Standard name
Human Ortholog
Description JmjC domain family histone demethylase; promotes global demethylation of H3K4 and repression of noncoding intergenic transcription during sporulation; removes methyl groups added by Set1p methyltransferase; negatively regulated by H3K14 acetylation; protein levels regulated by Not4p polyubiquitin-mediated degradation; regulates sporulation timing by extending period of active transcription in opposition to programmed global transcriptional quiescence; regulates rDNA silencing

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.06 0 0.07 0.14 0.09 0.12 0.09 0.11 0.09 0.07 0.11 0.09 0.07 0.18 0.19 0.06 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.05 0.31 0 0.07 0 0.33 0.34 0.17 0.67 0.61 0.72 0.46 0.13 0 0 0 0 0 0 0 0 0
Nucleus 0.89 0.85 0.9 0.78 0.87 0.72 0.74 0.76 0.65 0.63 0.6 0.69 0.85 0.76 0.73 0.88 0.8 0.8 0.75 0.64 0.46 0.41
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.09 0.19 0.1 0.1 0.17 0.22 0.35 0.34
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 4
Bud 0 1 0 1 1 3 6 2 13 9 14 7 1 0 0 0 2 1 2 2 8 10
Bud Neck 0 0 6 5 10 0 10 12 1 5 5 7 0 0 0 0 0 0 0 0 5 5
Bud Site 0 0 0 1 3 5 10 5 18 8 15 8 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 9 6 32 46 26 52 49 58 37 29 41 34 23 71 70 1 2 5 9 4 15 10
Endoplasmic Reticulum 0 2 6 1 0 0 0 0 0 0 0 1 2 0 2 1 1 0 0 3 1 3
Endosome 0 0 1 0 0 0 0 0 0 0 0 1 0 4 3 0 1 2 3 1 3 6
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 3 0
Mitochondria 8 66 9 22 9 150 192 89 271 242 280 172 42 13 10 0 2 4 8 2 9 13
Nucleus 136 179 390 259 254 322 414 407 263 251 233 258 277 302 264 14 134 192 367 132 183 149
Nuclear Periphery 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 3 3
Nucleolus 0 0 0 0 0 0 0 2 1 1 3 0 1 0 0 0 0 0 0 2 7 7
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
SpindlePole 0 0 8 6 2 4 13 13 3 8 5 9 0 1 1 0 2 3 8 2 10 14
Vac/Vac Membrane 7 7 0 13 5 17 12 17 4 10 4 12 11 25 32 3 16 24 81 46 141 122
Unique Cell Count 152 210 433 332 293 449 557 534 405 398 390 376 325 395 361 16 168 241 492 207 399 364
Labelled Cell Count 160 261 453 354 310 553 706 605 611 564 600 509 357 416 382 19 168 241 492 207 399 364


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.0 4.1 5.3 4.9 5.2 4.1 4.3 4.6 3.7 3.7 3.4 4.0 4.8 4.8 4.8 7.0 4.7 4.4 4.9
Std Deviation (1e-4) 1.1 0.6 0.7 1.3 0.9 0.8 0.8 0.9 0.7 0.9 0.7 0.6 1.0 1.2 1.5 0.9 1.5 1.3 1.9
Intensity Change (Log2) -0.11 -0.03 -0.37 -0.31 -0.22 -0.52 -0.54 -0.66 -0.42 -0.14 -0.15 -0.13 0.4 -0.18 -0.26 -0.11

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT3rpd3Δ_20246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin
Bud
Bud Neck
Bud Site
Cell Periphery
Cyto
Endoplasmic Reticulum
Endosome
Golgi
Mitochondria
Nuclear Periphery
Nuc
Nucleolus
Peroxisomes
SpindlePole
Vac
Cortical Patches
Cytoplasm
Nucleus
Vacuole

