Standard name
Human Ortholog
Description Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0.11 0.06 0.08 0.09 0.13 0.07 0.1 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0.11 0.05 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0.07 0 0 0.06 0.07 0.05 0.05 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.09 0.15 0.17 0.18 0.14 0.14 0.18 0.21 0.17 0.15 0.18 0.1 0.27 0.35 0.4 0.34 0.42 0.42 0.06 0.08 0.07 0.17 0.16 0.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0.06 0 0 0 0 0 0
Endosome 0.65 0.43 0.16 0.29 0.12 0 0.16 0.09 0.11 0.12 0.15 0.22 0.56 0.54 0.52 0.31 0.3 0.24 0.1 0.16 0.07 0.12 0.11 0.14
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.06 0 0 0 0.21 0.05 0.11 0.19 0.24 0.29 0.21 0 0 0 0.05 0 0.08 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.11 0.08 0 0 0 0.12 0.08 0.06 0.08 0.09 0.08 0.07 0 0 0 0.06 0.07 0.09 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0.48 0.47 0.72 0.61 0.72 0.59 0.68 0.6 0.57 0.58 0.43 0.58 0.37 0.27 0.28 0.38 0.29 0.31 0.75 0.65 0.76 0.59 0.58 0.45
Vac/Vac Membrane 0.1 0.07 0 0 0 0 0 0 0 0 0 0 0.1 0.08 0.06 0.06 0.1 0.1 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 4 6 2 3 7 7 3 1 4 2 3 1 0 0 1 0 1 1 2 2 2 6 14
Bud 4 9 10 4 9 26 20 32 25 31 14 27 0 2 1 1 1 8 8 3 4 5 16 19
Bud Neck 3 4 8 9 9 24 17 23 12 9 6 6 2 0 0 0 1 3 1 1 0 3 8 19
Bud Site 0 4 1 4 2 15 7 14 17 16 10 13 0 1 0 3 0 2 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1 2 1 2 0 1 0 0 0 0
Cytoplasm 32 61 57 38 30 32 61 80 47 37 35 27 107 192 232 150 157 158 22 42 28 56 83 111
Endoplasmic Reticulum 0 1 0 0 0 0 0 0 0 0 1 0 4 1 1 23 22 22 2 1 1 0 1 4
Endosome 228 180 54 60 24 8 54 34 30 29 29 58 224 295 304 138 111 90 39 82 28 39 57 78
Golgi 2 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1 1 1 2 1 2 4
Mitochondria 14 23 0 4 3 49 19 42 52 57 56 56 2 1 1 23 14 31 4 14 8 7 11 12
Nucleus 1 5 0 2 5 7 7 8 9 8 8 5 1 1 2 14 17 13 2 3 1 1 3 5
Nuclear Periphery 0 2 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0 1 1 1
Nucleolus 38 34 5 6 6 27 29 24 22 22 16 19 11 12 12 29 28 35 3 5 5 1 2 4
Peroxisomes 13 2 2 0 0 0 5 4 4 8 3 8 3 5 12 3 4 4 0 1 1 1 1 1
SpindlePole 168 198 240 126 150 134 234 232 158 141 85 153 149 148 165 168 108 116 288 344 301 199 300 244
Vac/Vac Membrane 36 29 12 4 8 2 9 5 5 8 7 9 39 43 34 27 36 37 3 9 4 6 6 10
Unique Cell Count 351 417 334 206 207 228 346 387 275 242 196 264 403 546 586 447 374 376 386 526 399 338 518 546
Labelled Cell Count 540 557 395 259 249 331 469 502 382 370 272 384 545 701 765 582 500 523 386 526 399 338 518 546


