Standard name
Human Ortholog
Description Subunit of the import motor (PAM complex); the PAM complex is a component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.13 0.17 0.14 0 0 0 0 0.05 0.06
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.08 0.07 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 – 0.08 0 0 0 0 0 0 0 0.08 0.07 0.09 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0.06 0 0 0.05 0 – 0 0 0 0 0 0 0 0.08 0.46 0.34 0.42 0 0.08 0.06 0.11 0.15 0.14
Mitochondria 0.92 0.86 0.96 0.98 0.93 0.9 – 0.8 0.9 0.88 0.91 0.91 0.87 0.9 0.9 0.08 0.12 0.07 0.87 0.79 0.82 0.71 0.63 0.62
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0.05 0 0 0.1 – 0.05 0.1 0.06 0.13 0.08 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.13 0.1 0.08 0.09 0.09 0.18 – 0.17 0.17 0.13 0.16 0.14 0 0.08 0.05 0.1 0.1 0.17 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.1 0.11 0.06 0 0.05 0 – 0 0.05 0 0 0.05 0.16 0.09 0.09 0.12 0.22 0.15 0 0.07 0.05 0.11 0.07 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 3 0 2 1 1 0 – 2 0 0 0 2 0 2 5 7 10 14 2 1 0 1 16 24
Bud 0 0 1 2 8 5 – 13 7 15 7 15 2 3 1 2 1 4 0 1 0 0 2 4
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 1 2 0 1 – 7 5 2 2 2 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 2 3 0 1 0 – 4 1 3 4 6 1 0 3 4 4 3 0 0 0 0 0 0
Cytoplasm 0 1 2 0 5 7 – 34 8 23 13 13 1 2 7 4 4 9 0 0 0 0 0 0
Endoplasmic Reticulum 2 1 0 0 0 1 – 0 1 3 0 2 0 1 1 2 1 3 0 0 0 0 1 1
Endosome 0 0 1 0 1 0 – 1 1 3 3 1 0 0 1 0 0 2 2 0 0 2 6 8
Golgi 10 6 2 1 19 1 – 0 0 1 1 2 4 13 37 24 20 43 17 8 6 12 48 57
Mitochondria 365 85 102 218 346 246 – 357 359 492 275 552 167 328 410 4 7 7 348 80 86 80 206 250
Nucleus 1 0 0 0 0 1 – 11 2 11 2 4 1 0 0 1 0 2 0 0 0 1 1 1
Nuclear Periphery 9 2 5 5 8 28 – 22 41 36 40 51 6 7 7 2 0 1 3 0 0 0 1 3
Nucleolus 50 10 8 21 35 49 – 78 67 72 49 85 7 28 22 5 6 17 4 0 0 1 6 6
Peroxisomes 0 0 0 2 0 1 – 5 1 3 0 3 3 5 6 2 1 5 1 0 3 1 13 11
SpindlePole 1 0 0 1 0 0 – 2 3 1 2 7 0 0 0 0 0 2 0 0 0 0 1 2
Vac/Vac Membrane 38 11 6 4 18 5 – 16 18 21 5 30 30 33 39 6 13 15 13 6 5 12 21 25
Unique Cell Count 395 99 106 222 372 273 446 399 561 302 609 192 363 456 52 59 103 398 102 106 114 329 402
Labelled Cell Count 480 118 133 257 442 345 552 514 686 403 775 222 422 539 63 67 127 398 102 106 114 329 402


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 19.2 23.6 10.8 13.9 14.9 12.1 – 10.2 9.8 9.8 9.1 9.1 19.0 18.9 18.4 25.7 28.0 22.8 20.9 20.5 21.1
Std Deviation (1e-4) 3.9 5.5 2.1 3.0 3.1 3.7 – 3.6 3.0 2.7 2.9 2.5 4.6 4.2 4.2 8.0 9.4 8.1 9.8 5.1 5.6
Intensity Change (Log2) – – – 0.37 0.46 0.16 – -0.08 -0.14 -0.15 -0.25 -0.24 0.81 0.81 0.77 1.25 1.37 1.08 0.95 0.92 0.97

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP7000102030WT3HU80HU120HU1600102030WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30102030WT1AF100AF140AF1800102030
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 3.2
Bud 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 – 2.2 0 0 0 0 0 0 0 0 0 2.2
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 0 0 2.3 7.1 5.8 7.0
Mitochondria 1.1 -1.2 -2.0 – -4.0 -2.0 -2.6 -1.7 -1.9 -2.6 -1.9 -2.1 -11.1 -11.0 -12.9
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 1.7 – 0.1 1.8 0.7 2.4 1.3 0 0 0 0 0 0
Nucleolus 0.6 0.6 2.5 – 2.5 2.4 1.5 2.2 1.8 -1.5 0.1 -1.1 0 0.6 2.0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 -0.3 0 – 0 -0.5 0 0 -0.3 2.5 1.1 1.0 0 3.2 2.1

