Standard name
Human Ortholog
Description Protein required for clearance of inclusion bodies; localizes to the inclusion bodies formed under protein misfolding stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.06 0.08 0.08 0.09 0 0 0.08 0 0 0 0 0.05 0 0 0.05 0 0 0 0 0 0 0
Cytoplasm 0.97 0.95 0.95 0.95 0.94 0.88 0.93 0.87 0.91 0.9 0.84 0.87 0.98 0.97 0.98 0.91 0.9 0.87 0.88 0.93 0.87 0.91 0.9 0.79
Endoplasmic Reticulum 0 0 0 0 0.05 0.09 0.06 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.06 0 0.05 0.08 0 0 0 0 0.09 0.09 0.14 0 0 0.05 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 3 0 1 0 0 1
Bud 2 2 0 0 0 0 2 1 3 1 2 1 2 0 0 0 0 0 2 1 1 0 4 8
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 1 0 2
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 8 11 12 12 18 18 8 6 16 1 3 3 7 12 5 4 8 6 0 1 0 0 1 0
Cytoplasm 205 297 201 147 202 184 246 151 179 104 103 130 196 217 200 178 133 148 189 298 207 62 162 115
Endoplasmic Reticulum 3 14 8 3 11 18 16 7 4 0 3 9 1 5 2 3 0 3 6 4 3 1 3 3
Endosome 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 1 1 0 0 0 0
Mitochondria 1 0 0 0 1 0 0 3 5 4 6 4 2 0 0 0 1 4 2 1 4 0 0 1
Nucleus 2 2 9 3 2 9 8 11 6 2 2 5 0 2 3 7 7 7 2 0 1 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 1 1 1 0 0 0 1 0 1 1 0 1 0 0 0
Nucleolus 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
SpindlePole 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 1 3 0 0 0 0 2 10 4 6 10 6 0 0 1 17 13 24 1 5 12 1 3 6
Unique Cell Count 211 314 211 154 214 209 265 173 196 116 123 150 200 223 205 195 147 170 215 322 239 69 180 147
Labelled Cell Count 222 330 231 165 234 229 284 189 218 119 130 160 209 236 211 211 163 193 215 322 239 69 180 147


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 9.7 10.9 9.2 8.3 10.7 9.8 9.6 9.4 8.3 7.4 7.3 8.5 11.0 11.7 11.6 12.5 13.0 12.2 9.6 9.7 11.3
Std Deviation (1e-4) 1.9 2.2 1.4 1.4 1.5 1.5 1.8 1.5 1.5 1.3 1.3 1.9 2.0 2.5 2.3 3.0 2.1 2.4 2.3 1.9 2.7
Intensity Change (Log2) – – – -0.14 0.22 0.09 0.07 0.03 -0.15 -0.32 -0.32 -0.1 0.26 0.35 0.34 0.44 0.5 0.41 0.06 0.08 0.3