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.4947 -0.3503 -0.5424 -0.6048 -0.9008 -0.3086 0.9924 0.8386 0.617 1.3307 2.5135 0.6866 0.6932 -0.3967 0.0094 -0.1057 -0.3603 -0.1837
Actin 0.0008 0.0001 0 0.0002 0.0002 0.0001 0.0236 0 0.0067 0.0013 0.0235 0.0007 0.0162 0 0.0124 0.0022 0.0001 0.0064
Bud 0.0001 0 0 0 0 0 0.0008 0.0001 0.0006 0.0003 0.0006 0.0001 0.0006 0 0.0001 0.0002 0 0.0001
Bud Neck 0.0018 0.0003 0.0002 0.0007 0.0004 0.0012 0.0029 0.0004 0.0017 0.0002 0.004 0.0011 0.0024 0.0004 0.0045 0.0007 0.0004 0.0014
Bud Periphery 0.0002 0 0 0 0 0 0.0018 0 0.0013 0.0013 0.0017 0.0003 0.0014 0 0.0002 0.0002 0 0.0004
Bud Site 0.0004 0.0004 0 0.0001 0 0.0001 0.0019 0.0009 0.0037 0.0005 0.0023 0.0003 0.0027 0.0003 0.0013 0.0001 0 0.0002
Cell Periphery 0.0001 0 0 0 0 0 0.0002 0 0.0001 0.0001 0.0045 0 0.0003 0 0.0001 0 0 0
Cytoplasm 0.017 0.0452 0.018 0.024 0.0031 0.0146 0.0154 0.0094 0.0085 0.0141 0.0224 0.0066 0.0168 0.0216 0.0103 0.0445 0.0062 0.0051
Cytoplasmic Foci 0.0053 0.0009 0.0008 0.0009 0.0003 0.0081 0.0028 0.0002 0.0003 0.0008 0.0056 0.0009 0.0166 0.0006 0.0057 0.0022 0.0001 0.0019
Eisosomes 0 0 0 0 0.0001 0 0.0002 0 0 0.0001 0.0004 0 0.0003 0 0.0001 0.0002 0 0.0001
Endoplasmic Reticulum 0.0028 0.0027 0.0007 0.0005 0.0002 0.0007 0.0033 0.0002 0.0005 0.0023 0.0106 0.0002 0.0046 0.0006 0.001 0.0017 0.0001 0.0004
Endosome 0.0068 0.0024 0.0009 0.0008 0.0004 0.0006 0.0114 0.0002 0.0007 0.0186 0.0259 0.0012 0.0279 0.0004 0.0034 0.0103 0.0003 0.0026
Golgi 0.0004 0 0 0 0 0.0001 0.0036 0 0.0004 0.0024 0.0128 0.0006 0.009 0 0.0016 0.0102 0 0.0019
Lipid Particles 0.0013 0.0002 0.0001 0.0002 0.0001 0.0019 0.0052 0 0.0001 0.003 0.0278 0.0047 0.0119 0 0.0061 0.0236 0 0.0038
Mitochondria 0.0017 0.0004 0.0002 0.0004 0.0003 0.0002 0.0107 0.0001 0.0003 0.0497 0.0316 0.0025 0.0084 0.0001 0.0008 0.0045 0.0002 0.0051
None 0.0363 0.0605 0.038 0.0996 0.037 0.0358 0.0137 0.0047 0.0086 0.01 0.0083 0.0123 0.0376 0.0382 0.0366 0.1077 0.0067 0.0136
Nuclear Periphery 0.0285 0.0255 0.0138 0.0201 0.0178 0.0062 0.0175 0.0074 0.0062 0.0194 0.0324 0.0044 0.0293 0.0085 0.0086 0.0149 0.0075 0.0065
Nucleolus 0.0115 0.0068 0.0044 0.0062 0.0085 0.0108 0.009 0.009 0.0056 0.0036 0.0125 0.01 0.0102 0.0056 0.0052 0.0042 0.008 0.0125
Nucleus 0.8572 0.8237 0.9017 0.7964 0.8605 0.8915 0.8601 0.9548 0.9375 0.8526 0.7117 0.9353 0.7666 0.9122 0.8769 0.7527 0.9465 0.9017
Peroxisomes 0.0002 0 0 0.0001 0 0.0019 0.0047 0 0.0001 0.0003 0.0092 0.0013 0.0045 0 0.0033 0.0013 0 0.0052
Punctate Nuclear 0.0244 0.0282 0.0203 0.0491 0.0707 0.0257 0.0085 0.0121 0.0162 0.0104 0.0185 0.0168 0.0259 0.0103 0.0213 0.0169 0.0236 0.0304
Vacuole 0.0023 0.0021 0.0006 0.0004 0.0001 0.0004 0.0018 0.0004 0.0008 0.0038 0.0194 0.0003 0.0044 0.0008 0.0004 0.0009 0.0001 0.0004
Vacuole Periphery 0.0009 0.0005 0.0001 0.0002 0.0001 0.0001 0.0011 0.0001 0.0001 0.0052 0.0144 0.0004 0.0026 0.0001 0.0002 0.0008 0.0001 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 5.2976 6.3143 4.6854 3.7395 3.5978 7.0595 5.8143 6.1557 4.2575 6.4108
Translational Efficiency

