Standard name
Human Ortholog
Description Nucleoside triphosphate pyrophosphohydrolase; active against various substrates including ITP, dITP and XTP; mediates exclusion of non canonical purines, pyrimidines from dNTP pools; functions with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress; yeast HAM1 can complement knockdown of human homolog ITPA

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.98 0.98 0.97 0.88 0.8 0.84 0.81 0.79 0.77 0.71 0.68 0.99 0.99 0.99 0.97 0.93 0.96 0.93 0.89 0.92 0.92 0.94 0.94
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0.09 0.09 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0.15 0.23 0.1 0.2 0.15 0.17 0.21 0.2 0 0 0 0 0.07 0 0 0.05 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 0 1 1 5 1 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 1 0 0 0 4 1 3 0 0 3 0 0 0 0 0 0 1 1 1 0 2 3
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 1 4 3 2 3 2 4 9 3 14 15 1 5 2 5 6 2 0 0 0 0 0 0
Cytoplasm 240 166 223 216 242 183 318 219 222 237 271 265 341 321 232 150 155 248 158 209 197 269 260
Endoplasmic Reticulum 2 0 2 2 2 1 3 5 6 1 13 2 2 0 7 5 5 4 0 1 1 3 1
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 3 0 0 1 1 2 1 1 0 1 0 0 0 1 0 0 1 1 1
Mitochondria 1 1 0 0 0 6 2 7 9 29 37 0 0 0 0 0 2 1 1 2 1 0 0
Nucleus 1 4 10 4 0 8 4 8 8 5 9 0 2 4 0 0 1 2 2 4 2 0 2
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 2 0 0 0 0 0 1 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
SpindlePole 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 3 2 3 37 71 21 78 42 49 69 80 0 3 1 7 12 5 1 8 4 1 1 2
Unique Cell Count 245 170 229 246 303 217 392 276 288 335 399 267 344 324 240 162 162 267 178 228 214 287 278
Labelled Cell Count 248 178 241 261 322 226 410 295 299 362 431 269 353 329 252 175 170 267 178 228 214 287 278


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 16.2 14.5 14.6 14.3 16.1 9.5 13.9 12.2 11.9 11.6 11.2 17.8 18.3 18.7 21.5 20.9 19.9 16.5 18.6 18.5
Std Deviation (1e-4) 4.3 4.5 3.3 3.0 3.0 3.0 3.2 3.1 2.6 2.8 2.6 4.0 4.6 4.6 6.0 6.0 6.5 3.6 4.4 4.5
Intensity Change (Log2) -0.03 0.14 -0.62 -0.08 -0.27 -0.3 -0.33 -0.38 0.29 0.32 0.36 0.55 0.52 0.44 0.17 0.34 0.34


