Standard name
Human Ortholog
Description Small subunit of the clathrin-associated adaptor complex AP-2; AP-2 is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.19 0.42 0.51 0.17 0.05 0.17 0 0.05 0.06 0.06 0.06 0.06 0.14 0.16 0.16 0.42 0.36 0.42 0.28 0.29 0.37 0.16 0.23 0.22
Bud 0.08 0.12 0.09 0.12 0.13 0.16 0.15 0.15 0.17 0.16 0.2 0.17 0.05 0 0 0.09 0.05 0.09 0.11 0.13 0.07 0.08 0.12 0.18
Bud Neck 0 0.06 0 0.05 0.06 0 0 0 0 0 0 0 0.09 0.1 0.12 0.08 0.1 0.12 0.26 0.37 0.27 0.43 0.35 0.3
Bud Site 0.15 0.2 0.11 0.11 0.19 0.18 0.1 0.11 0.12 0.09 0.1 0.07 0 0.05 0 0.13 0.16 0.12 – – – – – –
Cell Periphery 0 0.08 0.11 0.12 0 0.05 0.07 0.07 0.06 0.08 0.07 0.08 0.07 0.06 0.08 0.12 0.07 0.11 0.09 0 0.08 0.06 0.07 0.07
Cytoplasm 0.48 0.37 0.26 0.45 0.25 0.31 0.34 0.34 0.27 0.23 0.22 0.28 0.79 0.69 0.69 0.25 0.34 0.37 0.11 0.08 0.06 0.1 0.07 0.07
Endoplasmic Reticulum 0 0.07 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0.13 0.09 0 0 0 0 0 0
Endosome 0 0 0 0 0.13 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.06 0 0.2 0.1 0.17 0.44 0.44 0.44 0.54 0.52 0.61 0.56 0 0 0 0.09 0.05 0.08 0.06 0 0 0.08 0.06 0.06
Nucleus 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.12 0 0 0.14 0.23 0.07 0.08 0.08 0.08 0.09 0.07 0.07 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0.21 0 0 0.09 0.12 0 0 0.05 0.06 0.06 0.07 0.05 0.07 0.13 0.12 0.12 0.15 0.12 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 9 70 18 35 19 57 20 25 22 30 21 36 62 101 116 45 22 39 25 65 30 32 142 151
Bud 4 20 3 24 49 54 75 75 66 78 66 94 23 27 30 10 3 8 10 30 5 16 72 120
Bud Neck 1 10 1 11 20 14 13 12 5 6 2 7 40 64 92 9 6 11 24 84 22 87 213 204
Bud Site 7 33 4 22 69 59 49 52 46 46 33 40 13 30 16 14 10 11 – – – – – –
Cell Periphery 2 13 4 24 14 16 35 35 23 38 24 47 30 38 57 13 4 10 8 9 6 12 44 50
Cytoplasm 23 61 9 90 90 102 164 164 107 114 75 158 358 436 512 27 21 34 10 17 4 19 44 47
Endoplasmic Reticulum 0 11 0 6 6 19 19 12 6 17 3 24 5 14 21 3 8 8 0 2 2 2 7 9
Endosome 0 0 0 2 47 0 3 2 6 7 5 5 0 1 3 2 1 0 1 2 1 3 6 7
Golgi 0 0 0 1 0 0 0 0 0 0 0 0 0 0 2 0 1 0 0 1 1 0 1 4
Mitochondria 3 1 7 20 63 146 215 215 216 252 206 316 0 0 1 10 3 7 5 5 3 16 37 39
Nucleus 0 4 0 1 13 4 5 5 21 15 14 2 0 3 1 2 1 4 0 0 0 0 0 0
Nuclear Periphery 0 0 1 1 1 0 4 2 0 0 1 0 0 1 0 0 0 0 0 0 1 0 0 1
Nucleolus 0 0 1 1 5 1 8 8 6 10 9 7 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 6 4 0 28 83 25 39 38 33 43 22 42 0 2 1 4 1 2 0 0 0 0 0 1
