Standard name
Human Ortholog
Description Protein involved in an early step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0.11 0.14 0 0.12 0.05 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0.1 0 0.15 0.19 0.17 0.11 0.11 0.08 0.13 0.14 0 0 0 0.12 0 0.05 0 0 0 0 0.08 0.14
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.14 0 0 0 0.1 0.08 0.12 0.14 0.19 0.19 0.15 0 0 0 0.12 0.25 0 0 0 0 0 0 0
Nucleus 0.44 0.41 0.21 0 0.11 0.06 0.07 0.07 0.08 0.07 0.06 0.08 0.06 0.05 0.05 0.19 0 0.05 0.24 0.27 0.09 0.09 0 0
Nuclear Periphery 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0
Nucleolus 0.54 0.58 0.72 0.9 0.78 0.77 0.75 0.7 0.75 0.73 0.77 0.73 0.9 0.84 0.78 0.69 0.75 0.86 0.64 0.61 0.58 0.62 0.51 0.46
Peroxisomes 0 0 0 0.07 0.05 0.09 0.1 0.07 0.06 0.05 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0.11 0.48 0.28 0.39 0.47 0.39 0.33 0.37 0.33 0.38 0.46 0.44 0.39 0 0 0.05 0 0 0.13 0.15 0.21 0.19
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.12 0.08 0.05 0 0 0 0 0.05 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0
Bud 0 0 0 1 0 1 1 7 4 5 6 2 0 0 0 0 0 0 3 0 4 1 5 4
Bud Neck 0 0 1 13 5 3 3 2 1 0 2 0 2 11 15 0 0 0 0 0 2 0 3 4
Bud Site 0 0 0 2 0 5 5 8 13 9 14 4 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 5 0 11 7 11 16 7 22 14 5 11 10 4 29 50 0 3 1 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Endosome 3 0 33 9 39 81 81 59 32 25 56 57 1 5 10 2 1 1 5 4 13 5 27 43
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 4 0 0 1
Mitochondria 4 16 10 5 7 41 39 68 42 62 82 64 1 0 1 2 6 0 1 1 7 4 9 10
Nucleus 105 48 72 11 28 24 33 41 25 23 28 34 6 14 17 3 1 1 68 34 35 16 15 9
Nuclear Periphery 8 2 22 0 3 3 4 3 3 6 2 6 0 1 0 0 1 0 6 1 22 3 5 7
Nucleolus 131 68 244 232 202 330 345 391 227 239 342 306 87 233 274 11 18 18 179 76 230 114 183 144
Peroxisomes 0 0 1 17 13 39 46 40 17 16 14 26 2 3 2 0 0 0 0 0 0 0 3 4
SpindlePole 3 0 37 124 72 169 218 221 101 119 146 160 45 121 136 0 1 1 4 2 51 27 75 59
Vac/Vac Membrane 9 2 10 0 8 5 10 5 8 5 5 7 0 1 3 2 2 1 8 2 13 6 16 17
Unique Cell Count 241 118 337 259 259 430 463 561 304 326 443 417 97 276 351 16 24 21 283 126 395 183 358 317
Labelled Cell Count 268 136 441 421 388 718 792 867 487 514 708 676 148 418 508 20 33 23 283 126 395 183 358 317


Nucleolus, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 11.1 10.9 11.2 10.8 9.8 7.2 7.0 7.1 6.8 6.8 6.7 6.9 10.8 11.1 10.6 15.0 16.0 17.7 12.8 12.8 12.8
Std Deviation (1e-4) 3.1 2.4 3.5 3.3 4.2 2.6 2.6 2.8 2.2 2.5 2.1 2.5 2.5 4.3 3.6 6.1 7.4 4.2 4.6 3.6 4.0
Intensity Change (Log2) – – – -0.06 -0.19 -0.63 -0.67 -0.65 -0.72 -0.73 -0.75 -0.71 -0.05 -0.02 -0.09 0.42 0.51 0.66 0.19 0.2 0.19

