Standard name
Human Ortholog
Description Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the self-assembled oligomeric form of the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 – 0.09 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0.05 0 0 0 – 0 0 – 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 – 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0.05 0.06 0.09 0 0 0 0 0 0 0 – 0.12 0.1 – 0.19 0.33 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 – 0.05 0.06 0 0 0 0 0 0
Endosome 0.09 0 0.07 0.05 0.1 0 0 0 0 0 0 0 – 0.17 0.16 – 0.12 0.18 0.09 0.09 0.1 0.06 0.09 0.15
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 – 0 0.08 0 0 0 0 0 0
Mitochondria 0.77 0.89 0.86 0.85 0.67 0.79 0.75 0.78 0.88 0.91 0.9 0.88 – 0.46 0.31 – 0.14 0.19 0.75 0.69 0.7 0.66 0.64 0.52
Nucleus 0 0 0 0 0 0.1 0.11 0.11 0 0 0 0 – 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0.06 0.08 0.07 0.09 0.13 0.06 0.12 0.12 0.1 0.1 – 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0.06 0.05 0 0.06 0.11 0.17 0.18 0.19 0.18 0.18 0.19 – 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0.05 – 0.12 0 0 0 0.05 0.05 0.05 0.09
SpindlePole 0 0 0 0 0 0 0.05 0.06 0.05 0 0 0 – 0 0.09 – 0.22 0.07 0 0 0 0 0 0
Vac/Vac Membrane 0.38 0.27 0.16 0.09 0.22 0.08 0.05 0 0 0 0 0 – 0.38 0.41 – 0.14 0.21 0.05 0.1 0 0.08 0.06 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 0 0 0 0 0 0 0 0 0 0 – 3 3 – 3 1 0 2 5 1 7 5
Bud 0 4 2 2 2 1 9 14 10 12 11 19 – 4 4 – 8 3 1 0 0 2 2 2
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 – 2 0 1 3 1 2 6 8
Bud Site 0 1 0 0 3 5 8 14 21 20 12 14 – 0 0 – 2 0 – – – – – –
Cell Periphery 2 3 2 1 0 0 5 0 1 2 0 1 – 1 3 – 1 3 0 0 0 0 0 0
Cytoplasm 5 1 12 11 21 12 13 19 7 7 5 4 – 12 15 – 17 24 0 0 0 1 0 0
Endoplasmic Reticulum 2 1 4 3 0 2 4 0 0 0 1 0 – 3 1 – 4 4 0 0 1 0 2 1
Endosome 21 2 15 8 25 5 11 2 8 1 3 9 – 18 24 – 11 13 24 22 22 10 25 37
Golgi 3 0 2 0 0 0 0 0 0 0 0 0 – 2 4 – 1 6 6 6 6 2 10 10
Mitochondria 185 225 196 146 165 215 397 351 351 521 314 507 – 47 47 – 12 14 193 170 161 113 185 134
Nucleus 4 3 2 3 6 26 60 50 16 22 7 9 – 3 4 – 1 3 1 3 0 1 1 1
Nuclear Periphery 7 8 13 14 16 24 68 28 47 68 35 60 – 0 1 – 0 0 4 2 4 6 3 3
Nucleolus 4 14 11 5 14 30 92 79 75 104 61 108 – 2 1 – 3 1 0 2 1 1 3 4
Peroxisomes 2 0 8 3 5 2 11 4 7 6 0 7 – 1 7 – 11 1 6 3 12 8 15 23
SpindlePole 1 2 3 3 2 4 26 27 18 20 12 21 – 2 14 – 19 5 2 4 2 0 4 5
Vac/Vac Membrane 90 68 37 15 53 23 24 15 14 19 8 22 – 39 62 – 12 15 14 24 5 13 16 14
Unique Cell Count 239 252 229 172 245 271 529 449 399 572 347 579 103 151 88 72 259 249 231 172 290 256
Labelled Cell Count 326 333 307 214 312 349 728 603 575 802 469 781 137 190 107 93 259 249 231 172 290 256