SpindlePole 10 7 1 18 44 9 21 22 23 28 22 27 31 82 92 13 9 11 1 0 0 1 0 4
Vac/Vac Membrane 0 0 0 0 5 0 7 6 4 14 12 2 0 5 1 1 1 0 2 4 1 6 32 29
Unique Cell Count 48 165 35 201 363 334 489 488 400 488 336 562 455 628 740 106 61 93 92 225 82 203 609 684
Labelled Cell Count 65 234 49 284 528 506 677 673 584 698 515 807 562 804 945 153 91 145 92 225 82 203 609 684


Bud Neck, Cell Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.8 5.6 4.7 5.0 4.6 4.3 3.9 3.9 4.2 4.2 4.2 4.2 5.7 5.6 5.7 6.2 6.5 6.6 6.2 6.0 6.3
Std Deviation (1e-4) 0.6 0.7 1.1 1.8 1.7 1.5 1.4 1.4 1.4 1.0 1.0 1.0 0.8 1.0 0.8 1.2 1.3 1.2 1.0 1.1 1.4
Intensity Change (Log2) – – – 0.06 -0.03 -0.14 -0.29 -0.29 -0.16 -0.16 -0.19 -0.17 0.27 0.25 0.26 0.39 0.46 0.47 0.38 0.33 0.41

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -4.5 0 0 0 0 0 0 0 0 -5.8 -5.3 -5.5 -0.9 -1.5 -1.0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0.7 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2.1 -0.1 0.6 1.0 1.0 0.1 -0.3 -0.5 0.3 7.0 5.4 5.4 0 0.9 1.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.8115 1.6656 1.584 1.4106 2.4906 1.5406 1.2427 1.1326 1.4613 1.5196 1.3751 1.5538 -0.352 -0.0645 -0.1592 -0.2049 -0.3161 -0.043
Actin 0.1259 0.0327 0.0301 0.0075 0.0779 0.0747 0.0931 0.0229 0.0336 0.0173 0.064 0.0655 0.1622 0.0661 0.0338 0.0042 0.0549 0.0857
Bud 0.0064 0.0068 0.0019 0.0005 0.0022 0.0032 0.0029 0.0039 0.0013 0.0004 0.002 0.0018 0.0026 0.0034 0.002 0.0006 0.002 0.0038
Bud Neck 0.1415 0.0322 0.589 0.9436 0.5342 0.5281 0.1036 0.044 0.6274 0.818 0.6119 0.6714 0.1592 0.0408 0.6289 0.8971 0.6954 0.5912
Bud Periphery 0.0308 0.0141 0.0061 0.0027 0.019 0.0226 0.0208 0.0104 0.0048 0.0027 0.0131 0.0088 0.008 0.0081 0.0064 0.0028 0.0089 0.0365
Bud Site 0.2867 0.5671 0.2504 0.0058 0.0507 0.0204 0.4139 0.6191 0.2286 0.0074 0.01 0.0071 0.3914 0.6332 0.2455 0.023 0.0215 0.0115
Cell Periphery 0.0873 0.031 0.017 0.0072 0.0565 0.047 0.0701 0.0253 0.0134 0.0154 0.0193 0.0123 0.0523 0.0209 0.0058 0.0144 0.0224 0.0408
Cytoplasm 0.1972 0.2314 0.0501 0.0298 0.148 0.233 0.1401 0.1218 0.0224 0.0212 0.164 0.1065 0.1046 0.1066 0.0148 0.0528 0.1222 0.1597
Cytoplasmic Foci 0.0133 0.0039 0.0039 0.001 0.0017 0.0099 0.0087 0.0028 0.0024 0.0107 0.0044 0.005 0.0177 0.0045 0.0027 0.0011 0.0032 0.0107
Eisosomes 0.003 0.0016 0.0011 0.0001 0.0016 0.0019 0.0087 0.0023 0.0012 0.0017 0.0016 0.0012 0.0046 0.0038 0.0008 0 0.0005 0.0009
Endoplasmic Reticulum 0.006 0.0018 0.0003 0 0.0035 0.0019 0.0022 0.0051 0.0043 0.0002 0.0016 0.0011 0.0032 0.0023 0.0001 0.0013 0.0019 0.0012