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 1.4 0 2.0 1.8 0 0 0 0 0 0
Cytoplasm -3.9 -6.0 -4.8 -5.8 -6.1 -6.6 -8.0 -8.7 1.6 1.6 1.6 -0.5 -2.2 -0.9
Endoplasmic Reticulum 0 0 0 0 0 0 0 1.9 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 4.6 4.8 0 0 0 0 0 0
Nucleus -1.8 0 -0.4 -2.7 -0.9 -1.0 -2.1 -1.5 0 0 -2.3 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 5.4 7.3 3.9 6.6 5.5 5.9 6.7 6.7 0 0 0 0 3.1 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 7.7083 10.6838 9.3203 10.4012 7.8096 9.7571 10.0418 13.3109 11.2634 10.8589 14.4376 12.2634 12.8615 16.5161 14.0202 12.755 11.194 14.4926
Actin 0.02 0.0002 0.0097 0.0001 0.0013 0.0002 0.052 0.0002 0.0117 0.0003 0.0001 0.0025 0.0205 0.0002 0.0024 0.002 0.0033 0.001
Bud 0.0004 0.0001 0.0002 0.0001 0.0002 0.0001 0.0067 0.0001 0.0002 0.0001 0 0.0007 0.0003 0.0001 0.0001 0.0009 0.0003 0.0001
Bud Neck 0.0009 0.0002 0.0005 0.0005 0.0004 0.0009 0.0007 0.0002 0.0004 0.0003 0.0004 0.0007 0.0017 0.0001 0.0005 0.0003 0.0007 0.0008
Bud Periphery 0.0003 0 0.0002 0 0.0003 0 0.0016 0 0.0001 0 0 0.0003 0.0002 0 0.0001 0.002 0.0002 0.0001
Bud Site 0.0013 0.0002 0.0006 0 0.0003 0 0.0012 0.0001 0.0004 0.0001 0 0.0001 0.004 0.0001 0.0018 0.0003 0.0005 0.0001
Cell Periphery 0.0001 0 0 0 0.0001 0 0.0001 0 0 0 0 0 0.0001 0 0.0001 0.0001 0.0001 0
Cytoplasm 0.8664 0.9789 0.9339 0.9522 0.8734 0.9592 0.8248 0.9878 0.9581 0.9807 0.9842 0.9545 0.857 0.988 0.9508 0.9196 0.839 0.966
Cytoplasmic Foci 0.0112 0.0011 0.0056 0.0008 0.0042 0.002 0.0094 0.0006 0.0021 0.0016 0.0007 0.0063 0.0179 0.0004 0.0047 0.0043 0.0184 0.0014
Eisosomes 0.0001 0 0.0001 0 0 0 0.0003 0 0 0 0 0 0.0001 0 0 0 0 0
Endoplasmic Reticulum 0.0044 0.0011 0.0028 0.0005 0.0361 0.0035 0.0054 0.0003 0.0017 0.0006 0.0006 0.0017 0.0054 0.0005 0.0012 0.003 0.0099 0.0007
Endosome 0.0165 0.0006 0.0069 0.0003 0.0279 0.0016 0.0141 0.0001 0.0029 0.0004 0.0003 0.0082 0.0173 0.0003 0.004 0.0187 0.0327 0.0016
Golgi 0.0044 0 0.0036 0 0.0013 0 0.0043 0 0.0012 0 0 0.0009 0.0038 0 0.0018 0.0027 0.0027 0.0007
Lipid Particles 0.0046 0 0.0019 0 0.0007 0 0.003 0 0.0009 0 0 0.0005 0.0087 0 0.0053 0.0012 0.0115 0.003
Mitochondria 0.0019 0.0001 0.0107 0.0001 0.0108 0.0002 0.0013 0.0001 0.0004 0.0001 0.0001 0.0027 0.0013 0.0001 0.0003 0.0187 0.0017 0.001
None 0.0067 0.0013 0.0034 0.0012 0.0049 0.0009 0.0075 0.0007 0.0013 0.0009 0.0003 0.0014 0.0136 0.0006 0.0024 0.0018 0.0061 0.001
Nuclear Periphery 0.0133 0.0021 0.0038 0.0022 0.0156 0.0038 0.0208 0.0008 0.0036 0.0014 0.0012 0.0029 0.0069 0.0016 0.0032 0.0029 0.0209 0.0022
Nucleolus 0.0003 0 0.0001 0 0.0002 0 0.0002 0 0 0 0 0 0.0007 0 0.0003 0.0001 0.0011 0.0001
Nucleus 0.0252 0.0127 0.0118 0.0415 0.0117 0.0261 0.0386 0.0085 0.0127 0.0124 0.0117 0.0142 0.0244 0.0073 0.0167 0.0163 0.0278 0.0188
Peroxisomes 0.0147 0 0.0015 0 0.0001 0 0.0017 0 0.0005 0 0 0.0005 0.0056 0 0.0015 0.0004 0.0011 0.0004
Punctate Nuclear 0.0049 0.0007 0.0019 0.0003 0.0017 0.0006 0.0045 0.0002 0.001 0.0005 0.0002 0.0014 0.0087 0.0001 0.0021 0.0006 0.0189 0.0007
Vacuole 0.0015 0.0004 0.0004 0.0003 0.0059 0.0007 0.001 0.0001 0.0004 0.0003 0.0002 0.0004 0.0013 0.0005 0.0006 0.0025 0.0022 0.0002
Vacuole Periphery 0.0009 0.0001 0.0003 0.0001 0.0028 0.0003 0.0008 0 0.0002 0.0001 0.0001 0.0002 0.0004 0.0001 0.0001 0.0015 0.0009 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 39.938 49.817 54.2173 60.0795 62.6194 59.4098 61.7031 60.6267 63.5891 68.9334
Translational Efficiency 4.0547 3.3325 2.9764 2.6475 2.8486 2.6274 2.5867 2.515 2.4438 2.6427