Hit Data

Dataset Hit
Protein Concentration
Protein Localization
Gene Expression
Translational Efficiency

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
972 1099 167 1174 2018 1704 594 975 2990 2803 761 2149

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 629.45 729.04 1032.81 834.26 687.60 705.24 767.98 846.60 668.70 714.57 826.10 839.86
Standard Deviation 523.61 99.66 130.49 111.70 79.46 88.09 99.05 125.29 306.80 93.52 152.99 118.22
Intensity Change Log 2 0.211906 0.714411 0.406405 0.036545 0.159499 0.300111 0.123017 0.451320 0.351889

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000074 0.000168 0.001193 0.001206 0.000057 0.000278 0.000069 0.000717 0.000063 0.000235 0.000315 0.000984
Bud Neck 0.001612 0.004412 0.004699 0.017059 0.001388 0.004796 0.000842 0.011572 0.001461 0.004645 0.001689 0.014569
Bud Site 0.000624 0.001053 0.000991 0.018399 0.000288 0.002483 0.000239 0.015557 0.000397 0.001922 0.000404 0.017110
Cell Periphery 0.000285 0.000074 0.000069 0.000137 0.000089 0.000117 0.000277 0.000177 0.000153 0.000100 0.000231 0.000155
Cytoplasm 0.112377 0.035149 0.001954 0.039912 0.039234 0.036538 0.035976 0.033033 0.063011 0.035993 0.028510 0.036791
Cytoplasmic Foci 0.017635 0.005148 0.000173 0.002555 0.004535 0.006986 0.004169 0.001566 0.008794 0.006265 0.003292 0.002106
Eisosomes 0.000030 0.000019 0.000050 0.000030 0.000012 0.000020 0.000053 0.000024 0.000018 0.000020 0.000052 0.000027
Endoplasmic Reticulum 0.000615 0.002273 0.010528 0.006947 0.001102 0.002075 0.000938 0.007257 0.000943 0.002153 0.003042 0.007088
Endosome 0.000588 0.000593 0.000359 0.002503 0.000266 0.000809 0.000189 0.001602 0.000371 0.000725 0.000226 0.002095
Golgi 0.000116 0.000556 0.000069 0.001600 0.000142 0.000357 0.000026 0.000871 0.000133 0.000435 0.000036 0.001269
Lipid Particles 0.002041 0.001161 0.000448 0.001742 0.000747 0.001733 0.000600 0.000466 0.001168 0.001509 0.000566 0.001163
Mitochondria 0.002255 0.002197 0.000828 0.003949 0.000950 0.003165 0.000225 0.002671 0.001374 0.002785 0.000358 0.003369
Mitotic Spindle 0.000568 0.001250 0.000054 0.026469 0.000452 0.001769 0.000226 0.020868 0.000489 0.001565 0.000189 0.023928
None 0.024554 0.006959 0.001144 0.006058 0.006226 0.007347 0.033241 0.006790 0.012184 0.007195 0.026197 0.006390
Nuclear Periphery 0.000605 0.000696 0.000547 0.002094 0.000646 0.000796 0.000321 0.002003 0.000633 0.000757 0.000371 0.002053
Nuclear Periphery Foci 0.000167 0.000264 0.000175 0.001195 0.000140 0.000344 0.000052 0.001057 0.000149 0.000313 0.000079 0.001132
Nucleolus 0.003984 0.003934 0.002274 0.001335 0.002079 0.003923 0.002678 0.002050 0.002698 0.003927 0.002589 0.001660
Nucleus 0.829111 0.929839 0.967909 0.841244 0.940081 0.920779 0.917947 0.873706 0.904006 0.924331 0.928911 0.855972
Peroxisomes 0.001118 0.002222 0.000254 0.001230 0.000723 0.003097 0.000114 0.000548 0.000852 0.002754 0.000145 0.000920
Vacuole 0.001511 0.001805 0.006158 0.021431 0.000776 0.002269 0.001774 0.014310 0.001015 0.002087 0.002736 0.018200
Vacuole Periphery 0.000132 0.000226 0.000123 0.002905 0.000066 0.000320 0.000044 0.003154 0.000088 0.000283 0.000061 0.003018

