Standard name
Human Ortholog
Description Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 – 0 0 0 0 0.06 0 0.09 0.12 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0.05 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.07 0.06 0.09 0 0.05 0.07 – 0.08 0.11 0.1 0.06 0.16 0.17 0.3 0.26 0.22 0 0 0 0 0 0
Cytoplasm 0.06 0.1 0.18 0.21 0.2 0.22 0.17 0.16 – 0.13 0.2 0.17 0.11 0.13 0.15 0.21 0.32 0.24 0 0 0 0 0 0
Endoplasmic Reticulum 0.86 0.84 0.58 0.33 0.55 0.59 0.51 0.32 – 0.29 0.3 0.34 0.85 0.82 0.7 0 0 0 0.91 0.88 0.83 0.82 0.81 0.78
Endosome 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0.07 0.07 0.06 0 0 0 0 0 0
Mitochondria 0 0 0.3 0.38 0.22 0.26 0.44 0.52 – 0.44 0.57 0.57 0 0 0 0.12 0.07 0.06 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0.08 0 0 0 0.07 0 – 0.05 0 0.08 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.15 0.12 0 0.25 0.14 0.1 0.08 0.21 – 0.29 0.1 0.08 0 0 0.15 0.26 0.22 0.45 0 0 0 0 0.06 0.09
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 25 12 4 2 3 3 2 2 – 7 3 6 9 20 7 11 10 1 9 5 2 7 7 6
Bud 1 1 1 0 0 1 1 9 – 1 4 5 1 1 0 0 1 0 1 0 0 0 2 1
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 1 0 0 0 2 2
Bud Site 0 0 0 0 0 0 0 0 – 1 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 15 7 6 5 11 2 10 13 – 16 17 17 20 51 70 39 21 11 2 2 1 2 1 4
Cytoplasm 38 30 16 18 25 35 35 30 – 26 30 30 37 41 62 27 26 12 7 6 1 2 7 13
Endoplasmic Reticulum 505 241 52 28 69 92 105 58 – 59 45 61 279 264 279 2 1 2 589 282 85 229 308 358
Endosome 5 1 2 1 3 1 0 2 – 0 0 1 0 0 2 0 0 1 5 2 0 2 2 2
Golgi 9 3 0 3 0 0 0 1 – 0 0 0 2 3 1 9 6 3 2 3 2 4 4 4
Mitochondria 7 5 27 32 28 40 90 94 – 91 84 102 0 0 1 16 6 3 11 5 3 12 14 15
Nucleus 1 0 1 1 0 1 3 1 – 3 1 1 1 0 1 4 2 0 0 0 1 0 0 2
Nuclear Periphery 26 8 7 1 2 3 15 6 – 11 6 14 10 13 6 5 1 0 6 1 0 3 3 3
Nucleolus 0 0 0 1 0 0 0 0 – 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0
Vac/Vac Membrane 89 36 3 21 18 16 16 38 – 59 15 15 7 5 62 34 18 22 6 5 1 10 21 39
Unique Cell Count 587 288 89 85 125 156 205 182 206 148 178 327 323 401 129 81 49 650 321 104 279 380 460
Labelled Cell Count 721 344 119 113 159 194 277 254 275 205 253 366 398 491 149 93 55 650 321 104 279 380 460


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.2 9.7 7.2 7.9 7.9 7.6 6.8 7.2 – 7.1 7.1 7.2 10.5 10.5 10.5 10.4 10.3 10.4 11.4 11.0 11.1
Std Deviation (1e-4) 1.6 1.5 1.3 2.0 1.8 1.3 1.5 1.6 – 1.5 1.4 1.5 1.7 1.6 1.7 1.7 1.7 1.9 1.9 2.0 1.9
Intensity Change (Log2) – – – 0.14 0.13 0.08 -0.07 0.0 – -0.02 -0.03 0.0 0.54 0.55 0.54 0.54 0.51 0.53 0.66 0.61 0.63


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 – 0 0 0 0 0.6 0 1.2 1.9 0
Bud 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cell Periphery -0.2 0.5 0 0 0.1 – 0.3 1.2 0.8 -0.2 2.2 2.5 4.2 3.4 2.7
Cytoplasm 0.5 0.4 0.8 -0.2 -0.3 – -1.2 0.4 -0.2 -1.7 -1.3 -0.6 0.5 2.1 0.9
Endoplasmic Reticulum -3.4 -0.5 0.1 -1.1 -4.2 – -4.8 -4.2 -3.8 5.6 4.6 2.0 -9.6 -8.0 -6.3
Endosome 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Mitochondria 1.0 -1.3 -0.8 2.2 3.3 – 2.2 3.9 4.2 -10.3 -10.2 -11.1 -3.3 -3.8 -3.3
Nucleus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 -0.2 0 – -0.8 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Vacuole 4.1 2.7 1.9 1.4 3.8 – 4.9 1.9 1.6 0 0 3.0 4.4 3.7 6.1

