Standard name
Human Ortholog
Description Protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.06 0 0.05 0.05 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.07 0 0 0
Bud 0 0 0 0 0 0 0 0 0.06 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.05 0 0.06 0 0 0 0 0 0 0 0.05 0.05 0.05 0 0 0 0.06 0 0 0 0 0 0 0
Cytoplasm 0.88 0.89 0.87 0.79 0.77 0.71 0.73 0.71 0.57 0.62 0.62 0.59 0.97 0.99 1.0 0.93 0.91 0.91 0.78 0.76 0.68 0.81 0.75 0.76
Endoplasmic Reticulum 0.05 0.05 0 0 0.07 0.05 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0.06 0 0.07 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.09 0.15 0.18 0.16 0.08 0.45 0.29 0.44 0.41 0 0 0 0 0 0 0 0 0.06 0.05 0.05 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0.09 0.13 0.14 0.11 0.09 0.06 0.06 0 0 0 0.05 0.05 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 9 19 21 18 17 14 6 19 10 15 10 9 2 3 1 0 4 3 7 29 33 8 19 23
Bud 1 7 0 8 11 11 11 15 31 16 13 21 0 0 0 1 0 0 3 12 5 2 9 12
Bud Neck 0 0 1 1 1 0 0 1 0 1 0 0 0 0 0 0 0 0 8 24 20 9 13 15
Bud Site 0 1 0 1 0 0 1 2 2 2 0 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 8 14 28 12 5 16 16 24 18 14 20 17 19 30 13 12 24 5 0 3 7 0 4 5
Cytoplasm 141 477 378 261 188 326 282 451 298 272 239 216 365 678 608 366 342 247 139 439 326 298 373 428
Endoplasmic Reticulum 8 25 17 13 16 25 4 23 6 17 5 4 9 5 2 19 13 12 5 12 27 7 34 20
Endosome 0 4 9 13 0 18 7 7 9 13 7 7 1 0 0 6 10 5 6 8 10 4 7 6
Golgi 0 2 1 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 1 4 1 0 0 1
Mitochondria 6 12 6 31 36 80 61 51 235 128 170 152 0 0 0 11 4 3 2 17 29 19 26 21
Nucleus 0 0 1 1 7 0 7 11 3 4 0 2 1 0 0 2 5 5 0 1 1 1 1 0
Nuclear Periphery 0 0 0 0 0 0 0 0 3 3 0 2 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 3 1 1 1 3 1 0 0 0 0 0 0 2 0 0 0 0 0 0
Peroxisomes 1 0 0 2 1 2 0 2 4 0 1 2 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 7 4 2 9 1 10 2 4 3 3 0 1 0 2 2 3 0 3 4 1 0 5
Vac/Vac Membrane 0 2 12 13 6 39 52 90 56 39 24 22 1 0 0 18 17 11 0 14 3 7 3 7
Unique Cell Count 160 536 434 329 245 457 386 635 520 440 386 367 377 684 611 395 377 270 179 579 479 366 499 561
Labelled Cell Count 174 563 481 378 291 543 449 707 678 531 493 458 398 717 624 437 422 296 179 579 479 366 499 561


Ambiguous

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.1 5.6 7.4 6.8 6.0 6.4 6.1 6.4 5.4 5.8 5.5 5.6 7.2 7.1 6.8 6.7 8.2 7.5 7.2 7.7 8.3
Std Deviation (1e-4) 0.8 0.7 1.1 1.4 1.5 1.4 1.4 1.0 1.2 1.2 1.2 1.1 0.9 0.9 1.0 1.2 1.6 1.3 1.4 1.2 5.2
Intensity Change (Log2) – – – -0.11 -0.29 -0.2 -0.26 -0.19 -0.45 -0.33 -0.41 -0.41 -0.02 -0.05 -0.12 -0.14 0.16 0.02 -0.03 0.07 0.17


