Standard name
Human Ortholog
Description Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p, enters nucleus under oxidative stress to promote transcription of stress response genes; human ortholog SOD1 implicated in ALS complements a null allele; abundance increases under DNA replication stress and during exposure to boric acid; localization to mitochondrial intermembrane space is modulated by MICOS complex
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.0 0.94 0.99 1.0 1.0 0.97 – 0.89 0.94 0.89 0.87 0.84 0.99 0.99 1.0 1.0 1.0 0.96 0.98 0.93 0.96 0.94 0.96 0.91
Endoplasmic Reticulum 0 0 0 0 0 0 – 0.1 0.06 0.09 0.11 0.11 0 0 0 0 0.05 0.08 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.06 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 1 0 3 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 4 0 4 3 – 3 1 5 3 9 1 1 0 0 0 0 0 0 1 0 1 2
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 1 1 – 5 1 9 7 15 0 0 0 3 0 1 0 0 0 0 0 0
Cytoplasm 277 15 128 257 211 310 – 466 357 331 263 356 113 140 227 116 85 49 263 37 116 92 103 132
Endoplasmic Reticulum 0 0 0 1 0 6 – 50 21 35 33 48 1 1 0 5 4 4 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Mitochondria 0 1 0 0 0 0 – 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1
Nucleus 0 0 0 0 0 0 – 0 0 0 0 1 0 0 0 0 0 0 0 1 0 1 0 2
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 1 0 0 0 – 6 0 0 1 3 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 1 0 – 3 2 0 2 0 0 1 1 0 0 0 1 0 0 1 0 2
Unique Cell Count 277 16 129 258 212 318 525 380 371 303 422 114 142 228 116 85 51 269 40 122 99 108 146
Labelled Cell Count 277 16 133 258 217 320 533 382 381 309 437 115 143 228 124 89 54 269 40 122 99 108 146


Ambiguous, Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 135.2 159.1 86.4 145.4 157.1 137.5 – 118.2 120.1 119.0 112.9 117.7 186.3 184.3 187.5 231.3 208.9 222.2 132.9 154.2 153.9
Std Deviation (1e-4) 24.2 44.2 25.0 35.0 38.3 34.5 – 34.2 35.2 33.1 37.3 34.7 54.7 60.3 53.8 82.1 101.2 81.7 47.3 42.3 68.7
Intensity Change (Log2) – – – 0.75 0.86 0.67 – 0.45 0.48 0.46 0.39 0.45 1.11 1.09 1.12 1.42 1.27 1.36 0.62 0.84 0.83


