Standard name
Human Ortholog
Description Peroxisomal matrix protein with naturally active promoter; well-conserved in fungi; localized to peroxisomes under physiological growth conditions; levels of some amino acids are altered upon both knockout and overexpression, suggesting potential involvement of Pxp2p in amino acid metabolism or related cellular metabolic processes (needs further study); GFP-fusion protein displays inherent dual localization with large proportion localizing to cytosol
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.09 0 0.06 0 0 0.05 0.05
Bud 0.05 0.05 0.09 0.06 0 0 0 0 0.05 0 0 0.05 0 0 0 0.11 0.09 0.06 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.09 0 0 0.05 0 0 0.05 0 0 0 0 0.05 0.07 0.15 0.17 0.11 0.17 0 0 0 0 0.06 0.07
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0.06 0 0 0 0 0 0 0
Endosome 0.19 0 0.15 0.12 0.2 0.13 0.15 0.11 0 0 0 0 0.08 0.21 0.16 0.27 0.17 0.18 0.2 0.13 0.13 0.14 0.11 0.11
Golgi 0.05 0 0.07 0.07 0.05 0 0 0 0 0 0 0 0.18 0.16 0.09 0.05 0.27 0.24 0.08 0.07 0.05 0.1 0.07 0.08
Mitochondria 0.69 0.86 0.41 0.73 0.6 0.76 0.73 0.71 0.93 0.88 0.93 0.9 0.7 0.49 0.47 0.1 0.06 0.09 0.35 0.48 0.43 0.43 0.43 0.45
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Peroxisomes 0.12 0.06 0.33 0.18 0.12 0.05 0.06 0.05 0 0 0 0 0.07 0.12 0.12 0.35 0.17 0.1 0.23 0.14 0.3 0.15 0.18 0.14
SpindlePole 0.08 0 0.26 0.06 0.1 0.07 0.11 0.1 0.05 0.08 0.05 0.07 0.08 0.13 0.07 0.15 0.15 0.18 0 0 0 0 0 0
Vac/Vac Membrane 0.12 0.1 0.06 0 0.14 0.12 0.13 0.11 0.05 0.05 0.05 0 0.06 0.09 0.08 0.15 0.14 0.16 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 3 1 21 11 4 4 1 1 0 0 2 1 6 7 2 3 10 16 7 8 15 3 13 15
Bud 9 6 39 25 16 22 31 24 43 37 33 44 3 0 3 18 13 10 2 0 5 0 2 3
Bud Neck 0 0 0 0 1 0 0 0 0 2 0 1 0 0 0 0 0 0 0 1 0 0 2 0
Bud Site 4 2 8 2 1 3 5 2 14 7 8 13 0 0 0 4 1 5 – – – – – –
Cell Periphery 4 3 7 13 8 5 5 4 5 12 10 15 3 3 2 5 6 7 0 0 0 0 1 0
Cytoplasm 2 11 18 16 24 19 20 35 25 18 11 12 7 11 32 29 16 30 0 4 2 6 15 21
Endoplasmic Reticulum 5 3 1 4 3 2 3 0 4 3 3 5 3 5 12 7 9 4 0 0 1 0 0 3
Endosome 36 3 67 49 93 79 109 80 6 18 18 23 12 33 35 46 24 31 43 18 69 20 28 32
Golgi 10 3 33 30 22 4 3 4 1 0 3 0 26 25 20 8 39 42 17 10 28 14 19 25
Mitochondria 134 108 184 310 282 474 543 513 876 770 730 875 100 78 103 17 9 15 76 69 234 61 118 132
Nucleus 1 1 0 1 2 14 15 16 17 17 16 15 2 1 1 1 1 2 0 1 0 1 2 1
Nuclear Periphery 1 0 0 2 3 11 13 13 19 28 12 20 1 0 0 0 0 0 0 0 1 1 1 2
Nucleolus 3 0 2 4 5 13 14 26 21 16 13 15 2 0 1 3 0 9 0 0 0 0 0 2
Peroxisomes 24 7 150 76 57 31 42 37 16 25 7 20 10 19 26 59 24 17 49 19 164 22 48 41
SpindlePole 15 1 116 25 46 44 81 73 47 70 41 67 12 20 15 25 22 31 7 1 13 3 10 5
Vac/Vac Membrane 23 13 29 16 67 73 97 80 46 46 41 32 8 15 18 26 20 28 4 6 2 4 2 4
