Standard name
Human Ortholog
Description Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.15 0.2 0.33 0.25 0.24 0.15
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.07 0 0 0.06 0.08
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.07 0.1 0.09 0.12 0 0 0 0 0 0 0 0 0.17 0.2 0.12 0 0.07 0.1 0.15 0.24 0.28 0.21 0.25 0.23
Cytoplasm 0.92 0.94 0.9 0.91 0.91 0.85 0.74 0.75 0.67 0.7 0.51 0.58 0.98 0.97 0.99 0.95 0.95 0.95 0.28 0.32 0.11 0.29 0.28 0.31
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.14 0.12 0.09 0.1 0 0 0.05 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.1 0 0 0.11 0.14 0.35 0.42 0.32 0.53 0.5 0.64 0.65 0 0 0 0.05 0 0 0.12 0.06 0.1 0.07 0.06 0.09
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 2 11 14 3 0 0 0 0 0 0 0 0 1 4 1 0 1 1 31 79 108 29 70 39
Bud 1 2 7 5 6 10 3 7 15 19 2 9 1 1 1 0 2 0 4 4 3 0 5 7
Bud Neck 2 7 4 1 2 0 1 1 0 2 0 0 1 2 2 2 1 1 13 29 14 3 17 20
Bud Site 0 0 0 2 1 1 0 0 2 5 1 4 0 0 0 0 0 0 – – – – – –
Cell Periphery 14 37 27 36 11 9 10 4 7 9 1 1 29 61 31 16 18 16 30 93 93 25 72 60
Cytoplasm 177 346 282 273 338 346 373 273 337 437 57 148 162 303 255 371 252 146 58 126 35 34 83 82
Endoplasmic Reticulum 0 7 4 4 0 1 4 1 5 0 1 1 0 1 0 55 33 14 21 12 12 6 11 5
Endosome 1 0 0 0 2 0 2 1 0 1 1 0 0 1 0 5 0 0 4 2 6 0 4 5
Golgi 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 3 2 1 0 1 0
Mitochondria 20 2 10 32 52 141 212 115 268 317 71 167 2 1 1 18 11 3 25 24 33 7 16 24
Nucleus 1 0 0 0 0 1 1 1 5 4 1 2 1 0 2 1 1 0 0 0 0 1 0 0
Nuclear Periphery 0 2 0 1 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 1 1 0 0 0
Nucleolus 3 0 1 1 0 0 1 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 1 1 2 3 0 1 0 0 1 0 0 0 1 0 3 0 1 0 0 2 0 0 0
SpindlePole 1 2 6 7 4 1 8 7 2 12 0 6 1 0 0 5 1 1 0 0 1 0 0 1
Vac/Vac Membrane 0 0 0 0 1 1 2 3 3 4 0 2 0 0 0 2 5 1 6 11 5 4 2 8
Unique Cell Count 193 369 312 299 371 408 505 363 504 628 111 257 166 312 258 390 265 154 206 396 327 118 292 263
Labelled Cell Count 222 418 356 367 420 511 619 414 644 811 136 340 199 375 293 478 327 184 206 396 327 118 292 263


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.1 4.6 4.3 3.9 4.1 3.4 3.0 3.4 3.0 2.8 3.2 2.8 4.9 4.6 4.9 5.6 6.2 6.3 4.5 4.5 5.4
Std Deviation (1e-4) 1.6 0.7 1.3 1.1 1.7 1.3 1.1 1.4 1.0 0.9 1.4 1.0 1.3 1.3 1.6 1.9 2.0 2.0 1.2 1.1 1.7
Intensity Change (Log2) – – – -0.11 -0.07 -0.31 -0.5 -0.32 -0.49 -0.59 -0.4 -0.6 0.19 0.12 0.2 0.4 0.54 0.56 0.08 0.07 0.34


