Standard name
Human Ortholog
Description Cystathionine gamma-synthase, converts cysteine into cystathionine; STR2 has a paralog, YML082W, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.99 0.97 0.92 0.93 0.87 0.84 0.75 0.67 0.74 0.68 0.71 0.64 0.97 0.98 0.95 0.96 0.92 0.88 0.92 0.85 0.82 0.94 0.92 0.87
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0.07 0.05 0.18 0.1 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0.05 0 0 0 0 0.06 0.07 0.09 0.05 0.06 0 0 0 0 0 0 0 0.09 0.06 0 0 0.06
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0.07 0.11 0.17 0.18 0.22 0.29 0.18 0.23 0.14 0.29 0.05 0.09 0.07 0.06 0.14 0.11 0 0 0.06 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 4 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud 0 0 0 0 2 2 3 1 1 1 1 0 0 0 0 0 0 0 0 4 2 0 1 3
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 2 0 1 3 3 1 1 3 4 2 3 1 1 0 1 0 2 0 0 0 0 0 0
Cytoplasm 179 365 167 169 228 215 209 244 111 156 135 161 254 237 270 190 175 182 166 322 155 156 281 261
Endoplasmic Reticulum 2 2 4 1 1 2 3 6 3 6 3 0 3 0 2 7 1 6 0 0 4 0 2 1
Endosome 0 0 0 0 1 0 0 2 0 0 0 3 0 0 0 0 0 0 0 1 0 0 1 0
Golgi 0 1 0 1 1 0 2 1 0 0 0 0 0 0 2 0 0 2 0 3 0 0 0 0
Mitochondria 0 2 0 1 0 2 5 5 10 11 35 26 0 0 0 1 3 4 2 0 0 0 0 2
Nucleus 1 3 9 6 5 6 11 21 11 20 9 15 2 2 1 3 0 4 5 35 11 6 11 18
Nuclear Periphery 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 4 10 12 20 45 45 61 104 27 54 26 73 12 22 20 11 27 22 2 7 11 2 4 7
Unique Cell Count 181 375 181 182 261 256 280 362 149 230 190 251 261 242 283 198 190 207 182 378 189 166 308 300
Labelled Cell Count 186 385 192 199 286 275 297 389 167 254 211 281 272 262 295 213 206 224 182 378 189 166 308 300


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 16.8 17.4 17.5 16.3 15.7 12.9 11.9 11.4 9.5 10.1 8.4 9.1 16.6 16.3 16.1 22.9 21.3 20.3 17.1 17.0 17.3
Std Deviation (1e-4) 3.5 3.6 3.6 2.9 2.6 2.5 2.3 2.0 2.1 2.2 2.1 2.6 3.2 2.9 2.8 6.0 5.5 6.6 3.1 3.4 3.4
Intensity Change (Log2) – – – -0.1 -0.15 -0.43 -0.55 -0.62 -0.88 -0.79 -1.05 -0.94 -0.08 -0.1 -0.12 0.39 0.28 0.22 -0.03 -0.04 -0.01


