Standard name
Human Ortholog
Description Cytochrome c, isoform 1; also known as iso-1-cytochrome c; electron carrier of mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication; human homolog CYC1 can complement yeast null mutant; mutations in human CYC1 cause insulin-responsive hyperglycemia
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – 0 0.07 0.08 0.05 0.07 0.07
Bud 0 0 0 0 0 0 – 0 0 0 0.07 0 0 0 0 – – – 0 0 0 0.05 0.05 0.06
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Cytoplasm 0.81 0.54 0.28 0.28 0.26 0.2 – 0.13 0.11 0.07 0.1 0.07 0.68 0.75 0.7 – – – 0.5 0.26 0.11 0.12 0.14 0.13
Endoplasmic Reticulum 0.07 0 0 0 0 0 – 0 0 0 0 0 0.07 0.07 0 – – – 0 0.05 0.11 0 0.05 0
Endosome 0 0.1 0.08 0.07 0.27 0.07 – 0.07 0 0 0 0 0 0.08 0.1 – – – 0.14 0.16 0.17 0.17 0.2 0.13
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – 0 0.06 0.09 0.11 0.1 0.05
Mitochondria 0.05 0.05 0.64 0.63 0.38 0.73 – 0.77 0.84 0.9 0.88 0.93 0 0 0 – – – 0.09 0.18 0.29 0.25 0.22 0.29
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Vac/Vac Membrane 0.05 0.3 0.1 0.08 0.27 0.16 – 0.21 0.15 0.11 0.08 0.08 0.13 0.09 0.18 – – – 0.07 0.11 0 0.12 0.07 0.12
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 9 5 6 7 3 0 – 0 1 3 1 0 6 3 1 – – – 7 21 20 6 16 14
Bud 2 2 7 7 3 6 – 8 11 14 22 12 1 0 3 – – – 6 13 3 6 12 13
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – 5 5 2 1 2 7
Bud Site 0 0 0 0 0 0 – 1 1 4 3 8 0 0 0 – – – – – – – – –
Cell Periphery 2 10 8 8 3 0 – 2 5 10 3 4 6 1 4 – – – 0 1 4 1 1 2
Cytoplasm 178 135 67 67 71 45 – 42 38 37 31 33 113 141 149 – – – 129 83 27 15 31 27
Endoplasmic Reticulum 16 10 6 9 9 3 – 1 4 5 1 7 12 13 7 – – – 6 15 28 4 11 7
Endosome 3 25 18 18 75 15 – 22 10 11 4 4 7 16 21 – – – 37 50 42 21 45 29
Golgi 0 7 5 3 7 1 – 0 0 0 0 0 1 2 1 – – – 3 19 21 13 22 11
Mitochondria 10 13 152 152 106 165 – 255 293 503 272 417 6 4 8 – – – 24 57 71 32 50 64
Nucleus 1 1 0 0 0 3 – 5 2 11 8 5 0 1 0 – – – 5 3 0 0 1 2
Nuclear Periphery 0 2 0 0 1 0 – 4 7 10 3 11 0 2 0 – – – 3 3 1 1 1 2
Nucleolus 0 1 1 1 1 1 – 6 9 8 5 9 0 1 0 – – – 0 0 0 0 0 0
Peroxisomes 0 0 2 2 3 1 – 1 1 1 0 1 0 0 0 – – – 0 0 2 1 0 0
SpindlePole 0 1 1 1 4 1 – 5 4 5 9 7 0 0 0 – – – 4 3 8 2 7 5
Vac/Vac Membrane 12 76 24 20 74 37 – 68 53 64 25 38 22 17 38 – – – 17 35 5 16 15 25
Unique Cell Count 219 252 238 240 277 227 331 347 560 308 450 165 189 213 258 325 250 130 226 221
Labelled Cell Count 233 288 297 295 360 278 420 439 686 387 556 174 201 232 258 325 250 130 226 221


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.9 9.7 7.3 7.3 7.4 5.4 – 5.3 4.6 4.8 5.0 4.8 8.8 8.8 7.8 – – – 9.0 8.5 8.1