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70005101520WT3HU80HU120HU16005101520WT3rpd3Δ_1rpd3Δ_2rpd3Δ_305101520WT1AF100AF140AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 3.8 0 0 0 0 0 0 0 0 0 3.3 3.5 0 0 0
Bud Site 0 0 0 0 0 3.8 0 3.3 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -0.4 0.6 0.3 -1.7 0.5 0.9 -1.5 -0.7 -0.7 0 3.6 5.1 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome -3.0 2.0 3.5 3.1 0.3 0.3 -1.0 1.2 1.6 -2.8 -4.1 -3.8 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria -0.8 -0.2 3.6 3.2 4.7 5.0 6.6 6.7 5.7 0 0 -2.8 0 0 0
Nucleus -6.0 -3.4 -6.6 -5.9 -6.1 -4.6 -5.3 -6.2 -5.2 -3.4 -5.8 -6.5 0 0 0
Nuclear Periphery -4.2 -3.2 -4.5 -4.5 -5.3 -3.6 -3.0 -4.9 -3.7 0 -4.0 -4.9 0 0 0
Nucleolus 5.2 1.6 1.4 0.7 -0.9 0.6 0.3 1.5 0.3 3.5 3.6 1.7 -0.3 0.3 1.3
Peroxisomes 4.4 3.8 5.4 5.7 4.7 4.1 3.8 2.9 4.4 0 0 0 0 0 0
SpindlePole 10.1 5.3 8.8 10.8 9.1 6.8 7.7 7.2 8.5 7.9 9.3 8.4 0 0 0
Vacuole 0 0.1 -1.8 -0.7 -2.4 -0.3 -1.2 -1.9 -1.2 0 0 -2.0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin 0.0101 0 0.0021 0.0193 0 0.0272 0.0228 0 0.0021 0 0.001 0 – – – – – –
Bud 0.0002 0.0001 0.0003 0.0007 0 0.0002 0.0002 0 0.0001 0 0.0002 0 – – – – – –
Bud Neck 0.0006 0.0005 0.0003 0.0012 0.0002 0.0008 0.0039 0.0003 0.0029 0.0008 0.0006 0.0004 – – – – – –
Bud Periphery 0.0003 0.0002 0.0003 0.0017 0.0001 0.0006 0.0004 0.0001 0.0002 0.0002 0.0004 0.0002 – – – – – –
Bud Site 0.0011 0.0004 0.0015 0.0009 0.0001 0.0003 0.0047 0.0002 0.0025 0.0003 0.0009 0.0001 – – – – – –
Cell Periphery 0.0002 0.0004 0.0001 0.0003 0 0.0005 0.0007 0.0001 0.0003 0.0002 0.0005 0.0002 – – – – – –
Cytoplasm 0.0066 0.0001 0.0031 0.0007 0.0001 0.0001 0.0005 0 0.001 0 0.0009 0 – – – – – –
Cytoplasmic Foci 0.0301 0.002 0.0017 0.0015 0.0128 0.0023 0.0202 0.0018 0.0159 0.0085 0.015 0.0005 – – – – – –
Eisosomes 0.0001 0 0 0.0003 0 0.0002 0.0003 0 0.0001 0 0.0001 0 – – – – – –
Endoplasmic Reticulum 0.0074 0 0.0007 0.0094 0 0.0004 0.0006 0 0.0002 0 0.0006 0 – – – – – –
Endosome 0.0189 0.0004 0.0038 0.0069 0.0004 0.0057 0.0051 0.0001 0.0055 0.0004 0.0057 0.0001 – – – – – –
Golgi 0.0065 0.0001 0.0019 0.0015 0.0003 0.0109 0.0038 0.0002 0.0044 0.0004 0.003 0.0002 – – – – – –
Lipid Particles 0.0215 0.0022 0.0011 0.002 0.0338 0.0068 0.028 0.006 0.0288 0.0221 0.1119 0.0066 – – – – – –
Mitochondria 0.0114 0.0004 0.001 0.006 0.001 0.0272 0.0034 0.002 0.0187 0.0022 0.0044 0.0003 – – – – – –
None 0.0022 0.0001 0.0005 0.0009 0.0002 0.0001 0.0008 0 0.0075 0.0001 0.0013 0 – – – – – –
Nuclear Periphery 0.0083 0.0014 0.0054 0.0094 0.0792 0.0233 0.0083 0.0206 0.0017 0.0065 0.0672 0.0119 – – – – – –
Nucleolus 0.6731 0.768 0.8524 0.7823 0.5858 0.7279 0.7727 0.8705 0.8219 0.881 0.541 0.8782 – – – – – –
Nucleus 0.1277 0.1982 0.0968 0.131 0.2553 0.1534 0.0814 0.0759 0.0584 0.0614 0.1456 0.0808 – – – – – –
Peroxisomes 0.0122 0.0001 0.0002 0.0002 0.0005 0.0016 0.0047 0.0001 0.002 0.001 0.0024 0.0001 – – – – – –
Punctate Nuclear 0.0594 0.0175 0.0259 0.0212 0.0282 0.0064 0.0312 0.0185 0.0231 0.0128 0.0854 0.0175 – – – – – –
Vacuole 0.0013 0.0068 0.0006 0.0013 0.0004 0.0014 0.0022 0.0003 0.0014 0.0008 0.0035 0.0005 – – – – – –
Vacuole Periphery 0.0008 0.0013 0.0002 0.0012 0.0015 0.0025 0.004 0.0033 0.0012 0.001 0.0086 0.0026 – – – – – –