Unique Cell Count 193 126 454 423 470 625 740 718 941 872 784 970 142 158 217 169 142 175 215 146 551 144 272 297
Labelled Cell Count 274 162 675 584 634 798 982 908 1140 1069 948 1158 195 217 270 251 194 247 215 146 551 144 272 297


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.4 5.1 6.8 6.6 6.9 5.8 5.5 5.7 4.3 4.8 4.7 4.7 6.5 6.5 6.1 6.7 8.5 8.5 6.9 7.4 7.4
Std Deviation (1e-4) 0.8 1.0 1.3 1.5 1.6 1.3 1.3 1.3 1.0 1.1 0.9 0.9 1.4 1.4 1.6 1.5 1.7 1.5 1.7 2.0 1.9
Intensity Change (Log2) – – – -0.05 0.01 -0.25 -0.32 -0.27 -0.66 -0.5 -0.53 -0.53 -0.06 -0.08 -0.15 -0.03 0.31 0.32 0.01 0.12 0.12


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.6 -3.5 -4.3 -5.6 -5.5 0 0 0 0 -0.2 -0.1 -2.5 -1.6 1.1 2.2
Bud -1.5 -3.3 -3.6 -3.1 -3.9 0 0 0 0 -2.6 -3.8 -3.6 0.8 0.2 -1.2
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 1.5 0.2 -1.1 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -0.1 0.8 -0.8 -1.2 0.7 -1.3 -2.0 -2.9 -3.3 0.5 1.5 5.0 5.5 3.3 5.6
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome -1.4 2.0 -1.0 0 -1.8 0 0 0 0 -1.9 1.8 0.5 3.6 0.6 0.9
Golgi -0.1 -1.7 -5.9 -6.7 -6.4 0 0 0 0 3.8 3.2 0.9 -1.1 6.4 5.8
Mitochondria 9.8 5.9 11.7 11.3 10.5 0 0 0 0 6.2 1.9 1.7 -7.2 -7.6 -7.7
Nucleus 0 0 3.2 3.1 3.2 2.9 3.0 3.1 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 2.9 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 2.3 2.1 3.5 0 0 0 0 0 0 0 0 0 0
Peroxisomes -5.1 -7.6 -12.2 -12.5 -12.7 0 0 0 0 -6.1 -5.1 -5.8 0.4 -3.7 -5.9
SpindlePole -7.9 -6.3 -8.4 -6.6 -7.0 0 0 0 0 -4.3 -3.4 -5.7 -2.9 -2.5 -2.1
Vacuole -1.7 3.9 2.9 3.7 2.7 -1.2 -0.8 -0.9 -2.7 -0.3 1.3 0.9 3.5 2.9 3.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.3195 8.043 7.3109 6.1239 6.2226 7.7151 7.6608 9.8855 8.8 8.5183 8.7818 9.4067 5.6921 6.2359 6.8434 5.3323 5.8363 6.6298
Actin 0.0489 0.0556 0.0416 0.0407 0.0034 0.0093 0.1158 0.0188 0.0711 0.0137 0.0533 0.0509 0.0741 0.047 0.031 0.0509 0.0468 0.0316
Bud 0.0004 0.0035 0.0003 0.0006 0.0002 0.0001 0.0007 0.0004 0.0015 0.0001 0.0004 0.0002 0.0004 0.0015 0.0004 0.0155 0.0005 0.0044
Bud Neck 0.0006 0.0004 0.0004 0.0002 0.0001 0.0002 0.0008 0.0004 0.001 0.0001 0.0006 0.0003 0.0005 0.0005 0.0007 0.0006 0.0008 0.0011
Bud Periphery 0.0007 0.0021 0.0005 0.0011 0.0003 0.0002 0.0011 0.0005 0.0028 0.0002 0.001 0.0006 0.0007 0.0017 0.0005 0.0213 0.0009 0.0031
Bud Site 0.0015 0.0092 0.0017 0.0013 0.0003 0.0002 0.0032 0.0023 0.0064 0.0002 0.0046 0.0004 0.0024 0.0196 0.0025 0.0049 0.0027 0.0013
Cell Periphery 0.0003 0.0002 0.0002 0.0001 0.0001 0.0001 0.0003 0.0001 0.0001 0 0.0007 0.0002 0.0003 0.0004 0.0002 0.0004 0.0002 0.0002
Cytoplasm 0.0002 0.0002 0.0002 0.0001 0.0002 0.0001 0.0006 0.0052 0.0006 0 0.0015 0.0001 0.0007 0.0006 0.0003 0.0053 0.0003 0.0003