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0.8 1.1 1.2 -1.4 -1.0 1.0 0 -1.4 -1.7 -1.1 -0.1 -1.7 -1.9 -0.1 -1.0
Cytoplasm 0.1 -0.4 -2.7 -1.1 -2.8 -1.6 -1.9 -3.6 -2.9 1.5 1.1 1.3 -1.6 -1.8 -2.9
Endoplasmic Reticulum 0 0.7 2.0 1.1 0.1 -1.0 0 0 1.0 0 -0.9 0 -1.4 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus -1.2 -2.2 0 -0.7 0.9 -0.6 0 0 -0.5 0 -2.2 -1.7 -0.3 0.2 -0.1
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 4.4 4.4 5.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.9914 5.078 4.1939 4.0833 3.0964 4.7719 6.2077 6.7419 6.3925 6.0938 5.2671 6.3642 5.0688 5.3516 5.2368 4.7965 4.7145 5.1967
Actin 0.0362 0.002 0.0094 0.0012 0.0371 0.0032 0.0119 0.0042 0.0019 0.0081 0.0241 0.009 0.0303 0.0197 0.0121 0.0205 0.063 0.0049
Bud 0.0006 0.0016 0.001 0.0002 0.0078 0.0001 0.001 0.0021 0.0003 0.0005 0.0016 0.0008 0.001 0.0007 0.0003 0.0008 0.0021 0.0002
Bud Neck 0.0078 0.0007 0.0024 0.0021 0.0057 0.0095 0.008 0.0035 0.0029 0.0156 0.0125 0.0143 0.0028 0.0012 0.0021 0.002 0.007 0.0103
Bud Periphery 0.0007 0.0024 0.0027 0.0002 0.004 0.0001 0.0014 0.0014 0.0004 0.0007 0.0023 0.002 0.0018 0.0006 0.0003 0.0008 0.0018 0.0003
Bud Site 0.0106 0.0153 0.0129 0.0009 0.0188 0.0002 0.01 0.0176 0.0031 0.0012 0.0031 0.0004 0.0022 0.0149 0.009 0.0063 0.0414 0.0003
Cell Periphery 0.0036 0.001 0.0013 0.001 0.0071 0.0013 0.0011 0.0011 0.0009 0.0007 0.0005 0.0007 0.0013 0.0024 0.0013 0.0007 0.0009 0.001
Cytoplasm 0.7202 0.9023 0.8495 0.8858 0.6511 0.9269 0.8091 0.9272 0.9273 0.9298 0.874 0.9216 0.7764 0.9143 0.9093 0.8244 0.6033 0.9125
Cytoplasmic Foci 0.0401 0.0055 0.01 0.025 0.0495 0.0071 0.0169 0.0027 0.003 0.0025 0.0075 0.0038 0.0296 0.0025 0.0087 0.0121 0.0341 0.0077
Eisosomes 0.0006 0 0.0001 0 0.0003 0 0.0001 0 0.0001 0.0001 0.0004 0 0.0002 0.0001 0.0001 0.0002 0.0003 0
Endoplasmic Reticulum 0.0274 0.0117 0.0177 0.0089 0.0169 0.0166 0.0238 0.0087 0.0163 0.0117 0.0097 0.0094 0.0266 0.0086 0.0286 0.0234 0.0101 0.0055
Endosome 0.0274 0.0019 0.0082 0.0199 0.0262 0.0048 0.0153 0.0008 0.0015 0.001 0.006 0.0034 0.0422 0.0018 0.0028 0.0168 0.0782 0.0118
Golgi 0.0105 0.0003 0.0024 0.0035 0.0182 0.0011 0.0038 0.0002 0.0003 0.0003 0.0031 0.0007 0.008 0.0024 0.0019 0.0218 0.0181 0.0137
Lipid Particles 0.009 0.0005 0.0069 0.0039 0.0241 0.0009 0.0046 0.0002 0.0003 0.0002 0.0024 0.0003 0.0196 0.0039 0.0022 0.0072 0.0119 0.0076
Mitochondria 0.0069 0.0002 0.0017 0.0006 0.005 0.0002 0.0012 0.0001 0.0001 0.0001 0.0103 0.0003 0.0026 0.0013 0.0002 0.0054 0.0078 0.002
None 0.0545 0.0389 0.0458 0.0286 0.0596 0.015 0.0396 0.0192 0.0279 0.0182 0.0275 0.0205 0.0117 0.0211 0.0144 0.0487 0.007 0.0047
Nuclear Periphery 0.0144 0.0021 0.0042 0.0016 0.0052 0.0037 0.0147 0.0012 0.0026 0.0014 0.0042 0.003 0.0086 0.0007 0.0011 0.0016 0.0324 0.0014
Nucleolus 0.0018 0.0002 0.0076 0.0001 0.0057 0.0001 0.0014 0.0001 0.0002 0.0001 0.0002 0.0001 0.0003 0 0 0.0004 0.0341 0.0002
Nucleus 0.0086 0.0093 0.0092 0.005 0.0093 0.0049 0.0141 0.0074 0.0077 0.0063 0.0058 0.0063 0.0151 0.002 0.0013 0.0013 0.0134 0.0012
Peroxisomes 0.0051 0.0002 0.0021 0.0032 0.0277 0.0006 0.009 0.0001 0.0001 0.0001 0.0013 0.0001 0.0097 0.0008 0.003 0.0018 0.0097 0.0044
Punctate Nuclear 0.0089 0.0023 0.0022 0.0008 0.0141 0.002 0.0067 0.0008 0.002 0.0008 0.0021 0.0023 0.0057 0.0002 0.0008 0.0015 0.0189 0.0092
Vacuole 0.004 0.0018 0.0024 0.0072 0.006 0.0015 0.0054 0.0012 0.0011 0.0009 0.0011 0.001 0.0027 0.0005 0.0005 0.0019 0.003 0.0008
Vacuole Periphery 0.0011 0.0001 0.0003 0.0003 0.0008 0.0001 0.0009 0.0001 0.0001 0.0001 0.0004 0.0002 0.0018 0.0001 0 0.0005 0.0016 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 13.064 15.2718 21.6647 23.5865 16.2866 28.1222 25.4327 31.8785 35.2807 22.3858
Translational Efficiency 0.802 0.6875 0.6404 0.8568 0.5711 0.4848 0.6247 0.5833 0.6343 0.6407