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.0 6.0 6.2 5.7 5.4 4.8 4.5 4.5 4.5 4.0 4.3 4.5 – 6.5 6.7 4.9 5.2 6.9 6.7 7.1 7.6
Std Deviation (1e-4) 1.3 0.9 2.0 1.7 1.6 1.7 1.4 1.5 1.1 1.2 1.1 1.2 – 1.1 1.3 1.2 1.3 2.1 1.4 1.3 1.9
Intensity Change (Log2) – – – -0.12 -0.19 -0.36 -0.46 -0.46 -0.46 -0.61 -0.54 -0.46 – 0.07 0.13 -0.35 -0.25 0.16 0.11 0.2 0.3


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 – 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 – 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 – 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 – 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 – 0 0
Cytoplasm 0.5 1.4 -0.4 -2.0 -0.6 -2.5 -3.4 -2.6 0 – 2.1 1.7 – 3.9 6.4
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 – 0 0
Endosome -0.8 1.4 0 0 0 0 0 0 0 – 3.1 2.9 – 1.7 2.9
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 – 0 0
Mitochondria -0.2 -4.7 0 0 0 0 0 0 0 – -7.6 -10.8 – -12.1 -10.7
Nucleus 0 0 4.2 4.8 4.7 2.3 2.2 0 0 – 0 0 – 0 0
Nuclear Periphery 1.0 0.4 0 0 0 0 0 0 0 – 0 -2.5 – 0 0
Nucleolus -1.0 0.4 0 0 0 0 0 0 0 – 0 0 – 0 0
Peroxisomes 0 -1.0 0 0 0 0 0 0 0 – 0 0.6 – 3.0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 3.7 – 6.4 0
Vacuole -2.2 1.5 -2.6 -5.4 -5.9 -5.6 -6.4 -6.1 -6.1 – 4.4 5.4 – -0.6 0.9

