Standard name
Human Ortholog
Description Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0.05 0.11 0.06 0.16 – 0.19 0.22 0.17 0.3 0.25 0.12 0.17 0.07 0.18 0 0.13 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0.07 0.14 0 0 0 0 0 0 0 0.05 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0.08 0 0 0 0 0 0 0 0 0.18 0.07 0.08
Mitochondria 0.05 0 0.13 0.05 0.05 0.06 – 0 0 0 0.05 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Nucleus 0.19 0.18 0.22 0.21 0.1 0.21 – 0.29 0.22 0.2 0.16 0.11 0 0.06 0.07 0.23 0.1 0.09 0.1 0.07 0.06 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0.06 0 0 0 0.08 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.74 0.85 0.73 0.75 0.83 0.67 – 0.66 0.69 0.74 0.69 0.71 0.8 0.74 0.82 0.6 0.82 0.74 0.85 0.88 0.83 0.68 0.66 0.73
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 1 1 – 0 0 0 0 0 1 0 0 1 0 0 0 0 1 0 1 1
Bud 0 0 0 0 0 0 – 0 1 2 0 1 0 0 1 1 0 0 0 0 3 2 5 3
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 5 4 9 21 21 51 – 98 96 102 106 104 20 33 15 13 1 3 1 1 4 0 5 3
Endoplasmic Reticulum 1 0 0 1 2 1 – 0 0 2 2 2 2 0 0 3 2 0 0 0 0 0 1 1
Endosome 0 1 0 0 2 1 – 1 0 2 0 0 1 14 27 0 0 0 0 0 2 2 8 7
Golgi 0 2 2 1 4 0 – 4 0 2 1 0 13 7 2 3 1 1 0 0 1 14 12 14
Mitochondria 7 3 24 9 16 20 – 16 6 11 17 16 5 3 1 4 1 1 1 0 0 1 4 3
Nucleus 27 25 39 41 34 68 – 148 96 116 55 46 6 12 13 17 4 2 14 11 12 1 6 6
Nuclear Periphery 1 0 3 1 1 0 – 3 0 0 1 0 1 0 1 0 0 0 0 0 2 0 3 1
Nucleolus 5 3 3 2 10 4 – 11 4 4 7 1 9 7 6 2 3 0 2 1 2 1 7 5
Peroxisomes 0 0 0 0 1 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 1 0 4 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 103 121 133 146 288 218 – 341 293 434 244 293 128 145 164 44 32 17 123 133 169 55 119 144
Unique Cell Count 139 142 181 194 347 325 517 427 590 353 413 161 195 200 73 39 23 146 151 205 82 181 197
Labelled Cell Count 149 159 213 222 380 364 622 496 675 434 463 187 221 234 88 44 24 146 151 205 82 181 197


Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 28.3 35.4 19.9 24.9 35.2 30.7 – 28.8 28.1 28.6 25.9 25.0 24.0 17.7 14.9 56.4 52.8 54.1 23.0 27.1 26.6
Std Deviation (1e-4) 11.8 12.5 8.2 10.1 14.0 16.5 – 14.6 15.5 14.7 12.9 12.8 10.8 7.8 7.1 33.8 22.3 28.3 9.9 13.6 11.8
Intensity Change (Log2) – – – 0.32 0.82 0.63 – 0.53 0.5 0.52 0.38 0.33 0.27 -0.17 -0.42 1.5 1.41 1.44 0.21 0.45 0.42