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1800 1787 1311 1107 1399 1965 88 93 3199 3752 1399 1200

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 797.54 1037.13 1462.58 1250.25 938.34 945.98 1366.38 1374.53 859.12 989.39 1456.53 1259.88
Standard Deviation 118.48 189.58 262.35 273.12 146.78 154.06 211.25 300.99 148.99 177.82 260.48 277.37
Intensity Change Log 2 — 0.378968 0.874887 0.648588 — 0.011699 0.542176 0.550756 — 0.192097 0.704605 0.596529

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001036 0.002123 0.007483 0.001249 0.001116 0.001900 0.002748 0.001573 0.001071 0.002006 0.007185 0.001274
Bud Neck 0.016385 0.010860 0.021514 0.010726 0.009784 0.016526 0.006816 0.004260 0.013498 0.013827 0.020589 0.010225
Bud Site 0.033070 0.027663 0.068102 0.038240 0.018358 0.028033 0.024820 0.016778 0.026636 0.027857 0.065380 0.036577
Cell Periphery 0.001250 0.001116 0.016327 0.000545 0.001050 0.000649 0.003432 0.000545 0.001162 0.000872 0.015516 0.000545
Cytoplasm 0.623691 0.611776 0.503824 0.463299 0.621973 0.590329 0.276034 0.370512 0.622940 0.600544 0.489495 0.456108
Cytoplasmic Foci 0.126417 0.112078 0.034996 0.023639 0.106017 0.139531 0.068754 0.030533 0.117495 0.126455 0.037119 0.024173
Eisosomes 0.000640 0.000376 0.000490 0.000041 0.000496 0.000377 0.000442 0.000112 0.000577 0.000376 0.000487 0.000047
Endoplasmic Reticulum 0.004978 0.007822 0.007352 0.002579 0.006507 0.005021 0.016259 0.008087 0.005647 0.006355 0.007912 0.003005
Endosome 0.005250 0.005704 0.002689 0.013394 0.004325 0.008371 0.010542 0.015522 0.004846 0.007101 0.003183 0.013559
Golgi 0.003104 0.002038 0.000973 0.009932 0.001189 0.004311 0.000463 0.009562 0.002267 0.003229 0.000941 0.009903
Lipid Particles 0.004466 0.005931 0.027922 0.004995 0.004297 0.006694 0.014092 0.012755 0.004392 0.006331 0.027052 0.005597
Mitochondria 0.000962 0.001065 0.000228 0.009427 0.000516 0.002093 0.000104 0.002256 0.000767 0.001603 0.000220 0.008871
Mitotic Spindle 0.000288 0.001083 0.001525 0.092414 0.001586 0.002681 0.001219 0.015937 0.000856 0.001920 0.001506 0.086487
None 0.008225 0.004241 0.003848 0.011681 0.003816 0.002703 0.000339 0.000939 0.006297 0.003436 0.003627 0.010849
Nuclear Periphery 0.000106 0.000195 0.000422 0.001516 0.000167 0.000172 0.000930 0.002187 0.000133 0.000183 0.000454 0.001568
Nuclear Periphery Foci 0.003404 0.007993 0.016508 0.007924 0.005769 0.004668 0.023982 0.037232 0.004439 0.006251 0.016978 0.010195
Nucleolus 0.000817 0.000351 0.000114 0.000698 0.000439 0.000493 0.000250 0.000106 0.000652 0.000426 0.000123 0.000652
Nucleus 0.074925 0.086659 0.149965 0.146954 0.111969 0.081264 0.131750 0.070503 0.091125 0.083833 0.148819 0.141029
Peroxisomes 0.002014 0.001992 0.000302 0.000840 0.001166 0.003669 0.000474 0.000363 0.001644 0.002871 0.000313 0.000803
Vacuole 0.088414 0.108326 0.135167 0.151145 0.099213 0.099348 0.416394 0.380752 0.093137 0.103624 0.152857 0.168939
Vacuole Periphery 0.000557 0.000609 0.000248 0.008763 0.000248 0.001167 0.000156 0.019486 0.000422 0.000901 0.000242 0.009594

