Standard name
Human Ortholog
Description Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; has two translation start sites, one at the annotated start codon which produces an ER-targeted form required for anaerobic growth, and one at codon 32 which produces a mitochondrially-targeted form; OSM1 has a paralog, FRD1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.1 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.16 0 0.06 0 0 0 0 0 0
Cytoplasm 0.53 0.57 0.85 0.72 0.75 0.66 0.65 0.61 0.54 0.58 0.61 0.5 0.86 0.89 0.89 0.24 0.12 0.21 0.28 0.25 0.51 0.43 0.4 0.34
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.05 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.14 0.26 0.21 0.08 0.08 0 0 0.05 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.26 0.25 0 0 0 0 0 0
Mitochondria 0.55 0.41 0.13 0.27 0.22 0.42 0.44 0.44 0.52 0.52 0.55 0.61 0.1 0.07 0.08 0.12 0.12 0.06 0.49 0.38 0.3 0.36 0.34 0.3
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0 0 0 0 0 0
Vac/Vac Membrane 0.07 0.13 0 0 0 0 0 0 0 0 0 0 0 0 0 0.17 0.28 0.19 0 0.13 0 0 0 0.09
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 3 4 3 0 0 0 0 0 2 0 0 1 1 0 6 3 5 2 2 7 4 10 16
Bud 0 2 3 4 5 6 7 14 13 14 13 11 2 1 4 8 2 2 1 6 2 0 14 24
Bud Neck 0 0 3 2 3 5 4 10 7 4 4 7 1 0 0 0 0 0 1 4 0 1 3 9
Bud Site 0 0 0 0 0 1 3 3 3 5 1 2 0 0 0 1 0 0 – – – – – –
Cell Periphery 0 1 1 0 0 0 1 2 1 2 0 2 0 1 3 31 1 3 0 0 4 1 3 2
Cytoplasm 71 134 200 94 147 205 270 284 199 296 188 193 245 349 406 45 9 11 40 68 123 72 152 148
Endoplasmic Reticulum 4 8 4 1 1 1 0 1 1 1 2 3 2 5 0 17 4 3 2 4 2 1 3 4
Endosome 1 1 0 0 4 0 0 1 0 0 0 0 7 1 6 26 19 11 11 21 6 4 18 17
Golgi 2 2 0 1 2 0 0 0 0 0 0 0 0 1 1 18 19 13 3 5 0 2 6 8
Mitochondria 74 97 31 36 43 131 185 205 194 267 172 239 27 27 38 23 9 3 72 103 72 59 127 130
Nucleus 0 1 0 0 0 2 2 6 5 4 1 0 1 1 1 3 0 1 0 1 0 0 1 0
Nuclear Periphery 1 1 0 0 0 3 4 1 1 2 1 5 0 0 0 0 0 1 0 2 0 0 0 0
Nucleolus 0 0 0 0 1 3 1 1 0 1 2 2 1 0 0 1 0 0 0 0 0 0 0 1
Peroxisomes 0 0 0 0 3 0 0 0 1 0 0 0 1 2 0 14 2 2 2 1 1 2 5 5
SpindlePole 0 2 0 1 2 6 8 14 16 9 7 3 0 1 1 7 4 3 1 6 2 4 12 12
Vac/Vac Membrane 9 30 5 3 6 7 10 4 8 11 8 9 6 9 12 33 21 10 4 35 7 5 13 38
Unique Cell Count 135 236 236 131 197 309 418 466 371 510 310 389 284 390 454 190 74 52 147 270 242 167 381 431
Labelled Cell Count 162 282 251 145 217 370 495 546 449 618 399 476 294 399 472 233 93 68 147 270 242 167 381 431


Ambiguous, Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.7 4.1 3.1 3.2 3.6 3.0 2.7 3.0 2.9 2.7 2.7 2.6 4.4 4.2 4.2 5.7 6.5 7.6 4.4 4.3 4.7
