Standard name
Human Ortholog
Description Alpha arrestin; controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.12 0 0.11 0.13 0 0 0 0 0.05 0.06 0.06 0.08 0.07 0.08 0.1 0.22 0.2 0.22 0 0 0 0 0 0
Cytoplasm 0.96 0.96 0.96 0.96 0.91 0.81 0.68 0.7 0.66 0.63 0.62 0.63 0.97 0.98 1.0 0.87 0.89 0.9 0.89 0.89 0.85 0.87 0.86 0.89
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.07 0.09 0.28 0.41 0.37 0.49 0.44 0.52 0.45 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 2 0 1 0 2 3 2 3 2 9 7 15 0 0 0 6 5 4 1 2 6 2 6 3
Bud 0 1 1 1 5 6 22 23 18 27 34 22 2 0 0 1 0 0 0 0 1 0 3 4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 4 3 2 5 4
Bud Site 0 0 0 0 0 0 0 0 1 1 0 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 6 7 26 31 14 26 16 20 27 39 38 48 12 23 30 33 28 36 0 0 5 1 2 2
Cytoplasm 46 243 237 224 331 467 352 411 381 386 365 369 159 293 286 129 123 147 87 230 208 160 426 417
Endoplasmic Reticulum 0 4 1 0 6 15 7 5 14 13 10 11 1 5 1 5 3 5 0 0 7 4 17 12
Endosome 0 0 1 0 8 0 2 5 2 3 2 1 0 0 0 2 0 1 0 2 3 0 2 3
Golgi 0 0 2 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 1 1 0 3 2
Mitochondria 0 7 5 16 34 165 214 218 283 269 307 263 3 0 1 6 2 2 2 3 3 5 9 9
Nucleus 0 0 0 0 1 1 1 5 1 3 2 2 0 1 0 1 1 2 0 0 0 0 0 0
Nuclear Periphery 0 1 0 0 2 0 1 3 0 3 0 1 0 0 0 1 1 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 1 0 3 1 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0
Peroxisomes 0 0 1 0 1 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 1 0 1
SpindlePole 0 0 0 0 0 0 0 0 1 2 0 1 0 0 0 1 0 2 0 0 0 0 0 1
Vac/Vac Membrane 0 1 0 3 5 8 8 22 24 19 5 23 0 0 0 0 2 6 2 7 1 4 13 5
Unique Cell Count 48 253 246 234 363 580 517 585 579 615 586 583 164 298 287 148 138 163 99 259 244 185 497 471
Labelled Cell Count 54 264 275 275 409 692 625 718 755 776 770 757 179 322 318 185 167 205 99 259 244 185 497 471


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.8 5.7 5.9 5.9 5.8 4.8 5.0 5.4 5.0 5.4 5.2 5.4 6.7 7.1 7.2 7.7 8.0 7.6 6.5 6.8 7.0
Std Deviation (1e-4) 1.2 0.7 1.2 1.6 1.6 1.1 1.9 1.2 1.2 1.4 1.1 1.1 0.8 1.1 1.0 1.0 1.3 1.2 1.1 1.0 1.0
Intensity Change (Log2) – – – -0.01 -0.04 -0.31 -0.25 -0.13 -0.23 -0.13 -0.2 -0.14 0.17 0.26 0.28 0.38 0.43 0.36 0.14 0.21 0.23


