Standard name
Human Ortholog
Description Essential RNA-binding G protein effector of mating response pathway; ligand-activated RNA-binding protein that delivers RNAs involved in polarization and perpetualizing mating signal to shmoo tip during pheromone signaling; Scp160p-mediated RNA trafficking essential for chemotropism and successful mating; mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0.06 0 0 0 0 0.07 0.08 0.09 0.08 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0.05 0 0.05 0 0.08 0.06 0.06 0.07 0 0 0.07 0.11 0.05 0.15 0 0 0 0 0 0
Cytoplasm 0.62 0.65 0.23 0.11 0.11 0.19 0.22 0.14 0.24 0.21 0.26 0.16 0.73 0.71 0.9 0.87 0.92 0.9 0.24 0.28 0.05 0.07 0.09 0.1
Endoplasmic Reticulum 0.47 0.39 0.74 0.67 0.65 0.72 0.69 0.76 0.68 0.68 0.61 0.59 0.32 0.35 0.14 0 0 0 0.69 0.66 0.83 0.68 0.75 0.74
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0.1 0.32 0.32 0.11 0.1 0.08 0.06 0.07 0.07 0.15 0 0 0 0 0 0 0 0 0.05 0.16 0.09 0.08
Mitochondria 0 0 0 0 0 0 0 0.05 0.05 0.07 0.12 0.14 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 15 12 11 11 20 17 24 24 20 0 0 0 1 1 0 5 3 9 1 4 3
Bud 2 0 0 0 0 1 1 2 0 0 1 1 0 0 0 1 0 1 1 1 1 1 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 3 7 11 10 17 11 15 18 20 17 16 17 4 4 11 16 8 18 2 0 1 2 2 2
Cytoplasm 310 196 77 27 34 55 65 70 62 64 67 41 80 80 136 125 141 111 135 90 16 12 21 24
Endoplasmic Reticulum 234 117 244 157 204 204 204 389 176 205 159 149 35 40 21 1 5 3 382 212 287 122 176 178
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 1 0 0 0 0 3
Golgi 9 0 32 75 101 30 29 43 15 22 19 37 1 0 0 3 4 0 5 1 17 28 20 19
Mitochondria 0 0 1 5 0 4 2 27 12 20 31 35 0 0 0 2 5 0 0 0 5 0 1 2
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 2 0 2 2 4 0 0 0 0 0 0 1 1 0 0 0 1
Nucleolus 0 0 0 0 0 1 2 4 0 1 0 3 0 0 0 1 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 2 0 0 2 8 6 3 3 3 3 2 3 3 3 0 3 2 0 4 1 0 3 2 2
Unique Cell Count 499 300 331 235 314 283 297 509 258 301 261 253 110 113 151 144 154 123 554 320 345 180 235 241
Labelled Cell Count 560 320 366 291 376 323 332 578 305 358 321 310 123 127 168 155 166 134 554 320 345 180 235 241


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 73.3 83.1 67.0 58.7 56.9 51.6 48.6 45.6 44.2 41.8 39.4 39.8 51.3 51.3 57.4 45.9 56.1 68.2 59.7 68.2 73.5
Std Deviation (1e-4) 13.7 15.1 12.6 12.7 11.1 10.1 10.6 9.8 9.1 9.2 8.2 9.2 13.6 13.6 14.4 17.7 21.2 21.4 15.5 16.4 17.6
Intensity Change (Log2) – – – -0.19 -0.24 -0.38 -0.46 -0.56 -0.6 -0.68 -0.77 -0.75 -0.39 -0.39 -0.22 -0.54 -0.25 0.03 -0.17 0.03 0.13