Std Deviation (1e-4) 0.9 1.0 0.6 0.9 1.3 1.1 1.0 1.3 1.4 0.9 1.2 0.8 1.2 1.5 1.2 1.2 1.3 1.9 1.7 1.4 1.5
Intensity Change (Log2) – – – 0.05 0.23 -0.04 -0.2 -0.01 -0.09 -0.19 -0.15 -0.25 0.51 0.47 0.44 0.89 1.1 1.32 0.51 0.49 0.63

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 –
Bud Neck – – – – – – – – – – – – 0 0 –
Bud Site – – – – – – – – – – – – 0 0 –
Cell Periphery – – – – – – – – – – – – 0 0 –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 –
Endosome – – – – – – – – – – – – 0 0 –
Golgi – – – – – – – – – – – – 0 0 –
Mitochondria – – – – – – – – – – – – 0 0 –
Nuclear Periphery – – – – – – – – – – – – 0 0 –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 –
Peroxisomes – – – – – – – – – – – – 0 0 –
SpindlePole – – – – – – – – – – – – 0 0 –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 –
Cytoplasm – – – – – – – – – – – – 0 0 –
Nucleus – – – – – – – – – – – – 0 0 –
Vacuole – – – – – – – – – – – – 5.5 7.1 –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.6159 2.0951 1.7024 1.6074 1.1953 2.0669 -0.6086 0.4229 0.1026 -0.671 -0.4371 -0.2577 0.8491 0.0377 0.0678 0.851 2.3187 0.0871
Actin 0.0396 0.0064 0.0186 0.0076 0.0014 0.0114 0.0246 0.0043 0.0192 0.0014 0.0038 0.004 0.0005 0.0004 0.0011 0.0013 0.0036 0.0018
Bud 0.0016 0.0035 0.0087 0.0028 0.0025 0.0015 0.0004 0.0059 0.0013 0.0011 0.0031 0.0008 0.0002 0.0003 0.0006 0.0002 0.0019 0.0004
Bud Neck 0.0337 0.0007 0.0017 0.0018 0.0183 0.0167 0.001 0.0001 0.0026 0.0004 0.001 0.0008 0.0003 0.0002 0.0002 0.0005 0.0004 0.005
Bud Periphery 0.0019 0.0059 0.0224 0.0074 0.005 0.0035 0.0009 0.0328 0.0024 0.0059 0.0124 0.0051 0.0003 0.0003 0.001 0.0003 0.0019 0.0009
Bud Site 0.0246 0.0244 0.0142 0.0035 0.0071 0.0041 0.0033 0.0006 0.0115 0.0002 0.0013 0.0004 0.0005 0.0014 0.0038 0.0004 0.0086 0.0003
Cell Periphery 0.0017 0.0019 0.0024 0.0008 0.0019 0.0016 0.001 0.0003 0.0023 0.0016 0.0006 0.0005 0.0003 0.0007 0.0012 0.0003 0.0002 0.0012
Cytoplasm 0.1362 0.1974 0.2252 0.1405 0.2634 0.2066 0.1417 0.0411 0.1062 0.2241 0.051 0.1269 0.1091 0.1865 0.2039 0.3007 0.0216 0.2322
Cytoplasmic Foci 0.0732 0.0353 0.0404 0.0515 0.1195 0.0782 0.0584 0.0616 0.0793 0.0178 0.0878 0.0354 0.1694 0.0626 0.0429 0.0556 0.0887 0.0697
Eisosomes 0.0009 0.0004 0.0007 0.0004 0.0001 0.0004 0.0012 0.0005 0.0019 0.0003 0.0011 0.0003 0.0001 0.0002 0.0003 0.0001 0.0003 0.0008
Endoplasmic Reticulum 0.0439 0.0104 0.0106 0.0049 0.0052 0.0121 0.0125 0.0015 0.0051 0.0148 0.0008 0.0021 0.0042 0.0075 0.0036 0.0062 0.0009 0.0028