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.8756 1.774 1.6079 1.5511 1.7383 1.5866 3.8372 3.8537 3.6521 3.4355 3.381 3.695 3.5412 3.8937 3.6646 3.4385 3.4648 3.3628
Actin 0.0149 0.0184 0.009 0.0024 0.007 0.0097 0.0256 0.0144 0.0069 0.0004 0.0159 0.0053 0.02 0.0075 0.0124 0.0013 0.0032 0.0096
Bud 0.0014 0.0043 0.0013 0.0026 0.0027 0.001 0.0014 0.0044 0.0016 0.0004 0.0007 0.0007 0.0011 0.0027 0.002 0.0012 0.0049 0.0007
Bud Neck 0.0049 0.001 0.0011 0.0051 0.0027 0.0046 0.0073 0.0021 0.0107 0.0002 0.0009 0.0013 0.0032 0.0011 0.001 0.0014 0.0005 0.0014
Bud Periphery 0.004 0.0048 0.0023 0.0072 0.0066 0.0028 0.0031 0.0058 0.0031 0.0007 0.0008 0.0026 0.0027 0.0036 0.0042 0.0062 0.0127 0.0024
Bud Site 0.0068 0.0405 0.0111 0.0039 0.01 0.0018 0.0079 0.0457 0.0078 0.0003 0.0018 0.0009 0.0119 0.0249 0.0093 0.0015 0.0023 0.0012
Cell Periphery 0.0011 0.0007 0.0006 0.001 0.0005 0.0008 0.0011 0.0015 0.0008 0.0001 0.0002 0.0006 0.0015 0.0008 0.0014 0.0007 0.0006 0.0004
Cytoplasm 0.0057 0.0072 0.0062 0.0024 0.0028 0.0043 0.0167 0.0186 0.0081 0.0007 0.0069 0.0049 0.0058 0.0102 0.0092 0.0017 0.0059 0.0041
Cytoplasmic Foci 0.0334 0.0526 0.0421 0.0196 0.043 0.0226 0.0262 0.0588 0.0395 0.0208 0.0788 0.0264 0.0357 0.0536 0.0328 0.0254 0.0272 0.0183
Eisosomes 0.0005 0.0003 0.0003 0.0002 0.0003 0.0003 0.0005 0.0004 0.0003 0.0001 0.0002 0.0003 0.001 0.0003 0.0004 0.0002 0.0002 0.0002
Endoplasmic Reticulum 0.0051 0.0048 0.0016 0.0007 0.0005 0.0019 0.0068 0.0021 0.0011 0.0002 0.0052 0.0013 0.0058 0.0019 0.0013 0.0003 0.0006 0.0013
Endosome 0.141 0.1217 0.1209 0.0724 0.1717 0.1154 0.1618 0.1817 0.114 0.0765 0.2517 0.0475 0.1422 0.1482 0.0815 0.0803 0.1054 0.0745
Golgi 0.0739 0.0751 0.061 0.061 0.0602 0.0586 0.0579 0.0856 0.0861 0.0257 0.1498 0.0502 0.0763 0.1053 0.0725 0.071 0.0945 0.0545
Lipid Particles 0.0257 0.0307 0.0207 0.0068 0.0024 0.0177 0.0323 0.0277 0.0087 0.0043 0.027 0.0107 0.055 0.0076 0.0109 0.0157 0.0041 0.0097
Mitochondria 0.5709 0.5675 0.6332 0.7642 0.6642 0.6918 0.5309 0.4741 0.6603 0.8516 0.3965 0.795 0.5652 0.5689 0.7059 0.7499 0.6795 0.7883
None 0.0138 0.0007 0.007 0.0012 0.0004 0.0072 0.0286 0.0118 0.0007 0.0002 0.001 0.0124 0.0044 0.0009 0.007 0.0003 0.0263 0.0008
Nuclear Periphery 0.0164 0.005 0.0041 0.0005 0.0003 0.0018 0.0138 0.0012 0.0004 0.0001 0.0024 0.0009 0.0057 0.0006 0.0007 0.0001 0.0002 0.0002
Nucleolus 0.0015 0.0006 0.0006 0.0007 0.0007 0.0004 0.0022 0.0019 0.0003 0.0001 0.0003 0.0003 0.0027 0.0005 0.0003 0.0005 0.0002 0.0002
Nucleus 0.0119 0.0012 0.0044 0.0007 0.0007 0.0006 0.004 0.0014 0.0005 0.0001 0.0006 0.0004 0.0012 0.0005 0.0004 0.0005 0.0003 0.0002
Peroxisomes 0.0265 0.0373 0.0421 0.0341 0.0132 0.0289 0.025 0.0243 0.0281 0.0112 0.0502 0.0247 0.0241 0.0347 0.0272 0.0186 0.0227 0.0217
Punctate Nuclear 0.0035 0.0005 0.0023 0.0001 0.0002 0.0002 0.0117 0.0007 0.0003 0.0001 0.0017 0.0002 0.0007 0.0002 0.0013 0.0001 0.0001 0.0001
Vacuole 0.0205 0.0129 0.0166 0.0072 0.0055 0.0137 0.0233 0.0256 0.0128 0.0036 0.0043 0.0075 0.0216 0.0162 0.0103 0.0166 0.0046 0.0049
Vacuole Periphery 0.0165 0.012 0.0116 0.0059 0.0046 0.0138 0.0119 0.0105 0.0079 0.0025 0.0032 0.0059 0.0121 0.0098 0.0078 0.0065 0.004 0.0053

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 13.6318 9.197 8.5307 13.0557 12.0051 13.8813 14.9947 14.9061 15.4798 19.308
Translational Efficiency 0.5572 1.0008 0.7607 0.4879 0.6535 0.5702 0.5118 0.5523 0.4505 0.4593

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
147 840 981 1097 1866 1428 223 2160 2013 2268 1204 3257

