Standard name
Human Ortholog
Description Basic helix-loop-helix (bHLH) protein; forms homodimer to bind E-box consensus sequence CACGTG present at MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins, required for chromosome segregation; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.63 0.65 0.5 0.48 0.44 0.36 0.33 0.3 0.28 0.25 0.2 0.28 0.41 0.53 0.48 0.53 0.6 0.64 0.63 0.62 0.49 0.32 0.27 0.49
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.06 0.06 0.05 0.13 0.09 0.14 0.07 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.34 0.33 0.42 0.43 0.44 0.42 0.38 0.37 0.38 0.37 0.41 0.35 0.56 0.43 0.42 0.31 0.3 0.24 0.31 0.31 0.44 0.37 0.38 0.21
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.06 0.05 0.08 0 0 0.13 0.18 0.16 0.19 0.21 0.29 0.22 0 0 0.06 0 0 0.07 0 0 0 0.2 0.16 0.15
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0.06 0.12 0.13 0.15 0.16 0.2 0.16 0.21 0.19 0.22 0.06 0 0 0.15 0.09 0.09 0 0 0 0.07 0.1 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 1 0 2 0 0 0 0 0 0 0 0 0 0 1 0
Bud 0 0 0 0 0 1 3 4 7 3 11 5 0 0 0 0 0 0 4 1 0 1 5 6
Bud Neck 0 0 0 0 1 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0
Bud Site 0 0 0 0 0 0 2 0 2 6 5 0 1 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 1 0 1 2 3 4 1 2 4 2 0 0 0 7 2 2 0 0 0 0 1 1
Cytoplasm 120 130 85 115 124 104 121 132 66 82 68 79 66 106 94 145 96 129 124 135 86 45 71 90
Endoplasmic Reticulum 0 0 0 0 0 0 2 1 1 0 2 3 0 0 0 5 0 4 0 1 1 0 2 1
Endosome 1 0 0 1 0 1 0 0 2 2 0 0 0 0 0 0 0 1 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 4 1 1 0 1 0 0 0 0
Mitochondria 0 0 1 5 1 17 24 23 31 28 48 20 0 0 0 2 2 4 0 0 0 0 1 2
Nucleus 65 67 72 103 126 120 141 165 90 120 137 98 90 87 82 86 48 49 60 67 77 52 100 38
Nuclear Periphery 0 0 0 0 1 0 0 0 0 1 2 1 0 0 0 0 0 0 0 0 0 1 1 0
Nucleolus 11 10 13 9 10 37 65 72 46 68 98 60 5 7 12 10 7 14 4 3 4 28 42 27
Peroxisomes 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 1 0 0 0 0 0 0 3 1 0 0 2 0 1 0 6 1
Vac/Vac Membrane 2 5 11 29 36 44 59 90 38 69 63 61 9 8 6 41 15 18 0 3 3 10 25 11
Unique Cell Count 191 201 171 241 285 286 371 444 238 324 338 279 162 200 194 274 161 202 198 217 177 142 264 184
Labelled Cell Count 199 212 183 262 300 326 422 492 284 382 438 332 171 208 199 301 171 222 198 217 177 142 264 184


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 9.1 12.3 11.1 11.0 12.2 11.4 11.4 12.2 11.0 11.6 11.3 12.9 15.0 16.1 17.0 23.9 23.0 21.8 17.8 16.7 16.7
Std Deviation (1e-4) 4.6 5.9 4.2 4.7 4.3 3.9 4.0 3.8 3.6 4.1 4.0 4.2 6.6 5.9 6.8 8.6 7.8 7.4 8.7 7.8 8.2
Intensity Change (Log2) – – – -0.01 0.15 0.04 0.04 0.14 -0.01 0.07 0.02 0.22 0.44 0.54 0.62 1.11 1.05 0.98 0.68 0.6 0.6

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000102030WT3HU80HU120HU1600102030WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30102030WT1AF100AF140AF1800102030
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -0.4 -1.3 -2.8 -3.8 -4.6 -4.5 -5.5 -6.9 -4.6 -1.6 0.6 -0.2 0.7 1.8 2.8
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 2.9 3.0 2.6 4.6 3.6 4.9 3.2 0 0 0 0 0 0
Nucleus 0.1 0.4 0 -0.9 -1.1 -0.9 -1.1 -0.3 -1.5 2.5 0.3 0 -2.3 -2.3 -3.7
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus -1.7 -1.9 1.8 3.1 2.8 3.3 3.8 5.5 3.9 -1.8 -1.7 -0.5 -1.8 -1.2 -0.2
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 1.9 2.1 2.8 3.1 4.1 2.9 4.3 3.7 4.3 -0.3 -1.1 -1.5 2.7 1.0 0.9