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700020406080WT3HU80HU120HU160020406080WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3020406080WT1AF100AF140AF180020406080
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 4.3 3.2 3.2 3.1 3.3 4.4 4.9 5.3 4.9 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0.6 1.3 0.4 1.1 0.2 2.4 1.4 1.6 1.9 0 0 1.9 3.4 1.0 4.4
Cytoplasm -3.6 -4.2 -1.2 -0.4 -3.5 0.2 -0.6 0.7 -2.1 9.4 9.1 13.7 12.9 14.1 12.9
Endoplasmic Reticulum -1.8 -2.4 -0.5 -1.4 0.9 -1.5 -1.6 -3.3 -3.8 -7.9 -7.3 -12.2 -14.6 -14.5 -13.6
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 6.7 7.1 0.4 0 -0.6 -1.7 -1.1 -1.0 1.8 -3.0 -3.4 -4.0 -2.9 -2.8 -3.6
Mitochondria 0 0 0 0 3.9 3.6 4.4 6.2 6.7 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin 0.0269 0.0152 0.0242 0.0657 0.0799 0.0212 0.0392 0.0169 0.0262 0.003 0.0068 0.026 0.0417 0.0037 0.0001 0.0859 0.0763 0.0007
Bud 0.0005 0.0007 0.0004 0.009 0.0015 0.002 0.0015 0.0031 0.0006 0.0003 0.0005 0.0002 0.0003 0 0 0.0057 0.0066 0
Bud Neck 0.0007 0.0017 0.0029 0.0047 0.0069 0.0071 0.001 0.0013 0.0012 0.0012 0.0019 0.003 0.0002 0.0003 0 0.0177 0.0091 0.0003
Bud Periphery 0.0011 0.0012 0.0007 0.0082 0.0012 0.0024 0.0023 0.0029 0.0013 0.0001 0.0018 0.0002 0.0005 0 0 0.0041 0.0043 0
Bud Site 0.0011 0.0026 0.0004 0.0434 0.0071 0.0003 0.0019 0.018 0.0021 0 0.0001 0.0001 0.0003 0 0 0.0005 0.0007 0
Cell Periphery 0.0059 0.041 0.0159 0.011 0.0269 0.0076 0.0116 0.0142 0.01 0.001 0.0024 0.0018 0.0002 0.0002 0.0003 0.0038 0.0153 0.0005
Cytoplasm 0.1193 0.2668 0.1834 0.1795 0.1888 0.1398 0.079 0.1923 0.1526 0.1288 0.2069 0.0677 0.0429 0.5273 0.0007 0.6427 0.2059 0.0032
Cytoplasmic Foci 0.0243 0.0062 0.0097 0.0091 0.0249 0.0032 0.0143 0.0084 0.0089 0.001 0.0053 0.0035 0.0374 0.0029 0 0.0104 0.0049 0.0001
Eisosomes 0.0006 0.0028 0.0009 0.002 0.0045 0.0018 0.0024 0.0007 0.001 0.0001 0.0003 0.0006 0.0022 0 0 0.0001 0.0085 0.0001
Endoplasmic Reticulum 0.3522 0.4243 0.5165 0.3151 0.231 0.4218 0.3952 0.5549 0.5998 0.7918 0.4782 0.5797 0.0073 0.3342 0.9357 0.0682 0.2825 0.5036
Endosome 0.0244 0.0116 0.0139 0.0354 0.0249 0.0227 0.0365 0.0242 0.0205 0.0066 0.072 0.0253 0.0606 0.0047 0.0006 0.0651 0.0321 0.0025
Golgi 0.0123 0.0248 0.0314 0.0361 0.0257 0.0185 0.0264 0.0359 0.0312 0.0086 0.044 0.0438 0.0109 0.0013 0.0004 0.0292 0.0859 0.0042
Lipid Particles 0.0182 0.0214 0.0195 0.0129 0.0315 0.0081 0.0167 0.0146 0.0122 0.0003 0.0025 0.0107 0.0479 0.0009 0 0.0014 0.0041 0.0002
Mitochondria 0.01 0.0047 0.0054 0.0167 0.0097 0.0027 0.0251 0.0021 0.0093 0.0006 0.0404 0.0018 0.0085 0.0001 0.0001 0.003 0.0248 0.0003
None 0.0073 0.0017 0.0059 0.0014 0.0113 0.001 0.0138 0.0005 0.0017 0.0002 0.0011 0.0004 0.6041 0.0005 0 0.0012 0.002 0.0001
Nuclear Periphery 0.3319 0.1327 0.1328 0.176 0.2411 0.3079 0.2497 0.0898 0.0984 0.0457 0.0916 0.2143 0.058 0.1158 0.0583 0.0286 0.1987 0.467
Nucleolus 0.0011 0.0053 0.0006 0.0009 0.007 0.0003 0.0019 0.0006 0.0006 0 0.0001 0.0001 0.0041 0 0 0.0003 0.0009 0
Nucleus 0.0197 0.0102 0.007 0.0095 0.0136 0.0121 0.0187 0.0039 0.0035 0.0016 0.0035 0.0035 0.0074 0.0038 0.0004 0.0074 0.0074 0.0072
Peroxisomes 0.0056 0.0002 0.0015 0.001 0.0051 0.0002 0.017 0.0001 0.0004 0 0.0001 0.0012 0.0173 0 0 0.0002 0.0004 0
Punctate Nuclear 0.0104 0.0013 0.0024 0.0013 0.0141 0.0014 0.011 0.0006 0.0006 0.0001 0.0003 0.0007 0.0401 0.0011 0 0.001 0.0009 0.0003
Vacuole 0.0123 0.0168 0.0167 0.0219 0.0199 0.0076 0.0156 0.0095 0.0079 0.0051 0.0129 0.0036 0.0029 0.002 0.0009 0.0142 0.0054 0.0012
Vacuole Periphery 0.0141 0.0069 0.0078 0.0392 0.0234 0.0103 0.0191 0.0053 0.0101 0.0038 0.0272 0.0119 0.0051 0.0011 0.0025 0.0095 0.0232 0.0086