Endosome 0.0534 0.1053 0.0415 0.0563 0.0815 0.1011 0.0582 0.0749 0.0618 0.0646 0.0249 0.0671 0.1031 0.1458 0.0525 0.082 0.0177 0.0561
Golgi 0.0284 0.0302 0.0081 0.0292 0.0501 0.0354 0.0203 0.0452 0.0116 0.0133 0.0074 0.0124 0.031 0.015 0.0073 0.0061 0.0153 0.0086
Lipid Particles 0.0112 0.0048 0.0039 0.0076 0.0125 0.0091 0.0133 0.0324 0.0086 0.0243 0.0019 0.0173 0.015 0.0041 0.0028 0.0037 0.0136 0.0048
Mitochondria 0.0637 0.0778 0.0826 0.128 0.0118 0.1084 0.0431 0.0217 0.0937 0.0848 0.0711 0.0641 0.3929 0.0078 0.075 0.0158 0.0135 0.0245
None 0.4469 0.4406 0.4889 0.512 0.3698 0.3756 0.5596 0.6607 0.5601 0.5054 0.7132 0.6447 0.1595 0.5478 0.588 0.5124 0.7222 0.5701
Nuclear Periphery 0.0046 0.0117 0.0027 0.0015 0.001 0.0018 0.0234 0.001 0.0011 0.0022 0.0003 0.0006 0.0003 0.0025 0.0011 0.0011 0.0006 0.0008
Nucleolus 0.0014 0.0033 0.0013 0.0051 0.0002 0.0005 0.0013 0.0003 0.0009 0.0002 0.0004 0.0002 0.0003 0.0002 0.0006 0.0002 0.0006 0.0002
Nucleus 0.0032 0.0055 0.0033 0.0021 0.001 0.0018 0.0044 0.0004 0.0011 0.0007 0.0005 0.0004 0.0003 0.001 0.0014 0.0009 0.0006 0.0005
Peroxisomes 0.0134 0.0021 0.0022 0.0244 0.0068 0.0099 0.0127 0.009 0.0173 0.0161 0.0131 0.0029 0.0055 0.001 0.0042 0.0029 0.0823 0.0107
Punctate Nuclear 0.0047 0.0066 0.0043 0.0021 0.0007 0.0013 0.0097 0.0008 0.0014 0.0002 0.0009 0.0004 0.0013 0.0005 0.001 0.0005 0.0038 0.0004
Vacuole 0.01 0.0181 0.0135 0.007 0.0365 0.0152 0.0076 0.0038 0.0088 0.0135 0.0026 0.0101 0.004 0.0105 0.0059 0.0064 0.0014 0.0047
Vacuole Periphery 0.0017 0.0075 0.0029 0.0033 0.0037 0.0039 0.0015 0.001 0.0018 0.0071 0.0008 0.0035 0.0018 0.0037 0.0015 0.0023 0.0004 0.0036

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 22.7128 26.8535 25.7586 30.9703 17.5739 16.8421 28.9727 35.9805 35.3466 28.3964
Translational Efficiency 1.0723 0.8367 0.9899 0.8227 1.0363 1.5512 1.0121 0.7183 0.9291 0.862

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
237 1096 253 577 1728 846 1433 346 1965 1942 1686 923

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 600.83 679.45 832.59 790.09 640.13 693.30 798.67 826.76 635.39 685.48 803.76 803.84
Standard Deviation 62.95 90.42 102.50 116.35 84.12 108.25 105.75 120.05 82.85 98.82 105.96 119.08
Intensity Change Log 2 — 0.177411 0.470649 0.395060 — 0.115115 0.319235 0.369104 — 0.145612 0.394530 0.381729

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000091 0.001603 0.001009 0.005580 0.000401 0.001923 0.001168 0.008365 0.000364 0.001743 0.001144 0.006624