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1073.48 790.76 1026.15 1002.24 731.56 817.56 1086.32 990.03 756.53 807.63 1037.29 994.14
Standard Deviation 157.29 121.16 141.85 137.06 114.64 110.27 117.45 131.67 148.00 115.16 139.63 133.64
Intensity Change Log 2 — -0.440984 -0.065054 -0.099067 — 0.160348 0.570401 0.436496 — -0.166476 0.226900 0.142382

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.007622 0.000693 0.001330 0.001918 0.000203 0.000565 0.002637 0.000406 0.000745 0.000612 0.001572 0.000915
Bud Neck 0.007755 0.008553 0.006037 0.023426 0.016237 0.003908 0.021389 0.026318 0.015617 0.005628 0.008880 0.025344
Bud Site 0.154012* 0.022044 0.045884 0.225426* 0.018099 0.011009 0.139395* 0.126223* 0.028024 0.015096 0.063204 0.159636*
Cell Periphery 0.002393 0.000594 0.000415 0.001538 0.000659 0.000487 0.000971 0.001420 0.000786 0.000527 0.000518 0.001460
Cytoplasm 0.029423 0.006633 0.007873 0.024654 0.010318 0.004298 0.011555 0.027765 0.011713 0.005163 0.008555 0.026717
Cytoplasmic Foci 0.079318 0.043995 0.051984 0.017369 0.033907 0.038429 0.036703 0.009765 0.037223 0.040490 0.049154 0.012326
Eisosomes 0.000121 0.000075 0.000054 0.000081 0.000078 0.000070 0.000084 0.000065 0.000081 0.000072 0.000060 0.000070
Endoplasmic Reticulum 0.004556 0.000934 0.002236 0.001363 0.001058 0.000798 0.002593 0.001514 0.001313 0.000849 0.002302 0.001463
Endosome 0.105252 0.119237 0.096420 0.053231 0.106249 0.102041 0.094381 0.050201 0.106176 0.108410 0.096043 0.051221
Golgi 0.109766 0.101488 0.107520 0.038678 0.064791 0.118834* 0.046010 0.024127 0.068075 0.112409* 0.096128 0.029028
Lipid Particles 0.000786 0.005080 0.000696 0.000157 0.005537 0.002478 0.000631 0.000212 0.005190 0.003441 0.000684 0.000194
Mitochondria 0.107814* 0.566365* 0.345777* 0.289970* 0.608929* 0.618695* 0.280264* 0.351102* 0.572335* 0.599314* 0.333643* 0.330512*
Mitotic Spindle 0.024551 0.011231 0.082973 0.072662 0.006237 0.007709 0.113719* 0.046233 0.007574 0.009013 0.088668 0.055135
None 0.000178 0.001392 0.000548 0.000983 0.001209 0.000306 0.000463 0.001122 0.001134 0.000708 0.000532 0.001075
Nuclear Periphery 0.000454 0.000216 0.001663 0.000573 0.000546 0.000234 0.002725 0.000369 0.000540 0.000227 0.001860 0.000438
Nuclear Periphery Foci 0.000641 0.000877 0.002375 0.000498 0.000473 0.000289 0.001857 0.000227 0.000485 0.000506 0.002279 0.000318
Nucleolus 0.000169 0.001136 0.001087 0.001438 0.002099 0.000333 0.001341 0.002351 0.001958 0.000630 0.001134 0.002043
Nucleus 0.003087 0.002615 0.001513 0.003862 0.003675 0.000370 0.005051 0.005189 0.003632 0.001202 0.002168 0.004742
Peroxisomes 0.020216 0.023325 0.016517 0.014463 0.013109 0.014926 0.037871 0.005626 0.013628 0.018037 0.020472 0.008602
Vacuole 0.211830* 0.037112 0.104163 0.140700 0.049291 0.027219 0.116538 0.196994 0.061161 0.030883 0.106455 0.178034
Vacuole Periphery 0.130059* 0.046406 0.122933* 0.087009 0.057296 0.047003 0.083821 0.122770* 0.062609 0.046782 0.115689* 0.110725*