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 2.9 2.8 2.4 3.0 3.5 2.7 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0.9 -3.3 0 -4.2 -4.1 -3.2 -2.1 -2.0 -1.1 -1.1 -1.2 0 3.2 2.6 3.2
Cytoplasm -0.3 -2.5 -5.9 -8.7 -8.3 -9.3 -10.0 -10.0 -9.8 0.3 1.5 2.8 -3.4 -2.8 -2.5
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 2.6 3.6 0 11.2 10.5 12.9 11.9 13.7 12.1 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 3.1 3.2 2.8 0 3.2 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.177 1.674 1.4671 0.8457 0.6198 1.5289 2.5141 2.9802 2.7958 2.3897 2.5781 2.9422 1.5531 2.3059 1.8579 1.5961 1.5422 2.2126
Actin 0.0063 0.0117 0.002 0.0078 0.1067 0.0522 0.0351 0.0007 0.0119 0.0171 0.0051 0.0182 0.0468 0.0014 0.011 0.0003 0.0039 0.0431
Bud 0.0001 0.0008 0.0004 0.0004 0.0007 0.001 0.0009 0.0007 0.0032 0.003 0.0012 0.0008 0.0015 0.0001 0.0003 0.0001 0.001 0.0009
Bud Neck 0.0007 0.0006 0.0026 0.0007 0.0024 0.005 0.0076 0.0005 0.0022 0.0014 0.0011 0.0104 0.0007 0.0001 0.001 0.0001 0.0004 0.002
Bud Periphery 0.0001 0.0007 0.0007 0.0003 0.0009 0.0047 0.0014 0.0004 0.0033 0.0057 0.0035 0.0028 0.0026 0.0001 0.0003 0 0.0005 0.0013
Bud Site 0.0012 0.0195 0.0039 0.0006 0.0022 0.001 0.0085 0.0099 0.0182 0.0062 0.0029 0.0013 0.0111 0.0019 0.0066 0.0001 0.0008 0.0022
Cell Periphery 0.0025 0.0012 0.0006 0.0005 0.0008 0.004 0.0038 0.0006 0.0009 0.0005 0.0007 0.0017 0.0009 0.0006 0.0004 0.0002 0.0001 0.0005
Cytoplasm 0.8646 0.8816 0.9134 0.9109 0.8009 0.8313 0.7247 0.8516 0.8556 0.7639 0.8233 0.8547 0.7363 0.8694 0.8465 0.9518 0.7957 0.886
Cytoplasmic Foci 0.0061 0.0094 0.0051 0.0121 0.019 0.017 0.0267 0.0095 0.0119 0.018 0.0312 0.0096 0.0116 0.0057 0.0151 0.0034 0.0307 0.0048
Eisosomes 0.0003 0.0001 0.0001 0 0.0004 0.0003 0.0004 0 0.0001 0.0001 0.0001 0.0002 0.0002 0.0001 0.0001 0 0 0.0002
Endoplasmic Reticulum 0.0081 0.0037 0.0043 0.0074 0.0027 0.0056 0.0039 0.0018 0.0029 0.003 0.0026 0.0022 0.006 0.0046 0.0079 0.0046 0.0051 0.0048
Endosome 0.0021 0.0065 0.0043 0.0067 0.0183 0.0023 0.0188 0.004 0.0065 0.0144 0.0229 0.0079 0.0059 0.0025 0.0043 0.0019 0.0939 0.0063
Golgi 0.0009 0.0008 0.0006 0.002 0.0193 0.0015 0.0079 0.0013 0.0027 0.0032 0.0047 0.004 0.0107 0.0005 0.0054 0.0002 0.0434 0.0041
Lipid Particles 0.0009 0.0002 0.0003 0.0004 0.0103 0.0012 0.0196 0.0005 0.002 0.001 0.005 0.005 0.0036 0.0008 0.0015 0.0003 0.0005 0.0023
Mitochondria 0.0002 0.0002 0.0001 0.0002 0.0032 0.0003 0.0047 0.0005 0.0049 0.0041 0.011 0.0074 0.036 0 0.0054 0 0.0017 0.0013
None 0.1017 0.0593 0.0584 0.046 0.0029 0.0705 0.1005 0.1149 0.063 0.1372 0.0654 0.0592 0.1177 0.1098 0.0718 0.0346 0.0174 0.0349
Nuclear Periphery 0.0012 0.0005 0.0005 0.0007 0.0007 0.0003 0.0017 0.0002 0.0015 0.0008 0.0009 0.0019 0.0004 0.0006 0.0006 0.0005 0.0007 0.0018
Nucleolus 0.0002 0.0001 0 0 0.0001 0.0001 0.0007 0.0001 0.0002 0.0008 0.0005 0.0002 0.0002 0.0001 0.0001 0 0 0.0001
Nucleus 0.001 0.0007 0.0005 0.0006 0.0005 0.0004 0.0012 0.0006 0.0012 0.0021 0.001 0.0011 0.0005 0.0005 0.0004 0.0004 0.0003 0.0006
Peroxisomes 0.0002 0.0001 0 0.0002 0.0058 0.0004 0.0238 0.0003 0.0042 0.0122 0.0123 0.007 0.0053 0.0001 0.0197 0 0.0005 0.001
Punctate Nuclear 0.0007 0.0004 0.0002 0.0003 0.0012 0.0004 0.005 0.0003 0.001 0.001 0.0024 0.0028 0.0005 0.0004 0.0003 0.0002 0.0002 0.0012
Vacuole 0.001 0.0016 0.0018 0.0019 0.0007 0.0007 0.0025 0.0013 0.0024 0.0037 0.0016 0.0012 0.0013 0.0007 0.0011 0.0012 0.0021 0.0005
Vacuole Periphery 0.0001 0.0002 0.0002 0.0003 0.0002 0.0001 0.0005 0.0001 0.0004 0.0005 0.0005 0.0003 0.0003 0.0001 0.0002 0.0001 0.0011 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 10.1874 7.5368 16.7778 22.3763 10.0202 11.5862 15.0821 13.7154 14.5983 17.313
Translational Efficiency 0.5459 0.8119 0.6574 0.5757 0.6954 0.8037 0.5925 0.6292 0.8692 0.5362