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.2 -1.6 -2.6 -4.8 -6.4 -4.4 -6.0 -5.2 -6.7 2.5 2.8 1.4 1.5 -0.1 -1.4
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0.8 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 6.1 4.5 0 0 0 0 0 0
Nucleus -0.8 -1.8 -1.5 -0.5 0.4 0.9 1.5 -0.1 0.4 0 0 0 -1.9 0 -1.7
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 1.5 3.3 3.3 4.4 5.9 3.2 4.6 2.2 5.8 -0.9 0.9 0.2 -0.4 2.4 1.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.1021 12.236 10.1413 6.4773 7.1919 10.5139 7.2033 10.0009 9.1395 8.3561 7.3795 8.923 8.9311 12.0677 10.7868 10.7919 10.2386 10.3022
Actin 0.0697 0.0009 0.0088 0.0231 0.0372 0.0016 0.0122 0.0014 0.0062 0.0033 0.0006 0.0013 0.0335 0.0026 0.0011 0.0101 0.0081 0.0005
Bud 0.0008 0.0012 0.0007 0.0012 0.0011 0.0004 0.0006 0.0003 0.0006 0.0002 0.0004 0.0002 0.0009 0.0018 0.0005 0.0007 0.0016 0.0011
Bud Neck 0.0028 0.0007 0.0037 0.0018 0.0017 0.0015 0.0009 0.0003 0.0011 0.0007 0.0008 0.0013 0.0016 0.0002 0.0009 0.0005 0.0017 0.0015
Bud Periphery 0.0012 0.0012 0.0004 0.0008 0.0006 0.0007 0.0004 0.0001 0.0003 0.0001 0.0002 0.0001 0.0008 0.0007 0.0001 0.0013 0.0011 0.0004
Bud Site 0.0062 0.0023 0.0049 0.0021 0.0016 0.0001 0.0021 0.0006 0.0017 0.0005 0.0004 0.0001 0.005 0.0011 0.0012 0.0008 0.0006 0.0001
Cell Periphery 0.0004 0.0001 0.0002 0.0002 0.0001 0 0.0001 0 0.0001 0.0001 0.0001 0 0.0001 0.0001 0.0001 0.0001 0.0001 0
Cytoplasm 0.6388 0.908 0.8008 0.8217 0.7281 0.7571 0.7732 0.9161 0.8236 0.6939 0.7014 0.8309 0.7534 0.9269 0.8591 0.6969 0.6414 0.8056
Cytoplasmic Foci 0.0207 0.0038 0.0206 0.0109 0.019 0.0025 0.0257 0.0049 0.0142 0.0341 0.0139 0.0043 0.0194 0.0012 0.0038 0.0123 0.0158 0.0062
Eisosomes 0.0005 0 0.0002 0.0002 0.0002 0 0.0001 0 0 0 0 0 0.0002 0.0001 0 0.0002 0 0
Endoplasmic Reticulum 0.0085 0.0016 0.0023 0.0042 0.003 0.0039 0.0048 0.0026 0.0024 0.0054 0.0042 0.0026 0.0077 0.0009 0.0017 0.0056 0.003 0.0021
Endosome 0.0516 0.0023 0.0102 0.015 0.0247 0.0107 0.0343 0.0013 0.0123 0.0655 0.0547 0.0071 0.0233 0.0004 0.0082 0.03 0.0433 0.0037
Golgi 0.0189 0.0007 0.0081 0.0021 0.0434 0.0013 0.0061 0.0003 0.0087 0.0326 0.0016 0.0039 0.005 0.0001 0.0004 0.0095 0.0239 0.0003
Lipid Particles 0.0123 0.0034 0.0037 0.0021 0.0105 0.0016 0.0091 0 0.0022 0.0063 0.0157 0.0066 0.0081 0.0001 0.0003 0.0053 0.0135 0.0002
Mitochondria 0.0312 0.0018 0.0098 0.0117 0.0241 0.0074 0.0028 0.0005 0.0038 0.0042 0.002 0.0021 0.0056 0.0024 0.0009 0.0417 0.0046 0.0006
None 0.0058 0.0083 0.002 0.0038 0.0018 0.0011 0.0061 0.0016 0.0018 0.0039 0.0208 0.0024 0.0063 0.0011 0.0017 0.0031 0.0015 0.0018
Nuclear Periphery 0.0274 0.0056 0.0096 0.0088 0.0093 0.0235 0.0144 0.0034 0.0052 0.0047 0.0131 0.0073 0.0231 0.004 0.0072 0.011 0.0207 0.0099
Nucleolus 0.0005 0.0001 0.0019 0.0004 0.0002 0.0003 0.0005 0 0.0001 0.0001 0.0009 0.0004 0.0006 0.0001 0.0004 0.0004 0.0002 0.0001
Nucleus 0.0809 0.0544 0.1007 0.0785 0.0816 0.1792 0.0842 0.0598 0.1037 0.1379 0.1438 0.1222 0.0842 0.0548 0.1077 0.1547 0.2087 0.1613
Peroxisomes 0.0084 0.001 0.0033 0.0021 0.0054 0.0002 0.0085 0.0053 0.0077 0.0023 0.002 0.001 0.0065 0.0001 0.0002 0.0039 0.0033 0.0002
Punctate Nuclear 0.0023 0.0011 0.0058 0.0044 0.0043 0.0035 0.0064 0.0008 0.0021 0.0013 0.0086 0.005 0.0093 0.001 0.0032 0.0082 0.0041 0.0033
Vacuole 0.0065 0.0013 0.0018 0.004 0.0015 0.0023 0.0058 0.0005 0.0015 0.0021 0.0127 0.0008 0.0036 0.0004 0.0012 0.0016 0.0015 0.001
Vacuole Periphery 0.0045 0.0002 0.0006 0.0008 0.0007 0.0013 0.0018 0.0001 0.0007 0.0008 0.0023 0.0003 0.0016 0.0001 0.0003 0.002 0.0013 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 8.0457 7.7061 8.768 9.784 10.059 13.7849 18.3102 16.4776 16.0128 15.0017
Translational Efficiency 0.8939 1.0586 0.802 0.825 0.5765 0.6209 0.5689 0.5463 0.5501 0.5641