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 7.2105 6.6966 6.6204 6.4868 6.1704 6.5543 9.1138 8.8238 8.606 8.3927 8.633 8.725 7.3414 6.5636 6.5726 6.8127 6.419 6.3633
Actin 0.0004 0.0008 0.0004 0.0001 0.0002 0.0005 0.0317 0.0012 0.0066 0.0008 0.0229 0.0008 0.015 0.0046 0.0011 0.0182 0.0207 0.0002
Bud 0.0005 0.0091 0.0001 0 0 0.0005 0.0002 0 0.0004 0 0.0001 0 0.0004 0.0002 0.0001 0.0005 0.0002 0
Bud Neck 0.0001 0.0005 0.0005 0.0002 0.0002 0.0011 0.0007 0.0001 0.0002 0.0002 0.001 0.0001 0.0087 0.0004 0.0004 0.0019 0.0008 0.0013
Bud Periphery 0.0001 0.0024 0.0001 0 0 0.0002 0.0005 0 0.0059 0.0001 0.0005 0 0.0005 0.0002 0.0001 0.001 0.0006 0
Bud Site 0.0011 0.0077 0.0048 0 0 0.0001 0.0027 0.0001 0.0002 0 0.0002 0 0.0142 0.0033 0.0005 0.0014 0.0006 0
Cell Periphery 0.0004 0.001 0.0009 0.0002 0.0001 0.0007 0.0006 0.001 0.0008 0.0006 0.0005 0.0003 0.0018 0.0025 0.0013 0.0006 0.0007 0.0004
Cytoplasm 0.0281 0.0569 0.0402 0.0078 0.0177 0.0542 0.0171 0.0277 0.0077 0.0148 0.0212 0.0192 0.0568 0.1283 0.0503 0.0733 0.0328 0.0728
Cytoplasmic Foci 0.002 0.0048 0.0021 0.0017 0.0011 0.0022 0.0028 0.0008 0.0025 0.0068 0.0015 0.0033 0.0132 0.006 0.0041 0.0113 0.0171 0.0031
Eisosomes 0 0 0 0 0 0 0.0002 0 0.0004 0 0.0004 0 0.0002 0.0001 0 0.0003 0.0006 0
Endoplasmic Reticulum 0.9072 0.8025 0.8892 0.9409 0.9337 0.87 0.8549 0.9502 0.9236 0.9375 0.8644 0.9384 0.7652 0.7914 0.8993 0.7124 0.7896 0.875
Endosome 0.0066 0.0262 0.0069 0.0076 0.0086 0.0123 0.0169 0.003 0.0081 0.0098 0.0056 0.007 0.0264 0.0096 0.0088 0.045 0.0221 0.0139
Golgi 0.0003 0.0026 0.0007 0.0006 0.0005 0.0005 0.007 0.001 0.0018 0.0011 0.0004 0.001 0.0066 0.0035 0.0064 0.0288 0.0193 0.0003
Lipid Particles 0.0016 0.0055 0.0019 0.0199 0.0008 0.0021 0.0057 0.0064 0.003 0.0088 0.0011 0.0045 0.0147 0.0179 0.0102 0.0227 0.0251 0.0025
Mitochondria 0.0004 0.0013 0.0004 0.0002 0.0002 0.0007 0.0022 0.0001 0.0012 0.0004 0.0003 0.0003 0.0146 0.0004 0.0011 0.0342 0.0126 0.0002
None 0.0012 0.0015 0.0121 0.0002 0.003 0.0031 0.0129 0.0001 0.01 0.0076 0.0226 0.0013 0.0063 0.0091 0.0011 0.0046 0.0012 0.0006
Nuclear Periphery 0.0315 0.0401 0.0231 0.0161 0.027 0.0293 0.016 0.0058 0.0084 0.0061 0.052 0.009 0.028 0.0112 0.006 0.0219 0.0116 0.0194
Nucleolus 0.0013 0.0012 0.0008 0 0 0.0004 0.0126 0 0.0001 0 0.0001 0.0003 0.0004 0.0001 0 0.0005 0.0004 0
Nucleus 0.0079 0.0111 0.0062 0.0012 0.0036 0.0102 0.0072 0.0003 0.0098 0.0003 0.0013 0.0074 0.0105 0.0049 0.0011 0.0038 0.0015 0.0034
Peroxisomes 0 0.0001 0 0 0 0 0.0022 0 0.006 0.0002 0.0004 0.0002 0.0053 0.0001 0.0008 0.0064 0.0166 0
Punctate Nuclear 0.0042 0.0133 0.0051 0.0001 0.0003 0.0064 0.0004 0.0001 0.0002 0.0007 0.0003 0.0038 0.0015 0.0005 0.0002 0.0047 0.0222 0.0004
Vacuole 0.004 0.0102 0.0035 0.0025 0.0024 0.0048 0.0039 0.0019 0.0025 0.0035 0.0019 0.0023 0.0071 0.0052 0.0069 0.0046 0.002 0.0059
Vacuole Periphery 0.0011 0.0013 0.0008 0.0005 0.0005 0.0009 0.0015 0.0002 0.0006 0.0005 0.0011 0.0005 0.0026 0.0005 0.0003 0.0022 0.0017 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 42.5875 20.7658 28.2501 39.4785 30.1181 27.0862 31.4944 27.1612 37.6024 44.6658
Translational Efficiency 2.7724 3.8715 2.577 1.4564 2.8383 4.9022 2.5823 2.7826 1.6787 2.0608