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 239.5371 243.8384 228.0186 227.8882 228.4924 196.8738 218.9546 193.2785 170.5598 215.0478
Translational Efficiency 1.9577 1.9686 1.6803 1.8449 1.9029 2.1327 1.6143 1.5543 1.6365 1.642

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2035 1018 165 1079 1185 1425 2079 1753 3220 2443 2244 2832

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 4519.20 3880.95 5619.01 4558.04 2705.15 3827.29 5535.67 4868.74 3851.61 3849.65 5541.80 4750.36
Standard Deviation 1014.68 925.94 840.83 1231.05 683.63 799.13 872.12 1001.85 1260.17 854.67 870.13 1105.20
Intensity Change Log 2 — -0.219658 0.314249 0.012346 — 0.500615 1.033049 0.847840 — 0.093534 0.626709 0.383897

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001795 0.001742 0.000580 0.002679 0.002606 0.000686 0.000595 0.002034 0.002093 0.001126 0.000594 0.002280
Bud Neck 0.001988 0.002074 0.021248 0.005016 0.001043 0.001226 0.001108 0.001711 0.001640 0.001579 0.002589 0.002970
Bud Site 0.009203 0.008488 0.004374 0.036910 0.005823 0.004039 0.001599 0.014608 0.007959 0.005893 0.001803 0.023105
Cell Periphery 0.028606 0.015213 0.038833 0.096187 0.012998 0.014225 0.035666 0.093228 0.022862 0.014637 0.035899 0.094355
Cytoplasm 0.035702 0.017650 0.010788 0.114033 0.005549 0.009814 0.010841 0.063746 0.024605 0.013079 0.010837 0.082905
Cytoplasmic Foci 0.010150 0.014002 0.002891 0.017713 0.010139 0.010776 0.002909 0.022838 0.010146 0.012120 0.002908 0.020885
Eisosomes 0.000146 0.000297 0.000462 0.000155 0.000343 0.000133 0.000195 0.000220 0.000219 0.000201 0.000214 0.000195
Endoplasmic Reticulum 0.475749 0.528715 0.199369 0.070909 0.545345 0.647077 0.732798 0.322867 0.501361 0.597755 0.693575 0.226870
Endosome 0.020096 0.024363 0.015965 0.010639 0.017067 0.021940 0.007683 0.012566 0.018982 0.022950 0.008292 0.011832
Golgi 0.062861 0.127731 0.047374 0.065576 0.214320 0.098605 0.029263 0.078018 0.118599 0.110742 0.030594 0.073277
Lipid Particles 0.134683 0.091657 0.134046 0.316701 0.048408 0.063171 0.089783 0.246766 0.102933 0.075041 0.093038 0.273412
Mitochondria 0.001892 0.001245 0.000291 0.001585 0.006307 0.001006 0.000355 0.002087 0.003517 0.001106 0.000351 0.001896
Mitotic Spindle 0.002209 0.001786 0.003801 0.005194 0.000530 0.000416 0.000290 0.001383 0.001592 0.000987 0.000548 0.002835
None 0.003501 0.003148 0.000173 0.001248 0.002705 0.003105 0.001039 0.001526 0.003208 0.003123 0.000975 0.001420
Nuclear Periphery 0.005792 0.005840 0.056011 0.002133 0.003273 0.004909 0.006439 0.003513 0.004865 0.005297 0.010084 0.002987
Nuclear Periphery Foci 0.037800 0.041561 0.138464 0.019026 0.011823 0.029368 0.012849 0.015171 0.028240 0.034449 0.022085 0.016639
Nucleolus 0.000069 0.000100 0.000057 0.000148 0.000420 0.000047 0.000019 0.000119 0.000198 0.000069 0.000022 0.000130
Nucleus 0.000785 0.002237 0.000844 0.003080 0.008252 0.001557 0.000505 0.001250 0.003533 0.001840 0.000530 0.001947
Peroxisomes 0.000235 0.000089 0.000014 0.000671 0.000151 0.000099 0.000665 0.002063 0.000204 0.000095 0.000617 0.001533
Vacuole 0.143516 0.077051 0.292062 0.201227 0.035460 0.058991 0.056091 0.089460 0.103750 0.066516 0.073442 0.132043
Vacuole Periphery 0.023222 0.035012 0.032354 0.029172 0.067437 0.028811 0.009309 0.024827 0.039494 0.031395 0.011003 0.026483