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
82 1411 1424 118 905 2057 163 96 987 3468 1587 214

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 947.49 1616.97 1391.80 1090.16 1275.66 1466.89 1126.27 1054.93 1248.40 1527.95 1364.53 1074.36
Standard Deviation 163.56 322.26 214.32 151.41 231.96 283.07 117.14 130.23 244.46 308.57 221.64 143.38
Intensity Change Log 2 — 0.771110 0.554769 0.202357 — 0.201517 -0.179691 -0.274097 — 0.472132 0.179713 -0.051567

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001667 0.000229 0.000413 0.005704 0.000600 0.000153 0.000597 0.009637 0.000688 0.000184 0.000432 0.007469
Bud Neck 0.002809 0.000592 0.002026 0.002467 0.000659 0.001104 0.001706 0.001956 0.000838 0.000896 0.001993 0.002238
Bud Site 0.013680 0.001613 0.005249 0.034513 0.002318 0.001996 0.004128 0.052179 0.003262 0.001840 0.005134 0.042438
Cell Periphery 0.000436 0.000073 0.000095 0.000211 0.000141 0.000032 0.000190 0.000123 0.000165 0.000049 0.000104 0.000172
Cytoplasm 0.672443* 0.615449* 0.572186* 0.475906* 0.685634* 0.661981* 0.341179* 0.421286* 0.684538* 0.643049* 0.548460* 0.451403*
Cytoplasmic Foci 0.071977 0.004389 0.005479 0.024127 0.008345 0.004309 0.015770 0.016955 0.013631 0.004342 0.006536 0.020909
Eisosomes 0.000052 0.000003 0.000006 0.000079 0.000006 0.000002 0.000096 0.000050 0.000010 0.000003 0.000015 0.000066
Endoplasmic Reticulum 0.007010 0.000420 0.001038 0.003273 0.001739 0.000224 0.005691 0.002173 0.002177 0.000304 0.001516 0.002780
Endosome 0.003176 0.000252 0.000761 0.039272 0.000722 0.000575 0.008337 0.010584 0.000926 0.000443 0.001539 0.026403
Golgi 0.000929 0.000270 0.000160 0.079538 0.000516 0.000682 0.000148 0.001606 0.000550 0.000514 0.000159 0.044578
Lipid Particles 0.001876 0.000211 0.000484 0.001274 0.000487 0.000369 0.003611 0.001266 0.000602 0.000305 0.000805 0.001270
Mitochondria 0.000849 0.000268 0.000404 0.000381 0.000831 0.000827 0.000265 0.002878 0.000832 0.000599 0.000389 0.001502
Mitotic Spindle 0.005718 0.002589 0.008909 0.032572 0.000808 0.009712 0.000926 0.100921* 0.001216 0.006814 0.008089 0.063234
None 0.002356 0.013609 0.009771 0.003942 0.005420 0.014995 0.002022 0.005395 0.005166 0.014431 0.008975 0.004594
Nuclear Periphery 0.000262 0.000186 0.000610 0.001099 0.000182 0.000180 0.001665 0.001302 0.000189 0.000183 0.000718 0.001190
Nuclear Periphery Foci 0.010679 0.002349 0.001917 0.003745 0.005523 0.000701 0.005517 0.003338 0.005952 0.001372 0.002287 0.003562
Nucleolus 0.005269 0.000392 0.000186 0.000102 0.000628 0.000348 0.000395 0.000097 0.001013 0.000366 0.000207 0.000100
Nucleus 0.140149* 0.349520* 0.363155* 0.121234 0.266147* 0.293881* 0.251253* 0.058864 0.255679* 0.316519* 0.351661* 0.093255
Peroxisomes 0.000761 0.000188 0.000163 0.000191 0.000079 0.000377 0.000408 0.033666 0.000136 0.000300 0.000188 0.015208
Vacuole 0.056964 0.006981 0.026872 0.169216 0.017897 0.007011 0.355649* 0.228704* 0.021143 0.006999 0.060640 0.195902
Vacuole Periphery 0.000938 0.000418 0.000118 0.001151 0.001319 0.000541 0.000447 0.047021 0.001287 0.000491 0.000152 0.021728