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.0304 0.1641 0.5364 0.6806 1.0464 0.4297 1.0963 1.3345 1.2627 0.8258 1.0776 0.9505 4.014 2.0066 2.4639 4.5251 2.9671 2.1485
Actin 0.0247 0.0021 0.0111 0.0015 0.0101 0.0039 0.0095 0.0035 0.008 0.0053 0.001 0.0106 0.0468 0.0014 0.0077 0.0002 0.0192 0.0072
Bud 0.0012 0.0001 0.0005 0.0003 0.0036 0.0004 0.0014 0.0002 0.0015 0.0021 0.0001 0.0001 0.0004 0.0005 0.0044 0 0.0002 0.0007
Bud Neck 0.0129 0.0023 0.001 0.0022 0.0108 0.0029 0.0024 0.0023 0.0015 0.0012 0.0002 0.0019 0.0018 0.0011 0.005 0.0001 0.0005 0.001
Bud Periphery 0.0044 0.0004 0.0028 0.0013 0.0065 0.0031 0.0069 0.0005 0.0048 0.0064 0.0001 0.0003 0.0004 0.0019 0.0059 0.0001 0.0003 0.005
Bud Site 0.0413 0.0099 0.0024 0.0007 0.0335 0.0008 0.0071 0.0466 0.009 0.0021 0.0002 0.0002 0.0056 0.0091 0.0208 0 0.0009 0.0002
Cell Periphery 0.0443 0.0078 0.0099 0.0053 0.0024 0.0031 0.0101 0.0088 0.0072 0.0037 0.0008 0.001 0.0025 0.0112 0.007 0.0005 0.0018 0.0026
Cytoplasm 0.1878 0.3242 0.1834 0.3608 0.1893 0.2546 0.0913 0.3268 0.2301 0.486 0.2515 0.228 0.1286 0.1833 0.3998 0.0359 0.2425 0.205
Cytoplasmic Foci 0.0093 0.0098 0.0095 0.0197 0.0475 0.0078 0.0264 0.0051 0.0042 0.008 0.0598 0.0126 0.2134 0.0032 0.0071 0.0019 0.0155 0.003
Eisosomes 0.0034 0.0033 0.0019 0.0006 0.0017 0.0008 0.0014 0.0009 0.002 0.0015 0.0001 0.0005 0.0006 0.0013 0.0006 0.0004 0.0003 0.0006
Endoplasmic Reticulum 0.0408 0.0059 0.0028 0.0154 0.0045 0.0014 0.0016 0.0039 0.02 0.0047 0.0013 0.0015 0.0088 0.0045 0.0251 0.0008 0.0049 0.0028
Endosome 0.021 0.0008 0.0022 0.0051 0.0549 0.0009 0.0198 0.0004 0.0037 0.0267 0.0019 0.0004 0.2143 0.0003 0.0108 0.0001 0.0094 0.0035
Golgi 0.0027 0.0006 0.0016 0.0012 0.0208 0.0012 0.0134 0.0005 0.0008 0.0108 0.0008 0.0002 0.0144 0.0002 0.0019 0 0.0021 0.0027
Lipid Particles 0.0055 0.0014 0.0017 0.0087 0.0632 0.0008 0.0314 0.0005 0.0011 0.0038 0.0143 0.0004 0.0324 0.001 0.0009 0.0003 0.0017 0.0017
Mitochondria 0.0062 0.0002 0.0073 0.0014 0.1433 0.0188 0.0031 0.0001 0.0006 0.016 0.0002 0.0001 0.0024 0.0003 0.001 0.0001 0.0008 0.0105
None 0.478 0.6278 0.7585 0.5689 0.3598 0.6956 0.73 0.5983 0.697 0.404 0.6454 0.7409 0.1785 0.7776 0.4931 0.9588 0.6839 0.7511
Nuclear Periphery 0.0729 0.0003 0.0003 0.0004 0.0013 0.0001 0.0003 0.0002 0.0051 0.0007 0.0003 0.0001 0.0098 0.0003 0.0043 0.0001 0.0031 0.0002
Nucleolus 0.0022 0.0004 0.0003 0.0003 0.0022 0.0002 0.0004 0.0001 0.0003 0.0003 0.0003 0.0001 0.0009 0.0005 0.0004 0.0001 0.0002 0.0001
Nucleus 0.0166 0.0007 0.0004 0.0005 0.0017 0.0003 0.0004 0.0003 0.0012 0.001 0.0003 0.0002 0.0025 0.0008 0.0017 0.0001 0.0025 0.0002
Peroxisomes 0.0009 0.0002 0.0008 0.0005 0.0326 0.0024 0.0397 0.0002 0.0003 0.0009 0.0091 0.0003 0.0746 0.0003 0.0003 0.0001 0.0028 0.0009
Punctate Nuclear 0.011 0.0007 0.0005 0.0007 0.0011 0.0003 0.0009 0.0002 0.0006 0.0004 0.0116 0.0004 0.0397 0.0004 0.0011 0.0002 0.0069 0.0001
Vacuole 0.0073 0.001 0.0011 0.0041 0.007 0.0005 0.0023 0.0004 0.0009 0.0128 0.0005 0.0002 0.0161 0.0009 0.0011 0.0004 0.0005 0.0006
Vacuole Periphery 0.0058 0 0.0002 0.0003 0.0021 0.0001 0.0002 0 0.0002 0.0016 0 0 0.0054 0 0.0003 0 0.0001 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 5.7469 3.022 2.2424 5.8009 3.9447 4.0544 3.8194 7.4242 4.5213 5.8231
Translational Efficiency 0.6833 1.032 2.051 0.4482 0.7752 1.0716 1.1298 0.5476 0.8365 0.888