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP700020406080WT3HU80HU120HU160020406080WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3020406080WT1AF100AF140AF180020406080
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2.1 0.5 3.6 – 4.5 5.2 4.1 6.7 5.8 2.5 3.7 1.0 3.3 0 0
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 – 0 0 0 0 0 0 3.7 5.1 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 3.1 0 0 0 0 0
Mitochondria -2.9 -3.6 -2.7 – -5.1 -6.2 -6.4 -3.5 -4.2 -3.4 -4.4 -5.0 -1.8 0 0
Nucleus -0.1 -3.7 -0.2 – 1.9 0.3 -0.6 -1.7 -3.3 -4.9 -4.4 -4.3 0.3 -1.6 0
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 2.0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0.4 2.6 -1.5 – -1.9 -1.2 0 -1.0 -0.6 1.3 0.2 2.0 -2.1 1.1 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 13.2912 24.8568 20.9217 20.3554 17.6349 23.0594 14.1553 23.5251 19.7756 18.5567 17.6232 23.7671 15.3928 27.2499 24.3457 21.2749 21.1072 28.7351
Actin 0.0196 0 0.0004 0.0065 0.0001 0 0.0116 0 0.003 0.0017 0.0182 0 0.0084 0.0001 0.0009 0 0.0002 0.0001
Bud 0.0007 0.0001 0.0002 0.0003 0.0003 0.0001 0.0004 0.0007 0.0002 0.0003 0.0015 0.0001 0.0004 0.0002 0.0002 0.0004 0.0004 0.0001
Bud Neck 0.0036 0.0001 0.0003 0.0001 0.0002 0.0001 0.001 0.0003 0.0003 0.0002 0.0005 0.0002 0.0003 0.0004 0.0004 0.0007 0.0003 0.0003
Bud Periphery 0.0013 0.0003 0.0007 0.0005 0.0005 0.0003 0.0008 0.0006 0.0005 0.0007 0.0021 0.0004 0.0006 0.0005 0.0008 0.0011 0.001 0.0005
Bud Site 0.0036 0.0002 0.0003 0.0013 0.0003 0 0.0011 0.0004 0.0002 0.0007 0.0022 0.0001 0.0016 0.0009 0.0004 0.0006 0.0005 0.0001
Cell Periphery 0.0093 0.0087 0.0083 0.0075 0.003 0.0126 0.0113 0.013 0.0126 0.0068 0.0076 0.0143 0.0138 0.0169 0.0114 0.0179 0.0128 0.0158
Cytoplasm 0.0101 0.0024 0.0021 0.0006 0.0005 0.0001 0.0036 0.0005 0.0002 0.001 0.0022 0.0002 0.011 0.002 0.0006 0.0003 0.004 0.0002
Cytoplasmic Foci 0.0228 0.0012 0.0031 0.0103 0.003 0.0001 0.0157 0.0002 0.001 0.0142 0.0129 0.0001 0.0157 0.003 0.0067 0.0008 0.0061 0.0035
Eisosomes 0.0001 0 0 0.0003 0 0 0.0001 0 0.0001 0.0004 0.0001 0 0.0001 0 0 0 0 0
Endoplasmic Reticulum 0.0051 0.0003 0.0009 0.0011 0.0002 0.0002 0.0008 0.0003 0.0007 0.0014 0.0017 0.0004 0.0035 0.0003 0.0008 0.0002 0.0023 0.0003
Endosome 0.0601 0.0098 0.0241 0.0068 0.0527 0.0035 0.0216 0.0058 0.0144 0.0422 0.0587 0.0035 0.0543 0.0066 0.0242 0.0116 0.0486 0.0082
Golgi 0.0127 0.0028 0.0036 0.0032 0.0241 0.0002 0.0137 0.0004 0.0035 0.0041 0.0225 0.0001 0.0087 0.0005 0.0067 0.0004 0.0072 0.0065
Lipid Particles 0.0385 0.0105 0.0174 0.0278 0.0039 0.0075 0.0223 0.0037 0.0163 0.0183 0.0178 0.0022 0.0371 0.0037 0.0129 0.0094 0.0189 0.0224
Mitochondria 0.0201 0.0049 0.0218 0.0569 0.0118 0.003 0.0247 0.0024 0.0383 0.0318 0.067 0.0012 0.0471 0.0023 0.0329 0.0024 0.0101 0.032
None 0.0035 0.0014 0.0001 0.0012 0 0 0.0008 0 0.0002 0.0014 0.0001 0 0.0044 0.0002 0.0002 0 0.0024 0
Nuclear Periphery 0.0132 0.0012 0.0122 0.0011 0.0006 0.0026 0.0088 0.0022 0.0013 0.0013 0.0013 0.0021 0.0186 0.006 0.0017 0.0006 0.0088 0.0007
Nucleolus 0.014 0.0042 0.0172 0.0018 0.0013 0.0023 0.0206 0.0034 0.006 0.0064 0.0011 0.0016 0.0147 0.0137 0.0048 0.0177 0.0078 0.0038
Nucleus 0.0049 0.002 0.0038 0.0011 0.0013 0.0014 0.01 0.0023 0.0018 0.002 0.0007 0.0016 0.0052 0.0037 0.0019 0.0033 0.0046 0.0018
Peroxisomes 0.0036 0.0001 0.0008 0.0053 0.0011 0 0.0087 0.0001 0.0004 0.0031 0.0052 0 0.0033 0.0003 0.0008 0.0003 0.0007 0.0008
Punctate Nuclear 0.0029 0.0001 0.0001 0.0007 0 0 0.0012 0 0 0.0006 0.0004 0 0.0048 0.0001 0.0002 0 0.0006 0
Vacuole 0.3559 0.4824 0.4122 0.489 0.4876 0.471 0.4143 0.5072 0.4447 0.4563 0.3959 0.5427 0.3741 0.5004 0.449 0.5439 0.5291 0.5381
Vacuole Periphery 0.3943 0.4671 0.4702 0.3767 0.4073 0.495 0.407 0.4565 0.4543 0.4051 0.3805 0.4291 0.3724 0.438 0.4424 0.3882 0.3333 0.3648