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1511 1668 3254 56 2261 2259 2596 1805 3772 3927 5850 1861

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 752.19 856.43 957.70 4500.69 806.16 802.46 867.77 943.68 784.54 825.38 917.79 1050.72
Standard Deviation 88.40 117.34 115.58 1161.19 98.08 104.19 145.63 120.80 97.96 113.16 137.25 651.15
Intensity Change Log 2 — 0.187238 0.348477 2.580977 — -0.006637 0.106247 0.227232 — 0.090199 0.228249 1.804746

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000265 0.000838 0.000271 0.000338 0.000896 0.000854 0.001498 0.001407 0.000644 0.000847 0.000816 0.001375
Bud Neck 0.012237 0.014987 0.005148 0.000858 0.016853 0.037315 0.007783 0.006824 0.015004 0.027831 0.006317 0.006645
Bud Site 0.013833 0.029102 0.015297 0.000243 0.020835 0.043470 0.023647 0.038836 0.018030 0.037367 0.019002 0.037675
Cell Periphery 0.000329 0.000249 0.000084 0.001341 0.000518 0.000333 0.000190 0.000209 0.000442 0.000297 0.000131 0.000243
Cytoplasm 0.600332* 0.611749* 0.795536* 0.206031* 0.592555* 0.528233* 0.791663* 0.642259* 0.595670* 0.563706* 0.793817* 0.629132*
Cytoplasmic Foci 0.211541* 0.188164* 0.018416 0.002657 0.193462* 0.194486* 0.034838 0.046229 0.200704* 0.191801* 0.025703 0.044918
Eisosomes 0.000269 0.000209 0.000026 0.000012 0.000740 0.000405 0.000095 0.000075 0.000552 0.000322 0.000057 0.000073
Endoplasmic Reticulum 0.001137 0.001075 0.000228 0.000047 0.001762 0.001010 0.000286 0.000771 0.001512 0.001038 0.000254 0.000749
Endosome 0.016841 0.012381 0.001135 0.000007 0.013377 0.026723 0.001767 0.006694 0.014765 0.020631 0.001416 0.006493
Golgi 0.005926 0.005803 0.000124 0.000244 0.010059 0.011840 0.000358 0.001626 0.008403 0.009276 0.000228 0.001585
Lipid Particles 0.004897 0.002404 0.000317 0.000041 0.004741 0.002922 0.000562 0.000597 0.004803 0.002702 0.000426 0.000581
Mitochondria 0.001798 0.001043 0.000221 0.001053 0.002137 0.004095 0.000276 0.003365 0.002001 0.002798 0.000246 0.003295
Mitotic Spindle 0.000841 0.001842 0.004263 0.000000 0.000983 0.004637 0.001753 0.017202 0.000926 0.003450 0.003149 0.016685
None 0.002782 0.001650 0.002205 0.030372 0.002328 0.000874 0.002599 0.001265 0.002510 0.001203 0.002380 0.002141
Nuclear Periphery 0.000118 0.000074 0.000216 0.000139 0.000089 0.000124 0.000083 0.000129 0.000101 0.000103 0.000157 0.000129
Nuclear Periphery Foci 0.000955 0.000750 0.000264 0.000207 0.000466 0.000211 0.000471 0.000510 0.000662 0.000440 0.000356 0.000501
Nucleolus 0.000492 0.000266 0.000138 0.000330 0.000346 0.000300 0.000285 0.000248 0.000405 0.000286 0.000203 0.000251
Nucleus 0.033520 0.036132 0.063818 0.752300* 0.042927 0.022813 0.044233 0.023201 0.039159 0.028470 0.055127 0.045141
Peroxisomes 0.002012 0.003379 0.000393 0.000007 0.002737 0.006819 0.001115 0.001991 0.002446 0.005358 0.000714 0.001931
Vacuole 0.088348 0.086836 0.091800 0.003594 0.090637 0.110253 0.086306 0.205397* 0.089720 0.100307 0.089362 0.199324
Vacuole Periphery 0.001527 0.001067 0.000099 0.000180 0.001553 0.002281 0.000193 0.001163 0.001542 0.001765 0.000141 0.001134

