Standard name
Human Ortholog
Description Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.08 0 0 0 0 0 0 0 0 0.1 0.1 0.09 0.07 0.08 0.07 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0.07 0 0 0 0 0 0 0 0 0 0.05 0.13 0.08 0.08 0 0 0 0 0.05 0.07
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.08 0.15 0.21 0.2 0.2 0.4 0.36 0.47 0.46 0.49 0.5 0.53 0 0 0 0.13 0.1 0.09 0 0 0 0.1 0.14 0.21
Nucleus 0 0.06 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0 0.06 0.1 0.05 0 0 0 0 0 0
Nuclear Periphery 0.74 0.76 0.68 0.74 0.64 0.54 0.59 0.42 0.45 0.58 0.53 0.57 0.76 0.76 0.72 0.53 0.51 0.56 0.88 0.77 0.87 0.71 0.7 0.57
Nucleolus 0.12 0.08 0.2 0.23 0.19 0.31 0.27 0.3 0.3 0.35 0.37 0.33 0.09 0.09 0.08 0.18 0.15 0.18 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Vac/Vac Membrane 0.35 0.27 0.19 0.06 0.17 0.07 0.07 0.05 0.06 0.05 0 0 0.22 0.24 0.26 0.28 0.27 0.31 0 0.06 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 1 1 3 2 4
Bud 0 0 0 0 0 1 2 2 2 2 4 2 0 0 0 0 2 0 2 6 3 0 1 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 1 4 7 9 5 2 2 0 0 1 1 0 0 – – – – – –
Cell Periphery 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 1 2 0 0 0 0 0 0 0
Cytoplasm 7 6 7 8 8 7 7 11 11 4 4 3 14 14 16 20 24 13 0 1 0 0 1 0
Endoplasmic Reticulum 0 0 1 1 0 2 0 1 0 0 1 0 1 1 1 2 12 3 0 0 0 0 0 1
Endosome 3 1 11 3 16 10 12 11 10 5 5 7 6 6 9 39 23 15 3 9 2 5 15 18
Golgi 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 3 0 2 1 1 5 5
Mitochondria 24 49 55 21 45 115 125 224 224 167 134 192 0 0 3 37 29 18 6 12 11 14 47 56
Nucleus 10 19 5 3 6 3 7 19 19 15 12 12 8 8 7 19 27 10 3 5 1 0 0 0
Nuclear Periphery 221 244 180 77 144 155 204 201 215 199 143 205 112 109 125 157 145 111 289 278 252 100 238 152
Nucleolus 36 27 53 24 42 87 94 144 144 121 101 118 13 13 13 54 42 36 4 15 2 2 3 2
Peroxisomes 0 0 0 0 2 0 3 5 5 2 1 0 0 0 0 1 1 2 0 0 1 0 5 9
SpindlePole 1 0 2 0 3 3 7 8 8 4 1 2 2 2 5 12 13 7 1 2 3 3 4 3
Vac/Vac Membrane 103 87 51 6 38 20 24 24 27 16 8 12 33 35 45 81 77 61 10 21 4 4 10 9
Unique Cell Count 298 323 264 104 225 285 346 477 482 342 270 360 147 143 173 294 284 199 328 360 292 142 341 269
Labelled Cell Count 405 433 368 143 304 404 489 657 674 540 416 555 189 188 227 424 398 279 328 360 292 142 341 269


Nuclear Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 11.8 11.5 11.3 10.0 9.2 7.9 7.6 7.7 7.7 6.8 7.1 7.0 10.8 10.8 10.9 7.1 7.3 9.7 11.7 12.4 12.8
Std Deviation (1e-4) 2.7 2.9 3.3 2.6 2.2 2.5 2.2 2.6 2.6 1.9 2.0 2.0 3.0 3.0 3.5 1.3 1.9 2.4 2.6 2.5 3.1
Intensity Change (Log2) – – – -0.17 -0.3 -0.52 -0.57 -0.55 -0.55 -0.72 -0.67 -0.68 -0.07 -0.07 -0.06 -0.68 -0.63 -0.22 0.04 0.14 0.18