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 149.5909 139.8593 149.2999 154.4917 167.2606 150.8797 153.1959 192.561 184.4237 166.7941
Translational Efficiency 1.4596 1.4255 1.588 1.7621 1.4152 2.0226 1.6877 1.5178 1.8047 1.4557

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1310 1266 975 1395 904 1990 2177 1799 2214 3256 3152 3194

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1654.02 1994.21 1719.50 2798.47 2736.62 1843.29 2004.59 2566.85 2096.06 1901.97 1916.40 2668.01
Standard Deviation 541.90 555.80 285.54 683.40 1031.75 457.79 346.02 515.72 944.22 503.60 353.95 605.79
Intensity Change Log 2 — 0.269841 0.056012 0.758662 — -0.570112 -0.449088 -0.092396 — -0.194264 -0.237543 0.289233

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000183 0.000077 0.000304 0.004606 0.000151 0.000091 0.000690 0.004203 0.000170 0.000086 0.000570 0.004379
Bud Neck 0.002057 0.003314 0.004522 0.013732 0.000960 0.002458 0.005839 0.014847 0.001609 0.002791 0.005432 0.014360
Bud Site 0.008201 0.004247 0.005410 0.013303 0.000711 0.002114 0.009840 0.019262 0.005143 0.002943 0.008469 0.016659
Cell Periphery 0.030280 0.016144 0.003348 0.250824 0.034753 0.012142 0.028699 0.167145 0.032106 0.013698 0.020857 0.203693
Cytoplasm 0.002542 0.000335 0.000538 0.000649 0.000795 0.000488 0.000183 0.001984 0.001829 0.000429 0.000293 0.001401
Cytoplasmic Foci 0.001454 0.002272 0.011866 0.000892 0.001912 0.000912 0.003318 0.004429 0.001641 0.001441 0.005962 0.002884
Eisosomes 0.000252 0.001458 0.000062 0.003175 0.000816 0.001571 0.000150 0.001603 0.000482 0.001527 0.000122 0.002289
Endoplasmic Reticulum 0.002597 0.001462 0.001232 0.078750 0.000649 0.001612 0.018913 0.057382 0.001802 0.001553 0.013444 0.066715
Endosome 0.006135 0.002527 0.042828 0.026486 0.000451 0.003444 0.142263 0.075911 0.003814 0.003087 0.111505 0.054325
Golgi 0.005767 0.001600 0.034685 0.017807 0.000194 0.000752 0.042010 0.035493 0.003491 0.001082 0.039744 0.027769
Lipid Particles 0.001117 0.001184 0.007936 0.202388 0.000290 0.001494 0.035768 0.212508 0.000779 0.001374 0.027159 0.208088
Mitochondria 0.001301 0.001598 0.001969 0.001008 0.000446 0.003482 0.001119 0.001543 0.000952 0.002749 0.001382 0.001309
Mitotic Spindle 0.000030 0.000109 0.000420 0.000384 0.000005 0.000450 0.000495 0.000596 0.000020 0.000318 0.000472 0.000504
None 0.000931 0.000196 0.000076 0.000070 0.000390 0.000162 0.000027 0.000068 0.000710 0.000175 0.000042 0.000069
Nuclear Periphery 0.000081 0.000302 0.001807 0.002253 0.000021 0.000339 0.000345 0.000945 0.000056 0.000324 0.000797 0.001516
Nuclear Periphery Foci 0.000441 0.000662 0.006642 0.002456 0.000168 0.000661 0.002323 0.002887 0.000330 0.000662 0.003659 0.002699
Nucleolus 0.002839 0.005345 0.004681 0.000137 0.001186 0.005140 0.000267 0.000166 0.002164 0.005220 0.001632 0.000153
Nucleus 0.001837 0.001530 0.001257 0.000162 0.004267 0.001576 0.000082 0.000186 0.002829 0.001558 0.000445 0.000175
Peroxisomes 0.000166 0.000235 0.000905 0.001498 0.000042 0.000264 0.000115 0.001524 0.000115 0.000253 0.000360 0.001513
Vacuole 0.771993 0.854058 0.703034 0.364125 0.924914 0.889980 0.649947 0.380211 0.834432 0.876013 0.666368 0.373185
Vacuole Periphery 0.159796 0.101343 0.166480 0.015298 0.026880 0.070869 0.057607 0.017106 0.105525 0.082718 0.091285 0.016316