Bud Neck 0.030863 0.045433 0.005881 0.018108 0.038066 0.051129 0.021688 0.023036 0.037197 0.047915 0.019316 0.019955
Bud Site 0.003536 0.037830 0.007428 0.061015 0.022942 0.042502 0.047602 0.050656 0.020601 0.039866 0.041574 0.057132
Cell Periphery 0.000216 0.000201 0.000269 0.000408 0.000223 0.000300 0.000204 0.000218 0.000222 0.000244 0.000214 0.000337
Cytoplasm 0.367778 0.243637 0.158841 0.259648 0.342356 0.264241 0.405413 0.281052 0.345422 0.252612 0.368413 0.267671
Cytoplasmic Foci 0.250344 0.280660 0.055561 0.083674 0.268014 0.273807 0.062351 0.055903 0.265883 0.277675 0.061332 0.073263
Eisosomes 0.000228 0.000166 0.000155 0.000119 0.000180 0.000198 0.000073 0.000107 0.000186 0.000180 0.000085 0.000115
Endoplasmic Reticulum 0.001717 0.001050 0.006512 0.002704 0.001120 0.000950 0.001688 0.002028 0.001192 0.001006 0.002412 0.002451
Endosome 0.035118 0.063280 0.029865 0.047015 0.042368 0.050240 0.041807 0.025048 0.041494 0.057599 0.040015 0.038780
Golgi 0.007139 0.039443 0.014859 0.033177 0.020841 0.031270 0.013469 0.008612 0.019188 0.035883 0.013677 0.023969
Lipid Particles 0.024357 0.008679 0.008944 0.002706 0.013481 0.009434 0.003294 0.002007 0.014793 0.009008 0.004142 0.002444
Mitochondria 0.042289 0.070708 0.026324 0.063918 0.052898 0.069941 0.028401 0.031297 0.051619 0.070374 0.028089 0.051690
Mitotic Spindle 0.000510 0.016263 0.019537 0.035329 0.005804 0.014282 0.039941 0.051596 0.005165 0.015400 0.036880 0.041427
None 0.002374 0.003236 0.003356 0.003576 0.004990 0.002170 0.003858 0.006110 0.004674 0.002772 0.003783 0.004526
Nuclear Periphery 0.001926 0.000373 0.002161 0.001387 0.000535 0.000289 0.001147 0.001395 0.000702 0.000336 0.001299 0.001390
Nuclear Periphery Foci 0.000635 0.000480 0.003575 0.001287 0.000339 0.000232 0.000990 0.001476 0.000374 0.000372 0.001378 0.001358
Nucleolus 0.003000 0.004253 0.004122 0.000870 0.001863 0.001666 0.001247 0.000965 0.002000 0.003126 0.001678 0.000905
Nucleus 0.166544 0.053878 0.539157 0.163914 0.097858 0.061314 0.181418 0.297376 0.106142 0.057117 0.235100 0.213944
Peroxisomes 0.016152 0.055442 0.022030 0.030150 0.030311 0.053347 0.017309 0.049552 0.028604 0.054529 0.018018 0.037423
Vacuole 0.042216 0.067422 0.086410 0.176275 0.050694 0.066392 0.121283 0.100518 0.049672 0.066973 0.116050 0.147877
Vacuole Periphery 0.002966 0.005964 0.004001 0.009141 0.004716 0.004373 0.005649 0.002684 0.004505 0.005271 0.005402 0.006720

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.78 -5.63 -2.68 -1.36 -1.78 -3.28 -3.75 -2.34 -1.40 -1.96 -5.08 -4.68 -3.40 -1.92 -2.67