Nucleus, SpindlePole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.2 5.3 5.8 5.8 6.4 4.1 5.3 5.2 4.8 5.0 4.9 5.0 5.8 5.9 6.1 7.5 7.4 6.3 5.2 5.2 5.4
Std Deviation (1e-4) 0.7 0.8 0.8 1.5 2.2 1.3 1.6 1.5 2.0 1.5 1.8 1.1 1.0 1.4 1.5 1.7 1.8 1.4 1.2 1.2 1.6
Intensity Change (Log2) – – – -0.01 0.14 -0.5 -0.15 -0.16 -0.28 -0.23 -0.26 -0.22 -0.01 0.02 0.07 0.36 0.33 0.12 -0.17 -0.15 -0.1

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0.2 0 0 0 0 0 0 0 0 0 0 0
Bud -0.7 0.8 0 1.8 3.0 0 4.5 0 3.6 0 0 0 0 -2.9 -0.7
Bud Neck 1.3 1.3 0 1.7 2.3 0 0.9 0 -0.1 0 0 0 0 0 -1.7
Bud Site 0 0 0 0 3.1 0 4.4 0 3.7 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.4 -0.8 -1.0 0.2 1.2 0 -0.6 0.2 -2.4 3.1 5.8 7.1 5.2 7.2 7.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 4.2 4.5 4.5
Endosome 3.6 -1.5 0 -0.2 -3.0 0 -1.4 0 1.8 11.0 11.1 10.7 4.7 4.2 2.6
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 4.3 6.2 0 9.3 0 8.8 0 0 0 4.2 3.6 5.4
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 3.3 3.9 3.4
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 4.1 3.2 0 4.3 0 3.5 1.1 0.7 0.6 3.4 3.8 4.5
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 1.7 0 0 0
SpindlePole -2.6 0.2 0 -1.2 -3.4 0 -3.4 0 -3.6 -9.4 -13.0 -12.8 -9.5 -11.4 -10.9
Vacuole -1.1 0.2 -2.0 -0.7 -2.0 -1.3 -0.2 0 -0.1 3.2 2.5 1.5 1.6 3.2 3.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.1444 0.4913 0.1894 -0.1713 -0.126 0.0379 2.2964 1.8828 1.9128 1.7897 1.6187 1.7021 3.3785 4.6843 4.0348 4.202 3.5801 4.0409
Actin 0.0278 0.001 0.0163 0.0016 0.0091 0.0028 0.0112 0.0012 0.0016 0.0059 0.0013 0.0009 0.0011 0.0007 0.0005 0.0014 0.0001 0.001
Bud 0.0003 0.0002 0.0004 0.0001 0.0002 0.001 0.0006 0.0021 0.0017 0.0014 0.0003 0.0005 0.0004 0.0016 0 0 0 0.0001
Bud Neck 0.0027 0.0016 0.0014 0.0068 0.0026 0.0028 0.0065 0.0025 0.0036 0.0575 0.0026 0.0023 0.0008 0.0008 0.001 0.0022 0.0301 0.0016
Bud Periphery 0.0005 0.0001 0.0003 0 0.0002 0.0004 0.0014 0.0007 0.0009 0.0017 0.0007 0.0003 0.0001 0.0004 0 0.0001 0 0
Bud Site 0.0039 0.0069 0.0037 0.0003 0.0005 0.0004 0.0094 0.0156 0.0035 0.0037 0.003 0.0005 0.0035 0.0052 0.0006 0.0002 0.0004 0.0002
Cell Periphery 0.0001 0.0001 0.0001 0 0.0002 0.0001 0.0004 0.0001 0.0001 0.0002 0.0002 0 0.0001 0.0001 0 0 0 0
Cytoplasm 0.0482 0.1771 0.0291 0.0571 0.0388 0.0376 0.0685 0.2633 0.085 0.0701 0.0273 0.0514 0.0257 0.1414 0.0403 0.0242 0.0149 0.0337
Cytoplasmic Foci 0.1556 0.1338 0.0905 0.2175 0.2941 0.1131 0.0904 0.0852 0.09 0.1625 0.2053 0.0806 0.2583 0.1712 0.1604 0.2142 0.3516 0.1678