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 10.7206 10.8584 10.0135 9.7113 8.3877 10.2071 11.8167 10.6095 10.0916 9.6849 8.8113 9.6025 12.8194 10.8602 10.5845 9.6963 9.2304 10.919
Actin 0.0174 0 0.0249 0.0016 0.0149 0.0023 0.0535 0 0.0087 0.004 0.001 0.0041 0.0184 0 0.0004 0.0021 0.0086 0
Bud 0.0008 0 0.0008 0.0001 0.0025 0.0002 0.0005 0 0 0.0004 0.0001 0.0001 0.0002 0 0.0001 0.0003 0.0001 0
Bud Neck 0.0007 0.0001 0.0005 0.0001 0.0014 0.0007 0.0023 0 0.0003 0.0001 0.0002 0.0004 0.0006 0 0.0001 0.0002 0.0003 0.0002
Bud Periphery 0.0015 0.0001 0.0013 0.0003 0.0022 0.0004 0.0007 0 0 0.0005 0.0002 0.0002 0.0004 0 0.0003 0.0006 0.0004 0.0001
Bud Site 0.0026 0 0.0025 0.0003 0.0246 0.0002 0.0033 0 0.0002 0.0005 0.0002 0.0001 0.0021 0 0.0003 0.0007 0.0002 0
Cell Periphery 0.0008 0 0.0006 0.0002 0.0007 0.0003 0.0004 0 0 0 0.0001 0.0001 0.0001 0 0.0001 0.0006 0.0002 0
Cytoplasm 0.008 0 0.004 0.001 0.0049 0.0023 0.0028 0 0.0013 0.0006 0.0072 0.0003 0.0007 0 0.0015 0.0003 0.0003 0
Cytoplasmic Foci 0.0263 0 0.0203 0.0077 0.0389 0.0063 0.0053 0 0.0082 0.0099 0.0154 0.0022 0.0039 0 0.002 0.0099 0.0032 0
Eisosomes 0.0001 0 0.0002 0.0001 0.0002 0 0.0005 0 0.0001 0 0 0 0.0008 0 0 0 0.0003 0
Endoplasmic Reticulum 0.0024 0 0.0012 0.0021 0.0016 0.001 0.0028 0 0.0009 0.0005 0.0011 0.0013 0.0008 0 0.0008 0.0003 0.0003 0
Endosome 0.0206 0.0001 0.0127 0.0157 0.0295 0.0128 0.0084 0 0.0039 0.0129 0.0164 0.0071 0.0041 0 0.003 0.0032 0.0041 0
Golgi 0.0071 0 0.0086 0.003 0.0174 0.0037 0.0048 0 0.0027 0.0057 0.0063 0.0019 0.0033 0 0.0004 0.003 0.0047 0
Lipid Particles 0.009 0 0.0184 0.0097 0.0877 0.0087 0.0058 0 0.0018 0.0041 0.0426 0.0051 0.0021 0 0.002 0.0059 0.0482 0
Mitochondria 0.0118 0.0002 0.0239 0.0153 0.0443 0.0029 0.0037 0.0001 0.0004 0.0011 0.0106 0.013 0.0021 0.0002 0.0006 0.0043 0.0043 0.0002
None 0.0064 0 0.0022 0.0017 0.0021 0.0007 0.0019 0 0.0049 0.0003 0.0017 0.0006 0.0144 0 0.0008 0.0004 0.0022 0
Nuclear Periphery 0.008 0.001 0.005 0.0041 0.0079 0.0022 0.0044 0.0004 0.0066 0.0028 0.0092 0.0149 0.003 0.0003 0.0044 0.0026 0.019 0.0002
Nucleolus 0.0491 0.0171 0.025 0.029 0.1972 0.1428 0.0205 0.0157 0.0178 0.0083 0.1512 0.0892 0.016 0.0215 0.0157 0.0444 0.3089 0.0602
Nucleus 0.7836 0.9806 0.8278 0.8935 0.4635 0.8025 0.87 0.9835 0.9353 0.9366 0.6947 0.8444 0.9227 0.9779 0.9637 0.8985 0.5609 0.9387
Peroxisomes 0.0053 0 0.0065 0.0037 0.0245 0.0027 0.001 0 0.0013 0.0031 0.0131 0.0081 0.002 0 0.0003 0.0162 0.0136 0
Punctate Nuclear 0.0252 0.0002 0.0053 0.0019 0.0213 0.0042 0.0057 0.0001 0.0053 0.0079 0.0275 0.0054 0.0015 0.0001 0.0026 0.0008 0.0179 0.0001
Vacuole 0.0059 0.0004 0.004 0.0032 0.006 0.0017 0.0009 0 0.0001 0.0003 0.0006 0.0004 0.0003 0 0.0005 0.003 0.0006 0.0001
Vacuole Periphery 0.0075 0.0002 0.0042 0.0059 0.0066 0.0014 0.0008 0 0.0002 0.0003 0.0006 0.0009 0.0004 0 0.0003 0.0028 0.0018 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 31.8692 39.2309 34.656 35.1089 44.7066 38.6395 36.833 41.1143 46.2499 43.8858
Translational Efficiency 3.2708 2.919 2.6633 3.1889 2.8688 2.9086 2.5291 2.8201 2.4145 2.5757