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1827 1504 114 2796 2144 2110 149 350 3971 3614 263 3146

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 645.06 692.31 887.54 745.25 691.67 711.90 900.49 942.32 670.23 703.75 894.88 767.17
Standard Deviation 71.77 94.18 104.95 84.94 74.04 98.27 89.14 135.29 76.61 97.07 96.53 110.85
Intensity Change Log 2 — 0.101985 0.460379 0.208291 — 0.041591 0.380626 0.446133 — 0.071051 0.419663 0.336239

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.002279 0.004509 0.000568 0.000229 0.001899 0.003263 0.000205 0.000064 0.002074 0.003782 0.000363 0.000211
Bud Neck 0.032192 0.040697 0.003100 0.012480 0.029276 0.063509 0.001388 0.015404 0.030618 0.054015 0.002130 0.012805
Bud Site 0.008270 0.020767 0.003245 0.020431 0.007003 0.024373 0.002192 0.012035 0.007586 0.022872 0.002649 0.019496
Cell Periphery 0.001493 0.001029 0.000811 0.000481 0.002081 0.001397 0.000416 0.000366 0.001810 0.001244 0.000587 0.000468
Cytoplasm 0.492942* 0.377350* 0.227950* 0.538964* 0.520523* 0.460505* 0.295109* 0.640068* 0.507833* 0.425900* 0.265998* 0.550212*
Cytoplasmic Foci 0.191484* 0.280314* 0.078605 0.032141 0.134021 0.196995* 0.061933 0.013674 0.160459 0.231669* 0.069160 0.030087
Eisosomes 0.007851 0.004107 0.000300 0.000113 0.008405 0.004955 0.000194 0.000056 0.008150 0.004602 0.000240 0.000107
Endoplasmic Reticulum 0.001656 0.003246 0.006357 0.000977 0.001509 0.005353 0.002544 0.000766 0.001576 0.004476 0.004197 0.000954
Endosome 0.009496 0.024231 0.008057 0.002198 0.004359 0.014002 0.005359 0.000966 0.006723 0.018259 0.006528 0.002061
Golgi 0.011413 0.020630 0.000204 0.000274 0.007920 0.013239 0.000119 0.000083 0.009527 0.016315 0.000156 0.000252
Lipid Particles 0.027065 0.030137 0.009046 0.001210 0.014099 0.016577 0.005622 0.000796 0.020064 0.022220 0.007106 0.001164
Mitochondria 0.006579 0.010629 0.000239 0.000564 0.003856 0.009956 0.000196 0.001051 0.005109 0.010236 0.000215 0.000618
Mitotic Spindle 0.000390 0.000982 0.000634 0.004398 0.000455 0.001730 0.004823 0.001609 0.000425 0.001419 0.003007 0.004088
None 0.005232 0.002062 0.002111 0.002015 0.002601 0.001418 0.002144 0.004298 0.003812 0.001686 0.002130 0.002269
Nuclear Periphery 0.000158 0.000324 0.001356 0.000515 0.000174 0.000178 0.001209 0.000470 0.000167 0.000239 0.001273 0.000510
Nuclear Periphery Foci 0.000341 0.000611 0.005754 0.000282 0.000247 0.000338 0.001381 0.000128 0.000290 0.000452 0.003276 0.000265
Nucleolus 0.000614 0.000936 0.001057 0.000279 0.000380 0.000687 0.000845 0.000444 0.000488 0.000791 0.000937 0.000297
Nucleus 0.148875* 0.096301 0.505641* 0.322379* 0.223867* 0.112943 0.472827* 0.258703* 0.189364* 0.106017 0.487051* 0.315295*
Peroxisomes 0.011308 0.023334 0.000976 0.000748 0.008225 0.017813 0.000800 0.000186 0.009644 0.020111 0.000876 0.000685
Vacuole 0.039757 0.056323 0.143786 0.059052 0.028744 0.049745 0.140488 0.048670 0.033811 0.052482 0.141918 0.057897
Vacuole Periphery 0.000603 0.001482 0.000202 0.000273 0.000357 0.001025 0.000205 0.000164 0.000470 0.001215 0.000204 0.000260