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.5 0.4 -1.2 – -3.7 -2.4 -3.6 -4.0 -4.5 -0.1 -0.5 0.4 1.0 0.8 -1.5
Endoplasmic Reticulum 0 0 0 – 3.6 2.7 3.6 3.9 4.0 0 0 0 0 0 0
Endosome 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 165.2454 209.489 181.1895 173.5004 140.5843 149.521 163.8758 206.2967 188.0145 173.8322 150.7588 174.3131 174.3351 224.7937 209.6384 191.1788 175.6128 165.67
Actin 0.0072 0.0001 0.0008 0.0003 0.0055 0.0195 0.0014 0 0.0001 0.0016 0.0045 0.0011 0.0034 0.0001 0.0006 0.0003 0.0002 0.0001
Bud 0.0003 0 0.0003 0.0007 0.0049 0.0002 0.0006 0 0.0006 0.0008 0.0018 0.0105 0.0009 0 0 0.0029 0.0007 0.0001
Bud Neck 0.0005 0.0001 0.0013 0.0008 0.0006 0.0017 0.0002 0.0001 0.0001 0.0002 0.001 0.0007 0.0004 0.0001 0.0001 0.0002 0.0002 0.0002
Bud Periphery 0.0003 0 0.0001 0.0006 0.0014 0.0003 0.0004 0 0.0002 0.0005 0.0018 0.0016 0.0005 0 0 0.0007 0.0002 0
Bud Site 0.0003 0 0.0001 0.0229 0.0004 0.0004 0.0013 0 0.0001 0.0013 0.0019 0.0018 0.0008 0 0.0001 0.0003 0.0002 0.0002
Cell Periphery 0.0002 0 0.0001 0.0002 0.0003 0.0003 0.0003 0 0.0006 0 0.0025 0.0007 0.0006 0 0.0001 0.0001 0.001 0.0007
Cytoplasm 0.9424 0.9956 0.9643 0.9429 0.8278 0.7989 0.9141 0.9972 0.9611 0.9229 0.7524 0.8555 0.9113 0.9967 0.9829 0.9378 0.8884 0.7433
Cytoplasmic Foci 0.0026 0.0001 0.0041 0.0083 0.0085 0.0013 0.0142 0 0.0032 0.0055 0.0433 0.0418 0.0102 0.0001 0.0033 0.0152 0.0128 0.0249
Eisosomes 0.0007 0 0.0005 0 0.0004 0.0014 0.0001 0 0 0 0.0005 0.0002 0.0002 0 0 0 0.0004 0.0007
Endoplasmic Reticulum 0.0005 0 0.0002 0.0001 0.0017 0.0047 0.0027 0 0.0004 0.0001 0.0016 0.0027 0.001 0 0 0.0005 0.0009 0.0001
Endosome 0.001 0 0.0002 0.0053 0.0104 0.0043 0.005 0 0.0077 0.0075 0.0043 0.0018 0.0073 0 0.0004 0.0023 0.0003 0.0001
Golgi 0.0008 0 0.0001 0.0011 0.0016 0.0008 0.0034 0 0.0007 0.0116 0.0039 0.0004 0.001 0 0.0007 0.0004 0.0001 0.0001
Lipid Particles 0.0007 0 0.0012 0.0039 0.0056 0.0008 0.0031 0 0.0004 0.0001 0.0056 0.0035 0.0024 0 0.0011 0.0078 0.0025 0.0033
Mitochondria 0.0015 0.0001 0.0034 0.0004 0.011 0.0009 0.0058 0 0.0013 0.0057 0.0542 0.0248 0.0039 0 0.001 0.0022 0.007 0.009
None 0.0034 0.0002 0.0092 0.0003 0.0206 0.1139 0.0068 0.0001 0.0029 0.0001 0.0163 0.0219 0.0108 0.0001 0.0013 0.006 0.0373 0.0158
Nuclear Periphery 0.0071 0.0005 0.0008 0.0008 0.0096 0.0168 0.0068 0.0003 0.0009 0.0005 0.0015 0.0026 0.0095 0.0004 0.0007 0.0023 0.0056 0.0019
Nucleolus 0.0023 0 0.0056 0.0009 0.0543 0.0024 0.0106 0 0.0088 0.0337 0.0586 0.0041 0.0072 0 0.0008 0.0024 0.0159 0.1722
Nucleus 0.026 0.0032 0.0054 0.0041 0.0155 0.0202 0.0152 0.0017 0.005 0.0049 0.0102 0.0148 0.0227 0.0022 0.0047 0.0101 0.0168 0.0191
Peroxisomes 0.0003 0 0.0003 0.0026 0.0011 0.0004 0.0004 0 0.0001 0.0006 0.001 0.0007 0.0008 0 0.0017 0.0005 0.0005 0.0004
Punctate Nuclear 0.0009 0 0.0013 0.0008 0.0149 0.0092 0.0041 0 0.0002 0.002 0.0028 0.0036 0.0016 0 0.0002 0.0055 0.0015 0.003
Vacuole 0.0005 0 0.0003 0.0028 0.0024 0.0009 0.0023 0.0004 0.0042 0.0003 0.0139 0.0041 0.0024 0.0001 0.0001 0.0017 0.0049 0.0019
Vacuole Periphery 0.0004 0 0.0004 0.0002 0.0015 0.0008 0.0013 0 0.0013 0.0001 0.0162 0.0013 0.0011 0 0.0001 0.0009 0.0027 0.0028

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 1343.0686 1561.232 1671.6421 1500.8243 1612.1306 1700.4366 1427.889 1344.8053 1780.257 1350.8772
Translational Efficiency 2.1346 1.947 2.0486 2.3706 2.4967 2.1249 2.051 2.7756 2.0949 2.331

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1804 1403 46 1445 2616 1758 985 1631 4420 3161 1031 3076