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 26.2715 28.743 27.0509 27.5834 29.9951 24.2975 25.3407 21.0502 20.4777 26.3502
Translational Efficiency 2.7452 2.1372 1.9547 1.8752 1.5225 1.8554 1.7744 1.5866 1.3349 1.5411

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
125 522 175 1022 143 1539 105 1030 268 2061 280 2052

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1422.25 1088.75 1333.75 1645.40 1017.72 1125.05 1646.22 1598.00 1206.40 1115.86 1450.93 1621.61
Standard Deviation 218.54 223.13 195.76 425.36 160.19 177.51 250.88 360.53 276.94 190.75 265.40 394.87
Intensity Change Log 2 — -0.385502 -0.092687 0.210263 — 0.144648 0.693816 0.650927 — -0.140339 0.288434 0.410644

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000801 0.000614 0.000842 0.000843 0.000450 0.000360 0.000546 0.000710 0.000614 0.000425 0.000731 0.000776
Bud Neck 0.010662 0.007735 0.009516 0.016668 0.002257 0.002574 0.004714 0.012801 0.006177 0.003881 0.007715 0.014727
Bud Site 0.001009 0.000962 0.001986 0.004900 0.000174 0.000465 0.000783 0.002832 0.000563 0.000591 0.001535 0.003862
Cell Periphery 0.000045 0.000063 0.000068 0.000230 0.000018 0.000047 0.000023 0.000112 0.000031 0.000051 0.000051 0.000171
Cytoplasm 0.000468 0.000693 0.000543 0.000832 0.000109 0.000230 0.000068 0.000824 0.000276 0.000348 0.000365 0.000828
Cytoplasmic Foci 0.002154 0.000692 0.002245 0.015838 0.000064 0.000481 0.001996 0.007118 0.001039 0.000535 0.002151 0.011461
Eisosomes 0.000037 0.000051 0.000106 0.000163 0.000032 0.000054 0.000076 0.000109 0.000034 0.000053 0.000095 0.000136
Endoplasmic Reticulum 0.001173 0.003411 0.003211 0.000454 0.001937 0.001769 0.000691 0.000387 0.001581 0.002185 0.002266 0.000420
Endosome 0.006613 0.000698 0.000709 0.002196 0.000221 0.001316 0.000142 0.000849 0.003202 0.001160 0.000496 0.001520
Golgi 0.003607 0.000504 0.001055 0.002539 0.000096 0.000436 0.000406 0.001173 0.001734 0.000453 0.000812 0.001854
Lipid Particles 0.000176 0.000291 0.000558 0.000668 0.000091 0.001142 0.000117 0.000212 0.000131 0.000927 0.000393 0.000439
Mitochondria 0.002918 0.002056 0.001120 0.008767 0.001120 0.001301 0.002052 0.005142 0.001958 0.001492 0.001470 0.006948
Mitotic Spindle 0.015136 0.008549 0.053022 0.026233 0.000327 0.001716 0.011002 0.024241 0.007234 0.003447 0.037264 0.025233
None 0.000480 0.002719 0.001310 0.000974 0.000442 0.001197 0.000339 0.000942 0.000460 0.001583 0.000946 0.000958
Nuclear Periphery 0.016771 0.010441 0.002623 0.009205 0.003690 0.003221 0.016715 0.019676 0.009791 0.005049 0.007908 0.014461
Nuclear Periphery Foci 0.003739 0.018857 0.014994 0.005531 0.006291 0.004969 0.006745 0.011040 0.005101 0.008486 0.011901 0.008296
Nucleolus 0.632130 0.518263 0.599084 0.694755 0.555667 0.556356 0.777639 0.705617 0.591330 0.546708 0.666042 0.700207
Nucleus 0.277470 0.415950 0.279916 0.159709 0.423997 0.414706 0.145051 0.166504 0.355654 0.415021 0.229342 0.163119
Peroxisomes 0.005611 0.004889 0.023055 0.029144 0.002194 0.002652 0.026454 0.021447 0.003788 0.003218 0.024329 0.025280
Vacuole 0.009782 0.001251 0.003111 0.007759 0.000351 0.001981 0.001754 0.004906 0.004750 0.001796 0.002602 0.006327
Vacuole Periphery 0.009217 0.001309 0.000926 0.012593 0.000473 0.003027 0.002686 0.013358 0.004551 0.002592 0.001586 0.012977