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.72 4.23 6.50 8.37 2.91 -3.31 5.20 5.84 11.80 2.98 -4.94 6.77 8.27 13.35 2.79
Bud Neck -3.00 15.31 10.14 11.72 -7.40 -10.98 18.33 5.14 13.24 -4.95 -10.76 23.85 12.60 20.22 -10.82
Bud Site -7.53 4.07 -6.10 0.50 -8.43 -10.52 3.71 -1.35 3.85 -2.67 -12.89 5.37 -6.81 2.24 -9.17
Cell Periphery 3.58 4.84 12.84 5.15 3.50 3.54 9.11 8.25 8.00 0.85 4.74 10.42 12.71 11.97 2.63
Cytoplasm 14.39 14.50 -4.21 -17.94 -16.06 8.79 13.15 -5.39 -9.26 -14.14 15.58 19.08 -4.05 -16.71 -20.15
Cytoplasmic Foci -13.26 13.65 40.53 43.80 5.46 -12.61 12.87 31.51 39.87 7.13 -17.26 18.87 49.00 57.31 7.22
Eisosomes 6.07 15.22 15.67 10.66 6.49 6.26 17.38 17.72 16.74 9.69 8.66 23.11 23.58 19.43 8.65
Endoplasmic Reticulum -3.19 -5.34 2.28 4.50 5.85 -3.04 -4.11 2.87 3.59 5.23 -3.78 -6.42 3.16 4.43 7.26
Endosome -9.53 0.60 9.99 15.58 6.20 -10.79 -1.96 8.28 15.91 8.34 -13.73 -0.43 10.41 20.54 8.26
Golgi -6.75 16.48 16.32 17.29 -0.49 -5.83 14.82 14.88 17.75 1.66 -8.65 22.12 21.66 24.38 -1.09
Lipid Particles -1.28 8.31 15.36 16.15 6.53 -2.24 9.40 18.42 17.91 7.76 -1.74 11.78 21.69 23.13 9.24
Mitochondria -2.96 7.62 7.20 9.28 -3.00 -5.64 7.41 4.31 8.47 -1.73 -5.97 10.49 9.44 13.28 -3.89
Mitotic Spindle -1.09 -0.65 -4.67 -3.62 -3.46 -2.82 -0.89 -1.98 -0.30 0.44 -2.86 -0.98 -4.97 -3.39 -0.79
None 3.76 3.69 4.04 0.20 0.13 3.21 1.85 -1.50 -2.82 -2.40 4.96 4.14 3.09 -1.13 -0.71
Nuclear Periphery -2.43 -9.36 -20.60 -4.22 6.26 -0.20 -11.36 -5.01 -4.91 4.02 -2.32 -14.55 -20.50 -10.54 9.00
Nuclear Periphery Foci -2.18 -4.86 0.51 2.30 4.87 -2.01 -7.66 2.60 4.16 8.29 -2.83 -6.01 -0.47 2.58 5.99
Nucleolus -1.42 -2.86 7.60 2.87 5.16 -2.92 -3.66 -0.95 1.88 1.98 -2.84 -4.42 5.51 4.36 6.69
Nucleus 10.90 -12.46 -30.70 -38.81 5.83 21.64 -9.00 -3.78 -12.60 6.22 23.13 -15.06 -25.13 -42.40 7.56
Peroxisomes -7.86 14.49 14.81 16.48 1.58 -8.67 12.30 13.89 18.67 3.14 -11.51 18.91 19.07 24.15 1.23
Vacuole -6.44 -7.43 -10.84 -4.68 5.49 -11.28 -9.23 -6.64 -3.62 6.41 -12.10 -11.78 -14.72 -7.20 8.69
Vacuole Periphery -7.04 6.58 4.57 9.84 -0.73 -6.24 2.35 2.93 9.67 1.29 -9.23 5.77 3.52 11.67 -0.83
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (23%), ER (3%), mixed (57%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Bit61

Bit61


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Bit61-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available