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 7694.43 10331.50 21339.69 18800.00 9287.58 8428.74 16708.28 17258.84 8637.34 9273.27 16914.92 17982.82
Standard Deviation 1881.29 2840.47 4578.84 5080.59 2148.49 1937.76 3655.40 4357.43 2188.53 2561.85 3823.03 4773.37
Intensity Change Log 2 — 0.425163 1.471653 1.288846 — -0.139986 0.847189 0.893961 — 0.143671 1.163812 1.086346

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000031 0.000044 0.000148 0.000147 0.000017 0.000048 0.000055 0.000083 0.000023 0.000046 0.000059 0.000113
Bud Neck 0.000162 0.000264 0.002105 0.001159 0.000118 0.000250 0.000830 0.000540 0.000136 0.000256 0.000887 0.000830
Bud Site 0.000218 0.000543 0.000439 0.002486 0.000224 0.000238 0.000536 0.001056 0.000222 0.000373 0.000532 0.001728
Cell Periphery 0.000395 0.000515 0.004611 0.001060 0.000290 0.000410 0.000808 0.000529 0.000333 0.000457 0.000978 0.000778
Cytoplasm 0.672110* 0.645090* 0.293381* 0.630815* 0.772136* 0.644768* 0.585229* 0.708324* 0.731311* 0.644911* 0.572208* 0.671913*
Cytoplasmic Foci 0.002316 0.005489 0.049708 0.006885 0.001226 0.003410 0.010818 0.006543 0.001671 0.004333 0.012553 0.006703
Eisosomes 0.000000 0.000001 0.000007 0.000002 0.000000 0.000001 0.000001 0.000002 0.000000 0.000001 0.000002 0.000002
Endoplasmic Reticulum 0.000008 0.000014 0.000016 0.000060 0.000010 0.000013 0.000010 0.000019 0.000009 0.000014 0.000010 0.000038
Endosome 0.000005 0.000070 0.000018 0.000401 0.000007 0.000018 0.000014 0.000763 0.000006 0.000041 0.000014 0.000593
Golgi 0.000152 0.000205 0.001065 0.000481 0.000167 0.000216 0.000158 0.000260 0.000161 0.000211 0.000198 0.000363
Lipid Particles 0.000076 0.000102 0.000715 0.000543 0.000122 0.000108 0.000377 0.000366 0.000103 0.000105 0.000392 0.000449
Mitochondria 0.000115 0.000119 0.000590 0.000327 0.000108 0.000148 0.000178 0.000529 0.000111 0.000135 0.000196 0.000434
Mitotic Spindle 0.000051 0.000513 0.000056 0.006755 0.000036 0.000089 0.000240 0.000520 0.000042 0.000277 0.000232 0.003449
None 0.023158 0.025519 0.004925 0.017488 0.020469 0.020744 0.011610 0.018235 0.021567 0.022863 0.011312 0.017884
Nuclear Periphery 0.000055 0.000098 0.001529 0.000375 0.000049 0.000086 0.000331 0.000157 0.000052 0.000091 0.000385 0.000260
Nuclear Periphery Foci 0.000236 0.000353 0.000573 0.000921 0.000287 0.000327 0.000393 0.000315 0.000266 0.000339 0.000401 0.000600
Nucleolus 0.000032 0.000104 0.000132 0.000205 0.000031 0.000063 0.000062 0.000093 0.000031 0.000081 0.000065 0.000146
Nucleus 0.299420* 0.318648* 0.628557* 0.316460* 0.202843* 0.327210* 0.380142* 0.253906* 0.242260* 0.323410* 0.391225* 0.283292*
Peroxisomes 0.000001 0.000007 0.000006 0.000057 0.000003 0.000002 0.000002 0.000131 0.000002 0.000004 0.000003 0.000096
Vacuole 0.001390 0.002247 0.010595 0.012899 0.001511 0.001712 0.008142 0.007327 0.001462 0.001950 0.008251 0.009945
Vacuole Periphery 0.000067 0.000055 0.000823 0.000472 0.000346 0.000139 0.000064 0.000306 0.000232 0.000102 0.000098 0.000384

