.59 -8.82 -0.10 -16.61 -15.95 -15.97 -6.75 -0.64 -17.32 -23.12 -23.27 -10.96
Nuclear Periphery Foci -4.00 -3.93 -4.54 2.08 0.79 2.41 0.42 -4.11 -5.35 -4.34 -2.22 -0.36 -6.07 -2.95 -5.90
Nucleolus -2.14 1.12 2.00 3.12 1.28 -3.52 1.07 -1.29 2.82 -3.20 -3.83 2.22 0.26 4.48 -2.76
Nucleus 7.76 -18.44 -12.29 -18.40 10.09 2.54 -43.34 -9.33 -12.20 29.83 7.35 -46.94 -14.74 -22.00 30.11
Peroxisomes -2.79 4.45 4.44 6.68 0.32 -4.64 2.07 2.02 6.76 -0.23 -5.40 2.73 3.53 8.21 0.09
Vacuole -9.87 -7.17 -18.48 -6.78 -1.86 -5.16 -6.53 -22.76 -20.57 -18.19 -10.71 -9.53 -29.23 -22.50 -19.87
Vacuole Periphery -2.91 1.48 -0.46 1.64 -1.13 -3.86 2.06 -4.29 -3.73 -4.59 -4.55 3.01 -4.23 -3.17 -4.81
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; role in anaphase progression; required for recovery after DSB repair; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p
Localization
Cell Percentages cytoplasm (28%), nucleus (12%), mixed (47%)
Cell Cycle Regulation Yes
nucleus - S/G2 (1.4e-06)
Subcompartmental Group N/A

Rtt101

Rtt101


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rtt101-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available