Standard name
Human Ortholog
Description Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.95 1.0 0.99 1.0 0.93 0.88 0.83 0.79 0.69 0.76 0.69 0.74 0.99 0.98 0.96 0.78 0.86 0.88 0.9 0.93 0.91 0.93 0.93 0.92
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0.07 0.06 0.17 0.07 0.26 0.16 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0.06 0.06 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.08 0.09 0.12 0.12 0.17 0.14 0.1 0.12 0 0 0 0.23 0.16 0.14 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 0 0 0 0 0 1 0 1 1 1 0 0 0 0 1 0 1 1 1 0 0 0 0
Bud 3 0 0 0 0 0 1 3 1 1 5 0 0 0 0 1 0 0 0 1 2 1 2 3
Bud Neck 1 0 0 0 0 0 0 2 0 0 0 0 0 0 0 1 0 0 1 0 0 0 1 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 – – – – – –
Cell Periphery 0 0 3 2 2 1 5 2 6 10 8 7 0 2 2 9 8 6 0 0 0 0 0 0
Cytoplasm 166 218 184 261 356 356 457 461 236 345 343 347 276 396 426 235 258 340 168 211 168 62 193 240
Endoplasmic Reticulum 2 1 1 0 1 3 7 14 3 10 7 8 0 4 3 6 5 9 0 0 2 0 0 1
Endosome 0 0 0 0 0 0 2 1 1 0 1 2 0 4 2 10 6 6 1 0 0 0 1 2
Golgi 1 1 0 0 0 0 0 0 0 0 1 0 0 1 0 3 6 6 1 0 0 0 0 0
Mitochondria 5 2 0 0 0 9 37 33 57 32 126 73 0 0 0 4 0 5 3 4 3 0 0 0
Nucleus 1 0 1 3 3 11 10 20 20 26 27 18 1 5 0 2 3 1 0 1 0 1 0 3
Nuclear Periphery 0 0 0 1 0 0 1 0 0 0 2 0 0 0 1 1 4 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 2 6 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 1 1 0 0 0 1 1 4 1 3 1 2 0 0 0 1
Vac/Vac Membrane 0 0 1 2 31 38 66 70 58 64 51 57 5 2 15 68 48 53 4 0 4 0 5 4
Unique Cell Count 174 219 185 262 381 406 548 581 340 453 494 467 279 406 443 302 300 385 187 229 185 67 209 260
Labelled Cell Count 180 222 190 269 393 418 587 606 384 490 572 512 282 415 450 352 342 436 187 229 185 67 209 260


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.2 5.5 6.7 6.5 8.0 7.0 7.2 7.1 6.5 6.9 6.3 6.5 6.7 7.0 6.7 12.5 13.3 12.4 6.3 6.6 7.1
Std Deviation (1e-4) 0.7 1.0 1.0 1.4 1.6 1.6 2.0 1.7 1.5 1.6 1.7 1.6 1.6 1.7 1.8 3.5 3.3 3.3 1.8 1.6 2.1
Intensity Change (Log2) – – – -0.05 0.26 0.07 0.11 0.09 -0.03 0.05 -0.09 -0.03 0.01 0.06 0.01 0.9 0.99 0.89 -0.1 -0.01 0.09