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.54 -12.87 -6.27 -5.71 1.40 -2.05 -2.13 -11.59 -5.52 -10.79 -2.63 -9.51 -10.02 -7.16 -6.38
Bud Neck -3.32 -4.81 -10.30 -7.72 -6.84 -4.79 1.39 -8.78 -5.63 -9.00 -5.88 -2.53 -13.63 -9.54 -12.81
Bud Site -1.22 -3.81 -6.06 -5.80 -5.71 -2.84 0.00 -4.92 -3.68 -4.92 -3.12 -1.42 -7.86 -6.50 -7.78
Cell Periphery 6.46 6.11 4.76 -4.59 -3.42 -1.81 -4.53 -2.32 -1.14 2.54 3.63 -2.21 0.97 -2.42 2.72
Cytoplasm 11.58 18.92 11.67 -0.62 -14.26 0.67 1.25 1.01 0.41 -0.31 8.34 9.83 8.15 -0.20 -3.14
Cytoplasmic Foci 5.36 9.11 8.39 3.46 -2.61 -2.69 0.77 4.27 6.06 3.68 1.49 6.14 9.04 6.92 3.21
Eisosomes 3.64 -5.52 -4.58 -8.94 2.52 -5.36 -6.44 -11.14 -6.97 1.38 -1.70 -7.19 -12.70 -11.21 1.65
Endoplasmic Reticulum -11.92 -12.35 -20.95 -16.57 2.74 -3.22 -1.12 -18.00 -13.46 -16.92 -6.25 -9.45 -27.24 -20.32 -13.51
Endosome 0.03 0.58 -3.31 -4.11 -4.81 -3.96 1.32 -5.77 -2.68 -6.20 -3.08 1.48 -6.81 -4.58 -8.19
Golgi -1.33 1.41 -1.68 -0.30 -1.81 -1.66 1.59 -1.61 -0.39 -2.34 -2.02 1.96 -2.18 -0.58 -2.73
Lipid Particles 2.11 3.74 1.67 -0.02 -1.29 -3.48 1.23 0.13 3.65 -1.26 -1.55 3.74 0.81 2.02 -1.63
Mitochondria 0.06 1.25 -0.78 -1.14 -5.04 -2.66 2.64 -3.59 0.89 -6.93 -2.10 2.56 -3.07 -0.02 -8.79
Mitotic Spindle -0.93 0.90 -6.76 -6.49 -6.96 -1.79 0.87 -6.10 -5.63 -6.17 -2.04 1.16 -9.14 -8.53 -9.27
None 6.67 9.94 7.82 1.01 -7.96 -1.03 -5.55 0.54 1.34 5.62 4.27 -3.45 6.21 1.79 5.36
Nuclear Periphery -1.48 -2.09 -16.34 -15.68 -14.29 -1.96 3.22 -9.20 -8.49 -9.82 -2.39 2.08 -17.41 -16.24 -17.65
Nuclear Periphery Foci -1.14 -1.33 -4.56 -4.12 -4.16 -1.53 3.17 -4.37 -3.47 -4.61 -1.84 2.01 -6.33 -5.10 -6.58
Nucleolus 0.17 2.08 0.09 -0.07 -2.08 -3.68 -1.51 -1.72 1.55 -0.68 -2.65 0.58 -1.39 0.79 -1.88
Nucleus -10.52 -14.88 -0.29 10.85 15.64 4.06 2.58 10.51 7.28 6.68 -3.63 -3.98 9.86 12.85 11.78
Peroxisomes -1.36 2.38 1.43 2.42 -1.59 -3.24 1.84 0.94 3.97 -1.80 -3.51 2.88 1.36 4.56 -2.70
Vacuole -1.32 -4.78 -11.94 -11.71 -7.71 -2.89 -4.60 -10.85 -9.94 -10.26 -3.31 -6.03 -16.06 -15.19 -14.23
Vacuole Periphery -1.67 -0.49 -2.29 -2.08 -2.27 -3.19 2.49 -1.80 -1.48 -1.83 -3.68 2.20 -2.83 -2.38 -2.87
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Componentsactinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description JmjC domain family histone demethylase; promotes global demethylation of H3K4 and repression of noncoding intergenic transcription during sporulation; removes methyl groups added by Set1p methyltransferase; negatively regulated by H3K14 acetylation; protein levels regulated by Not4p polyubiquitin-mediated degradation; regulates sporulation timing by extending period of active transcription in opposition to programmed global transcriptional quiescence; regulates rDNA silencing
Localization
Cell Percentages nucleus (92%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Jhd2

Jhd2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)

Molecular Function (Gene Ontology)

Cellular Component (Gene Ontology)


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Jhd2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available