Eisosomes 0.0005 0.0001 0.0002 0 0.0006 0 0.0007 0 0 0.0001 0.0001 0 0 0 0 0.0001 0 0
Endoplasmic Reticulum 0.0036 0.0045 0.0014 0.0007 0.0008 0.0013 0.0048 0.0034 0.0015 0.0039 0.0007 0.0009 0.0008 0.0032 0.0014 0.0006 0.0002 0.0008
Endosome 0.0536 0.0202 0.0172 0.018 0.0374 0.0166 0.047 0.0248 0.0247 0.0363 0.0495 0.0196 0.0168 0.0231 0.0141 0.0049 0.0081 0.0128
Golgi 0.0124 0.0015 0.0035 0.0057 0.0042 0.0019 0.0079 0.0021 0.0055 0.0065 0.0061 0.0021 0.0021 0.0017 0.0015 0.0019 0.002 0.0014
Lipid Particles 0.0514 0.0056 0.0118 0.032 0.0638 0.0207 0.0394 0.0032 0.0069 0.0149 0.0303 0.0085 0.0098 0.0048 0.0136 0.007 0.0073 0.01
Mitochondria 0.012 0.0006 0.0159 0.0022 0.0022 0.0009 0.0241 0.0013 0.0033 0.0305 0.0201 0.0022 0.0002 0.0006 0.0001 0.0002 0 0.0002
None 0.0647 0.2088 0.0394 0.1101 0.0569 0.0599 0.0317 0.1171 0.0525 0.0532 0.0655 0.0475 0.0235 0.1224 0.0529 0.0882 0.0322 0.0482
Nuclear Periphery 0.0198 0.0116 0.0094 0.004 0.0028 0.009 0.0427 0.0085 0.0078 0.0106 0.0027 0.0052 0.0023 0.0064 0.0031 0.0016 0.0007 0.0035
Nucleolus 0.006 0.0046 0.0074 0.0039 0.0294 0.0066 0.0095 0.0066 0.006 0.0041 0.0232 0.0054 0.0019 0.0025 0.0023 0.0013 0.0003 0.0016
Nucleus 0.033 0.0599 0.0449 0.02 0.0089 0.0348 0.0672 0.1246 0.1008 0.0689 0.0079 0.055 0.0085 0.053 0.0262 0.0042 0.0011 0.0299
Peroxisomes 0.0261 0.0052 0.0128 0.0373 0.0383 0.0113 0.0408 0.0076 0.021 0.0511 0.0172 0.0097 0.0073 0.004 0.0049 0.0137 0.0141 0.0084
Punctate Nuclear 0.4747 0.3542 0.6895 0.4821 0.407 0.677 0.4859 0.3247 0.5804 0.412 0.5172 0.7059 0.6362 0.4545 0.6763 0.6338 0.5365 0.6785
Vacuole 0.0019 0.002 0.0042 0.0004 0.0013 0.0012 0.0059 0.0047 0.0023 0.0036 0.0153 0.0013 0.0005 0.0021 0.0006 0.0002 0.0001 0.0003
Vacuole Periphery 0.0013 0.0004 0.0004 0.0002 0.0007 0.0005 0.0041 0.0006 0.0008 0.0013 0.0033 0.0003 0.0001 0.0003 0.0001 0 0 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 9.195 4.1099 9.1492 6.9529 3.9739 9.1899 7.2722 8.4141 10.0042 9.2882
Translational Efficiency 0.3895 1.2454 0.5263 0.496 0.9156 0.5785 0.6888 0.8242 0.5408 0.5565

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2595 1061 1593 1905 1669 2204 2345 1704 4264 3265 3938 3609

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 736.44 749.26 889.89 839.00 675.40 800.82 852.91 834.19 712.55 784.06 867.87 836.73
Standard Deviation 85.81 129.99 106.00 120.43 78.15 98.88 106.69 128.17 88.09 112.58 107.94 124.17
Intensity Change Log 2 — 0.024898 0.273059 0.188103 — 0.245736 0.336651 0.304634 — 0.134766 0.303830 0.245025