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.08 -5.78 -8.15 -6.81 2.30 -4.35 -13.03 -6.54 -1.40 2.42 -4.96 -12.43 -10.66 -5.48 0.25
Bud Neck -5.16 -5.30 -12.98 -11.52 1.53 -6.10 -12.65 -13.53 -8.67 7.36 -8.10 -13.09 -17.55 -14.16 4.74
Bud Site -2.24 -3.47 -6.04 -4.99 -4.57 -1.06 -11.94 -9.07 -8.75 -0.15 -2.46 -12.71 -8.92 -7.76 -2.75
Cell Periphery -1.91 -7.32 -5.72 -3.21 6.44 -2.75 -10.38 -4.04 -1.34 7.79 -3.28 -11.63 -7.13 -3.53 7.33
Cytoplasm 5.30 14.09 13.75 8.51 -10.40 25.99 32.24 17.50 -6.22 -17.72 22.86 29.04 22.62 1.94 -14.09
Cytoplasmic Foci -7.24 -6.74 -11.10 -2.97 5.96 -8.27 -13.65 -12.50 -7.06 7.84 -10.84 -14.42 -16.95 -7.21 9.14
Eisosomes -2.97 -4.83 -12.31 -6.25 3.65 -5.05 -14.37 -8.84 -5.21 7.06 -4.90 -14.42 -15.20 -8.26 5.68
Endoplasmic Reticulum -0.99 -3.84 -4.07 -2.90 -1.48 -1.41 -6.42 -1.10 0.60 2.42 -1.71 -7.00 -4.14 -1.99 -0.97
Endosome -1.18 -4.87 -1.54 -0.82 -1.28 -1.23 -9.07 -1.07 -1.01 -0.92 -1.52 -9.73 -1.49 -1.24 -1.22
Golgi -0.80 -3.23 -1.33 -0.75 2.60 -1.12 -2.91 0.19 1.10 2.29 -1.36 -4.53 -1.00 0.03 1.64
Lipid Particles -2.64 -5.88 -9.64 -8.20 0.28 -0.58 -8.99 -4.86 -4.77 3.40 -1.84 -9.82 -9.67 -8.97 2.58
Mitochondria 0.22 -2.90 -5.44 -5.39 2.06 -2.13 -7.31 -1.46 -0.97 -0.41 -1.83 -7.51 -2.56 -2.04 -0.36
Mitotic Spindle -1.28 -0.22 -2.94 -2.41 -2.93 -2.20 -3.80 -5.12 -2.97 0.65 -1.82 -3.76 -3.50 -2.80 -2.09
None 0.12 11.07 8.41 7.66 -3.39 0.81 12.31 7.30 6.33 -1.54 0.53 14.48 11.21 9.94 -1.74
Nuclear Periphery -9.12 -7.55 -13.78 -11.49 5.29 -6.37 -15.29 -19.68 -12.96 10.67 -10.35 -16.39 -19.27 -15.20 8.52
Nuclear Periphery Foci -3.14 -4.94 -4.19 -1.87 -1.41 -2.40 -8.31 -5.19 -2.95 2.82 -3.93 -9.23 -5.92 -2.93 0.56
Nucleolus -1.99 -2.84 -6.51 -1.57 -1.10 -2.95 -11.43 -9.13 -1.84 1.97 -3.00 -11.61 -9.25 -2.24 -1.36
Nucleus -3.69 -11.15 -6.52 -2.98 9.33 -25.14 -26.76 -12.02 11.22 16.10 -21.16 -23.08 -13.87 5.49 13.21
Peroxisomes -1.48 -2.58 -2.11 -1.59 -1.59 1.01 -3.52 -1.12 -1.14 -1.04 -1.03 -4.64 -1.54 -1.47 -1.37
Vacuole -6.15 -4.25 -19.51 -17.99 -4.40 -4.38 -14.85 -17.25 -16.30 2.75 -7.59 -15.15 -25.85 -24.11 -0.34
Vacuole Periphery 0.88 -1.87 -1.65 -1.88 1.34 0.96 1.07 0.94 -0.01 -0.27 1.03 0.76 0.51 -1.12 -0.54
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p, enters nucleus under oxidative stress to promote transcription of stress response genes; human ortholog SOD1 implicated in ALS complements a null allele; abundance increases under DNA replication stress and during exposure to boric acid; localization to mitochondrial intermembrane space is modulated by MICOS complex
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-1

Sod1

Sod1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sod1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available