Endosome 0.0064 0.0005 0.0002 0.0001 0.0034 0.0009 0.0016 0.0003 0.0005 0.0001 0.0002 0.0006 0.0029 0.0008 0.0003 0.0002 0.0003 0.0018
Golgi 0.0045 0.0009 0.0004 0.0002 0.0051 0.0014 0.0024 0.0005 0.0005 0.0003 0.0006 0.001 0.0028 0.0011 0.0006 0.0003 0.0006 0.0021
Lipid Particles 0.0052 0.0004 0.0001 0 0.0025 0.0007 0.0026 0.0007 0.0008 0.0006 0.0002 0.0013 0.0027 0.0055 0.0002 0.0002 0.0004 0.0012
Mitochondria 0.0015 0.0003 0.0001 0 0.001 0.0004 0.0004 0.0002 0.0006 0.0002 0.0001 0.0003 0.0003 0.0004 0.0003 0 0.0001 0.0018
None 0.0621 0.0715 0.047 0.0006 0.0849 0.0487 0.1161 0.138 0.0513 0.0979 0.1055 0.1128 0.079 0.0982 0.0559 0.0002 0.0628 0.044
Nuclear Periphery 0.0028 0.0003 0 0 0.0038 0.0002 0.0011 0.0002 0.0011 0 0.0001 0.0002 0.0004 0.0004 0 0.0001 0.0002 0.0021
Nucleolus 0.0012 0.0006 0.0004 0.0001 0.0003 0.0004 0.0017 0.0002 0.0006 0.0012 0.0001 0.0003 0.0005 0.0003 0.0002 0.0002 0.0002 0.0003
Nucleus 0.0016 0.0011 0.0005 0.0002 0.0007 0.0007 0.0014 0.0004 0.0006 0.0006 0.0003 0.0003 0.0007 0.0006 0.0003 0.0003 0.0006 0.0007
Peroxisomes 0.0119 0.0004 0.0003 0 0.0005 0.0012 0.0048 0.0003 0.0011 0.0007 0.0002 0.0012 0.0013 0.0008 0.0008 0 0.0002 0.0016
Punctate Nuclear 0.0014 0.0004 0.0002 0.0001 0.0011 0.0004 0.0019 0.0002 0.0003 0.003 0.0001 0.0008 0.0023 0.0006 0.0002 0.0001 0.0004 0.0009
Vacuole 0.003 0.0012 0.0007 0.0003 0.0009 0.0024 0.0017 0.0012 0.0028 0.0003 0.0007 0.0005 0.0013 0.0015 0.0003 0.001 0.0013 0.0012
Vacuole Periphery 0.0003 0.0001 0 0 0.0004 0.0001 0.0001 0 0.0004 0 0 0 0.0001 0.0001 0 0 0 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 23.6089 24.4372 18.1335 31.3692 16.1105 29.8052 31.4472 41.6914 34.8201 34.2198
Translational Efficiency 1.1609 1.0813 1.5972 1.0799 2.0381 1.3187 1.3621 0.8471 1.2567 1.2507

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1420 1691 1880 885 1216 1663 2220 1089 2636 3354 4100 1974

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 578.72 748.01 804.86 831.63 719.06 722.55 809.20 865.62 643.46 735.39 807.21 850.38
Standard Deviation 77.25 103.29 95.12 109.20 81.64 201.37 90.55 105.72 105.76 160.15 92.70 108.61
Intensity Change Log 2 — 0.370192 0.475872 0.523076 — 0.006985 0.170384 0.267622 — 0.180320 0.314648 0.387153

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.007241 0.026483 0.013859 0.057844 0.015608 0.022270 0.016579 0.039589 0.011101 0.024394 0.015332 0.047773