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.2 -3.2 -4.7 -5.7 -6.5 -8.2 -7.1 -8.4 -7.4 -0.6 -1.6 -2.3 -6.7 -5.1 -4.6
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 3.6 3.3 5.9 3.7 7.6 5.7 0 0 0 0 0 0
Nucleus 0 0 0 0 2.1 3.0 3.0 2.9 2.3 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 3.7 4.0 4.7 4.7 5.7 5.1 4.3 4.7 0 0 0 6.7 5.5 5.0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.6132 1.155 0.8385 1.2351 1.0602 0.6845 0.423 0.6419 0.4942 0.5339 0.1549 0.562 -0.41 0.1981 0.1717 0.1635 -0.0432 0.0437
Actin 0.0164 0.0004 0.0014 0.0036 0.0265 0.0002 0.0596 0.0003 0.0195 0.0027 0.0003 0.0034 0.0086 0.001 0.0006 0.007 0.0006 0.0026
Bud 0.0024 0.0025 0.0008 0.001 0.0015 0.0001 0.0024 0.0001 0.0004 0.0004 0 0.0005 0.0039 0.0034 0.0016 0.0011 0.0008 0.0009
Bud Neck 0.0053 0.0004 0.0003 0.0009 0.0079 0.0005 0.003 0.0001 0.0008 0.0007 0.0001 0.0039 0.0003 0.0004 0.0002 0.0013 0.001 0.0041
Bud Periphery 0.0058 0.0011 0.0012 0.001 0.002 0.0001 0.007 0.0001 0.0004 0.0009 0 0.0007 0.0014 0.0036 0.0018 0.0031 0.0008 0.0006
Bud Site 0.0116 0.0104 0.0033 0.0018 0.0235 0 0.0141 0.0006 0.002 0.0035 0 0.0003 0.0033 0.0049 0.0017 0.0041 0.001 0.0003
Cell Periphery 0.0009 0.0002 0.0003 0.0002 0.0006 0 0.0006 0.0001 0.0001 0.0004 0 0 0.0002 0.0002 0.0001 0.0002 0.0001 0.0001
Cytoplasm 0.1851 0.35 0.3613 0.477 0.4488 0.3793 0.1699 0.2948 0.2633 0.3287 0.3605 0.3997 0.256 0.3994 0.3707 0.355 0.3516 0.4448
Cytoplasmic Foci 0.0133 0.0067 0.0157 0.0225 0.0123 0.0078 0.0419 0.0057 0.0126 0.0145 0.0024 0.0104 0.0184 0.0168 0.0084 0.0082 0.0165 0.0147
Eisosomes 0.0005 0.0001 0.0004 0.0001 0.0002 0 0.0006 0.0001 0.0001 0.0004 0.0001 0 0.0002 0.0002 0.0001 0.0002 0 0
Endoplasmic Reticulum 0.0036 0.0015 0.0043 0.0045 0.0042 0.0022 0.004 0.0026 0.0027 0.0037 0.0016 0.0015 0.0016 0.0023 0.0016 0.0014 0.002 0.0016
Endosome 0.0206 0.0021 0.0049 0.0198 0.0238 0.0049 0.0235 0.0018 0.0165 0.021 0.0011 0.0083 0.0022 0.006 0.0019 0.0052 0.0074 0.0054
Golgi 0.0035 0.0002 0.0012 0.0061 0.0107 0.0001 0.0063 0.0002 0.0054 0.0057 0.0001 0.0033 0.0003 0.0003 0.0001 0.0004 0.0005 0.0003
Lipid Particles 0.0228 0.0002 0.0049 0.0112 0.0029 0.0006 0.0154 0.0002 0.0063 0.0176 0.0004 0.001 0.0009 0.0003 0.0002 0.0003 0.0004 0.0002
Mitochondria 0.0121 0.0003 0.0011 0.0076 0.0029 0.0003 0.007 0.0002 0.0059 0.0036 0.0003 0.0047 0.0023 0.0005 0.0006 0.0008 0.0005 0.0008
None 0.6624 0.6036 0.5739 0.3916 0.4062 0.5867 0.5859 0.6885 0.6483 0.5817 0.6285 0.5482 0.686 0.5459 0.5999 0.5848 0.6006 0.5016
Nuclear Periphery 0.0091 0.001 0.0015 0.005 0.0046 0.0018 0.0095 0.0007 0.0012 0.0012 0.0009 0.0009 0.0017 0.0013 0.0011 0.0015 0.0019 0.0014
Nucleolus 0.003 0.0012 0.0005 0.0006 0.0016 0.0003 0.0021 0.0001 0.0002 0.0004 0.0001 0.0006 0.0011 0.0004 0.0003 0.0005 0.0003 0.0004
Nucleus 0.0037 0.0103 0.0038 0.0306 0.0082 0.0074 0.013 0.0015 0.0025 0.0042 0.0022 0.0025 0.004 0.0075 0.0039 0.019 0.0071 0.009
Peroxisomes 0.0075 0.0003 0.014 0.0024 0.0014 0.0001 0.0192 0.0002 0.0085 0.0046 0.0001 0.0022 0.0007 0.0003 0.0004 0.0007 0.0005 0.0003
Punctate Nuclear 0.0051 0.0062 0.0033 0.0069 0.0058 0.0065 0.0096 0.0012 0.0014 0.0018 0.0007 0.0072 0.0056 0.003 0.0039 0.0036 0.0047 0.01
Vacuole 0.0041 0.0011 0.0014 0.0037 0.0034 0.0009 0.0037 0.0008 0.0015 0.0019 0.0004 0.0006 0.001 0.002 0.0008 0.0016 0.0015 0.0009
Vacuole Periphery 0.0013 0.0001 0.0002 0.0017 0.0009 0.0002 0.0016 0.0001 0.0004 0.0004 0.0001 0.0003 0.0002 0.0002 0.0001 0.0003 0.0003 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 33.6675 30.0967 26.1254 28.5066 23.8847 41.9023 31.5791 31.3893 35.1973 27.3218
Translational Efficiency 0.8171 0.8735 0.8747 0.986 0.8621 0.6312 0.814 0.7864 0.7436 0.6834