Cytoplasmic Foci 0.0158 0.0172 0.0122 0.0119 0.0127 0.0045 0.0294 0.0265 0.0149 0.0167 0.0149 0.008 0.0265 0.0207 0.0133 0.0214 0.0132 0.0102
Eisosomes 0.0006 0.0004 0.0006 0.0005 0.0002 0.0003 0.0009 0.0008 0.0008 0.0003 0.0016 0.0007 0.0005 0.0004 0.0003 0.0003 0.0006 0.0007
Endoplasmic Reticulum 0.0002 0.0001 0.0002 0.0001 0.0002 0.0002 0.0028 0.0008 0.0002 0 0.0025 0.0001 0.0003 0.0003 0.0002 0.0008 0.0006 0.0002
Endosome 0.0248 0.0257 0.0269 0.0051 0.046 0.0125 0.0298 0.0362 0.012 0.0043 0.0122 0.0149 0.0363 0.0428 0.0211 0.0154 0.0317 0.0191
Golgi 0.0762 0.0843 0.064 0.0146 0.0423 0.0633 0.1 0.0691 0.0553 0.013 0.0662 0.0887 0.0994 0.1209 0.075 0.0312 0.0966 0.0859
Lipid Particles 0.0455 0.0132 0.0298 0.0181 0.0277 0.0117 0.0536 0.0059 0.0371 0.0304 0.016 0.0123 0.0595 0.0101 0.0247 0.0239 0.0129 0.0386
Mitochondria 0.669 0.6849 0.7143 0.7472 0.7767 0.8174 0.545 0.7275 0.7288 0.8324 0.7203 0.7276 0.6073 0.6365 0.7716 0.7086 0.6964 0.7102
None 0.0134 0.0001 0.0001 0.0002 0.0001 0.0001 0.0006 0.0001 0.0002 0 0.0061 0.0001 0.0018 0.0001 0.0001 0.0027 0.0003 0.0001
Nuclear Periphery 0.0002 0.0001 0.0001 0.0002 0.0003 0.0001 0.0068 0.0003 0.0001 0 0.001 0 0.0007 0.0002 0.0001 0.0027 0.0005 0.0005
Nucleolus 0.0002 0.0001 0.0001 0.0001 0.0002 0.0001 0.0014 0.0001 0.0001 0 0.0005 0.0001 0.0054 0.0002 0.0003 0.0003 0.0001 0.0002
Nucleus 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0008 0.0001 0.0001 0 0.0005 0.0001 0.0009 0.0002 0.0001 0.0016 0.0002 0.0002
Peroxisomes 0.096 0.1001 0.1019 0.1563 0.0823 0.0762 0.0894 0.1021 0.064 0.0876 0.0936 0.091 0.068 0.089 0.0541 0.0753 0.0907 0.0889
Punctate Nuclear 0.0003 0.0001 0.0001 0.0001 0.0001 0 0.0017 0.0002 0.0002 0.0004 0.001 0 0.0022 0.0001 0.0003 0.0152 0.0004 0.0003
Vacuole 0.0022 0.001 0.0017 0.0004 0.003 0.0011 0.0094 0.001 0.0009 0.0001 0.0007 0.0019 0.0059 0.0034 0.0015 0.0012 0.0012 0.0008
Vacuole Periphery 0.0028 0.0013 0.0032 0.001 0.0033 0.0024 0.0059 0.0017 0.0019 0.0002 0.0007 0.0018 0.006 0.0038 0.0018 0.0005 0.0026 0.0021

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 14.2458 19.6812 9.4498 15.8238 10.9143 10.3549 16.388 15.8011 15.2589 18.7968
Translational Efficiency 1.2376 0.9744 1.5344 0.8658 1.5903 1.4586 1.071 0.7982 0.9027 0.9159

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1165 1255 1932 1683 1908 2266 691 1179 3073 3521 2623 2862

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 790.21 866.61 910.52 882.57 823.12 981.89 886.48 899.90 810.64 940.80 904.19 889.71
Standard Deviation 100.99 136.29 135.36 122.51 111.87 126.75 113.32 118.29 109.05 141.45 130.35 121.09
Intensity Change Log 2 — 0.133147 0.204455 0.159475 — 0.254459 0.106985 0.128662 — 0.196313 0.155549 0.143836

