Standard name
Human Ortholog
Description Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0.05 0 0.06
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.06 0.07 0.11 0.11 0.3 0.29 0.17 0.28 0.18 0.2 0.11 0.15 0.19 0.21 0.22 0.14 0.17 0.19 0 0 0.06 0.06 0 0.06
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.12 0.13 0.12 0 0 0 0.06 0.09 0.11
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.09 0 0 0 0 0.31 0.48 0.37 0.67 0.6 0.77 0.52 0 0 0 0 0 0 0 0 0 0 0.06 0.05
Nucleus 0.68 0.57 0.79 0.71 0.48 0.38 0.41 0.39 0.28 0.27 0.27 0.37 0.69 0.64 0.64 0.36 0.29 0.32 0.67 0.68 0.64 0.48 0.39 0.31
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.06 0.06 0 0 0 0.07 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0.06 0.08 0.1
Vac/Vac Membrane 0.27 0.43 0.12 0.19 0.19 0.19 0.18 0.13 0.12 0.12 0.08 0.17 0.15 0.2 0.15 0.43 0.45 0.4 0.11 0.11 0.15 0.15 0.18 0.18
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 3
Bud 0 1 0 0 0 0 9 4 3 5 8 4 0 0 0 0 0 0 17 16 5 12 12 23
Bud Neck 0 0 1 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 2 1 1 2 3 5
Bud Site 0 1 0 0 1 0 3 1 3 5 5 4 0 0 0 0 0 1 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Cytoplasm 20 18 19 19 54 50 36 53 34 43 21 26 39 46 60 63 34 64 13 13 13 15 13 22
Endoplasmic Reticulum 0 0 0 0 0 3 1 0 0 0 0 0 1 0 1 24 12 21 0 0 1 1 1 4
Endosome 4 4 2 5 6 3 0 1 0 2 0 0 2 6 11 54 25 40 10 6 3 15 30 43
Golgi 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 5 2 1 1 8 9
Mitochondria 31 2 0 2 4 53 103 70 124 130 141 89 2 0 0 20 6 5 3 2 6 4 21 21
Nucleus 226 150 142 119 87 66 88 74 51 59 50 64 144 141 178 162 58 109 249 213 139 120 138 125
Nuclear Periphery 2 0 0 0 1 0 0 1 1 2 0 0 0 0 0 2 0 0 0 0 0 2 2 2
Nucleolus 0 1 0 0 1 0 1 0 2 1 1 1 0 0 1 33 12 19 10 9 2 16 14 12
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 2 0 0 0 0 3 7
SpindlePole 2 1 1 1 4 0 0 1 1 4 0 4 2 0 2 21 4 7 15 9 6 13 29 38
Vac/Vac Membrane 89 112 22 32 34 32 39 24 23 25 15 29 31 44 41 191 90 137 40 34 33 36 63 71
Unique Cell Count 331 263 180 168 181 172 216 191 185 215 183 172 210 221 277 449 199 345 375 313 218 249 356 405
Labelled Cell Count 375 291 187 180 192 207 281 229 242 276 241 221 221 237 294 573 243 407 375 313 218 249 356 405


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.9 7.7 7.0 6.4 5.5 4.5 4.4 4.9 4.0 4.3 3.9 4.2 7.4 7.2 7.2 9.0 9.6 8.9 7.2 6.7 6.9
Std Deviation (1e-4) 1.5 2.0 1.5 1.2 1.5 1.2 1.1 1.4 0.9 1.1 1.2 1.0 1.6 1.4 1.7 2.6 2.8 2.5 2.2 1.8 2.1
Intensity Change (Log2) – – – -0.13 -0.35 -0.64 -0.68 -0.53 -0.83 -0.7 -0.85 -0.76 0.08 0.04 0.02 0.35 0.44 0.33 0.03 -0.07 -0.02


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.2 4.6 4.4 1.8 4.2 2.1 2.6 0.3 1.3 2.2 2.8 3.1 1.2 1.8 2.4
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 3.2 3.3 3.4
Endosome 0 0 0 0 0 0 0 0 0 0 0 1.8 4.3 4.3 4.2
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 9.0 0 0 0 0 0 0 0 2.9 0 0
Nucleus -1.7 -6.1 -7.7 -7.7 -7.8 -9.8 -10.2 -9.8 -7.9 -2.3 -3.3 -3.3 -9.7 -9.7 -10.3