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2030 980 1206 817 2230 1970 362 2177 4260 2950 1568 2994

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 688.65 685.75 1165.91 1041.41 685.25 741.90 1281.72 1153.62 686.87 723.25 1192.65 1123.00
Standard Deviation 79.65 138.71 233.25 243.43 83.30 100.04 231.20 248.26 81.60 117.36 237.84 251.96
Intensity Change Log 2 — -0.006088 0.759614 0.596695 — 0.114594 0.903379 0.751466 — 0.055365 0.833108 0.675964

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000040 0.000232 0.000337 0.002489 0.000063 0.000234 0.000410 0.000311 0.000052 0.000233 0.000354 0.000905
Bud Neck 0.008926 0.012056 0.002188 0.011244 0.009778 0.025701 0.002357 0.006901 0.009372 0.021168 0.002227 0.008086
Bud Site 0.002527 0.005854 0.002606 0.037589 0.002598 0.010897 0.004784 0.022147 0.002564 0.009221 0.003109 0.026361
Cell Periphery 0.000117 0.000115 0.000103 0.000360 0.000086 0.000098 0.000244 0.000088 0.000100 0.000103 0.000136 0.000162
Cytoplasm 0.618933* 0.530275* 0.502738* 0.480320* 0.584435* 0.518516* 0.534708* 0.589452* 0.600874* 0.522422* 0.510119* 0.559672*
Cytoplasmic Foci 0.149925 0.162556 0.005589 0.023126 0.162110 0.172356 0.031547 0.014564 0.156304 0.169100 0.011582 0.016900
Eisosomes 0.000088 0.000085 0.000015 0.000052 0.000089 0.000076 0.000071 0.000010 0.000089 0.000079 0.000028 0.000021
Endoplasmic Reticulum 0.000737 0.000794 0.002427 0.003479 0.000527 0.000487 0.002966 0.000522 0.000627 0.000589 0.002552 0.001329
Endosome 0.005784 0.012112 0.001528 0.012925 0.004686 0.018178 0.005175 0.005040 0.005209 0.016163 0.002370 0.007192
Golgi 0.001042 0.002452 0.000191 0.011334 0.001395 0.002750 0.000229 0.002310 0.001227 0.002651 0.000200 0.004772
Lipid Particles 0.003937 0.004953 0.000806 0.002387 0.005208 0.003593 0.002374 0.000560 0.004602 0.004044 0.001168 0.001058
Mitochondria 0.002405 0.003234 0.001260 0.011247 0.002828 0.008834 0.000212 0.002308 0.002626 0.006974 0.001018 0.004747
Mitotic Spindle 0.000069 0.003721 0.017665 0.094592 0.001282 0.012720 0.010969 0.177768* 0.000704 0.009731 0.016119 0.155071*
None 0.007883 0.019021 0.007389 0.008039 0.004650 0.002725 0.003384 0.011030 0.006191 0.008139 0.006465 0.010214
Nuclear Periphery 0.000375 0.000537 0.001310 0.001282 0.000445 0.000571 0.001035 0.000916 0.000411 0.000560 0.001246 0.001016
Nuclear Periphery Foci 0.000301 0.000729 0.001599 0.003625 0.000275 0.000323 0.006119 0.001574 0.000287 0.000458 0.002643 0.002134
Nucleolus 0.000824 0.002667 0.000249 0.001729 0.001123 0.002028 0.000447 0.000864 0.000981 0.002240 0.000294 0.001100
Nucleus 0.153978* 0.155305* 0.411255* 0.142441* 0.180747* 0.113636 0.201752* 0.109881 0.167991* 0.127479 0.362888* 0.118766
Peroxisomes 0.001376 0.008346 0.000177 0.002881 0.002477 0.007538 0.000275 0.001712 0.001952 0.007806 0.000199 0.002031
Vacuole 0.039773 0.073875 0.040307 0.138644 0.034594 0.096636 0.190644 0.047521 0.037062 0.089075 0.075015 0.072386
Vacuole Periphery 0.000961 0.001082 0.000261 0.010214 0.000604 0.002104 0.000298 0.004522 0.000774 0.001765 0.000269 0.006075