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000149 0.000466 0.000665 0.002196 0.000222 0.000384 0.000258 0.000498 0.000178 0.000411 0.000423 0.001394
Bud Neck 0.014429 0.008840 0.007868 0.011403 0.010142 0.016017 0.004570 0.009065 0.012751 0.013685 0.005904 0.010299
Bud Site 0.005715 0.009309 0.025898 0.053804 0.004707 0.018678 0.006747 0.049354 0.005321 0.015633 0.014494 0.051703
Cell Periphery 0.000129 0.000142 0.000137 0.000379 0.000137 0.000111 0.000140 0.000203 0.000132 0.000121 0.000139 0.000296
Cytoplasm 0.191785 0.151961 0.210038 0.265554 0.220238 0.227274 0.262831 0.485370 0.202922 0.202800 0.241475 0.369341
Cytoplasmic Foci 0.365503 0.267218 0.016259 0.032261 0.346342 0.256359 0.019634 0.041883 0.358004 0.259888 0.018269 0.036804
Eisosomes 0.000088 0.000093 0.000051 0.000028 0.000099 0.000057 0.000042 0.000051 0.000092 0.000068 0.000045 0.000039
Endoplasmic Reticulum 0.000942 0.001731 0.002917 0.000891 0.001018 0.001031 0.001152 0.001314 0.000972 0.001258 0.001866 0.001091
Endosome 0.023920 0.030915 0.005863 0.017193 0.018882 0.035282 0.004494 0.011752 0.021948 0.033863 0.005048 0.014624
Golgi 0.007986 0.013146 0.000576 0.009860 0.007489 0.009114 0.002640 0.003959 0.007791 0.010424 0.001805 0.007074
Lipid Particles 0.068653 0.026120 0.002043 0.001579 0.028640 0.018582 0.001695 0.001512 0.052991 0.021032 0.001836 0.001547
Mitochondria 0.007715 0.007696 0.001393 0.008637 0.004783 0.011899 0.001232 0.002957 0.006567 0.010533 0.001297 0.005955
Mitotic Spindle 0.149233 0.306176 0.417745 0.443450 0.131029 0.262627 0.385500 0.157836 0.142107 0.276779 0.398544 0.308596
None 0.013675 0.030359 0.014023 0.009361 0.020056 0.010159 0.014603 0.010776 0.016172 0.016723 0.014368 0.010029
Nuclear Periphery 0.001369 0.000721 0.001786 0.001310 0.001044 0.000921 0.001267 0.001908 0.001242 0.000856 0.001477 0.001592
Nuclear Periphery Foci 0.014921 0.017598 0.012240 0.003463 0.020536 0.007905 0.005990 0.001781 0.017119 0.011055 0.008518 0.002668
Nucleolus 0.042414 0.023153 0.015765 0.002435 0.043205 0.021499 0.015105 0.004171 0.042724 0.022036 0.015372 0.003255
Nucleus 0.061184 0.058189 0.229946 0.075384 0.103394 0.059766 0.250129 0.135787 0.077706 0.059254 0.241964 0.103903
Peroxisomes 0.023674 0.029698 0.003393 0.005399 0.031181 0.029223 0.001638 0.005286 0.026612 0.029377 0.002348 0.005346
Vacuole 0.005942 0.014848 0.031038 0.048486 0.006430 0.012000 0.019283 0.071025 0.006133 0.012926 0.024038 0.059128
Vacuole Periphery 0.000574 0.001619 0.000356 0.006927 0.000426 0.001112 0.001049 0.003513 0.000516 0.001277 0.000769 0.005315