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.6 -0.1 -0.5 -0.3 -0.3 0 -1.0 0 3.0 3.1 3.0 2.3 2.9 2.0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 3.0 0
Endosome 0 1.4 -0.4 -0.4 -1.4 -1.7 -2.1 -1.6 -1.6 0 0 0.5 3.8 1.9 1.6
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria -0.1 -0.2 4.9 4.1 7.0 6.9 7.1 7.0 8.2 -5.9 -5.9 -5.8 -2.6 -3.4 -3.4
Nucleus 0 0.6 0 0.1 1.5 1.5 1.7 1.7 1.1 0 0 0 2.7 3.8 1.9
Nuclear Periphery 1.1 -1.0 -3.3 -2.3 -6.8 -6.2 -2.5 -3.6 -2.9 1.7 1.7 0.9 -3.6 -4.1 -2.7
Nucleolus 0.6 -0.4 2.8 2.0 3.0 2.9 4.1 4.4 3.5 -3.0 -2.9 -3.6 -0.5 -1.6 -0.5
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 2.5 2.7 0
Vacuole -3.2 -0.7 -4.3 -4.6 -6.2 -5.9 -5.7 -6.0 -6.5 0.8 1.2 1.7 2.3 2.2 2.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.4948 7.1391 6.2739 6.3773 5.6201 6.1661 8.2773 8.6007 7.5013 6.3457 6.6794 7.4757 10.2296 8.9191 8.9538 8.8107 9.407 8.6231
Actin 0.0026 0.0003 0.0007 0.0015 0.0013 0.0001 0.0036 0.0004 0.0008 0.001 0.0073 0.0005 0.0001 0.0002 0.0003 0.0008 0.0002 0.0001
Bud 0.0001 0 0 0.0001 0 0 0.0002 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0.0001 0 0 0.0001 0.0001 0 0.0002 0 0 0 0 0 0 0 0 0 0 0
Bud Periphery 0.0004 0.0001 0.0001 0.0003 0.0002 0 0.0007 0.0002 0.0002 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0002 0.0001 0
Bud Site 0.0001 0 0.0001 0.0002 0 0 0.0013 0.0001 0 0 0.0001 0 0 0 0 0 0 0
Cell Periphery 0.0001 0 0 0.0001 0.0001 0 0.0003 0.0001 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.0011 0 0.0003 0.0005 0.0001 0 0.0011 0 0.0001 0 0 0 0 0 0 0 0 0
Cytoplasmic Foci 0.0038 0.0011 0.0005 0.0013 0.0002 0.0001 0.0014 0.0033 0.0002 0.0009 0.0025 0.0008 0.0001 0.0001 0.0001 0.0001 0 0
Eisosomes 0.0001 0 0 0.0001 0.0001 0 0.0003 0.0001 0 0 0.0001 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0019 0.0014 0.001 0.0019 0.0016 0.0003 0.0021 0.001 0.0016 0.0013 0.0007 0.0003 0.0003 0.0006 0.0007 0.0009 0.0004 0.0002
Endosome 0.0055 0.0006 0.0009 0.0032 0.0022 0.0009 0.0037 0.0015 0.0014 0.0005 0.0014 0.0003 0.0002 0.0003 0.0004 0.0005 0.0004 0.0002
Golgi 0.0013 0.001 0.0004 0.0009 0.0013 0.0003 0.0016 0.0057 0.0007 0.0005 0.0043 0.0003 0.0001 0.0002 0.0002 0.0004 0.0004 0.0002
Lipid Particles 0.0194 0.0453 0.0093 0.0058 0.0177 0.0067 0.0032 0.0262 0.0085 0.0042 0.0122 0.0037 0.0024 0.0032 0.0032 0.0021 0.0047 0.002
Mitochondria 0.0093 0.0018 0.0019 0.0021 0.0071 0.0011 0.0147 0.006 0.0025 0.0035 0.0083 0.0033 0.0011 0.0006 0.0008 0.0012 0.0034 0.0008
None 0.0038 0.0002 0.0004 0.001 0.0006 0.0001 0.0015 0.0003 0.0005 0.0002 0.0001 0.0001 0.0002 0.0001 0.0002 0.0002 0.0002 0.0001
Nuclear Periphery 0.9022 0.8996 0.9236 0.908 0.9024 0.9653 0.9039 0.8861 0.9258 0.8976 0.9001 0.9668 0.963 0.9497 0.9513 0.9575 0.9588 0.9812
Nucleolus 0.001 0.001 0.0036 0.0041 0.0028 0.0012 0.0008 0.0061 0.0017 0.0004 0.0003 0.0002 0.0003 0.0028 0.0006 0.0005 0.0006 0.0003
Nucleus 0.0042 0.0128 0.0088 0.0276 0.0233 0.0028 0.0037 0.0024 0.0085 0.0039 0.0014 0.001 0.0017 0.0057 0.0038 0.0023 0.0016 0.0013
Peroxisomes 0.0011 0.0005 0.0001 0.0002 0.0002 0 0.0012 0.0009 0.0001 0.0521 0.0347 0.007 0 0 0.0001 0.0001 0 0
Punctate Nuclear 0.0048 0.0018 0.0125 0.0095 0.0018 0.0023 0.0177 0.0021 0.0014 0.0007 0.0007 0.0006 0.0005 0.0031 0.002 0.001 0.001 0.0008
Vacuole 0.0011 0.0005 0.0006 0.0011 0.0009 0.0003 0.001 0.0009 0.0007 0.0003 0.0003 0.0001 0.0003 0.0004 0.0003 0.0003 0.0003 0.0001
Vacuole Periphery 0.0359 0.0321 0.035 0.0303 0.036 0.0184 0.0358 0.0566 0.0452 0.0327 0.0252 0.0147 0.0295 0.033 0.0358 0.0318 0.0278 0.0126