Bud Neck -1.93 3.46 2.31 9.72 -4.13 -3.00 6.31 5.31 6.94 0.95 -3.40 7.30 8.22 11.89 1.27
Bud Site -11.88 -2.50 -7.73 -0.35 -6.52 -4.63 -5.18 -1.80 1.49 1.47 -6.87 -5.13 -4.30 0.66 -0.09
Cell Periphery 0.39 -1.74 -1.34 -2.38 0.30 -1.64 1.87 1.91 2.63 0.73 -0.83 0.98 -0.78 -0.02 -1.56
Cytoplasm 6.36 9.78 5.10 -1.34 -6.49 6.56 -5.13 4.67 -0.06 7.80 10.34 -1.63 7.56 -0.97 8.51
Cytoplasmic Foci -1.93 14.19 13.67 28.46 -1.80 -0.54 36.49 33.95 25.71 2.81 -1.57 39.23 37.09 37.91 0.27
Eisosomes 2.71 2.27 4.91 5.18 3.55 -1.40 12.24 5.95 6.40 -3.16 0.54 11.71 8.05 8.28 -4.03
Endoplasmic Reticulum 0.66 -5.11 -1.81 -7.56 5.36 0.51 -2.68 -6.37 -6.27 -4.37 0.66 -5.44 -7.84 -9.80 -2.13
Endosome -3.95 1.34 1.10 8.08 -0.48 -1.87 2.21 8.17 8.62 5.70 -5.00 2.63 6.23 11.06 3.50
Golgi -8.32 -0.93 -2.51 4.60 -1.12 -2.90 4.73 8.06 8.03 3.59 -6.09 4.24 2.56 7.30 -0.56
Lipid Particles 3.44 3.33 4.84 7.03 4.80 2.89 11.65 13.10 6.10 1.95 5.04 11.18 13.24 9.21 3.45
Mitochondria -2.45 1.87 0.73 4.63 -1.58 -2.29 6.78 6.10 6.71 1.38 -3.54 7.05 4.64 7.43 -0.79
Mitotic Spindle -6.36 -2.94 -5.65 -1.92 -1.48 -3.35 -8.39 -4.19 -2.86 -0.01 -5.35 -8.78 -6.19 -3.36 0.55
None -1.17 -1.06 -1.01 0.16 0.05 3.25 1.47 0.31 -2.68 -1.09 2.53 1.37 1.22 -1.46 -0.32
Nuclear Periphery 2.21 -0.74 -0.41 -8.73 0.78 2.38 -6.43 -7.08 -8.78 -3.08 2.99 -5.75 -7.76 -11.98 -3.58
Nuclear Periphery Foci 0.57 -3.25 -4.20 -5.62 2.07 2.89 -4.38 -4.17 -4.44 -2.31 -0.23 -5.35 -7.33 -7.20 -1.47
Nucleolus -1.16 -0.40 2.63 3.71 2.08 0.75 3.21 4.59 2.92 1.72 -1.94 1.79 5.91 4.31 2.89
Nucleus 9.70 -15.45 -2.79 -14.65 13.98 6.65 -14.17 -13.05 -15.03 -6.57 11.65 -18.82 -14.96 -20.56 0.21
Peroxisomes -8.20 -0.18 -0.21 7.74 0.01 -5.32 6.10 0.52 3.76 -2.07 -8.16 5.68 2.15 8.36 -1.74
Vacuole -4.77 -6.65 -18.99 -17.22 -10.34 -3.69 -17.27 -11.29 -9.73 -4.11 -5.73 -18.39 -22.08 -19.54 -10.54
Vacuole Periphery -3.23 -0.22 -1.31 0.73 -1.09 0.50 0.08 4.54 3.69 3.77 -1.14 0.10 0.96 1.74 0.82
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; has two translation start sites, one at the annotated start codon which produces an ER-targeted form required for anaerobic growth, and one at codon 32 which produces a mitochondrially-targeted form; OSM1 has a paralog, FRD1, that arose from the whole genome duplication
Localization
Cell Percentages mitochondrion (26%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Osm1

Osm1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Osm1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available