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1199 840 3252 1600 1479 52 125 1103 2678 892 3377 2703

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1098.59 1366.74 1565.68 1626.65 1373.38 1479.32 1792.38 1830.97 1250.35 1373.30 1574.07 1710.03
Standard Deviation 331.60 366.15 743.37 449.39 311.50 314.86 257.64 410.64 348.55 364.31 732.41 445.46
Intensity Change Log 2 — 0.315086 0.511136 0.566251 — 0.107203 0.384146 0.414877 — 0.203305 0.441967 0.484118

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000596 0.000508 0.000513 0.000532 0.000507 0.000712 0.000858 0.000677 0.000546 0.000520 0.000526 0.000591
Bud Neck 0.001256 0.002841 0.010584 0.005702 0.002261 0.002819 0.007489 0.011434 0.001811 0.002839 0.010470 0.008041
Bud Site 0.001583 0.000564 0.000693 0.000550 0.000562 0.000293 0.000749 0.002187 0.001019 0.000548 0.000695 0.001218
Cell Periphery 0.000239 0.000142 0.000229 0.000149 0.000077 0.000020 0.000024 0.000117 0.000149 0.000135 0.000221 0.000136
Cytoplasm 0.002135 0.000436 0.001451 0.000566 0.000093 0.000020 0.000047 0.000601 0.001007 0.000412 0.001399 0.000580
Cytoplasmic Foci 0.000220 0.000122 0.000405 0.000039 0.000266 0.000059 0.000680 0.000948 0.000245 0.000119 0.000416 0.000410
Eisosomes 0.000187 0.000120 0.000115 0.000041 0.000210 0.000115 0.000148 0.000045 0.000200 0.000120 0.000116 0.000043
Endoplasmic Reticulum 0.000894 0.000543 0.000930 0.000472 0.000674 0.001199 0.000631 0.000440 0.000772 0.000581 0.000919 0.000459
Endosome 0.000057 0.000061 0.000114 0.000028 0.000054 0.000016 0.001069 0.001551 0.000055 0.000058 0.000150 0.000650
Golgi 0.000132 0.000143 0.000104 0.000029 0.000225 0.000038 0.000225 0.001135 0.000183 0.000137 0.000109 0.000481
Lipid Particles 0.000046 0.000027 0.000009 0.000004 0.000012 0.000020 0.000053 0.000049 0.000027 0.000027 0.000010 0.000022
Mitochondria 0.000794 0.001894 0.001372 0.001738 0.000670 0.001369 0.002072 0.003000 0.000726 0.001863 0.001398 0.002253
Mitotic Spindle 0.000021 0.000039 0.000441 0.001400 0.000038 0.000016 0.001159 0.005332 0.000030 0.000037 0.000467 0.003004
None 0.007752 0.003453 0.003110 0.000866 0.000464 0.000604 0.000376 0.001027 0.003727 0.003287 0.003009 0.000932
Nuclear Periphery 0.000036 0.000026 0.000284 0.000291 0.000015 0.000108 0.000321 0.000559 0.000025 0.000031 0.000286 0.000400
Nuclear Periphery Foci 0.000403 0.000091 0.000042 0.000070 0.000058 0.000020 0.000345 0.000185 0.000212 0.000087 0.000053 0.000117
Nucleolus 0.026226 0.021958 0.010357 0.012100 0.027220 0.048777 0.019912 0.016649 0.026775 0.023522 0.010710 0.013956
Nucleus 0.954331 0.965040 0.968256 0.974480 0.963933 0.936613 0.955557 0.949201 0.959634 0.963383 0.967786 0.964165
Peroxisomes 0.001632 0.001359 0.000243 0.000506 0.001781 0.005069 0.003369 0.000839 0.001714 0.001575 0.000358 0.000642
Vacuole 0.001084 0.000424 0.000443 0.000285 0.000641 0.000550 0.002119 0.002305 0.000840 0.000431 0.000505 0.001109
Vacuole Periphery 0.000380 0.000208 0.000307 0.000152 0.000238 0.001563 0.002794 0.001719 0.000301 0.000287 0.000399 0.000791