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.06 -0.60 -0.28 -3.51 0.47 1.46 -1.53 -4.24 -8.67 -1.67 3.56 -2.04 -2.79 -10.21 -0.09
Bud Neck 1.76 1.17 -1.36 -8.26 -7.08 -0.57 -2.76 -11.42 -12.13 -4.73 2.29 -0.46 -5.03 -17.02 -8.09
Bud Site 0.30 -1.72 -5.35 -6.43 -4.88 -2.81 -2.18 -8.97 -8.12 -2.53 0.40 -3.50 -8.94 -10.78 -5.30
Cell Periphery -1.26 -1.77 -5.14 -4.67 -4.34 -2.68 -1.68 -4.85 -3.31 -3.89 -2.10 -2.89 -6.97 -5.86 -5.44
Cytoplasm -0.69 -0.42 -1.67 -1.01 -1.22 -1.66 -0.40 -2.84 -2.47 -2.73 -0.58 -0.75 -3.17 -3.04 -2.24
Cytoplasmic Foci 0.68 -0.72 -7.40 -8.36 -6.81 -2.77 -1.59 -8.15 -7.54 -1.74 0.43 -1.98 -10.29 -11.14 -6.32
Eisosomes -2.71 -8.95 -14.21 -12.57 -4.53 -3.99 -6.97 -11.70 -7.00 -3.26 -4.28 -11.33 -18.36 -12.94 -4.78
Endoplasmic Reticulum -3.48 -3.09 2.25 5.29 4.92 0.51 3.22 5.31 7.06 0.71 -2.12 -1.46 5.32 8.77 4.80
Endosome 1.38 1.38 1.02 -3.02 -2.89 -2.60 -0.33 -2.11 0.93 -1.91 0.96 1.32 0.81 -0.71 -3.20
Golgi 0.95 0.71 0.30 -2.71 -1.65 -3.16 -2.77 -2.88 -1.85 -1.45 0.82 0.43 -0.16 -3.32 -1.95
Lipid Particles -0.83 -2.55 -2.83 -1.79 -0.30 -1.87 -0.97 -4.08 1.63 0.15 -1.89 -2.87 -3.67 1.17 0.18
Mitochondria 1.92 4.53 -5.60 -6.88 -8.34 -0.82 -2.91 -7.59 -7.07 -4.95 1.97 1.95 -8.69 -10.00 -10.05
Mitotic Spindle 0.53 -3.09 -1.49 -4.90 2.59 -2.63 -2.09 -7.76 -7.25 -1.29 0.74 -4.01 -4.29 -9.89 1.99
None -1.55 -2.21 -4.77 1.20 0.78 -1.97 0.23 -3.37 0.51 -3.33 -2.42 -2.18 -5.39 1.26 -0.25
Nuclear Periphery 0.79 2.03 1.11 0.71 -3.82 0.36 -1.65 -5.61 -6.18 -0.35 1.34 0.48 -1.16 -5.36 -1.95
Nuclear Periphery Foci -4.74 -3.02 -1.09 4.49 2.71 0.72 -0.42 -1.80 -3.35 -0.79 -2.41 -2.62 -2.00 0.74 1.68
Nucleolus 3.73 0.90 -2.04 -11.35 -4.12 -0.01 -7.08 -6.40 -13.17 3.02 2.38 -3.20 -5.75 -17.07 -1.78
Nucleus -5.20 0.74 5.36 20.20 5.68 0.46 11.18 12.33 28.01 -1.46 -3.38 7.07 12.17 35.72 4.09
Peroxisomes 0.45 -6.23 -14.02 -14.52 -0.96 -1.53 -6.64 -15.29 -14.92 1.69 0.89 -9.22 -20.43 -21.91 0.58
Vacuole 1.38 1.02 0.12 -8.71 -5.82 -3.57 -2.27 -11.39 -5.49 -2.85 0.97 0.51 -0.98 -9.16 -6.22
Vacuole Periphery 2.58 2.72 -0.99 -7.59 -7.98 -2.88 -3.35 -9.52 -6.15 -7.07 1.10 2.00 -4.86 -8.35 -11.07
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein involved in an early step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
Localization
Cell Percentages nucleolus (28%), nucleus (13%), mixed (32%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Mak11

Mak11


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mak11-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available