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -8.44 -16.12 -4.10 -2.49 0.28 -2.05 -11.29 -9.85 -8.32 -0.54 -8.99 -20.31 -5.66 -4.17 -0.33
Bud Neck 0.87 -8.54 -7.66 -7.42 1.02 -6.14 -8.19 -8.81 -2.61 -2.64 -4.67 -11.25 -11.36 -5.63 -1.47
Bud Site -5.44 -10.35 -13.01 -9.81 -5.31 -5.42 -11.86 -11.71 -8.56 -7.65 -7.21 -15.67 -17.39 -12.33 -9.57
Cell Periphery -4.53 -6.43 -3.87 -2.07 -1.75 3.36 -1.44 -4.86 -7.21 -4.03 -0.51 -5.94 -5.47 -5.19 -3.27
Cytoplasm -1.81 0.27 -14.35 -10.33 -14.07 -5.14 -1.23 -24.38 -20.10 -24.23 -6.35 -1.48 -27.62 -20.19 -26.35
Cytoplasmic Foci 12.85 63.04 58.22 28.56 -7.82 4.50 44.04 37.30 35.97 -8.29 12.45 75.29 67.51 47.89 -10.05
Eisosomes -2.37 -3.69 3.81 4.58 5.87 12.10 6.11 1.67 -8.29 -3.68 6.85 0.93 3.14 -2.95 1.79
Endoplasmic Reticulum -3.28 -17.10 -9.72 -2.89 11.41 0.14 -11.97 -6.59 -5.36 3.85 -2.10 -20.33 -11.50 -6.70 10.80
Endosome -4.71 12.22 9.99 11.50 -0.89 -5.53 12.02 7.31 11.50 -4.06 -6.96 17.61 12.37 15.96 -3.48
Golgi -4.30 13.70 5.45 7.65 -2.09 1.94 11.51 9.62 6.67 -0.74 -1.29 16.23 9.67 9.22 -1.96
Lipid Particles 11.04 22.22 22.30 12.62 0.60 5.64 17.23 16.71 12.01 -2.03 13.85 26.80 26.63 17.19 -1.20
Mitochondria -0.72 9.04 1.90 1.96 -2.14 -3.27 9.04 4.23 5.15 -1.64 -2.93 12.65 3.76 4.88 -2.75
Mitotic Spindle -13.43 -26.28 -26.92 -8.27 0.84 -8.75 -28.15 -5.18 2.79 21.11 -16.23 -40.12 -23.04 -6.65 14.15
None -2.96 0.81 5.04 4.64 3.86 6.26 5.70 6.47 0.30 1.78 1.16 4.62 7.95 4.24 4.14
Nuclear Periphery 6.52 -16.29 -12.83 -15.34 0.56 -0.79 -14.35 -5.94 -5.72 0.38 4.26 -20.81 -12.30 -13.69 -0.10
Nuclear Periphery Foci 0.64 2.31 11.56 7.82 8.04 9.05 4.03 12.49 5.24 10.22 8.36 4.36 17.10 8.67 12.78
Nucleolus 13.45 9.41 24.90 7.73 14.08 8.18 7.26 17.56 10.65 12.09 14.11 11.68 29.87 14.35 18.80
Nucleus -2.78 -23.42 -17.67 -12.44 10.99 2.66 -15.97 -16.32 -19.27 0.17 -1.06 -28.90 -24.64 -22.79 7.86
Peroxisomes -2.84 24.55 19.34 12.65 -3.71 2.08 20.81 13.86 12.40 -5.41 -1.22 31.77 22.50 19.01 -6.28
Vacuole -5.93 -14.17 -21.66 -18.97 -11.12 -5.21 -12.38 -21.55 -20.22 -15.49 -8.30 -18.94 -30.58 -27.96 -19.30
Vacuole Periphery -4.83 -2.14 -2.86 -1.32 -2.73 -2.63 -1.20 -4.11 -2.60 -3.64 -4.66 -1.62 -4.31 -2.62 -4.02
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4
Localization
Cell Percentages spindle pole (38%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Mcm22

Mcm22


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mcm22-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available