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.61 -13.28 1.12 4.10 13.60 -2.11 -3.10 -0.96 0.61 1.70 -3.89 -13.35 0.91 4.40 13.64
Bud Neck 4.29 -4.24 4.70 0.36 9.73 -5.03 1.46 -0.07 2.62 -0.87 -0.27 -7.07 3.17 3.40 9.52
Bud Site 2.44 -9.21 4.40 2.27 12.36 -4.63 -1.83 -1.19 0.94 0.65 -0.69 -12.03 2.17 2.70 12.33
Cell Periphery 1.50 -14.22 11.51 9.64 15.33 4.99 -2.97 4.26 0.79 3.90 4.67 -14.40 13.61 9.43 15.41
Cytoplasm 2.38 20.13 27.39 24.46 7.71 3.89 15.48 11.96 10.86 -1.31 4.61 23.52 30.64 27.28 7.26
Cytoplasmic Foci 2.81 25.53 33.40 28.82 13.55 -6.82 8.08 16.94 23.29 2.94 -2.95 29.14 40.02 42.29 13.77
Eisosomes 4.97 4.85 15.14 8.77 13.22 2.06 2.45 7.65 9.02 5.14 5.28 4.27 17.08 14.39 13.66
Endoplasmic Reticulum -2.75 -1.77 4.64 7.03 7.80 1.50 -2.31 2.55 1.52 3.43 -1.04 -1.63 6.72 8.54 8.39
Endosome -0.84 8.07 3.12 3.39 -1.14 -6.97 -3.81 -0.81 1.93 1.81 -5.87 6.63 2.38 5.82 -0.79
Golgi 3.09 10.72 1.83 0.46 -0.94 -4.88 7.08 -0.38 1.55 -0.94 -2.41 10.95 0.87 1.89 -1.06
Lipid Particles -3.07 -14.78 0.55 3.10 14.71 -4.00 -3.49 -1.50 -0.96 -0.06 -5.01 -15.08 -0.62 2.70 14.19
Mitochondria -0.14 6.35 -1.22 -1.00 -2.18 -3.32 3.00 -0.16 2.57 -1.20 -2.47 6.32 -1.46 -0.31 -2.22
Mitotic Spindle -2.05 -3.90 -9.41 -9.22 -9.10 -1.12 -0.60 -2.05 -1.93 -1.85 -2.00 -1.78 -9.49 -9.21 -9.28
None 4.04 6.08 0.59 -3.48 -5.53 2.10 7.45 4.63 3.57 -2.79 4.89 6.24 -0.87 -4.65 -5.54
Nuclear Periphery -2.36 -17.63 -20.84 -18.78 -15.75 -0.18 -6.01 -5.55 -5.54 -1.91 -2.41 -18.02 -21.36 -20.46 -15.79
Nuclear Periphery Foci -8.27 -15.65 -3.74 4.26 12.32 2.05 -5.08 -1.49 -1.70 1.10 -5.19 -15.47 -2.52 0.73 11.42
Nucleolus 2.74 4.12 1.60 -2.63 -6.33 -0.43 2.78 0.49 0.73 -0.81 2.21 5.18 1.20 -1.36 -6.35
Nucleus -3.60 -18.47 -18.69 -16.52 -3.84 7.95 0.35 2.32 -0.36 1.09 2.86 -15.12 -15.79 -17.23 -3.35
Peroxisomes 0.21 13.26 10.33 7.36 -2.21 -6.64 6.06 6.09 9.15 0.54 -5.33 14.78 10.40 10.93 -2.18
Vacuole -5.78 -16.06 -25.16 -22.05 -13.12 0.27 -13.65 -13.18 -13.24 0.18 -4.16 -18.12 -27.22 -25.80 -12.48
Vacuole Periphery -0.16 3.46 -2.06 -1.86 -2.98 -3.66 2.91 -1.02 -0.72 -1.04 -2.88 2.90 -2.57 -1.44 -3.07
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein required for clearance of inclusion bodies; localizes to the inclusion bodies formed under protein misfolding stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (84%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Iml2

Iml2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Iml2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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