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1258 1447 2323 349 1830 1680 805 1918 3088 3127 3128 2267

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 878.44 948.55 1092.24 1014.83 869.43 929.82 1040.66 985.44 873.10 938.49 1078.97 989.96
Standard Deviation 472.96 150.48 154.61 149.99 164.45 135.89 134.88 125.93 327.38 143.13 151.47 130.36
Intensity Change Log 2 — 0.110780 0.314274 0.208222 — 0.096882 0.259357 0.180698 — 0.103883 0.287218 0.194597

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000832 0.001360 0.001258 0.000712 0.000744 0.001105 0.001429 0.000654 0.000780 0.001223 0.001302 0.000663
Bud Neck 0.001882 0.000823 0.000954 0.002147 0.000934 0.000390 0.000287 0.000551 0.001320 0.000590 0.000782 0.000796
Bud Site 0.011229 0.006483 0.002837 0.005158 0.004200 0.002001 0.001609 0.001741 0.007063 0.004075 0.002521 0.002267
Cell Periphery 0.003523 0.002453 0.000354 0.000658 0.000917 0.000939 0.000403 0.000495 0.001979 0.001640 0.000366 0.000520
Cytoplasm 0.087033 0.044537 0.051651 0.124755* 0.060224 0.059103 0.021095 0.031196 0.071145 0.052363 0.043787 0.045599
Cytoplasmic Foci 0.021395 0.007714 0.003414 0.019678 0.028164 0.012944 0.000752 0.003059 0.025407 0.010524 0.002729 0.005617
Eisosomes 0.000441 0.000305 0.000142 0.000135 0.000229 0.000398 0.000049 0.000073 0.000315 0.000355 0.000118 0.000082
Endoplasmic Reticulum 0.750957* 0.886037* 0.831413* 0.455023* 0.782701* 0.840974* 0.944547* 0.923315* 0.769769* 0.861827* 0.860528* 0.851222*
Endosome 0.008101 0.004384 0.006521 0.018165 0.010091 0.005811 0.003261 0.004804 0.009280 0.005150 0.005682 0.006861
Golgi 0.009300 0.008728 0.000959 0.002318 0.016786 0.009867 0.000696 0.002295 0.013737 0.009340 0.000891 0.002299
Lipid Particles 0.031292 0.012053 0.006779 0.024812 0.028453 0.022944 0.002803 0.005043 0.029609 0.017904 0.005756 0.008086
Mitochondria 0.003922 0.003161 0.000973 0.000830 0.008556 0.005824 0.000334 0.000882 0.006668 0.004592 0.000809 0.000874
Mitotic Spindle 0.000176 0.000091 0.001371 0.001885 0.000435 0.000612 0.000050 0.000400 0.000330 0.000371 0.001031 0.000629
None 0.008644 0.005635 0.001455 0.002102 0.011566 0.003118 0.000779 0.002106 0.010375 0.004283 0.001281 0.002106
Nuclear Periphery 0.010898 0.001900 0.028897 0.096497 0.008161 0.006996 0.003847 0.004413 0.009276 0.004638 0.022450 0.018590
Nuclear Periphery Foci 0.019537 0.006123 0.043743 0.133353 0.015087 0.014604 0.013178 0.012058 0.016900 0.010680 0.035877 0.030731
Nucleolus 0.000759 0.000103 0.000069 0.001178 0.001114 0.000079 0.000008 0.000032 0.000969 0.000090 0.000053 0.000208
Nucleus 0.014108 0.002373 0.008885 0.042282 0.007453 0.004370 0.001074 0.002554 0.010164 0.003446 0.006875 0.008670
Peroxisomes 0.002002 0.001531 0.000249 0.000678 0.002134 0.001962 0.000203 0.000339 0.002081 0.001762 0.000237 0.000392
Vacuole 0.010351 0.003022 0.007771 0.066499 0.008493 0.004228 0.003501 0.003676 0.009250 0.003670 0.006672 0.013348
Vacuole Periphery 0.003616 0.001185 0.000307 0.001136 0.003557 0.001731 0.000093 0.000314 0.003581 0.001478 0.000252 0.000441