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 21.9694 21.6252 26.8539 32.3119 26.5639 24.1776 28.3356 30.8705 30.1059 31.1292
Translational Efficiency 1.6071 1.4054 1.0882 0.9036 1.0276 1.1344 1.0607 0.8299 0.8547 0.8968

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
437 1254 1576 1323 1686 1693 222 1426 2123 2947 1798 2749

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1249.16 1157.54 1321.82 1346.80 1052.04 1095.56 1409.80 1331.89 1092.62 1121.93 1332.68 1339.07
Standard Deviation 177.17 235.71 199.26 248.80 206.14 336.51 190.93 238.66 215.77 299.39 200.35 243.71
Intensity Change Log 2 — -0.109896 0.081567 0.108577 — 0.058479 0.422301 0.340285 — -0.030475 0.247370 0.219141

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000958 0.000578 0.000338 0.000841 0.000294 0.000501 0.000177 0.000493 0.000430 0.000534 0.000318 0.000661
Bud Neck 0.002718 0.000884 0.000868 0.007657 0.000396 0.000639 0.000564 0.006899 0.000874 0.000744 0.000830 0.007264
Bud Site 0.000606 0.000145 0.000060 0.001344 0.000181 0.000238 0.000061 0.001385 0.000268 0.000198 0.000060 0.001366
Cell Periphery 0.000067 0.000058 0.000019 0.000148 0.000048 0.000094 0.000016 0.000127 0.000052 0.000079 0.000019 0.000137
Cytoplasm 0.000232 0.000482 0.000148 0.000474 0.000191 0.000963 0.000059 0.000903 0.000199 0.000758 0.000137 0.000697
Cytoplasmic Foci 0.004555 0.002089 0.000201 0.009189 0.000583 0.001958 0.000964 0.009686 0.001401 0.002014 0.000295 0.009447
Eisosomes 0.000017 0.000017 0.000005 0.000040 0.000009 0.000016 0.000006 0.000026 0.000010 0.000016 0.000005 0.000032
Endoplasmic Reticulum 0.004686 0.003461 0.001132 0.001766 0.002559 0.003999 0.000750 0.001747 0.002997 0.003770 0.001085 0.001756
Endosome 0.003503 0.001012 0.000252 0.003500 0.001348 0.001901 0.000159 0.004200 0.001791 0.001523 0.000240 0.003863
Golgi 0.002323 0.000612 0.000115 0.003348 0.000432 0.000758 0.000173 0.003032 0.000821 0.000696 0.000123 0.003184
Lipid Particles 0.004999 0.004388 0.000196 0.008480 0.002847 0.007431 0.000307 0.005531 0.003290 0.006136 0.000210 0.006951
Mitochondria 0.005149 0.004395 0.001752 0.010310 0.004716 0.007117 0.000895 0.005611 0.004805 0.005959 0.001646 0.007873
Mitotic Spindle 0.062634 0.003902 0.009129 0.051326 0.001093 0.002660 0.006467 0.067180 0.013761 0.003188 0.008800 0.059550
None 0.000444 0.002325 0.000221 0.000680 0.000612 0.002060 0.000074 0.000622 0.000577 0.002173 0.000203 0.000650
Nuclear Periphery 0.549859 0.558063 0.720551 0.468423 0.599909 0.581559 0.717158 0.456093 0.589607 0.571561 0.720133 0.462027
Nuclear Periphery Foci 0.316660 0.349879 0.210546 0.331919 0.347172 0.334054 0.247161 0.333825 0.340892 0.340788 0.215067 0.332908
Nucleolus 0.015988 0.031841 0.024737 0.048734 0.014079 0.022339 0.013258 0.052665 0.014472 0.026382 0.023320 0.050773
Nucleus 0.008469 0.021952 0.025890 0.014203 0.011198 0.015380 0.008435 0.024450 0.010636 0.018177 0.023734 0.019519
Peroxisomes 0.001183 0.001658 0.000463 0.002271 0.000515 0.000876 0.000516 0.002293 0.000653 0.001209 0.000470 0.002282
Vacuole 0.007715 0.003118 0.000593 0.012722 0.003570 0.004415 0.000452 0.009614 0.004423 0.003863 0.000575 0.011110
Vacuole Periphery 0.007234 0.009143 0.002785 0.022625 0.008249 0.011040 0.002347 0.013619 0.008040 0.010233 0.002731 0.017953