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.95 1.06 -1.32 3.62 -1.79 0.16 -1.16 -0.34 -0.68 0.87 -1.12 -0.29 -1.25 -0.66 -1.22
Bud Neck -2.04 9.06 14.06 12.78 7.57 -11.41 11.03 11.99 19.23 1.48 -10.77 14.72 13.24 19.99 -0.27
Bud Site -8.68 2.37 18.83* 18.06* 10.75 -10.32 0.59 -3.21 5.06 -3.43 -13.07 3.03 -4.34 3.82 -5.64
Cell Periphery 4.28 16.44 -1.85 -1.97 -2.23 5.15 10.84 10.46 5.16 0.27 6.44 17.37 6.86 2.80 -2.71
Cytoplasm -1.28 -18.55 12.33 12.63 16.53 9.11 -25.52 -2.02 -9.30 17.79 6.03 -31.12 -0.16 -4.24 19.14
Cytoplasmic Foci 3.95 45.06 48.99 43.05 16.44 -0.20 42.46 38.35 35.80 -3.48 2.32 62.84 49.34 44.64 -8.50
Eisosomes 2.93 14.36 14.86 14.90 3.43 4.18 8.56 8.93 12.49 1.34 4.73 10.80 10.59 15.07 -1.38
Endoplasmic Reticulum 0.28 5.45 7.10 6.02 13.42 2.62 6.49 3.27 1.27 -0.79 2.45 8.24 3.01 1.55 -0.83
Endosome 3.63 15.84 16.94 16.30 17.86 -10.27 21.00 12.07 17.33 -7.91 -6.36 25.84 15.01 18.26 -8.71
Golgi 0.32 18.31 16.87 12.42 -1.39 -2.04 18.11 15.20 15.06 -3.22 -1.51 23.55 17.47 16.72 -3.68
Lipid Particles 4.33 8.02 8.65 15.45 12.56 5.79 15.99 16.14 12.45 0.84 7.08 15.79 15.46 16.59 -1.71
Mitochondria 1.30 2.79 1.26 -0.05 -4.18 -3.82 6.98 -0.10 2.18 -2.68 -2.08 6.37 -0.24 0.80 -2.72
Mitotic Spindle -1.01 -3.07 1.27 2.49 5.58 -3.49 -1.13 -6.03 -3.66 -5.76 -3.46 -3.43 -6.07 -4.47 -5.05
None 2.99 1.70 -2.61 -2.72 -2.67 5.54 0.60 4.23 -0.95 2.49 5.92 1.41 1.32 -1.91 0.44
Nuclear Periphery 1.38 -8.29 -0.72 -2.04 6.22 -0.50 -0.87 -2.87 -0.70 -4.76 -0.05 -7.76 -3.12 -1.71 7.50
Nuclear Periphery Foci 1.43 8.64 4.66 2.63 0.48 8.56 -1.76 -0.42 -6.31 1.09 3.49 6.26 3.86 -0.51 -1.11
Nucleolus 5.23 7.81 1.56 -1.06 -2.22 1.90 2.28 1.41 0.75 -0.06 5.36 7.64 2.26 0.51 -0.70
Nucleus -1.84 -24.83 -20.13 -20.04 -18.68 14.61 -5.55 10.22 -4.12 14.45 10.03 -21.90 -3.18 -6.46 6.18
Peroxisomes -5.85 14.01 18.91 16.36 5.79 -9.71 9.01 3.24 11.30 -3.44 -11.02 14.83 2.79 11.17 -5.18
Vacuole 0.03 -12.57 25.47 24.52 34.89* -5.55 -8.05 -26.31 -22.16 -20.31 -4.38 -14.93 -26.31 -23.98 -18.70
Vacuole Periphery 2.18 8.03 6.64 5.85 -1.14 -3.23 10.51 2.70 4.77 -2.38 -1.38 13.34 2.90 3.64 -2.55
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Alpha arrestin; controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Aly2

Aly2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Aly2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available