Standard name
Human Ortholog
Description Molecular chaperone of the endoplasmic reticulum lumen; involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.6 0.61 0.92 0.94 0.85 0.86 0.83 0.84 0.84 – 0.81 0.85 0.93 0.99 0.99 0.35 0.4 0.48 0.1 0.1 0.2 0.22 0.16 0.22
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0.08 0.05 0 0 0 0 0 0
Endosome 0.06 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.05 0 0 0.05 0.09 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.09 0 0 0 0 0.05 0 0.16 – 0.21 0.12 0 0 0 0 0 0 0 0 0.05 0 0 0
Nucleus 0 0 0 0 0 0 0.06 0.05 0 – 0 0 0 0 0 0.12 0.09 0.11 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.37 0.37 0.09 0.09 0.24 0.19 0.19 0.21 0.22 – 0.15 0.14 0.05 0 0 0.64 0.62 0.57 0.76 0.75 0.68 0.68 0.74 0.62
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 2 0 0 0 1 2
Bud 0 0 2 0 0 0 1 3 2 – 1 1 2 1 1 0 0 0 1 1 1 2 4 7
Bud Neck 0 0 8 0 0 0 1 0 0 – 0 0 0 0 0 0 0 0 0 0 2 1 1 3
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 1 0 0 0 – 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 160 114 300 201 311 269 410 364 332 – 261 276 205 241 290 45 35 45 32 21 71 35 52 55
Endoplasmic Reticulum 3 7 1 0 1 0 2 1 0 – 0 0 0 0 0 2 7 5 3 0 1 5 4 6
Endosome 15 6 2 0 2 3 0 1 0 – 0 0 1 1 1 6 3 1 16 19 8 0 3 3
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 2 0 2 1 0 0 0 2
Mitochondria 11 16 0 1 1 10 23 16 62 – 69 40 2 0 0 1 2 1 6 5 16 6 12 8
Nucleus 5 3 3 3 5 5 32 20 6 – 11 6 0 0 1 15 8 10 1 0 1 0 0 0
Nuclear Periphery 0 2 0 0 0 0 0 2 0 – 3 1 1 0 1 0 0 0 1 0 0 0 0 1
Nucleolus 0 0 0 0 0 1 0 0 0 – 1 0 1 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 2 0 0 0 0 0 0 0 0 – 0 1 0 0 0 0 0 0 1 1 2 0 0 1
Vac/Vac Membrane 99 69 28 19 89 61 93 91 86 – 48 47 12 3 3 82 55 53 235 164 240 111 240 153
Unique Cell Count 265 186 326 214 365 313 494 432 397 321 325 221 243 294 128 88 93 310 221 356 164 325 248
Labelled Cell Count 295 217 345 224 409 350 562 498 488 395 372 224 246 297 151 112 115 310 221 356 164 325 248


Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.5 4.5 5.0 4.6 5.5 4.7 4.5 4.8 4.2 – 3.9 4.3 4.2 4.1 4.3 7.9 7.9 7.5 4.3 4.3 4.8
Std Deviation (1e-4) 0.7 0.9 1.3 1.4 1.5 1.7 1.1 1.4 1.3 – 1.5 1.1 1.3 1.5 1.8 2.2 2.2 2.6 1.6 1.6 1.8
Intensity Change (Log2) – – – -0.11 0.13 -0.09 -0.16 -0.05 -0.27 – -0.36 -0.22 -0.24 -0.27 -0.23 0.66 0.66 0.58 -0.22 -0.24 -0.08