Bud Neck 0.283091 0.245278 0.246706 0.102810 0.333673 0.331515 0.251738 0.160209 0.306425 0.288037 0.249431 0.134475
Bud Site 0.105534 0.263867 0.349929 0.298903 0.226193 0.239601 0.351871 0.283159 0.161195 0.251835 0.350980 0.290217
Cell Periphery 0.015157 0.004769 0.004838 0.006882 0.007618 0.009152 0.004219 0.007716 0.011680 0.006942 0.004503 0.007342
Cytoplasm 0.300394 0.217164 0.207355 0.229673 0.258492 0.217795 0.228145 0.256339 0.281064 0.217477 0.218612 0.244384
Cytoplasmic Foci 0.106073 0.104396 0.032102 0.042662 0.066817 0.062754 0.017356 0.032512 0.087964 0.083749 0.024118 0.037063
Eisosomes 0.012851 0.005280 0.000898 0.002849 0.006341 0.007654 0.000734 0.002761 0.009848 0.006457 0.000809 0.002800
Endoplasmic Reticulum 0.003678 0.001706 0.002159 0.005020 0.001679 0.000842 0.000916 0.002322 0.002756 0.001278 0.001486 0.003531
Endosome 0.014877 0.022149 0.005711 0.004804 0.009474 0.014978 0.005103 0.003957 0.012385 0.018594 0.005381 0.004337
Golgi 0.015904 0.015528 0.001010 0.001033 0.007209 0.012620 0.000949 0.001212 0.011893 0.014086 0.000977 0.001132
Lipid Particles 0.023281 0.009047 0.001976 0.002759 0.004498 0.004797 0.001057 0.001664 0.014616 0.006940 0.001478 0.002155
Mitochondria 0.039231 0.010305 0.001466 0.000473 0.005789 0.020253 0.001515 0.000653 0.023804 0.015237 0.001493 0.000572
Mitotic Spindle 0.000243 0.001294 0.003244 0.004904 0.000366 0.001392 0.002914 0.001295 0.000299 0.001343 0.003065 0.002913
None 0.003777 0.000697 0.000634 0.000596 0.000558 0.000278 0.000878 0.000485 0.002292 0.000489 0.000766 0.000535
Nuclear Periphery 0.000134 0.000057 0.000165 0.000145 0.000034 0.000023 0.000087 0.000077 0.000088 0.000040 0.000123 0.000107
Nuclear Periphery Foci 0.000173 0.000558 0.001192 0.001133 0.000198 0.000096 0.000243 0.000624 0.000184 0.000329 0.000678 0.000852
Nucleolus 0.000359 0.000341 0.000169 0.000099 0.000216 0.000130 0.000148 0.000070 0.000293 0.000236 0.000158 0.000083
Nucleus 0.030620 0.018021 0.049616 0.040990 0.020188 0.010673 0.038290 0.042014 0.025808 0.014377 0.043483 0.041555
Peroxisomes 0.020250 0.021589 0.009744 0.018328 0.012772 0.022548 0.010237 0.013696 0.016801 0.022064 0.010011 0.015773
Vacuole 0.014992 0.030089 0.067042 0.177747 0.021636 0.019315 0.066613 0.149517 0.018056 0.024747 0.066809 0.162173
Vacuole Periphery 0.002138 0.001381 0.000186 0.000349 0.000642 0.001314 0.000408 0.000128 0.001448 0.001348 0.000306 0.000227