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 13.3382 14.1558 13.3844 13.9158 10.4468 13.2667 14.661 14.6739 13.9518 13.8045 13.6804 14.0177 17.7806 17.2387 17.7349 17.227 15.0113 17.2529
Actin 0.012 0.0058 0.0048 0.0257 0.0018 0.0087 0.0243 0.0037 0.0041 0.0092 0.002 0.0037 0.0133 0.0116 0.0051 0.0006 0.0172 0.0046
Bud 0.0027 0.0059 0.001 0.009 0.0001 0.0004 0.0005 0.0044 0.0013 0.0002 0.0001 0.0003 0.0007 0.0017 0.0015 0.0007 0.0003 0.0006
Bud Neck 0.0004 0.0007 0.0007 0.0007 0.0001 0.0019 0.0006 0.0019 0.0004 0.0005 0.0003 0.0006 0.0008 0.0006 0.0004 0.0008 0.0005 0.0091
Bud Periphery 0.0022 0.0106 0.0018 0.0151 0.0003 0.0005 0.0008 0.0075 0.0012 0.0005 0.0001 0.0006 0.0011 0.0025 0.0018 0.0012 0.0003 0.0013
Bud Site 0.0038 0.0301 0.0047 0.0045 0.0001 0.0008 0.0022 0.0239 0.0048 0.0004 0.0001 0.0004 0.0044 0.0058 0.0053 0.0021 0.0007 0.0006
Cell Periphery 0.0007 0.0026 0.0004 0.0008 0.0002 0.0003 0.0009 0.0035 0.0013 0.0004 0.0002 0.0005 0.0009 0.0016 0.0006 0.0007 0.0004 0.0003
Cytoplasm 0.0034 0.001 0.0005 0.0064 0.0001 0.0004 0.0012 0.0017 0.001 0.0001 0 0.0001 0.0036 0.0081 0.0003 0 0.0001 0.0028
Cytoplasmic Foci 0.0167 0.0071 0.0125 0.0067 0.0043 0.0082 0.0094 0.0127 0.0088 0.0005 0.002 0.0056 0.0124 0.0075 0.0032 0.0037 0.0075 0.0036
Eisosomes 0.0003 0.0002 0.0003 0.0002 0.0001 0.0002 0.0005 0.0003 0.0003 0.0005 0.0002 0.0002 0.0004 0.0002 0.0001 0.0001 0.0002 0.0002
Endoplasmic Reticulum 0.0014 0.0003 0.0005 0.0033 0.0001 0.0005 0.001 0.0005 0.0002 0.0004 0 0.0001 0.0007 0.0001 0.0001 0 0 0.0014
Endosome 0.013 0.0072 0.0099 0.0146 0.006 0.0216 0.0216 0.0264 0.0078 0.0033 0.0064 0.0097 0.0147 0.0113 0.0045 0.001 0.0018 0.0062
Golgi 0.0069 0.0173 0.0113 0.0041 0.0055 0.0302 0.0144 0.0188 0.0135 0.0069 0.0266 0.0263 0.0116 0.0148 0.012 0.0013 0.0122 0.0159
Lipid Particles 0.0296 0.0081 0.0126 0.0022 0.0707 0.0133 0.0216 0.0107 0.0125 0.0033 0.0262 0.0131 0.0241 0.0224 0.0115 0.0111 0.0043 0.0048
Mitochondria 0.8686 0.8728 0.9044 0.8945 0.8925 0.8941 0.8114 0.8008 0.8786 0.9589 0.9213 0.9223 0.8409 0.8175 0.9173 0.9527 0.9064 0.9222
None 0.0026 0.0003 0.0004 0.0017 0.0002 0.0002 0.0015 0.0002 0.0003 0.0007 0 0 0.0028 0.0001 0.0009 0 0.0002 0.0001
Nuclear Periphery 0.0061 0.0002 0.0008 0.002 0.0008 0.0005 0.0043 0.0011 0.001 0.002 0.0001 0 0.0013 0.0002 0.0001 0 0 0.0008
Nucleolus 0.0008 0.0032 0.0014 0.0002 0.0003 0.0002 0.0136 0.0104 0.0123 0.0005 0.0005 0.0061 0.0074 0.0117 0.005 0.0129 0.035 0.0009
Nucleus 0.0014 0.0008 0.0003 0.0007 0.0001 0.0002 0.0019 0.0026 0.0024 0.0006 0.0001 0.0004 0.0027 0.0013 0.0008 0.0007 0.0017 0.0014
Peroxisomes 0.0122 0.0069 0.0077 0.0017 0.0099 0.0057 0.0183 0.014 0.0067 0.0021 0.0029 0.0043 0.0161 0.02 0.008 0.006 0.0091 0.0088
Punctate Nuclear 0.0031 0.0007 0.0024 0.002 0.0007 0.0011 0.0021 0.0002 0.0034 0.0003 0 0 0.0016 0.0001 0.0008 0.0001 0.0003 0.0009
Vacuole 0.0053 0.0087 0.0057 0.0015 0.0017 0.0033 0.0184 0.0283 0.0246 0.0034 0.0013 0.0024 0.019 0.0267 0.0111 0.0027 0.0009 0.0036
Vacuole Periphery 0.0067 0.0095 0.0159 0.0024 0.0043 0.0078 0.0292 0.0263 0.0135 0.0054 0.0096 0.0033 0.0195 0.0343 0.0096 0.0014 0.0011 0.01