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 12.4 11.2 10.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.5191 2.394 2.1826 1.3739 1.9102 1.8068 -0.3469 0.2224 -0.0559 -0.1171 -0.4109 -0.1548 -0.0808 0.8652 0.514 0.5162 0.2699 0.9296
Actin 0.0204 0.0026 0.011 0.0051 0.0206 0 0.0103 0.0001 0.0031 0.0205 0.0027 0.0014 0.0057 0.0011 0.0013 0.0012 0.0112 0.0013
Bud 0.0008 0.0008 0.0005 0.0022 0.0013 0.0004 0.0014 0.0076 0.0047 0.002 0.0006 0.002 0.0159 0.0397 0.0378 0.0251 0.0221 0.0181
Bud Neck 0.0175 0.0016 0.0008 0.002 0.003 0.0075 0.0045 0.0021 0.0016 0.0025 0.0011 0.0031 0.0018 0.004 0.0035 0.0039 0.0067 0.0147
Bud Periphery 0.0019 0.0014 0.0014 0.0085 0.0025 0.0013 0.0036 0.0066 0.0059 0.0021 0.0014 0.0025 0.0141 0.0244 0.0247 0.0219 0.0271 0.0175
Bud Site 0.009 0.0045 0.0021 0.003 0.0033 0.001 0.0057 0.01 0.0129 0.0057 0.0009 0.001 0.0222 0.1061 0.0325 0.011 0.0076 0.0045
Cell Periphery 0.0021 0.0028 0.0014 0.0016 0.0009 0.0018 0.0013 0.0017 0.0009 0.0007 0.0003 0.0009 0.0024 0.0033 0.0022 0.0032 0.002 0.002
Cytoplasm 0.1134 0.1341 0.0795 0.0516 0.0589 0.1099 0.1053 0.1174 0.1014 0.0662 0.0602 0.1026 0.0828 0.1165 0.075 0.0774 0.06 0.1581
Cytoplasmic Foci 0.0595 0.0315 0.0465 0.0503 0.0809 0.0376 0.0706 0.0694 0.0815 0.0618 0.0469 0.0612 0.1514 0.083 0.1174 0.1454 0.2077 0.1331
Eisosomes 0.0006 0.0003 0.0003 0.0005 0.0004 0.0001 0.0004 0 0.0001 0.0001 0.0001 0 0.0003 0.0001 0.0002 0.0002 0.0002 0.0001
Endoplasmic Reticulum 0.0122 0.0035 0.0062 0.0076 0.0029 0.005 0.0069 0.0054 0.0073 0.0033 0.0038 0.0037 0.0078 0.0059 0.0027 0.0028 0.0022 0.0036
Endosome 0.1347 0.0614 0.1441 0.2153 0.1318 0.119 0.2789 0.2123 0.2841 0.3513 0.2801 0.2509 0.165 0.1082 0.136 0.1116 0.1408 0.089
Golgi 0.0072 0.0019 0.0089 0.0193 0.0114 0.0017 0.0219 0.004 0.0126 0.0218 0.0275 0.0051 0.0053 0.0028 0.0044 0.0082 0.0155 0.0025
Lipid Particles 0.034 0.01 0.0181 0.0136 0.0534 0.0126 0.0345 0.0134 0.0139 0.0216 0.0333 0.0083 0.0234 0.0081 0.0261 0.0065 0.0291 0.013
Mitochondria 0.0222 0.0133 0.0161 0.047 0.0061 0.0094 0.0381 0.0165 0.0248 0.0293 0.0536 0.0109 0.0168 0.0095 0.015 0.0396 0.0145 0.0042
None 0.3704 0.3906 0.4216 0.2082 0.1864 0.2505 0.1671 0.1339 0.1557 0.0489 0.0881 0.1125 0.295 0.2186 0.2966 0.2955 0.1768 0.2516
Nuclear Periphery 0.0108 0.0028 0.0065 0.0026 0.0035 0.0047 0.0128 0.0031 0.0054 0.0031 0.0038 0.0035 0.0057 0.0069 0.005 0.0037 0.0035 0.0074
Nucleolus 0.0165 0.0057 0.0046 0.0034 0.0043 0.0035 0.0055 0.0035 0.0044 0.0071 0.0014 0.0029 0.0091 0.0141 0.0164 0.0167 0.0211 0.0126
Nucleus 0.0089 0.0085 0.0069 0.0056 0.007 0.0094 0.0172 0.0082 0.0062 0.0056 0.004 0.0156 0.0121 0.0247 0.0267 0.0204 0.0152 0.0558
Peroxisomes 0.0143 0.0023 0.0125 0.0025 0.0464 0.0017 0.0066 0.0014 0.0135 0.0242 0.0667 0.0017 0.0068 0.0026 0.0054 0.0042 0.0244 0.0026
Punctate Nuclear 0.0051 0.0009 0.0014 0.001 0.0167 0.0006 0.0026 0.0021 0.0035 0.0014 0.0006 0.0043 0.0183 0.0155 0.0341 0.0381 0.0275 0.0454
Vacuole 0.1262 0.3011 0.1893 0.3044 0.3258 0.3843 0.1847 0.3468 0.2226 0.2977 0.2947 0.3707 0.1262 0.1908 0.1228 0.1444 0.1727 0.1501
Vacuole Periphery 0.0122 0.0184 0.0201 0.0446 0.0325 0.038 0.0202 0.0344 0.0338 0.0231 0.0283 0.0352 0.0119 0.014 0.0143 0.0191 0.0123 0.0128