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.03 -1.03 0.23 1.26 1.30 -0.92 -0.67 0.33 1.15 0.75 -1.41 -1.37 0.49 1.76 1.64
Bud Neck 2.39 2.19 -0.78 -3.09 -2.93 3.13 3.39 1.35 -0.63 -0.99 3.37 2.43 1.76 -1.06 -0.11
Bud Site 2.07 4.51 2.62 0.47 -2.04 2.28 2.23 2.59 0.41 -0.14 2.62 4.55 4.89 2.15 0.54
Cell Periphery 1.33 5.52 4.87 3.01 -2.68 -0.13 3.30 2.93 3.54 -0.90 0.93 6.44 5.77 4.00 -2.34
Cytoplasm 8.34 6.70 -3.62 -7.83 -7.06 0.26 11.79 8.92 7.60 -3.76 5.95 8.57 7.35 1.95 -0.57
Cytoplasmic Foci 6.58 9.17 0.15 -5.13 -7.02 6.24 13.80 12.34 6.77 -4.65 9.03 15.60 12.95 4.57 -4.54
Eisosomes 0.59 1.24 1.33 2.48 0.02 -1.37 3.38 2.89 2.88 -1.33 -0.34 1.68 2.39 4.09 0.50
Endoplasmic Reticulum -12.37 -7.36 15.36 24.02 21.09 -5.91 -18.49 -16.53 -11.08 3.62 -12.63 -12.45 -9.89 1.72 1.30
Endosome 4.40 1.86 -5.28 -7.44 -6.32 5.13 8.61 5.93 1.35 -2.20 6.88 6.05 3.18 -2.62 -1.74
Golgi 0.41 8.03 4.42 4.05 -1.06 4.01 11.64 9.99 6.65 -3.44 3.75 13.88 11.29 8.28 -3.19
Lipid Particles 7.77 10.48 1.56 -3.92 -5.63 2.11 12.40 11.42 9.63 -2.68 6.40 15.09 13.14 7.54 -2.58
Mitochondria 0.97 5.12 5.49 4.03 0.96 2.23 9.58 8.83 5.49 -2.50 2.68 10.36 10.08 6.58 -0.27
Mitotic Spindle 2.18 -2.54 -1.68 -1.77 -0.45 -0.49 2.49 0.06 0.47 -1.42 -0.20 -2.00 -1.15 -0.88 0.96
None 1.69 5.01 4.30 2.66 -0.92 4.60 6.27 5.18 1.06 -1.90 4.60 7.65 6.43 2.51 -1.31
Nuclear Periphery 7.18 -8.37 -9.56 -10.69 -7.39 0.81 3.11 2.77 2.69 -0.64 4.74 -8.20 -4.95 -8.32 2.08
Nuclear Periphery Foci 7.65 -9.38 -12.60 -14.27 -9.72 0.30 0.91 1.74 1.57 0.58 4.87 -9.91 -6.36 -9.91 2.29
Nucleolus 4.58 4.89 -1.15 -3.06 -3.16 5.32 5.70 5.58 3.27 -4.04 6.80 7.11 5.41 -2.09 -2.77
Nucleus 7.93 3.16 -6.08 -9.09 -7.49 2.99 6.59 4.79 3.16 -3.34 7.85 3.26 1.32 -6.16 -1.72
Peroxisomes 1.07 4.91 3.42 2.61 -2.85 0.29 7.38 7.16 5.24 -1.06 0.99 8.79 7.95 6.30 -1.72
Vacuole 5.89 1.80 -8.57 -9.65 -8.95 4.18 3.08 4.98 0.74 0.01 7.11 2.60 -3.54 -7.94 -5.30
Vacuole Periphery 3.30 5.11 3.58 0.12 -3.19 3.52 8.80 8.18 4.11 -4.26 4.90 9.43 8.81 4.10 -2.96
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages ER (99%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Spc1

Spc1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Spc1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available