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.021686 0.023676 0.039936 0.032685 0.021001 0.010278 0.013447 0.037435 0.021261 0.015054 0.032958 0.034642
Bud Neck 0.002735 0.002763 0.005174 0.011557 0.000566 0.000991 0.016798 0.009408 0.001388 0.001622 0.008236 0.010672
Bud Site 0.009127 0.013163 0.057594 0.084847 0.002331 0.002839 0.054798 0.089348 0.004907 0.006519 0.056858 0.086701
Cell Periphery 0.000571 0.000397 0.000269 0.000596 0.000173 0.000189 0.000220 0.000423 0.000324 0.000263 0.000256 0.000524
Cytoplasm 0.002905 0.002957 0.021831 0.039745 0.001246 0.001113 0.036575 0.049418 0.001875 0.001770 0.025715 0.043730
Cytoplasmic Foci 0.068153 0.055079 0.142585 0.112142 0.060191 0.061876 0.173885 0.166197 0.063209 0.059453 0.150831 0.134410
Eisosomes 0.000199 0.000189 0.000174 0.000209 0.000167 0.000129 0.000165 0.000257 0.000179 0.000150 0.000171 0.000229
Endoplasmic Reticulum 0.000431 0.000323 0.002707 0.001959 0.000171 0.000142 0.003649 0.002347 0.000270 0.000207 0.002955 0.002119
Endosome 0.093014 0.082876 0.104457 0.089131 0.067123 0.101294 0.118957 0.082066 0.076939 0.094729 0.108277 0.086221
Golgi 0.099436 0.087703 0.152961* 0.104838 0.098722 0.106355 0.083163 0.123292* 0.098992 0.099707 0.134574* 0.112440*
Lipid Particles 0.021229 0.009737 0.003322 0.003656 0.009464 0.009203 0.013196 0.003221 0.013925 0.009393 0.005923 0.003477
Mitochondria 0.385961* 0.547786* 0.174168* 0.225520* 0.570089* 0.604197* 0.099486 0.130102* 0.500285* 0.584091* 0.154494* 0.186213*
Mitotic Spindle 0.005226 0.007868 0.104455* 0.081965 0.004890 0.005811 0.102401* 0.061771 0.005017 0.006544 0.103914* 0.073646
None 0.000193 0.000174 0.000241 0.000873 0.000100 0.000096 0.001286 0.000459 0.000135 0.000124 0.000516 0.000702
Nuclear Periphery 0.000053 0.000064 0.000417 0.000398 0.000052 0.000050 0.000820 0.000202 0.000052 0.000055 0.000523 0.000317
Nuclear Periphery Foci 0.000273 0.000212 0.001081 0.000648 0.000074 0.000231 0.002233 0.000561 0.000150 0.000225 0.001385 0.000612
Nucleolus 0.000212 0.000349 0.000472 0.000613 0.000014 0.000118 0.004687 0.000359 0.000089 0.000200 0.001582 0.000508
Nucleus 0.000531 0.000578 0.003162 0.005865 0.000018 0.000121 0.023335 0.006359 0.000212 0.000284 0.008477 0.006069
Peroxisomes 0.280936* 0.158096* 0.133445* 0.122349* 0.159770* 0.088851 0.169882* 0.182221* 0.205705* 0.113532* 0.143044* 0.147013*
Vacuole 0.003688 0.003251 0.039122 0.065533 0.001307 0.002998 0.072297 0.047473 0.002209 0.003088 0.047862 0.058093
Vacuole Periphery 0.003441 0.002760 0.012425 0.014872 0.002532 0.003120 0.008721 0.007079 0.002877 0.002992 0.011449 0.011662

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.65 -5.41 -3.09 -2.52 2.22 5.17 3.12 -4.25 -7.99 -6.45 3.60 -4.79 -5.21 -8.53 -0.37