Std Deviation (1e-4) 1.9 2.1 2.5 2.5 2.5 2.0 – 2.1 1.5 1.5 1.6 1.4 2.2 2.4 2.0 – – – 2.6 2.3 1.9
Intensity Change (Log2) – – – -0.0 0.03 -0.44 – -0.45 -0.66 -0.59 -0.53 -0.59 0.27 0.28 0.1 – – – 0.31 0.23 0.16


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0.3 0 0 – 0 0 0 0 0 0 0 0 – – –
Bud 0 0 -0.2 – -0.4 0 0 2.2 0 0 0 0 – – –
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 – – –
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 – – –
Cell Periphery 0 -1.8 0 – 0 0 0 0 0 0.1 0 -1.0 – – –
Cytoplasm -0.1 -0.6 -2.1 – -4.6 -5.3 -8.3 -5.5 -7.4 8.0 9.5 8.9 – – –
Endoplasmic Reticulum 0.8 0.5 0 – 0 0 0 0 0 2.3 2.2 0.5 – – –
Endosome 0 5.7 -0.4 – -0.4 0 0 -3.7 0 -1.4 0.3 0.9 – – –
Golgi 0 0.3 0 – 0 0 0 0 0 0 0 0 – – –
Mitochondria -0.1 -5.8 2.0 – 3.4 0 0 6.8 0 -12.2 -13.2 -13.3 – – –
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 – – –
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 – – –
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 – – –
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 – – –
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 – – –
Vacuole -0.7 4.8 2.0 – 3.3 1.8 0.6 -0.8 -0.7 1.0 -0.4 2.4 – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.572 6.5602 5.8206 5.449 4.4412 5.9994 4.7345 6.505 7.1294 6.6103 4.9566 7.1751 6.2097 8.9913 8.2635 8.3549 6.0155 7.8441
Actin 0.0697 0.0429 0.042 0.0098 0.0773 0.0407 0.0561 0.0582 0.0621 0.0389 0.0111 0.0216 0.058 0.0748 0.0629 0.0227 0.1221 0.0392
Bud 0.0024 0.0079 0.0073 0.0104 0.0112 0.0036 0.0051 0.0091 0.0077 0.0182 0.0016 0.0029 0.0034 0.0101 0.0049 0.0066 0.0103 0.0071
Bud Neck 0.0034 0.0031 0.007 0.0024 0.0021 0.0117 0.002 0.0018 0.0027 0.0023 0.0015 0.007 0.024 0.0021 0.0058 0.0022 0.0028 0.0091
Bud Periphery 0.0019 0.0051 0.0106 0.0151 0.0085 0.0032 0.0133 0.0058 0.0067 0.0157 0.0005 0.0023 0.0019 0.0061 0.0027 0.0043 0.0187 0.0057
Bud Site 0.0099 0.0425 0.0108 0.0048 0.0044 0.0041 0.0074 0.0261 0.0144 0.0108 0.0018 0.0025 0.0237 0.049 0.0115 0.0024 0.0182 0.019
Cell Periphery 0.0006 0.0011 0.0007 0.0009 0.0007 0.0006 0.001 0.0009 0.0009 0.0006 0.0001 0.0004 0.0004 0.0009 0.0005 0.0003 0.0006 0.0009
Cytoplasm 0.2508 0.3905 0.3268 0.2479 0.3289 0.319 0.2589 0.3899 0.387 0.3151 0.4677 0.4024 0.3263 0.3888 0.5054 0.482 0.1223 0.3693
Cytoplasmic Foci 0.1244 0.1159 0.1093 0.1802 0.0669 0.131 0.1001 0.1287 0.1272 0.0632 0.144 0.1208 0.1335 0.1176 0.0996 0.1385 0.1524 0.0789
Eisosomes 0.0005 0.0002 0.0002 0.0002 0.0004 0.0001 0.0003 0.0002 0.0005 0.0002 0.0001 0.0001 0.0002 0.0002 0.0004 0.0001 0.0006 0.0003