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0.4 1.1 -1.4 -2.6 -1.6 -2.5 -1.1 -1.7 -1.8 -3.7 -4.9 -5.2 -4.4 -3.1 -2.7
Bud 0 0 3.3 3.5 3.2 5.2 4.0 3.9 5.0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -1.7 -2.6 -2.0 -1.5 -2.0 -2.1 -2.3 -0.8 -1.1 -0.9 -1.5 -3.5 -2.3 0 -2.8
Cytoplasm -2.9 -3.5 -5.8 -5.1 -6.2 -10.1 -8.6 -8.3 -9.1 5.0 8.6 8.6 2.6 1.6 1.8
Endoplasmic Reticulum 0 1.5 1.1 -2.6 -0.2 -2.8 0 -2.3 -2.5 -1.2 -3.7 -4.3 0.6 -0.4 0.3
Endosome 1.5 0 1.6 -0.3 -1.3 -0.4 0.8 -0.3 -0.2 0 0 0 -0.6 0.5 -0.2
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 5.1 6.9 8.1 7.5 4.8 15.5 11.4 14.9 14.2 0 0 0 1.4 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0.4 0 0 0 -0.9 0 0 0 0 0 0 0 0
Vacuole 0.9 -0.2 3.7 5.7 6.2 4.8 3.8 2.4 2.3 -2.8 0 0 1.4 1.3 1.0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 7.2482 6.2062 6.7072 6.2817 6.247 6.6079 8.7123 7.4213 8.2119 7.5305 7.8086 8.4766 5.3029 4.8848 4.801 4.5195 4.5697 5.1155
Actin 0.0664 0.0028 0.0175 0.0026 0.002 0.0296 0.0462 0.0097 0.0169 0.0037 0.0186 0.0237 0.0157 0.0019 0.007 0.0092 0.0012 0.0119
Bud 0.0013 0.0018 0.0045 0.0045 0.001 0.0025 0.0028 0.0055 0.0023 0.0091 0.0055 0.0031 0.0016 0.0019 0.0037 0.0007 0.0007 0.0012
Bud Neck 0.0089 0.0012 0.0025 0.0013 0.0024 0.0983 0.0175 0.0014 0.0054 0.0007 0.0052 0.0879 0.0068 0.0008 0.0042 0.0003 0.0389 0.0855
Bud Periphery 0.0028 0.0012 0.0024 0.012 0.0009 0.0063 0.0047 0.0058 0.0028 0.0102 0.0094 0.0049 0.003 0.002 0.0051 0.0008 0.0006 0.0017
Bud Site 0.0131 0.0407 0.012 0.0016 0.0008 0.0038 0.0191 0.0458 0.0195 0.0147 0.0229 0.0022 0.0254 0.0314 0.0281 0.001 0.0004 0.0023
Cell Periphery 0.0077 0.0026 0.002 0.0011 0.0004 0.0027 0.0064 0.0046 0.0031 0.0016 0.0013 0.002 0.0071 0.0034 0.0026 0.0006 0.0003 0.0011
Cytoplasm 0.7102 0.8419 0.8032 0.8419 0.8096 0.7535 0.6711 0.8112 0.7927 0.887 0.7035 0.7676 0.7992 0.8388 0.8256 0.9018 0.9202 0.7546
Cytoplasmic Foci 0.0323 0.0104 0.02 0.0146 0.0078 0.0195 0.0381 0.0203 0.0224 0.0071 0.0395 0.0225 0.0133 0.0173 0.0134 0.0157 0.0105 0.0262
Eisosomes 0.001 0.0001 0.0004 0 0 0.0001 0.0005 0.0001 0.0004 0 0.0002 0.0001 0.0018 0.0001 0.0002 0 0 0.0001
Endoplasmic Reticulum 0.0261 0.0043 0.005 0.0072 0.019 0.0079 0.018 0.0056 0.0088 0.0124 0.0064 0.0106 0.0136 0.004 0.0061 0.0032 0.0039 0.0087
Endosome 0.0295 0.0047 0.011 0.0139 0.0071 0.0092 0.0441 0.0135 0.026 0.0099 0.0759 0.015 0.0072 0.0147 0.0136 0.0166 0.0079 0.0147
Golgi 0.0162 0.0014 0.0054 0.0027 0.001 0.0056 0.0205 0.0069 0.0076 0.0011 0.0307 0.0097 0.0032 0.0024 0.0025 0.0016 0.001 0.0071
Lipid Particles 0.0077 0.0003 0.0018 0.0002 0.0001 0.0009 0.0114 0.0009 0.0077 0.0007 0.0027 0.0005 0.0072 0.0003 0.0006 0.0008 0 0.0005
Mitochondria 0.0047 0.0003 0.0025 0.0006 0.0003 0.0021 0.0141 0.0024 0.0046 0.0004 0.0172 0.0021 0.0017 0.0005 0.0009 0.0004 0.0007 0.0014
None 0.0398 0.0821 0.0977 0.0896 0.1435 0.0498 0.043 0.0565 0.0639 0.0257 0.0171 0.0419 0.0826 0.0728 0.0752 0.0371 0.0101 0.0779
Nuclear Periphery 0.0109 0.0004 0.0006 0.0006 0.0006 0.0005 0.0118 0.0008 0.001 0.0023 0.013 0.0005 0.0012 0.0005 0.0011 0.0005 0.0002 0.0004
Nucleolus 0.0005 0.0001 0.0002 0.0001 0 0.0007 0.001 0.0003 0.0004 0.0003 0.002 0.0001 0.0011 0.0002 0.0002 0 0 0.0001
Nucleus 0.0035 0.0009 0.001 0.0011 0.0009 0.0011 0.0077 0.0018 0.0012 0.0028 0.01 0.0008 0.0015 0.0015 0.0016 0.0007 0.0005 0.0007
Peroxisomes 0.0094 0.0002 0.0065 0.0002 0.0001 0.0025 0.0095 0.0009 0.0054 0.0001 0.0028 0.0022 0.0015 0.0003 0.0003 0.0003 0.0002 0.0015
Punctate Nuclear 0.003 0.0003 0.0008 0.0005 0.0002 0.0017 0.0045 0.0011 0.0028 0.0014 0.0036 0.0004 0.0014 0.0005 0.0006 0.0005 0.0001 0.0009
Vacuole 0.0037 0.0024 0.0025 0.0034 0.002 0.0017 0.0064 0.0044 0.0046 0.0081 0.0103 0.0016 0.0037 0.0044 0.0068 0.0069 0.002 0.0014
Vacuole Periphery 0.0011 0.0002 0.0003 0.0005 0.0003 0.0003 0.0018 0.0004 0.0006 0.0007 0.0022 0.0003 0.0003 0.0004 0.0008 0.0014 0.0003 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 11.8646 13.7881 7.0832 7.8346 9.9989 11.858 13.1368 18.4567 8.123 10.6602
Translational Efficiency 1.6938 1.3397 2.1869 1.5791 1.8236 1.6569 1.4999 1.0082 2.2102 1.643