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.64 -16.42 -3.04 -2.50 -1.65 -2.46 -10.06 -8.56 -0.41 5.57 -3.82 -18.77 -4.45 -2.44 0.41
Bud Neck -2.01 7.84 -0.26 1.56 -5.52 -9.64 8.87 3.27 11.70 -6.87 -9.74 12.15 2.50 11.22 -9.49
Bud Site -5.12 -2.90 -8.11 -6.60 -7.70 -8.46 -5.98 -9.79 -1.92 -6.23 -9.72 -5.19 -12.78 -5.60 -11.20
Cell Periphery 0.36 -3.17 -3.73 -3.76 -2.83 -1.71 -7.46 3.84 4.13 8.24 -0.36 -8.66 -1.15 -0.85 5.03
Cytoplasm 9.06 21.35 19.78 9.29 2.40 8.20 8.86 14.67 5.75 -0.86 12.78 22.34 23.87 9.65 -1.54
Cytoplasmic Foci -1.89 39.11 31.35 23.21 -7.31 -1.51 31.22 38.19 34.70 3.31 -2.72 54.16 50.59 41.92 -5.30
Eisosomes 0.29 18.57 9.27 7.59 -9.27 2.92 4.25 18.78 24.15 8.01 2.78 18.76 23.64 23.71 3.53
Endoplasmic Reticulum -0.52 -11.20 -7.32 -7.22 1.79 0.45 -10.45 -2.24 -3.32 10.04 0.32 -15.13 -6.41 -7.47 11.33
Endosome -6.12 8.83 0.31 5.63 -5.31 -12.47 -0.05 5.66 14.61 5.17 -13.60 9.40 5.11 15.84 -2.90
Golgi -2.12 7.25 -2.01 -0.69 -2.82 -2.65 6.76 3.02 4.17 -2.45 -3.55 9.62 -0.36 2.54 -3.61
Lipid Particles -1.86 9.80 3.56 4.55 -5.03 3.22 5.25 8.39 9.22 6.53 1.73 11.04 10.20 10.14 -1.55
Mitochondria -0.66 1.87 -0.96 -0.32 -2.29 -4.85 8.23 4.98 6.48 -5.57 -4.72 4.21 2.01 5.79 -2.18
Mitotic Spindle -2.70 -7.58 -10.63 -9.93 -7.61 -5.79 -2.62 -26.22* -23.51* -22.48* -6.54 -7.77 -28.04 -25.43 -23.44
None -3.54 1.86 -0.26 3.26 -1.66 3.12 2.55 -8.79 -12.63 -12.38 -1.52 1.31 -5.85 -2.30 -8.68
Nuclear Periphery -1.69 -14.61 -12.19 -12.65 -2.25 -1.10 -10.37 -18.88 -12.73 -4.46 -1.73 -19.50 -22.51 -17.20 -4.80
Nuclear Periphery Foci -5.02 -11.69 -7.71 -6.81 -4.62 -0.71 -10.93 -9.98 -9.68 7.05 -3.74 -15.45 -12.35 -11.31 0.36
Nucleolus -6.18 7.62 -2.56 2.15 -4.15 -2.81 4.81 -2.61 0.68 -7.15 -5.52 7.50 -4.10 1.71 -8.54
Nucleus -0.52 -36.25 -3.45 -2.41 26.96 13.86 -2.60 4.12 -9.30 4.66 10.21 -31.67 0.71 -8.26 30.72
Peroxisomes -4.80 6.29 0.31 4.77 -2.80 -6.78 9.15 5.89 9.43 -3.29 -8.49 11.09 4.81 10.05 -4.48
Vacuole -9.63 -8.89 -23.09 -17.64 -17.67 -18.82 -16.87 -23.55 -8.12 8.74 -20.81 -17.05 -31.82 -16.75 -7.98
Vacuole Periphery -0.46 4.82 -2.30 -2.22 -3.21 -5.76 6.37 -1.11 2.32 -2.02 -5.14 6.64 -2.09 0.51 -3.61
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (60%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Ura8

Ura8


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ura8-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available