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 3.7 3.3 3.2
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 2.5 0 0
Vacuole 1.8 1.7 1.7 1.6 0.1 0.1 -0.2 -1.3 1.2 0.7 2.1 0.8 7.3 7.0 6.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.5244 1.4034 1.5028 2.209 1.8838 1.3267 0.7586 0.5539 0.4859 0.4058 -0.0258 0.4148 0.5026 0.0453 -0.1586 0.0752 0.6304 -0.0897
Actin 0.0164 0.002 0.0018 0.0218 0.0031 0.0083 0.0001 0.0008 0.0004 0.0002 0.0002 0.0004 0.0071 0.0006 0.0007 0.0114 0.0075 0.0004
Bud 0.001 0.0014 0.0031 0.0046 0.0012 0.0028 0.0001 0.0007 0.0002 0.0001 0 0.0002 0.0004 0.0007 0.0025 0.0034 0.0144 0.0009
Bud Neck 0.0053 0.0009 0.0015 0.0048 0.002 0.0101 0.0005 0.001 0.0007 0.0009 0.0008 0.0031 0.0038 0.0007 0.0048 0.0106 0.0019 0.0077
Bud Periphery 0.0017 0.0008 0.0022 0.0091 0.0024 0.0029 0.0001 0.0004 0.0002 0.0001 0 0.0002 0.0003 0.0006 0.002 0.0014 0.0043 0.0006
Bud Site 0.0062 0.0035 0.0039 0.021 0.003 0.0017 0.0003 0.0052 0.0004 0.0002 0.0001 0.0002 0.0057 0.0079 0.0035 0.0013 0.0014 0.0005
Cell Periphery 0.0005 0.0001 0.0001 0.0014 0.0002 0.0001 0.0001 0.0001 0 0 0 0 0.0001 0.0001 0.0002 0.0002 0.0001 0
Cytoplasm 0.0846 0.1429 0.083 0.0726 0.1039 0.0646 0.0949 0.1316 0.0685 0.0802 0.0677 0.1054 0.112 0.2163 0.1421 0.061 0.2495 0.1314
Cytoplasmic Foci 0.0342 0.006 0.0135 0.0159 0.0731 0.0075 0.0026 0.004 0.0022 0.0031 0.0015 0.003 0.0473 0.0041 0.0087 0.0067 0.0598 0.0027
Eisosomes 0.0002 0.0001 0.0001 0.0003 0.0001 0.0001 0 0.0001 0 0 0 0 0.0001 0 0 0.0002 0.0001 0
Endoplasmic Reticulum 0.0081 0.0036 0.0022 0.0036 0.0043 0.0019 0.001 0.003 0.0009 0.0014 0.0009 0.001 0.0054 0.0056 0.003 0.0013 0.0067 0.0017
Endosome 0.0661 0.0048 0.0175 0.0325 0.1062 0.012 0.0011 0.0022 0.001 0.0036 0.0012 0.0015 0.0359 0.0077 0.0176 0.0053 0.018 0.0028
Golgi 0.0142 0.0003 0.0048 0.0092 0.0223 0.0034 0 0.0001 0 0.0001 0 0 0.0054 0.0021 0.0027 0.008 0.0132 0.0001
Lipid Particles 0.0299 0.0004 0.0143 0.0107 0.0168 0.0045 0.0001 0.0003 0.0001 0.0001 0.0001 0.0001 0.0168 0.0002 0.0042 0.0018 0.0442 0.0001
Mitochondria 0.0062 0.0069 0.0063 0.0279 0.0337 0.0088 0.0003 0.0008 0.0006 0.0008 0.0003 0.0005 0.001 0.0034 0.0085 0.1097 0.0041 0.0004
None 0.1751 0.3065 0.2424 0.2425 0.225 0.1675 0.186 0.2906 0.2139 0.2051 0.1683 0.1679 0.1365 0.1769 0.124 0.1656 0.1752 0.0612
Nuclear Periphery 0.0386 0.0172 0.0188 0.0136 0.0268 0.0153 0.0068 0.0115 0.0101 0.0123 0.0119 0.0074 0.0144 0.0205 0.0136 0.0108 0.0167 0.0094
Nucleolus 0.0126 0.0066 0.0124 0.0145 0.0034 0.011 0.0037 0.0064 0.0051 0.0085 0.008 0.0066 0.0095 0.0023 0.004 0.0037 0.0027 0.0062
Nucleus 0.3866 0.4315 0.5069 0.3678 0.2871 0.5739 0.6563 0.4601 0.6391 0.5655 0.6379 0.6017 0.5686 0.5313 0.6347 0.5348 0.226 0.7313
Peroxisomes 0.0185 0.0007 0.0077 0.0091 0.0199 0.0022 0.0001 0.0005 0.0001 0.0002 0 0.0001 0.007 0.0009 0.0041 0.004 0.044 0.0001
Punctate Nuclear 0.072 0.0611 0.0507 0.0668 0.0437 0.0952 0.0441 0.0789 0.0554 0.1145 0.1006 0.0999 0.016 0.0138 0.0161 0.0566 0.1045 0.0411