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
167 1791 2854 1236 1642 1534 2591 1723 1809 3325 5445 2959

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 894.15 899.05 908.72 921.23 719.52 919.35 878.15 956.56 735.64 908.42 894.17 941.80
Standard Deviation 119.35 127.63 110.93 126.05 84.67 122.33 112.28 125.04 101.87 125.62 112.61 126.67
Intensity Change Log 2 — 0.007884 0.023319 0.043045 — 0.353579 0.287433 0.410821 — 0.172324 0.147089 0.218690

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.002837 0.006075 0.003775 0.003234 0.002704 0.003245 0.002096 0.001867 0.002716 0.004770 0.002976 0.002438
Bud Neck 0.027973 0.020882 0.029641 0.007526 0.034162 0.039314 0.020244 0.010227 0.033591 0.029385 0.025170 0.009098
Bud Site 0.073251 0.130758* 0.062682 0.069169 0.060334 0.065637 0.041443 0.054970 0.061527 0.100714* 0.052575 0.060901
Cell Periphery 0.001645 0.000693 0.000156 0.000311 0.000438 0.000577 0.000169 0.000127 0.000549 0.000639 0.000162 0.000204
Cytoplasm 0.398105* 0.497156* 0.673445* 0.581190* 0.399719* 0.415962* 0.582010* 0.670417* 0.399570* 0.459697* 0.629936* 0.633146*
Cytoplasmic Foci 0.277085* 0.227593* 0.061016 0.079446 0.306134* 0.221468* 0.062662 0.067345 0.303452* 0.224767* 0.061799 0.072400
Eisosomes 0.001360 0.000535 0.000087 0.000109 0.000770 0.000731 0.000101 0.000050 0.000824 0.000626 0.000094 0.000075
Endoplasmic Reticulum 0.003699 0.002720 0.000619 0.000454 0.003375 0.003487 0.000761 0.000286 0.003405 0.003074 0.000686 0.000356
Endosome 0.053788 0.018075 0.004572 0.009882 0.043023 0.050658 0.009695 0.006486 0.044017 0.033107 0.007010 0.007904
Golgi 0.026992 0.033125 0.001400 0.003981 0.047372 0.020682 0.000697 0.001950 0.045490 0.027384 0.001066 0.002798
Lipid Particles 0.008580 0.002903 0.001289 0.000732 0.011228 0.009574 0.002380 0.000591 0.010984 0.005980 0.001808 0.000650
Mitochondria 0.001937 0.004991 0.000582 0.001581 0.011374 0.010017 0.000419 0.000734 0.010503 0.007310 0.000504 0.001088
Mitotic Spindle 0.001496 0.001405 0.003981 0.025052 0.000640 0.005405 0.004409 0.016885 0.000719 0.003250 0.004185 0.020296
None 0.000086 0.000716 0.000756 0.000380 0.001561 0.001704 0.001297 0.000794 0.001425 0.001172 0.001013 0.000621
Nuclear Periphery 0.000109 0.000028 0.000130 0.000409 0.000058 0.000167 0.000218 0.000396 0.000062 0.000092 0.000172 0.000402
Nuclear Periphery Foci 0.000864 0.000278 0.000539 0.001062 0.000223 0.000294 0.000580 0.000926 0.000282 0.000285 0.000558 0.000983
Nucleolus 0.000152 0.000158 0.000210 0.000106 0.000296 0.000588 0.000484 0.000119 0.000283 0.000356 0.000340 0.000114
Nucleus 0.008042 0.005452 0.048354 0.009077 0.009322 0.018835 0.057715 0.013084 0.009204 0.011626 0.052808 0.011410
Peroxisomes 0.010442 0.007294 0.008453 0.006383 0.009735 0.009883 0.004508 0.005574 0.009800 0.008488 0.006576 0.005912
Vacuole 0.098107 0.035233 0.097947 0.196106 0.052085 0.115436 0.207588* 0.146532 0.056333 0.072235 0.150120 0.167239
Vacuole Periphery 0.003450 0.003930 0.000367 0.003808 0.005450 0.006337 0.000525 0.000640 0.005266 0.005041 0.000442 0.001963