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.37 2.80 -1.73 -1.28 -4.69 4.11 3.64 1.05 -3.81 -3.14 2.21 3.54 -0.62 -3.18 -4.60
Bud Neck 0.28 -6.19 -7.79 -6.93 5.08 -0.96 -1.05 -4.15 -2.76 -1.62 1.00 -3.03 -6.86 -7.02 -1.01
Bud Site 0.71 3.70 -10.10 -10.09 -11.87 1.46 3.97 -5.45 -7.06 -9.65 2.42 8.19 -10.17 -11.95 -16.30
Cell Periphery 7.99 -1.90 -14.40 -17.69 -8.73 -0.73 -11.32 -24.86 -25.36 -17.31 6.55 -7.79 -26.91 -30.83 -19.98
Cytoplasm 5.36 5.78 -11.57 -14.38 -14.27 -2.36 -3.46 -14.30 -13.22 -13.30 5.74 7.65 -15.12 -19.19 -20.41
Cytoplasmic Foci -2.20 5.61 -4.61 -2.07 -8.12 -0.44 7.85 -6.53 -5.90 -11.44 -1.79 10.95 -8.03 -5.96 -14.46
Eisosomes -1.60 -1.22 -0.17 1.54 1.20 3.84 2.60 2.29 -3.33 -0.80 0.38 0.11 0.92 0.17 0.67
Endoplasmic Reticulum -4.50 12.40 42.34 37.87 5.89 -7.70 -15.53 18.54 28.28 40.87 -10.89 -20.78 32.41 41.77 52.33
Endosome -3.66 2.84 11.17 12.98 4.12 -5.04 13.18 5.90 11.73 -10.76 -5.25 20.03 12.71 17.39 -8.24
Golgi -11.17 2.88 -0.09 10.43 -2.77 14.76 27.23 19.13 4.33 -17.23 1.69 26.09 12.52 10.06 -17.90
Lipid Particles 6.90 -0.29 -17.78 -22.08 -10.14 -4.08 -10.21 -32.06 -28.27 -23.07 7.07 1.85 -29.26 -35.26 -29.33
Mitochondria 1.63 5.77 0.60 -0.54 -2.60 3.44 3.93 2.76 -2.42 -5.42 3.89 5.42 2.58 -2.20 -5.58
Mitotic Spindle 1.02 -0.90 -2.71 -3.42 -0.51 1.61 2.25 -3.85 -4.79 -5.08 2.14 3.29 -2.20 -4.41 -5.46
None 0.30 4.81 2.98 2.21 -5.15 -0.32 2.41 1.69 1.80 -2.34 0.12 4.29 3.37 2.72 -2.58
Nuclear Periphery 0.07 -7.38 10.17 8.63 7.98 -4.05 -7.09 -0.59 4.40 7.66 -1.07 -7.49 7.45 8.92 10.93
Nuclear Periphery Foci -0.60 -7.12 9.11 7.51 8.65 -8.11 -1.26 -2.45 7.11 -1.30 -2.38 3.30 8.77 10.41 3.93
Nucleolus -0.58 1.03 -2.68 -1.37 -4.15 2.65 2.86 2.00 -1.29 -1.82 2.43 3.44 1.11 -1.68 -3.21
Nucleus -1.45 -0.16 -6.90 -2.15 -6.59 2.97 3.73 3.35 0.34 -3.53 1.69 3.88 1.22 -1.05 -7.37
Peroxisomes 2.86 4.62 -2.63 -3.68 -4.21 0.73 -3.07 -5.35 -5.63 -3.73 2.32 -2.94 -5.82 -6.37 -3.48
Vacuole 12.69 -7.62 -7.53 -17.66 4.47 -6.77 -6.82 -14.93 -7.95 -8.53 11.08 7.89 -6.20 -17.51 -13.83
Vacuole Periphery -4.94 -1.88 -2.26 2.56 0.68 10.23 17.17 12.25 2.07 -13.92 4.09 18.79 8.08 3.36 -13.97
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Essential RNA-binding G protein effector of mating response pathway; ligand-activated RNA-binding protein that delivers RNAs involved in polarization and perpetualizing mating signal to shmoo tip during pheromone signaling; Scp160p-mediated RNA trafficking essential for chemotropism and successful mating; mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
Localization
Cell Percentages ER (68%)
Cell Cycle Regulation No
Subcompartmental Group ER-4

Scp160

Scp160


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Scp160-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available