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 45.0369 33.923 29.5982 34.9169 37.8469 41.261 36.4668 37.0143 33.5299 46.4245
Translational Efficiency 1.2606 1.258 1.0682 0.9886 1.1009 1.2347 0.8538 0.836 0.9476 0.9076

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1805 496 760 267 1865 2582 1761 89 3670 3078 2521 356

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 656.14 780.36 946.27 947.80 721.03 746.95 867.97 950.02 689.12 752.33 891.57 948.36
Standard Deviation 75.47 99.03 129.69 101.62 84.89 129.30 102.89 134.13 86.69 125.52 117.29 110.65
Intensity Change Log 2 — 0.250136 0.528248 0.530579 — 0.050952 0.267586 0.397899 — 0.149286 0.397659 0.462637

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000061 0.000216 0.000473 0.000376 0.000134 0.000224 0.000176 0.000301 0.000098 0.000223 0.000265 0.000357
Bud Neck 0.036778 0.025971 0.009107 0.010248 0.021525 0.043109 0.005482 0.003508 0.029027 0.040347 0.006575 0.008563
Bud Site 0.010552 0.009962 0.010997 0.011742 0.007154 0.024493 0.010684 0.113169 0.008825 0.022151 0.010778 0.037099
Cell Periphery 0.000146 0.000091 0.000230 0.000291 0.000065 0.000146 0.000153 0.000298 0.000105 0.000137 0.000176 0.000293
Cytoplasm 0.244546 0.281862 0.294072 0.237691 0.327018 0.255199 0.443738 0.393133 0.286457 0.259496 0.398618 0.276552
Cytoplasmic Foci 0.089021 0.147174 0.025903 0.054920 0.100200 0.127421 0.016624 0.029301 0.094702 0.130604 0.019422 0.048515
Eisosomes 0.000074 0.000071 0.000077 0.000173 0.000053 0.000088 0.000044 0.000062 0.000064 0.000085 0.000054 0.000145
Endoplasmic Reticulum 0.001141 0.000583 0.010194 0.008637 0.000870 0.000915 0.002761 0.001628 0.001003 0.000862 0.005002 0.006885
Endosome 0.089280 0.079284 0.014349 0.007539 0.045045 0.087685 0.003890 0.004161 0.066801 0.086331 0.007043 0.006694
Golgi 0.001100 0.003938 0.000138 0.000094 0.001147 0.004511 0.000124 0.000109 0.001124 0.004419 0.000128 0.000098
Lipid Particles 0.005053 0.003171 0.005170 0.004479 0.003346 0.005080 0.001689 0.001808 0.004185 0.004772 0.002739 0.003812
Mitochondria 0.002540 0.004462 0.000457 0.000170 0.002081 0.008807 0.000926 0.000403 0.002307 0.008107 0.000784 0.000228
Mitotic Spindle 0.000079 0.006331 0.004080 0.000401 0.001710 0.004008 0.003850 0.062318 0.000908 0.004383 0.003919 0.015880
None 0.001099 0.001753 0.002216 0.001981 0.000519 0.001410 0.003048 0.013423 0.000804 0.001465 0.002797 0.004841
Nuclear Periphery 0.000329 0.000317 0.004022 0.002066 0.000339 0.000266 0.002217 0.001408 0.000334 0.000274 0.002761 0.001901
Nuclear Periphery Foci 0.000211 0.000471 0.010498 0.007259 0.000247 0.000209 0.001658 0.005409 0.000229 0.000251 0.004323 0.006797
Nucleolus 0.001251 0.000991 0.002002 0.000415 0.000949 0.001325 0.000454 0.000638 0.001098 0.001271 0.000921 0.000471
Nucleus 0.036532 0.043067 0.381070 0.213025 0.062350 0.032805 0.401748 0.092412 0.049652 0.034459 0.395514 0.182872
Peroxisomes 0.003495 0.013107 0.000805 0.002182 0.002922 0.007661 0.000438 0.000230 0.003204 0.008539 0.000549 0.001694
Vacuole 0.471817 0.373573 0.223596 0.436189 0.419951 0.387988 0.100065 0.276103 0.445460 0.385665 0.137306 0.396168
Vacuole Periphery 0.004893 0.003607 0.000542 0.000122 0.002374 0.006651 0.000231 0.000180 0.003613 0.006161 0.000325 0.000137