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.18 1.72 0.50 -1.55 -2.95 -3.53 1.68 -3.55 -0.14 -4.00 -0.73 1.40 -1.73 -1.52 -3.84
Bud Neck 4.07 4.11 -7.03 -11.43 -11.51 -2.11 -0.78 -11.07 -10.59 -10.28 1.07 0.21 -15.12 -15.57 -15.20
Bud Site 2.32 2.65 -2.34 -5.47 -5.80 -0.57 1.22 -6.75 -6.61 -7.75 0.95 2.65 -7.19 -8.40 -9.53
Cell Periphery 0.63 3.22 -3.66 -4.95 -7.40 -2.46 2.39 -5.34 -1.98 -7.30 -2.09 3.87 -6.72 -4.41 -10.97
Cytoplasm -1.66 1.69 -2.81 -0.46 -4.46 -2.88 1.78 -4.82 -0.20 -5.91 -3.30 1.13 -5.48 -0.20 -6.85
Cytoplasmic Foci 2.06 3.74 -3.45 -8.43 -11.30 -3.93 -1.06 -8.00 -6.75 -7.47 -1.75 4.19 -10.78 -10.15 -12.76
Eisosomes 0.20 1.99 -2.93 -5.17 -8.30 -3.18 0.69 -5.77 -2.95 -4.69 -2.71 2.89 -7.64 -5.82 -10.59
Endoplasmic Reticulum 1.20 3.43 2.79 4.96 -2.87 -3.32 6.09 2.39 5.90 -5.04 -1.99 6.02 3.67 7.64 -4.47
Endosome 3.15 4.15 -0.03 -6.23 -8.50 -1.33 4.08 -4.85 -3.85 -7.69 0.80 5.52 -4.91 -6.29 -11.02
Golgi 2.18 2.84 -1.10 -4.82 -5.81 -1.16 1.07 -3.39 -2.97 -3.92 0.37 2.78 -4.50 -5.16 -6.61
Lipid Particles 0.41 3.31 -1.96 -3.32 -8.37 -4.24 5.43 -2.87 1.47 -6.33 -3.53 6.50 -4.62 -0.93 -10.54
Mitochondria 0.37 1.62 -2.11 -4.20 -6.39 -1.94 3.84 -0.99 1.08 -5.11 -1.19 3.90 -2.99 -2.16 -8.03
Mitotic Spindle 6.78 6.11 1.20 -11.64 -9.99 -2.43 -2.68 -14.61 -14.20 -12.45 5.46 2.13 -12.99 -18.38 -15.52
None -2.06 0.70 -0.81 1.87 -4.58 -3.18 4.47 -0.33 3.11 -5.88 -3.51 3.13 -0.82 3.34 -6.17
Nuclear Periphery -0.68 -11.93 5.41 8.79 26.98 2.22 -7.93 15.73 13.49 17.18 2.51 -17.42 17.42 16.00 35.09
Nuclear Periphery Foci -2.97 10.20 -1.24 2.34 -17.13 1.79 7.63 2.17 0.55 -6.16 0.00 21.24 1.73 1.89 -20.69
Nucleolus -3.75 -2.47 -6.87 -3.85 -5.64 -3.68 0.25 -9.89 -7.49 -8.46 -5.95 -4.24 -12.68 -8.23 -8.59
Nucleus -5.10 -6.33 -3.11 2.63 4.01 -2.05 0.94 -6.01 -4.03 -5.32 -4.39 -5.52 -5.92 -1.37 1.33
Peroxisomes -0.72 2.38 -2.32 -1.52 -6.28 -3.53 -0.05 -5.32 -4.33 -4.64 -2.94 2.10 -6.92 -4.31 -8.03
Vacuole 2.19 3.34 -2.01 -8.85 -11.65 -0.95 4.90 -5.10 -4.42 -8.78 0.80 5.72 -6.80 -8.86 -14.25
Vacuole Periphery -1.07 3.02 -6.65 -6.60 -10.94 -2.21 6.82 -4.00 -1.77 -10.02 -2.20 7.07 -7.94 -6.20 -14.32
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75
Localization
Cell Percentages nuclear periphery (93%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Nup85

Nup85


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nup85-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available