Endoplasmic Reticulum 0.0249 0.0128 0.0256 0.0083 0.021 0.0165 0.03 0.0124 0.0155 0.0059 0.0029 0.0315 0.0266 0.0148 0.0185 0.0053 0.0084 0.0242
Endosome 0.2495 0.1107 0.1732 0.1673 0.1311 0.2108 0.2442 0.1342 0.1168 0.1311 0.1223 0.1776 0.1731 0.1357 0.1013 0.0842 0.1502 0.1513
Golgi 0.0954 0.1003 0.1067 0.0826 0.1263 0.1088 0.0745 0.1351 0.108 0.1247 0.1585 0.102 0.0762 0.0846 0.0959 0.0897 0.1136 0.086
Lipid Particles 0.0142 0.0034 0.0077 0.0028 0.0057 0.0073 0.0158 0.0012 0.0031 0.0232 0.0082 0.0023 0.0196 0.0027 0.0034 0.0074 0.0206 0.0017
Mitochondria 0.0607 0.1047 0.1023 0.219 0.1303 0.0971 0.0782 0.0621 0.1103 0.1986 0.0234 0.0734 0.0302 0.0623 0.0408 0.0723 0.0906 0.1348
None 0.0027 0.0078 0.0041 0.0033 0.0253 0.0032 0.0071 0.0017 0.002 0.0011 0.0016 0.0046 0.0364 0.0024 0.015 0.0016 0.0159 0.0043
Nuclear Periphery 0.0243 0.0033 0.0122 0.0054 0.0125 0.007 0.018 0.0023 0.003 0.0097 0.0013 0.0098 0.0186 0.0045 0.0037 0.0019 0.0116 0.0287
Nucleolus 0.0004 0.0016 0.0003 0.0005 0.0005 0.0002 0.0006 0.0001 0.0003 0.0005 0.0001 0.0007 0.0005 0.0003 0.0002 0.0001 0.0011 0.0003
Nucleus 0.0188 0.0049 0.0082 0.006 0.003 0.0067 0.0212 0.0037 0.0076 0.0046 0.0044 0.0096 0.0057 0.0128 0.0037 0.0334 0.0037 0.0175
Peroxisomes 0.0254 0.0191 0.026 0.0213 0.0121 0.0121 0.0214 0.0172 0.0117 0.0191 0.0388 0.0124 0.0153 0.0188 0.014 0.0343 0.1022 0.0077
Punctate Nuclear 0.0024 0.0013 0.0023 0.0021 0.01 0.0033 0.0034 0.0007 0.0035 0.0004 0.0021 0.0016 0.0135 0.0014 0.0014 0.001 0.0248 0.0037
Vacuole 0.0114 0.0183 0.0106 0.0062 0.0124 0.0085 0.0297 0.0058 0.0064 0.0085 0.0056 0.0097 0.0095 0.0079 0.0066 0.0074 0.005 0.0061
Vacuole Periphery 0.0063 0.0027 0.0061 0.0037 0.0094 0.0043 0.0117 0.0026 0.0025 0.0078 0.0024 0.0049 0.0036 0.0025 0.002 0.0022 0.0041 0.0043

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 30.0928 50.8133 24.3978 36.7987 65.0278 26.7344 25.6886 19.3779 24.4892 35.553
Translational Efficiency 3.4221 1.8929 3.5331 3.0988 3.7195 3.0959 2.6325 4.4127 2.8324 3.0744

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
76 1306 1127 1013 394 1214 2110 1471 470 2520 3237 2484

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 820.15 1041.60 1028.16 1039.22 635.25 1025.02 1046.28 1041.61 665.15 1033.61 1039.97 1040.64
Standard Deviation 178.67 181.25 163.02 179.07 158.04 170.60 159.92 180.96 175.31 176.39 161.24 180.19
Intensity Change Log 2 — 0.344842 0.326105 0.341541 — 0.690256 0.719873 0.713419 — 0.505857 0.511306 0.515743