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 30.6501 41.647 47.1691 47.4728 30.2018 41.6611 38.2308 55.346 60.9035 57.4892
Translational Efficiency 2.9933 2.1175 1.7319 2.2742 2.8046 2.4941 3.2196 2.2186 2.0505 2.03

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1392 1328 336 1354 1458 50 418 1626 2850 1378 754 2980

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1225.01 1576.63 1764.39 1958.56 1333.67 1693.92 1879.95 1944.22 1280.60 1580.89 1828.45 1950.74
Standard Deviation 275.78 391.03 442.21 407.33 345.09 378.63 336.95 391.45 317.84 391.21 391.64 398.81
Intensity Change Log 2 — 0.364051 0.526376 0.677000 — 0.344964 0.495293 0.543790 — 0.354134 0.510258 0.609102

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001996 0.004584 0.014825 0.003257 0.002237 0.003378 0.005633 0.002609 0.002119 0.004541 0.009729 0.002903
Bud Neck 0.002727 0.002668 0.015404 0.003331 0.000997 0.003916 0.007244 0.000492 0.001842 0.002714 0.010880 0.001782
Bud Site 0.007809 0.006643 0.034553 0.004307 0.002829 0.005271 0.009876 0.000988 0.005261 0.006594 0.020873 0.002496
Cell Periphery 0.000505 0.000209 0.000919 0.000666 0.001611 0.000419 0.000346 0.000575 0.001070 0.000216 0.000601 0.000616
Cytoplasm 0.001592 0.000613 0.003058 0.000480 0.000248 0.000719 0.000810 0.000228 0.000904 0.000617 0.001812 0.000342
Cytoplasmic Foci 0.026301 0.024373 0.059782 0.006038 0.005903 0.075143 0.031522 0.004039 0.015866 0.026215 0.044115 0.004947
Eisosomes 0.000285 0.000549 0.000675 0.000480 0.001095 0.001044 0.000391 0.000462 0.000700 0.000567 0.000518 0.000470
Endoplasmic Reticulum 0.000387 0.000182 0.008639 0.000232 0.000160 0.001259 0.000535 0.000116 0.000271 0.000221 0.004146 0.000169
Endosome 0.019108 0.008507 0.039099 0.002456 0.001414 0.014712 0.010460 0.001350 0.010056 0.008732 0.023222 0.001853
Golgi 0.027592 0.024712 0.051922 0.015923 0.004320 0.046871 0.022871 0.011212 0.015687 0.025516 0.035817 0.013352
Lipid Particles 0.009117 0.006607 0.010521 0.003651 0.003251 0.020436 0.005695 0.000567 0.006116 0.007109 0.007846 0.001968
Mitochondria 0.853484 0.883398 0.629822 0.895468 0.956363 0.721956 0.797372 0.958303 0.906115 0.877540 0.722708 0.929753
Mitotic Spindle 0.001281 0.002345 0.020059 0.002505 0.000138 0.028642 0.021616 0.000506 0.000696 0.003300 0.020922 0.001414
None 0.001961 0.002017 0.003113 0.002997 0.002958 0.001603 0.002444 0.001588 0.002471 0.002002 0.002742 0.002228
Nuclear Periphery 0.000586 0.000436 0.002143 0.000753 0.000181 0.009385 0.002611 0.000092 0.000378 0.000760 0.002402 0.000392
Nuclear Periphery Foci 0.000709 0.000373 0.002336 0.000372 0.000202 0.006297 0.001451 0.000055 0.000450 0.000588 0.001845 0.000199
Nucleolus 0.001178 0.001069 0.002506 0.001110 0.000653 0.000925 0.001953 0.000177 0.000909 0.001064 0.002200 0.000601
Nucleus 0.000365 0.000221 0.000531 0.002887 0.000096 0.000209 0.000220 0.000029 0.000228 0.000221 0.000358 0.001328
Peroxisomes 0.013410 0.012008 0.013946 0.003671 0.005963 0.029634 0.013550 0.002381 0.009600 0.012647 0.013726 0.002967
Vacuole 0.014000 0.010297 0.050131 0.016980 0.003928 0.018957 0.030224 0.003303 0.008848 0.010611 0.039095 0.009517
Vacuole Periphery 0.015607 0.008189 0.036017 0.032435 0.005456 0.009225 0.033177 0.010930 0.010414 0.008227 0.034443 0.020701