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -8.42 -4.55 -10.66 -5.08 -8.79 -2.47 -0.21 -5.90 -4.22 -6.56 -7.68 -2.82 -12.17 -6.47 -10.91
Bud Neck 3.46 4.18 19.42 18.41 18.27 0.16 8.14 16.62 18.78 11.41 2.26 8.48 24.40 25.21 20.06
Bud Site -19.91 -27.50 -13.81 1.03 7.31 -1.40 -11.52 -2.40 -1.31 8.05 -14.50 -27.37 -11.81 -0.12 10.88
Cell Periphery 8.04 8.56 7.38 -1.24 -1.57 -1.77 5.28 0.86 2.55 -4.06 5.86 10.03 6.65 0.95 -4.16
Cytoplasm 8.94 9.17 6.00 -1.71 -2.19 4.10 2.48 -0.66 -4.82 -3.22 9.34 8.30 3.71 -4.84 -3.90
Cytoplasmic Foci 0.25 16.62 12.50 12.17 -3.52 0.88 13.60 7.74 7.27 -6.94 1.10 21.87 15.03 14.26 -7.14
Eisosomes 5.68 10.26 8.56 3.80 -3.98 -1.47 9.45 5.81 7.05 -6.06 4.09 13.16 10.20 7.63 -7.05
Endoplasmic Reticulum 2.98 1.82 -1.07 -3.17 -2.41 2.08 1.73 -1.35 -3.86 -3.59 3.69 2.73 -1.25 -4.43 -3.67
Endosome -3.93 7.04 7.90 11.50 1.77 -4.12 4.11 5.30 10.33 1.83 -5.36 8.17 9.59 15.36 2.56
Golgi 0.28 14.62 14.55 13.69 0.53 -4.78 8.49 7.54 11.98 -0.37 -2.32 16.72 15.95 18.04 -0.13
Lipid Particles 6.81 11.36 10.70 5.93 -1.99 -0.37 8.36 6.54 4.20 -3.08 6.43 12.58 11.72 7.42 -3.16
Mitochondria 9.98 13.44 13.99 11.53 2.13 -8.11 5.72 7.07 11.95 2.95 4.72 14.11 14.87 15.87 3.45
Mitotic Spindle -3.14 -3.78 -2.68 -1.99 -0.63 -2.00 -3.94 -2.15 0.00 1.93 -3.42 -5.48 -3.27 -1.79 0.35
None 3.77 3.83 3.51 0.13 -0.01 1.51 -0.68 0.24 -1.01 0.79 4.01 3.02 3.55 -0.32 0.64
Nuclear Periphery 3.76 -1.68 -1.23 -3.34 0.15 3.78 -8.04 -7.18 -8.47 0.20 4.39 -3.41 -2.68 -5.57 0.25
Nuclear Periphery Foci -1.89 -4.02 -7.93 -3.30 -0.34 3.43 -2.35 -4.66 -5.49 -4.00 -1.41 -4.30 -8.98 -5.08 -1.89
Nucleolus 0.01 4.25 6.66 2.97 3.12 1.47 1.08 2.31 2.43 2.34 0.95 3.35 5.78 3.49 3.69
Nucleus 6.12 -7.59 -5.34 -9.64 1.57 6.01 -8.91 -9.02 -12.63 -1.35 8.64 -11.04 -9.72 -15.61 0.14
Peroxisomes -0.71 6.62 1.61 2.19 -3.08 -4.96 1.62 0.08 4.29 -1.22 -3.85 5.93 1.58 4.70 -2.95
Vacuole -8.65 -18.30 -25.53 -23.60 -17.57 1.40 -17.04 -23.47 -23.82 -14.55 -5.58 -25.21 -34.59 -33.19 -22.61
Vacuole Periphery 1.83 5.12 4.40 4.50 -0.58 -3.02 1.19 4.31 6.22 1.60 0.41 4.96 5.49 7.70 0.83
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Small subunit of the clathrin-associated adaptor complex AP-2; AP-2 is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
Localization
Cell Percentages cytoplasm (13%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-10

Aps2

Aps2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Aps2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available