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.005680 0.009235 0.002022 0.017408 0.002325 0.005180 0.007243 0.013365 0.002868 0.007281 0.005425 0.015013
Bud Neck 0.042108 0.012443 0.021124 0.020583 0.037479 0.021563 0.034952 0.018411 0.038228 0.016837 0.030138 0.019297
Bud Site 0.120990* 0.121815* 0.048650 0.192838* 0.070075 0.093279 0.140799* 0.148140* 0.078308 0.108068* 0.108716* 0.166368*
Cell Periphery 0.000414 0.000408 0.000185 0.000357 0.000701 0.000266 0.000149 0.000216 0.000655 0.000340 0.000161 0.000274
Cytoplasm 0.117757* 0.077519 0.349183* 0.213542* 0.135437* 0.087976 0.241442* 0.194955* 0.132578* 0.082557 0.278953* 0.202535*
Cytoplasmic Foci 0.259140* 0.181283* 0.093060 0.129561 0.227588* 0.196017* 0.094005 0.123767 0.232690* 0.188381* 0.093676 0.126130
Eisosomes 0.000257 0.000116 0.000060 0.000119 0.000300 0.000114 0.000059 0.000086 0.000293 0.000115 0.000060 0.000100
Endoplasmic Reticulum 0.001699 0.003953 0.005068 0.005364 0.005517 0.002385 0.002263 0.002846 0.004900 0.003198 0.003239 0.003873
Endosome 0.068282 0.079842 0.037791 0.032090 0.096559 0.099816 0.034949 0.055390 0.091986 0.089465 0.035939 0.045888
Golgi 0.057747 0.135438* 0.009479 0.033084 0.038752 0.115688* 0.028135 0.043442 0.041824 0.125923* 0.021639 0.039218
Lipid Particles 0.009698 0.002920 0.004716 0.002522 0.029176 0.003418 0.001372 0.002907 0.026027 0.003160 0.002536 0.002750
Mitochondria 0.087245 0.159072* 0.009715 0.017978 0.111783* 0.144102* 0.053295 0.047571 0.107815* 0.151860* 0.038122 0.035502
Mitotic Spindle 0.049115 0.081639 0.096315 0.109853* 0.020064 0.070515 0.150165* 0.105824* 0.024761 0.076280 0.131416* 0.107467*
None 0.001347 0.000490 0.002788 0.002252 0.016870 0.001047 0.000901 0.001902 0.014360 0.000758 0.001558 0.002045
Nuclear Periphery 0.000497 0.000260 0.001971 0.000475 0.001123 0.000245 0.000777 0.000976 0.001022 0.000253 0.001192 0.000772
Nuclear Periphery Foci 0.000764 0.001189 0.003520 0.001778 0.004328 0.000844 0.000846 0.001177 0.003752 0.001023 0.001777 0.001422
Nucleolus 0.001005 0.000662 0.002332 0.001075 0.018847 0.002205 0.001470 0.001560 0.015962 0.001405 0.001770 0.001362
Nucleus 0.023173 0.005241 0.133231* 0.028323 0.071255 0.009839 0.037451 0.017351 0.063480 0.007456 0.070798 0.021826
Peroxisomes 0.095655 0.037642 0.012840 0.057422 0.035571 0.044874 0.033318 0.056363 0.045287 0.041126 0.026188 0.056795
Vacuole 0.046894 0.064475 0.156664 0.125037 0.052980 0.079848 0.125831 0.148679 0.051996 0.071881 0.136566 0.139038
Vacuole Periphery 0.010536 0.024357 0.009283 0.008339 0.023268 0.020778 0.010579 0.015072 0.021209 0.022633 0.010128 0.012326