Bud Neck -0.04 -4.06 -8.69 -8.48 -6.18 -2.51 -10.34 -12.12 -11.44 4.30 -0.83 -12.25 -14.58 -14.11 -2.82
Bud Site -1.68 -16.64 -18.98 -17.09 -5.85 -0.83 -12.13 -19.67 -19.55 -5.28 -1.68 -22.82 -28.09 -27.23 -7.93
Cell Periphery 2.06 3.82 -0.18 -1.82 -3.13 -0.89 -2.13 -4.37 -4.10 -3.46 1.79 2.07 -2.72 -3.87 -4.01
Cytoplasm -0.03 -11.86 -16.35 -16.52 -7.29 1.28 -10.90 -15.24 -15.27 -2.26 0.55 -16.63 -22.61 -22.71 -7.94
Cytoplasmic Foci 3.51 -17.62 -10.40 -14.10 6.59 -0.57 -18.20 -21.03 -20.78 0.98 1.62 -26.77 -22.29 -23.82 4.09
Eisosomes 0.59 1.61 -0.48 -1.46 -3.05 4.87 -0.15 -5.94 -8.83 -5.57 3.55 0.84 -4.58 -8.49 -5.92
Endoplasmic Reticulum 1.38 -7.96 -7.76 -8.66 2.44 1.54 -8.42 -6.03 -6.11 2.50 1.98 -11.47 -9.88 -10.27 3.02
Endosome 1.85 -2.04 1.19 -0.81 3.79 -8.36 -6.91 -2.91 4.67 4.79 -5.41 -8.18 -2.11 3.27 6.14
Golgi 2.16 -8.96 -0.24 -2.45 8.84 -1.66 3.76 -3.07 -1.78 -5.83 -0.20 -7.72 -2.11 -1.96 5.29
Lipid Particles 4.10 7.48 7.23 3.74 -0.61 0.17 -2.11 5.40 5.30 6.34 3.23 6.50 8.82 6.26 4.00
Mitochondria -10.54 17.27 12.98 25.68* -5.03 -2.94 43.25* 42.08* 47.69* -3.27 -8.93 41.75* 37.88* 50.35* -4.07
Mitotic Spindle -2.62 -22.69* -17.50 -16.66 3.55 -1.19 -12.94 -13.88 -13.51 4.61 -2.46 -26.18 -22.26 -21.51 6.06
None 0.96 -0.58 -1.54 -1.65 -1.48 0.70 -2.42 -1.89 -1.90 1.53 1.19 -2.82 -2.17 -2.25 -0.61
Nuclear Periphery -0.60 -4.20 -6.75 -6.47 0.15 0.20 -6.65 -4.46 -4.58 4.95 -0.28 -6.83 -8.09 -8.07 2.64
Nuclear Periphery Foci 0.81 -4.39 -3.96 -5.13 2.24 -1.63 -5.50 -6.24 -3.17 4.18 -1.01 -7.47 -7.99 -5.19 4.46
Nucleolus -0.15 -1.07 -1.79 -1.19 -0.98 -2.43 -5.05 -4.94 -3.26 4.68 -0.71 -5.52 -3.93 -2.78 3.93
Nucleus -0.06 -3.96 -6.44 -6.22 -3.08 -2.39 -7.93 -7.38 -7.30 5.02 -0.32 -8.95 -9.83 -9.69 1.19
Peroxisomes 10.45 13.84 15.01 4.42 1.73 9.91 -0.29 -1.82 -10.89 -1.24 14.46 9.53 9.29 -5.37 -0.47
Vacuole 0.52 -16.06 -19.11 -19.56 -7.34 -6.10 -15.09 -15.53 -15.07 3.40 -2.39 -22.58 -24.99 -24.73 -4.33
Vacuole Periphery 1.13 -8.99 -8.77 -9.95 -1.47 -1.67 -5.60 -5.47 -4.84 1.16 -0.36 -11.64 -10.76 -10.97 -0.02
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Peroxisomal matrix protein with naturally active promoter; well-conserved in fungi; localized to peroxisomes under physiological growth conditions; levels of some amino acids are altered upon both knockout and overexpression, suggesting potential involvement of Pxp2p in amino acid metabolism or related cellular metabolic processes (needs further study); GFP-fusion protein displays inherent dual localization with large proportion localizing to cytosol
Localization
Cell Percentages mitochondrion (85%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Pxp2

Pxp2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pxp2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available