Vacuole 0.0157 0.0022 0.0056 0.0405 0.0176 0.004 0.0017 0.0016 0.0006 0.0026 0.0004 0.0006 0.0055 0.0037 0.0021 0.0016 0.0046 0.0012
Vacuole Periphery 0.0062 0.0004 0.0012 0.0098 0.0041 0.0021 0.0001 0.0003 0.0002 0.0005 0.0001 0.0002 0.0015 0.0008 0.0007 0.0007 0.0014 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 17.4168 10.0744 15.6309 15.5554 29.2233 10.2395 16.4369 10.3125 11.908 29.5219
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1039 921 2919 1802 1447 1991 1742 884 2486 2912 4661 2686

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 715.73 906.28 1047.32 957.62 752.34 843.81 1060.23 925.34 737.04 863.57 1052.14 947.00
Standard Deviation 109.47 153.34 214.06 165.40 112.14 132.83 191.10 129.63 112.49 142.63 205.87 155.28
Intensity Change Log 2 — 0.340541 0.549215 0.420038 — 0.165533 0.494921 0.298599 — 0.253508 0.521646 0.359082

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000313 0.000962 0.000473 0.001456 0.000304 0.000276 0.000610 0.002851 0.000307 0.000493 0.000524 0.001915
Bud Neck 0.004444 0.010427 0.019862 0.021903 0.003659 0.013212 0.008872 0.017396 0.003987 0.012331 0.015755 0.020420
Bud Site 0.002348 0.005847 0.006548 0.022636 0.001264 0.004864 0.001739 0.029511 0.001717 0.005175 0.004751 0.024898
Cell Periphery 0.000205 0.000164 0.000171 0.000194 0.000120 0.000161 0.000119 0.000189 0.000156 0.000162 0.000152 0.000192
Cytoplasm 0.129650* 0.086984 0.050954 0.112835* 0.064015 0.116999* 0.019205 0.118837* 0.091447 0.107506* 0.039088 0.114810*
Cytoplasmic Foci 0.015359 0.006974 0.000492 0.006196 0.004639 0.007434 0.000324 0.005735 0.009119 0.007289 0.000429 0.006044
Eisosomes 0.000033 0.000031 0.000013 0.000030 0.000021 0.000020 0.000015 0.000037 0.000026 0.000023 0.000014 0.000032
Endoplasmic Reticulum 0.003283 0.007730 0.003053 0.008258 0.003556 0.003592 0.003926 0.007316 0.003442 0.004901 0.003379 0.007948
Endosome 0.001014 0.001967 0.000511 0.004807 0.000627 0.001821 0.000570 0.004883 0.000789 0.001867 0.000533 0.004832
Golgi 0.000412 0.001369 0.000190 0.002208 0.000328 0.000748 0.000148 0.001034 0.000363 0.000944 0.000174 0.001822
Lipid Particles 0.001940 0.001990 0.000121 0.001007 0.000924 0.001290 0.000140 0.000827 0.001348 0.001511 0.000128 0.000948
Mitochondria 0.003953 0.002390 0.003390 0.004727 0.001487 0.006271 0.001416 0.002007 0.002518 0.005043 0.002652 0.003831
Mitotic Spindle 0.003303 0.014256 0.006897 0.070401 0.002110 0.014167 0.003080 0.114124* 0.002608 0.014195 0.005470 0.084791
None 0.015699 0.009338 0.008912 0.006900 0.007788 0.010447 0.005101 0.012987 0.011094 0.010096 0.007488 0.008903
Nuclear Periphery 0.001095 0.002098 0.002016 0.004885 0.001136 0.002768 0.001006 0.002366 0.001119 0.002556 0.001639 0.004056
Nuclear Periphery Foci 0.000974 0.002657 0.000293 0.002440 0.000904 0.000487 0.000203 0.002530 0.000933 0.001173 0.000260 0.002469
Nucleolus 0.005360 0.005656 0.000930 0.002558 0.003754 0.004933 0.001285 0.003009 0.004425 0.005162 0.001063 0.002706