Hit Data

Dataset Hit
Protein Concentration
Protein Localization
Gene Expression
Translational Efficiency

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
388 1565 143 1668 2116 2181 1115 1371 2504 3746 1258 3039

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1023.58 1412.54 1906.21 1651.97 1128.82 1469.40 1677.79 1742.38 1112.51 1445.65 1703.76 1692.76
Standard Deviation 188.93 306.00 317.91 348.61 193.97 253.98 295.96 369.02 196.92 278.32 307.22 360.78
Intensity Change Log 2 0.464668 0.897083 0.690564 0.380412 0.571747 0.626244 0.421094 0.735624 0.657189

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000525 0.000250 0.001085 0.000299 0.000105 0.000150 0.000219 0.000456 0.000170 0.000192 0.000317 0.000370
Bud Neck 0.002122 0.000454 0.003933 0.004304 0.000574 0.000772 0.000751 0.002513 0.000814 0.000639 0.001112 0.003496
Bud Site 0.017491 0.002835 0.005451 0.010474 0.002087 0.004144 0.001294 0.008388 0.004474 0.003597 0.001767 0.009533
Cell Periphery 0.000232 0.000085 0.000551 0.000082 0.000045 0.000033 0.000123 0.000097 0.000074 0.000055 0.000172 0.000088
Cytoplasm 0.772508* 0.831467* 0.504339* 0.649107* 0.862061* 0.863265* 0.649792* 0.683991* 0.848184* 0.849981* 0.633258* 0.664844*
Cytoplasmic Foci 0.104204 0.009078 0.016546 0.010946 0.023454 0.011152 0.004231 0.011298 0.035967 0.010286 0.005631 0.011105
Eisosomes 0.000019 0.000003 0.000013 0.000009 0.000003 0.000002 0.000002 0.000007 0.000006 0.000002 0.000003 0.000008
Endoplasmic Reticulum 0.003253 0.000486 0.001700 0.000603 0.000692 0.000189 0.000189 0.000355 0.001089 0.000313 0.000361 0.000491
Endosome 0.002680 0.000499 0.002332 0.008849 0.000643 0.000869 0.000200 0.007913 0.000959 0.000714 0.000443 0.008427
Golgi 0.001935 0.000814 0.000793 0.006582 0.000811 0.000678 0.000167 0.010984 0.000985 0.000735 0.000238 0.008568
Lipid Particles 0.000937 0.000253 0.002406 0.004555 0.000333 0.000198 0.000335 0.001001 0.000427 0.000221 0.000571 0.002951
Mitochondria 0.000469 0.000236 0.000397 0.002412 0.000292 0.000127 0.000153 0.005559 0.000320 0.000172 0.000181 0.003832
Mitotic Spindle 0.001680 0.002313 0.003580 0.074975 0.003171 0.005938 0.003340 0.075162 0.002940 0.004423 0.003367 0.075060
None 0.002738 0.011146 0.004590 0.006589 0.010279 0.010084 0.015303 0.011973 0.009111 0.010528 0.014086 0.009018
Nuclear Periphery 0.000102 0.000071 0.001075 0.000844 0.000200 0.000089 0.000219 0.001494 0.000185 0.000082 0.000316 0.001137
Nuclear Periphery Foci 0.002522 0.002485 0.007873 0.001915 0.001647 0.001233 0.001908 0.006638 0.001782 0.001756 0.002586 0.004045
Nucleolus 0.000206 0.000212 0.000241 0.000976 0.000145 0.000247 0.000091 0.000222 0.000155 0.000232 0.000108 0.000636
Nucleus 0.058012 0.128214 0.374867* 0.136292* 0.082068 0.091474 0.310553* 0.125357 0.078340 0.106823 0.317863* 0.131359*
Peroxisomes 0.000561 0.000113 0.000120 0.001228 0.000111 0.000208 0.000018 0.000460 0.000181 0.000168 0.000030 0.000882
Vacuole 0.026410 0.008325 0.067886 0.068977 0.010683 0.008790 0.011069 0.038305 0.013120 0.008596 0.017528 0.055139
Vacuole Periphery 0.001395 0.000662 0.000220 0.009985 0.000594 0.000358 0.000041 0.007828 0.000718 0.000485 0.000061 0.009012