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.09 -1.60 -6.05 -6.20 -5.88 0.79 -4.63 -7.45 -7.62 -6.38 1.89 -5.19 -9.53 -9.75 -8.53
Bud Neck -2.28 -4.93 -11.24 -9.23 -8.25 -4.01 -11.91 -16.39 -13.90 -9.85 -3.65 -11.50 -19.25 -16.51 -12.56
Bud Site 3.02 2.07 -2.94 -5.21 -4.56 -3.38 -13.87 -11.37 -10.33 -5.45 3.01 -4.39 -9.01 -11.38 -6.63
Cell Periphery 5.38 11.75 -33.21 -36.46 -39.26 8.65 2.21 -23.64 -30.23 -26.53 10.09 5.94 -39.61 -46.42 -44.28
Cytoplasm 2.36 2.18 1.76 -1.50 -0.98 0.93 2.08 -1.96 -2.80 -3.65 2.48 2.88 0.48 -3.14 -3.90
Cytoplasmic Foci -0.86 -7.03 1.76 1.44 7.50 0.79 -0.89 -1.61 -4.84 -1.17 0.31 -5.01 -1.76 -2.55 4.12
Eisosomes -8.38 8.27 -10.21 -5.36 -10.90 -4.69 6.97 -2.61 -0.07 -5.11 -9.92 8.58 -8.70 -3.35 -10.65
Endoplasmic Reticulum 5.83 6.22 -19.87 -20.17 -20.22 -7.77 -15.86 -20.66 -20.31 -12.91 1.98 -14.31 -28.38 -28.51 -21.95
Endosome 3.76 -12.15 -10.77 -13.58 4.86 -4.94 -34.41 -24.23 -22.96 12.84 1.11 -34.40 -25.10 -25.78 15.63
Golgi 3.61 -9.20 -6.64 -10.43 5.09 -2.33 -19.18 -16.66 -16.31 2.16 3.62 -19.38 -16.17 -19.27 5.38
Lipid Particles -0.46 -5.12 -26.24 -26.23 -24.97 -6.75 -15.21 -31.54 -31.35 -24.73 -4.48 -15.71 -40.98 -40.85 -33.85
Mitochondria -0.85 -1.87 0.78 1.56 2.57 -4.55 -2.52 -2.69 2.65 -1.21 -4.17 -2.04 -1.38 3.09 0.15
Mitotic Spindle -0.92 -2.11 -2.98 -1.87 0.43 -2.29 -1.46 -2.76 -0.57 -0.31 -2.41 -1.96 -3.66 -1.08 -0.09
None 2.98 3.54 3.54 4.12 0.12 1.29 2.03 1.76 3.32 -2.13 3.30 4.16 3.95 5.27 -2.29
Nuclear Periphery -3.99 -4.95 -17.44 -14.27 -1.09 -5.96 -15.99 -18.09 -8.23 -10.86 -6.86 -6.76 -23.32 -16.14 -5.51
Nuclear Periphery Foci -1.51 -5.00 -4.36 -3.72 3.16 -2.76 -9.61 -5.92 -4.93 -1.16 -2.95 -8.09 -7.28 -6.18 1.88
Nucleolus -3.14 -1.83 5.80 7.85 4.99 -5.23 3.51 3.88 7.11 7.53 -5.27 1.28 6.80 10.16 5.20
Nucleus 0.48 0.97 3.59 7.26 2.99 1.66 2.54 2.47 7.93 -3.82 1.72 3.22 3.59 10.68 2.25
Peroxisomes -0.96 -4.85 -5.13 -4.70 -1.93 -2.83 -3.11 -6.81 -5.46 -6.48 -2.44 -4.78 -8.35 -7.18 -6.63
Vacuole -9.84 7.19 41.38 53.45 32.57 5.94 37.68 64.95 65.53 30.10 -7.68 26.37 67.52 85.12 43.03
Vacuole Periphery 8.04 -0.80 24.65 18.01 27.34 -11.03 -9.16 3.21 18.47 20.82 5.03 3.28 22.80 25.63 31.73
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles
Localization
Cell Percentages vacuole (52%), cytoplasm (9%), mixed (25%)
Cell Cycle Regulation Yes
cytoplasm - S/G2 (0.00048)
Subcompartmental Group N/A

Sna3

Sna3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sna3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available