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.13 0.97 0.73 -0.67 -0.38 -1.96 -4.06 -2.97 -0.32 1.94 0.53 0.20 -1.31 -2.00 -2.15
Bud Neck -5.73 -14.55 -10.33 -6.19 5.90 -0.34 -8.14 -10.76 -5.37 -4.31 -3.58 -13.96 -14.25 -10.91 2.51
Bud Site 1.42 1.21 1.31 -0.21 0.49 1.35 -0.65 -2.29 -2.73 -2.16 1.39 0.91 -0.72 -2.28 -1.85
Cell Periphery 1.74 0.07 1.16 -0.16 0.86 2.79 2.56 -0.82 -2.42 -2.30 0.39 -1.06 0.29 -0.07 1.12
Cytoplasm 2.09 0.81 1.64 -0.74 1.42 1.82 1.10 -2.11 -2.37 -2.29 1.53 -0.72 0.62 -1.15 1.47
Cytoplasmic Foci 1.31 -0.99 2.74 1.64 1.65 1.46 -0.61 -1.44 -2.13 -0.40 1.40 -0.90 -0.71 -1.64 0.41
Eisosomes 2.03 2.32 4.78 5.68 8.10 5.26 3.67 12.42 5.22 10.33 4.07 4.90 10.07 5.99 8.88
Endoplasmic Reticulum 3.61 -0.33 5.02 1.03 7.64 -1.59 0.31 2.00 2.37 1.93 2.18 -1.71 4.34 1.82 8.23
Endosome -0.02 -0.98 1.56 0.97 1.53 1.16 -0.95 -2.05 -2.12 -0.38 0.02 -1.33 -1.98 -1.98 -1.60
Golgi -0.06 0.29 1.24 1.10 0.87 1.07 0.13 -1.38 -1.83 -1.45 0.38 0.64 -1.00 -1.25 -1.42
Lipid Particles 0.72 1.66 1.89 1.18 1.51 -0.46 -0.96 -1.80 -1.39 -0.02 0.11 1.53 0.46 0.20 -1.41
Mitochondria -1.07 -4.59 -6.32 0.07 -1.56 -2.33 -3.81 -7.84 -4.09 -2.20 -1.18 -5.58 -10.19 -0.52 -4.09
Mitotic Spindle -0.84 -1.76 -1.97 -1.95 -1.32 0.90 -0.98 -3.36 -3.38 -2.44 -0.29 -1.85 -3.89 -3.88 -3.22
None 2.31 2.82 4.58 2.26 2.93 -1.72 2.04 -4.64 -3.27 -5.26 0.36 0.79 4.07 2.16 2.79
Nuclear Periphery 1.18 -3.02 -3.98 -4.15 0.04 -1.03 -1.06 -3.48 -2.53 -0.96 -0.88 -3.24 -5.09 -4.99 -0.90
Nuclear Periphery Foci 1.69 2.03 1.85 0.21 -0.89 0.98 -0.80 -1.91 -3.09 0.40 1.27 1.91 1.15 -0.46 -1.94
Nucleolus 1.64 8.12 6.06 4.13 -1.63 -1.63 2.19 3.26 2.24 0.21 1.40 11.13 6.94 3.79 -3.73
Nucleus -2.57 -3.66 -5.00 -2.16 -2.13 1.59 0.90 4.04 -0.42 1.28 -1.12 -2.91 -0.45 0.71 2.15
Peroxisomes 0.93 9.04 6.90 3.08 -4.63 -2.50 -2.46 3.01 3.17 3.94 0.50 8.61 6.23 3.22 -5.69
Vacuole 1.67 1.57 2.01 1.24 1.92 0.30 -0.82 -2.04 -2.09 -0.17 1.95 1.50 -0.64 -2.05 -1.76
Vacuole Periphery 1.55 0.52 2.05 1.46 3.50 -0.91 -0.94 -2.22 0.00 0.37 0.13 -0.88 -1.74 -1.72 -1.29
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Basic helix-loop-helix (bHLH) protein; forms homodimer to bind E-box consensus sequence CACGTG present at MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins, required for chromosome segregation; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages nucleus (99%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-2

Cbf1

Cbf1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cbf1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available