Nucleus 0.804520* 0.825503* 0.889919* 0.692137* 0.899849* 0.797615* 0.949009* 0.646068* 0.860007* 0.806435* 0.912003* 0.676975*
Peroxisomes 0.001030 0.002607 0.000229 0.001414 0.000451 0.001452 0.000076 0.002175 0.000693 0.001817 0.000172 0.001665
Vacuole 0.004618 0.010192 0.004646 0.031359 0.002830 0.010587 0.003073 0.025110 0.003577 0.010462 0.004058 0.029303
Vacuole Periphery 0.000446 0.000858 0.000379 0.001651 0.000235 0.000858 0.000084 0.001008 0.000323 0.000858 0.000268 0.001439

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.25 -4.79 -7.69 -1.77 -5.55 0.38 -8.08 -4.67 -4.73 -3.65 -4.35 -8.37 -8.19 -6.74 -6.07
Bud Neck -5.25 -13.89 -16.08 -11.06 -4.61 -8.35 -9.27 -12.39 -8.14 -8.19 -9.78 -17.10 -20.76 -13.23 -8.81
Bud Site -2.71 -3.68 -8.82 -5.54 -6.73 -5.13 -3.30 -9.39 -7.87 -8.99 -5.22 -5.48 -13.44 -10.21 -11.11
Cell Periphery 1.44 2.08 2.02 0.54 -0.27 -1.50 0.20 -3.74 -0.78 -5.08 -0.28 1.00 -0.87 -0.32 -2.73
Cytoplasm 5.23 13.01 6.18 0.23 -10.74 -9.94 13.13 -1.90 6.84 -12.19 -3.49 16.14 2.23 6.09 -16.03
Cytoplasmic Foci 4.44 9.03 7.28 3.93 -4.84 -3.17 6.74 -0.32 2.49 -5.46 1.58 11.00 6.23 5.28 -7.21
Eisosomes 0.05 8.48 -3.96 -3.66 -17.87 0.58 1.24 -12.92 -13.41 -13.87 1.35 7.56 -13.70 -15.27 -21.77
Endoplasmic Reticulum -9.26 -2.20 -16.06 -2.71 -15.33 -0.21 -3.95 -12.90 -12.73 -11.40 -6.14 -3.64 -20.56 -14.21 -19.05
Endosome -3.65 4.31 -5.81 -1.73 -8.79 -5.49 0.66 -7.00 -4.57 -7.00 -6.25 3.50 -9.68 -4.79 -11.08
Golgi -2.22 2.46 -1.36 1.16 -2.63 -1.10 0.84 -1.38 0.09 -3.51 -2.02 1.61 -1.80 0.53 -3.59
Lipid Particles -0.08 8.38 4.22 2.36 -9.54 -1.89 7.75 -5.26 -2.55 -10.97 -0.74 11.18 0.61 1.21 -14.32
Mitochondria 1.43 0.61 -0.26 -3.86 -2.00 -5.58 -0.43 -2.29 4.88 -4.18 -3.64 -0.34 -2.23 2.57 -3.27
Mitotic Spindle -3.73 -2.22 -13.03 -9.14 -12.39 -5.54 -2.50 -14.01 -12.36 -13.49 -6.60 -3.67 -19.12 -15.33 -18.13
None 3.07 4.79 4.72 1.20 -0.47 -1.68 2.83 -1.68 -0.02 -5.02 1.10 4.89 2.74 1.63 -3.79
Nuclear Periphery -5.31 -8.29 -15.05 -11.08 -10.72 -7.32 -2.26 -15.35 -6.61 -14.64 -8.78 -8.81 -19.29 -11.51 -14.99
Nuclear Periphery Foci -2.34 4.52 -5.16 -1.70 -6.85 1.50 2.73 -6.61 -7.06 -7.31 -0.78 4.43 -8.32 -7.74 -9.99
Nucleolus -0.08 5.20 -3.60 -3.51 -8.46 -2.13 2.54 -7.55 -6.72 -8.25 -1.23 5.93 -8.47 -7.59 -11.75
Nucleus -1.35 -10.29 9.56 10.74 24.76 13.66 -7.18 25.41 16.46 29.66 8.54 -10.13 26.12 17.96 37.60
Peroxisomes -1.87 5.38 0.55 2.01 -3.10 -3.12 4.08 -4.02 -1.41 -4.91 -3.20 6.26 -2.76 1.21 -5.56
Vacuole -5.00 -2.75 -17.17 -12.10 -16.51 -7.49 -2.79 -14.65 -12.77 -14.21 -8.77 -4.89 -22.68 -18.25 -21.63
Vacuole Periphery -1.79 1.35 -1.32 0.84 -2.52 -3.58 2.71 -1.78 1.83 -3.12 -3.80 1.63 -2.55 1.61 -3.64
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication
Localization
Cell Percentages nucleus (89%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Hms2

Hms2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Hms2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available