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.99 2.91 -5.12 -3.21 -9.19 -2.75 -4.28 -7.12 -4.74 -3.97 -4.63 -2.77 -9.73 -5.14 -8.07
Bud Neck 2.92 1.89 2.02 -5.39 0.70 3.14 0.27 4.01 1.74 9.30 4.89 1.54 4.33 -1.99 8.47
Bud Site 0.03 3.93 -2.31 -5.84 -17.80 -2.94 -6.98 -7.86 -6.50 -1.88 -4.07 -2.73 -9.28 -8.04 -11.16
Cell Periphery 0.05 2.74 0.98 1.17 -2.80 4.90 6.41 5.67 2.67 -3.13 3.88 6.70 5.25 2.35 -4.09
Cytoplasm 1.88 -9.41 -4.74 -16.50 9.27 4.24 -10.58 -6.69 -15.21 4.78 5.25 -14.78 -8.41 -22.61 9.20
Cytoplasmic Foci 3.13 7.26 5.76 9.92 -6.41 2.95 13.59 10.66 13.23 -6.54 4.55 15.45 12.05 16.52 -9.14
Eisosomes 3.30 4.53 3.26 -0.06 -6.13 2.58 3.33 2.97 4.67 -7.38 2.92 3.81 3.20 3.04 -9.15
Endoplasmic Reticulum -2.48 -8.64 -4.90 -1.03 0.88 2.54 2.43 2.23 -0.85 -0.44 1.51 1.19 1.11 -0.89 -0.10
Endosome -1.02 3.09 3.60 15.13 2.09 -0.52 9.10 6.48 11.82 -6.27 0.25 9.52 8.11 17.46 -4.20
Golgi -5.47 3.71 2.33 19.70 -6.74 -12.00 3.46 0.60 14.80 -4.39 -15.57 5.57 2.21 24.18 -6.75
Lipid Particles 1.48 1.10 1.51 0.18 3.37 6.32 6.76 6.43 0.96 -4.04 6.51 6.65 6.59 0.72 -0.83
Mitochondria -3.45 3.89 3.58 21.17 -2.98 -2.75 6.04 6.41 14.63 1.19 -4.37 7.75 7.98 24.45 0.95
Mitotic Spindle -2.71 -3.30 -4.18 -2.68 -1.37 -7.73 -17.48 -11.45 -4.24 5.32 -9.54 -16.81 -12.99 -4.77 3.70
None 1.13 -1.66 -0.63 -2.38 1.08 4.55 4.57 4.35 -0.84 -0.95 4.63 4.40 4.30 -2.06 -0.40
Nuclear Periphery 0.62 -4.84 -0.65 -2.86 6.84 4.59 0.27 0.26 -3.09 0.10 4.51 -2.80 0.44 -3.98 3.41
Nuclear Periphery Foci -0.66 -5.51 -2.69 -2.23 3.93 4.50 4.35 4.01 -1.88 -1.31 4.12 2.85 3.36 -2.47 1.88
Nucleolus 0.65 -3.23 -0.32 -1.90 4.73 4.94 5.12 5.15 1.19 0.47 5.15 4.94 5.16 0.12 2.57
Nucleus 1.86 -11.48 -1.29 -11.17 17.59 7.76 1.91 5.75 -6.93 9.88 8.25 -3.52 4.92 -13.09 18.86
Peroxisomes 3.15 4.64 2.49 -2.75 -10.63 -1.95 1.53 -2.76 -1.07 -6.11 0.82 4.78 -0.79 -2.81 -10.68
Vacuole -1.15 -9.92 -8.97 -13.89 0.83 -4.81 -16.07 -17.34 -14.52 -4.25 -4.25 -19.90 -20.17 -20.51 -2.96
Vacuole Periphery -3.98 0.92 1.20 9.62 0.68 0.68 5.24 3.64 4.52 -2.57 -0.76 5.40 4.51 9.42 -1.67
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cytochrome c, isoform 1; also known as iso-1-cytochrome c; electron carrier of mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication; human homolog CYC1 can complement yeast null mutant; mutations in human CYC1 cause insulin-responsive hyperglycemia
Localization
Cell Percentages mitochondrion (46%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Cyc1

Cyc1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cyc1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available