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.15 -6.53 3.42 0.82 9.39 -1.20 -7.59 -4.29 -2.09 3.46 -0.91 -8.99 -2.27 -0.69 8.66
Bud Neck 5.21 -7.17 -2.13 -10.49 6.34 -1.23 -8.06 -10.18 -8.99 -5.61 1.44 -9.63 -12.16 -13.19 -3.23
Bud Site 6.79 3.55 5.80 -2.87 4.50 -2.67 -2.73 -7.84 -2.80 -6.68 1.47 2.05 -2.36 -3.61 -5.16
Cell Periphery 2.89 -7.06 3.14 0.80 9.59 2.61 -11.25 -6.95 -7.83 4.61 1.67 -11.81 -3.38 -6.29 10.40
Cytoplasm -4.85 18.60 12.38 29.51 -12.32 1.34 38.27 33.43 32.51 -1.05 1.08 39.53 42.78 44.91 -4.41
Cytoplasmic Foci 13.56 10.19 14.22 4.64 6.01 8.28 11.09 8.32 0.10 -3.54 14.79 14.81 16.62 3.78 2.40
Eisosomes 5.10 -0.73 3.91 -5.66 7.31 1.99 -3.62 -7.30 -9.10 -3.97 4.79 -1.64 -2.09 -10.67 -0.34
Endoplasmic Reticulum 3.99 1.73 4.35 2.03 5.84 4.60 3.82 4.56 -0.32 2.54 5.22 4.24 6.00 1.53 5.06
Endosome 6.40 -0.71 1.70 -3.36 2.16 -0.86 4.37 -3.17 -2.06 -4.21 1.70 3.20 -2.94 -3.61 -4.16
Golgi 2.39 1.73 1.45 -0.92 0.11 0.58 2.07 -1.06 -1.36 -1.95 1.04 2.62 -0.87 -1.71 -2.77
Lipid Particles 5.18 -7.81 -1.89 -3.52 5.03 1.38 -6.26 -9.40 -10.26 -5.85 2.70 -8.87 -6.03 -6.86 -1.83
Mitochondria 1.54 -0.78 -0.86 -2.32 -0.38 2.33 1.20 -1.13 -1.45 -1.30 2.05 1.13 -1.63 -2.25 -1.96
Mitotic Spindle -0.71 -3.04 -8.78 -8.43 -5.28 -1.71 -1.64 -10.53 -9.75 -9.76 -1.17 -2.28 -13.00 -12.55 -11.33
None -8.19 -0.91 -5.67 4.82 -8.56 0.69 -1.54 -0.23 -1.41 1.86 -1.06 -1.98 0.58 2.91 3.75
Nuclear Periphery 1.78 -12.15 -16.66 -17.47 6.88 0.87 -2.29 -5.55 -8.07 -5.27 0.97 -4.65 -7.35 -14.44 -5.33
Nuclear Periphery Foci -0.39 -6.58 2.71 5.05 8.24 0.99 -4.27 -3.51 -3.99 -1.34 -0.97 -6.49 -2.06 -1.46 3.65
Nucleolus 0.01 -1.75 -2.67 -2.31 -1.84 -1.14 0.73 -6.74 -1.46 -9.52 -1.16 0.29 -4.59 -2.62 -4.90
Nucleus -12.38 -17.67 -18.43 -8.24 11.40 -4.52 -39.69 -17.35 -13.84 24.62 -12.33 -43.41 -27.10 -16.72 27.00
Peroxisomes 6.66 5.85 2.98 -1.72 -0.76 -1.09 3.55 -1.29 0.74 -5.19 -0.03 6.14 -0.57 -0.33 -3.38
Vacuole 4.45 -8.17 -18.51 -28.62 0.07 -1.55 -9.75 -23.78 -23.35 -16.56 1.83 -11.64 -35.69 -36.85 -19.78
Vacuole Periphery 1.34 2.60 -0.44 -1.60 -2.57 1.20 3.27 -1.01 -1.56 -2.25 1.09 4.12 -1.79 -2.38 -3.70
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Componentsactinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Nucleoside triphosphate pyrophosphohydrolase; active against various substrates including ITP, dITP and XTP; mediates exclusion of non canonical purines, pyrimidines from dNTP pools; functions with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress; yeast HAM1 can complement knockdown of human homolog ITPA
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Ham1

Ham1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)

Molecular Function (Gene Ontology)

Cellular Component (Gene Ontology)


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ham1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available