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.33 -0.61 1.05 5.14 2.63 -0.86 2.18 3.84 3.01 1.44 -4.00 0.32 3.56 6.15 3.26
Bud Neck 0.91 0.41 2.97 10.56 11.49 -1.74 6.78 12.05 14.22 7.06 1.78 5.41 13.01 17.20 13.01
Bud Site -5.00 1.90 2.42 15.36 1.54 -1.23 6.89 5.86 6.56 -1.03 -9.96 5.35 5.86 16.94 0.99
Cell Periphery 3.33 5.38 5.07 6.24 -1.00 -1.69 6.78 8.11 6.71 4.03 -1.42 8.70 7.85 9.91 0.22
Cytoplasm -5.53 -14.31 -8.29 -5.34 9.80 -1.70 -21.00 -24.83 -22.16 -6.10 -7.88 -30.58 -24.87 -19.41 2.57
Cytoplasmic Foci 3.42 15.53 14.71 29.01 -2.84 11.94 45.06 43.05 28.87 -0.41 13.36 48.76 46.30 41.17 -2.17
Eisosomes 2.22 3.51 3.52 6.05 0.26 0.35 12.96 13.97 6.85 6.60 2.37 12.71 13.08 9.27 2.91
Endoplasmic Reticulum 0.89 2.93 3.25 6.37 5.31 -0.16 7.09 8.47 5.47 5.25 0.68 7.74 8.94 8.22 7.63
Endosome 6.28 8.81 8.25 10.52 -3.87 -2.71 18.01 20.51 20.74 4.63 5.32 21.56 21.68 23.05 0.64
Golgi -1.41 6.12 5.79 19.50 -1.68 13.28 28.02 27.02 16.47 -1.68 9.90 28.32 27.28 25.67 -2.15
Lipid Particles 3.94 5.05 5.49 11.37 4.18 1.41 10.65 13.03 10.61 4.97 5.92 12.22 13.80 13.04 6.35
Mitochondria -4.58 3.06 1.62 6.33 -0.96 0.97 12.11 11.87 8.92 -0.64 3.21 12.16 11.61 11.27 -1.08
Mitotic Spindle 0.05 -1.76 -5.33 -5.79 -4.92 -4.06 -4.08 -6.54 -3.84 -4.56 -3.91 -6.33 -8.89 -7.09 -6.75
None -5.26 -8.11 -5.24 2.12 3.16 -0.18 0.70 1.42 2.04 1.30 0.49 0.97 1.59 2.39 2.01
Nuclear Periphery 1.54 -1.66 -1.66 -2.39 -1.12 -4.90 -5.94 -1.63 -1.00 -0.63 -2.26 -9.16 -2.43 -2.17 -1.12
Nuclear Periphery Foci 3.82 1.47 -1.65 -8.41 -5.00 -1.24 -7.99 -3.10 -2.71 -0.97 -0.06 -9.44 -5.42 -5.30 -2.54
Nucleolus 0.05 -1.28 0.53 1.03 3.27 -2.43 -1.42 3.39 4.05 2.67 -1.05 -0.88 3.49 4.16 3.29
Nucleus 1.51 -20.66 -3.32 -11.96 24.13 -7.51 -25.38 -9.75 -0.09 18.77 -3.25 -36.31 -10.47 -6.45 29.53
Peroxisomes 0.83 0.83 1.58 3.97 3.46 -0.18 8.79 7.69 6.58 -0.41 1.88 5.98 7.91 7.63 2.66
Vacuole 5.73 -2.71 -12.96 -31.88 -17.74 -13.49 -34.96 -26.51 -13.28 2.23 -5.20 -34.01 -36.04 -32.52 -11.26
Vacuole Periphery -0.82 5.73 1.33 2.11 -2.27 -1.43 15.37 14.77 10.90 0.25 0.56 16.36 9.12 8.78 -2.19
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate
Localization
Cell Percentages cytoplasm (81%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-10

Acf4

Acf4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Acf4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available