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.56 2.32 2.08 -2.92 -1.33 -2.92 -4.02 -4.64 1.23 3.68 0.57 -3.08 -0.75 -1.88 2.87
Bud Neck -0.35 1.45 -9.04 -7.11 -11.54 7.39 -1.72 -4.45 -12.44 -1.16 6.23 4.01 -5.28 -14.05 -11.37
Bud Site 7.39 5.98 -3.83 -25.03* -21.34 3.58 -9.52 -25.53 -27.62* 1.02 5.34 -8.28 -30.68 -36.23* -18.03
Cell Periphery 3.72 4.10 1.65 -4.48 -5.38 1.36 -0.63 -3.94 -5.12 -0.90 2.27 1.90 -4.13 -6.69 -5.77
Cytoplasm 3.05 2.90 0.54 -8.09 -7.79 4.39 -0.87 -8.71 -13.03 -7.60 4.73 2.07 -8.73 -15.24 -12.04
Cytoplasmic Foci 3.57 2.74 6.47 9.97 11.69 -1.88 -0.56 13.71 16.33 6.11 -1.47 -4.08 13.94 19.01 15.13
Eisosomes 1.82 2.68 1.61 -1.10 -7.20 1.46 -0.83 3.55 1.11 2.64 1.95 4.98 2.85 0.49 -3.73
Endoplasmic Reticulum 3.92 2.15 3.47 -2.47 1.49 1.63 -2.15 -2.58 -4.14 1.53 3.02 -1.99 -0.94 -4.78 1.71
Endosome -1.46 0.79 5.65 10.52 9.55 0.76 1.42 13.32 11.93 5.59 -0.48 2.01 14.21 15.91 12.02
Golgi 0.41 0.03 4.66 10.52 12.54 -10.04 3.34 13.72 19.80 4.15 -9.88 -5.62 13.08 22.34 15.57
Lipid Particles -3.22 0.41 2.89 3.74 5.39 2.99 5.49 6.42 3.65 1.51 1.80 5.82 6.49 5.19 4.95
Mitochondria -22.88* -12.42 -9.68 18.30 4.19 -0.89 14.98 25.15 24.45 -3.21 -2.60 19.48 25.54 30.18 0.53
Mitotic Spindle 2.01 -7.21 -6.49 -13.98 1.45 -1.14 -8.74 -15.08 -14.45 5.30 -1.17 -16.56 -20.09 -19.89 6.17
None -1.39 -11.35 -4.36 0.46 -2.35 2.78 2.30 0.35 -9.77 -7.28 1.00 2.02 0.28 -1.08 -6.47
Nuclear Periphery 1.62 -2.46 -0.54 -2.12 2.19 1.96 -1.06 1.07 -2.34 1.15 2.15 -2.38 0.62 -3.11 2.62
Nuclear Periphery Foci -0.66 -2.35 0.62 1.12 2.59 1.75 -1.33 2.73 0.87 1.55 -0.15 -2.91 1.77 1.42 3.20
Nucleolus -2.79 -3.63 -4.97 -0.71 -1.03 4.22 0.48 -0.43 -4.36 -0.81 3.28 1.68 -0.21 -4.12 -2.16
Nucleus 0.71 1.41 -0.07 -1.21 -2.77 4.34 -0.84 -1.64 -6.99 0.16 3.06 1.57 -1.46 -5.54 -3.50
Peroxisomes -0.48 0.61 0.97 3.06 0.87 -0.96 -3.64 5.83 5.63 4.76 -2.59 -3.07 3.81 6.33 5.69
Vacuole 8.96 5.56 3.64 -17.76 -5.67 8.48 -7.09 -30.16 -36.51 -7.73 10.34 -9.89 -26.91 -39.82 -14.19
Vacuole Periphery 5.33 0.32 2.70 -7.82 5.39 2.93 -2.88 -14.72 -16.91 -4.09 4.89 -9.80 -12.52 -18.52 1.06
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the self-assembled oligomeric form of the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication
Localization
Cell Percentages mitochondrion (90%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Mdv1

Mdv1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mdv1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available