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.47 -5.33 -1.60 1.25 4.61 -1.16 -2.25 -0.43 0.69 1.90 -3.33 -5.58 -1.35 1.91 4.77
Bud Neck 0.12 -7.36 -1.31 -1.42 6.62 -2.30 -5.93 2.28 2.72 6.51 -2.08 -9.24 -0.27 1.70 9.01
Bud Site 0.65 -4.71 2.09 1.21 5.29 -0.93 -2.86 1.83 1.74 3.77 -0.85 -5.37 2.93 2.80 6.34
Cell Periphery 2.09 -2.54 -0.87 -3.26 1.63 1.74 1.97 1.60 -0.50 -1.21 2.58 1.28 1.30 -3.65 0.11
Cytoplasm 1.93 -1.57 1.87 -0.15 2.64 -2.46 -3.14 0.22 2.53 3.20 1.11 -1.98 1.94 1.10 3.22
Cytoplasmic Foci 0.73 -5.23 9.71 9.17 8.59 -4.15 -6.11 2.02 4.26 6.60 -4.72 -7.55 9.60 10.81 10.72
Eisosomes -5.80 -4.09 -4.12 1.19 1.92 0.12 4.70 3.89 1.41 -0.59 1.67 2.04 2.60 1.39 0.59
Endoplasmic Reticulum 3.07 -2.87 1.54 -1.53 2.91 -1.36 -1.01 1.27 1.41 1.13 1.04 -2.97 2.07 0.90 3.03
Endosome 4.81 -3.90 8.69 5.06 7.67 -2.40 -5.35 0.13 2.41 5.39 0.90 -5.17 8.35 5.99 8.98
Golgi 0.93 -3.81 4.20 3.25 5.84 -2.78 -5.11 -4.47 2.32 3.06 -4.02 -5.68 1.49 5.09 6.41
Lipid Particles 1.67 -0.89 3.47 2.29 4.19 -1.56 -1.98 4.79 1.80 4.57 -0.88 -1.68 5.16 5.07 6.07
Mitochondria -3.09 10.36 -4.02 -0.86 -12.28 4.90 10.50 -0.40 -4.95 -10.69 3.69 13.87 -4.13 -6.89 -15.76
Mitotic Spindle -1.24 -5.26 -2.25 -0.52 4.78 -1.40 -4.43 -2.83 1.38 4.35 -2.40 -6.53 -2.64 1.54 6.23
None -0.30 -3.07 -5.78 -4.78 0.17 4.06 1.92 8.59 0.05 3.60 2.76 -1.15 1.96 -1.45 2.27
Nuclear Periphery 1.04 -4.58 -1.48 -2.30 4.07 -1.28 -3.82 2.35 1.30 3.96 -1.33 -5.27 -0.31 1.27 5.23
Nuclear Periphery Foci 2.55 -3.79 2.45 -0.01 4.68 -1.28 -2.62 2.89 1.31 2.94 -0.68 -4.27 3.52 2.03 5.10
Nucleolus 0.21 -2.10 -0.25 -0.53 2.17 -0.83 -2.82 3.13 2.57 4.05 -0.43 -3.33 1.00 1.14 4.31
Nucleus 1.19 -1.38 -3.14 -3.24 -2.95 -2.05 -3.04 3.68 3.44 5.12 0.14 -1.85 -3.08 -3.09 -2.81
Peroxisomes 0.67 -0.19 5.72 5.47 4.81 -1.74 -2.75 2.77 2.01 4.45 -1.76 -2.15 6.25 6.63 6.37
Vacuole 2.20 -6.67 -1.56 -3.43 6.00 -1.96 -6.43 0.84 2.04 6.57 -1.30 -9.06 -0.72 0.71 8.77
Vacuole Periphery 4.39 -4.53 -5.73 -9.20 0.73 -1.59 -6.44 -3.27 -0.63 4.95 1.94 -7.68 -6.24 -7.74 4.14
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the import motor (PAM complex); the PAM complex is a component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain
Localization
Cell Percentages mitochondrion (98%)
Cell Cycle Regulation No
Subcompartmental Group mito-3

Pam16

Pam16


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pam16-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available