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.28 1.83 0.99 -1.13 -0.62 3.94 -0.25 -1.21 -1.68 -1.17 4.29 1.14 -1.09 -2.06 -1.39
Bud Neck 3.32 -0.29 -1.49 -6.40 -1.69 -2.02 -6.64 -2.64 -1.94 -0.25 -0.92 -7.48 -5.71 -5.24 -0.87
Bud Site 4.24 2.63 0.30 -3.21 -1.88 0.93 -3.91 -2.38 -2.48 -1.85 2.78 -2.73 -3.37 -3.87 -2.51
Cell Periphery 3.20 2.86 2.89 -1.53 0.36 7.97 -1.09 2.07 -6.40 3.41 6.84 1.85 2.68 -5.35 1.49
Cytoplasm 1.89 4.60 9.02 12.08 8.44 4.07 21.43 11.17 10.15 -2.46 6.16 19.26 17.78 16.06 8.48
Cytoplasmic Foci 6.21 6.10 5.54 -3.02 -2.48 5.22 -1.53 -1.54 -3.75 -0.57 7.34 5.55 1.17 -4.85 -3.33
Eisosomes 3.61 3.12 -0.34 -9.58 -8.38 5.44 -13.79 -8.07 -8.69 4.13 5.46 -4.86 -10.72 -12.98 -9.04
Endoplasmic Reticulum 4.02 3.43 2.44 -5.86 -3.32 6.69 -7.07 -2.63 -6.43 4.50 7.42 0.97 -1.94 -8.77 -3.00
Endosome 5.96 4.33 -1.02 -2.22 -1.90 1.44 -8.23 -3.35 -3.68 2.07 3.58 -3.41 -2.70 -3.09 -2.29
Golgi 1.99 2.27 -1.17 -1.27 -1.29 -0.18 2.21 0.81 0.88 -1.36 0.56 2.44 -1.20 -1.23 -1.30
Lipid Particles 4.10 2.50 0.61 -9.13 -4.56 1.06 -7.31 -5.51 -5.08 4.09 2.42 -4.26 -7.11 -8.49 -3.45
Mitochondria 1.32 0.76 1.13 -0.87 2.44 0.13 1.09 0.28 0.12 -1.45 0.56 0.74 0.73 0.15 0.05
Mitotic Spindle 0.55 -1.19 -1.59 -2.03 -1.13 -5.28 -1.53 -1.73 -0.90 -1.34 -5.12 -5.82 -2.78 -1.97 -1.42
None -11.93 -10.16 -2.96 5.09 2.14 -17.73* 6.07 0.54 8.09 -1.86 -17.93 -5.96 -0.37 9.52 2.82
Nuclear Periphery 0.79 -15.13 -10.62 -10.99 -5.70 -3.15 -13.26 -7.68 -7.40 2.13 -2.20 -23.10 -13.26 -13.00 -5.26
Nuclear Periphery Foci 1.34 1.38 1.23 -1.03 -1.54 6.77 0.00 2.80 -5.62 3.20 5.57 4.05 3.25 -4.83 -1.41
Nucleolus 1.40 1.44 1.44 0.50 -0.62 0.33 0.59 0.98 1.54 2.62 1.13 1.52 1.56 1.41 0.81
Nucleus -11.02 -11.88 -1.31 10.71 11.66 -4.99 0.31 3.71 5.59 2.65 -9.59 -12.00 5.50 10.98 12.78
Peroxisomes 2.92 3.72 3.78 0.07 0.04 -1.32 -3.91 -1.09 -1.04 -1.04 -0.96 -0.86 -1.08 -1.02 -1.07
Vacuole 4.14 0.55 -11.23 -14.62 -12.75 3.51 -16.40 -12.07 -12.42 0.88 5.56 -13.36 -18.31 -19.14 -14.63
Vacuole Periphery 1.27 2.15 1.80 0.40 -1.19 0.97 1.21 -0.83 -0.96 -0.98 1.07 1.43 -0.64 -0.93 -1.02
Standard name
Human Ortholog
Description Cystathionine gamma-synthase, converts cysteine into cystathionine; STR2 has a paralog, YML082W, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (98%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Str2

Str2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Str2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available