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.82 -10.14 -9.96 -2.47 3.33 -1.14 -1.17 -2.75 -2.04 -2.92 -2.32 -5.86 -6.85 -3.71 -1.83
Bud Neck 3.51 10.40 9.29 4.71 0.89 -10.37 10.14 11.17 21.79 2.48 -6.05 15.53 10.34 14.97 0.01
Bud Site 0.52 -0.08 1.51 1.16 1.22 -10.61 -0.68 -1.35 0.26 -1.25 -9.68 -0.06 -0.81 3.42 -0.76
Cell Periphery 2.34 -4.76 -3.68 -5.62 1.13 -5.75 -9.16 -2.89 0.72 0.34 -2.49 -6.52 -6.62 -3.22 -1.97
Cytoplasm -3.20 -1.51 7.22 8.23 7.56 8.81 -5.47 2.65 -0.13 4.55 4.12 -8.04 9.18 6.91 13.35
Cytoplasmic Foci -7.83 20.77 13.82 15.79 -1.07 -6.13 27.09 18.07 23.48 -1.26 -9.98 34.97 20.24 26.41 -2.71
Eisosomes 0.44 -2.04 -10.60 -10.54 -9.24 -7.40 -0.21 -4.69 1.06 -4.66 -5.14 0.12 -12.38 -8.02 -12.72
Endoplasmic Reticulum 3.29 -15.00 -11.40 -12.54 3.42 -0.54 -17.05 -5.20 -5.09 0.70 1.27 -20.14 -12.34 -12.68 -1.81
Endosome 2.06 23.10 26.90 12.52 5.28 -14.09 22.00 21.49 33.50 -0.92 -6.63 32.19 33.21 35.42 1.70
Golgi -2.22 5.49 5.87 3.12 5.32 -8.38 3.88 3.69 14.42 -1.56 -9.21 6.26 6.38 13.58 0.65
Lipid Particles 3.32 -0.05 3.03 -1.03 2.42 -3.40 4.37 2.70 5.81 -1.26 -1.33 3.94 2.96 3.91 -1.46
Mitochondria -0.91 3.96 4.52 2.29 7.42 -7.24 2.59 3.06 9.93 1.28 -7.08 4.42 5.75 10.55 4.19
Mitotic Spindle -2.51 -2.89 -3.16 2.15 2.36 -2.26 -2.10 -2.55 -2.36 -2.38 -3.99 -3.97 -2.54 -1.45 -1.52
None -0.79 -3.65 -1.02 0.21 0.76 -3.35 -12.11 -2.33 -1.75 -0.76 -2.47 -11.10 -2.70 -1.31 0.80
Nuclear Periphery -0.18 -13.50 -10.77 -10.73 4.63 2.34 -22.85 -7.93 -8.15 0.66 1.91 -25.25 -13.19 -13.47 3.43
Nuclear Periphery Foci -4.05 -8.84 -10.89 -10.16 4.39 0.70 -8.29 -6.23 -6.27 -3.39 -0.75 -11.02 -12.45 -12.32 -0.59
Nucleolus 1.43 -0.63 5.80 3.41 2.21 -2.73 4.26 4.49 6.19 1.06 -1.66 1.48 6.64 6.55 2.35
Nucleus -2.05 -31.36 -11.88 -11.02 9.94 9.88 -50.28 -4.12 -6.08 17.49 6.93 -60.83 -11.81 -13.13 17.70
Peroxisomes -2.87 5.62 4.56 3.82 -0.04 -7.62 5.98 6.37 16.24 2.20 -7.38 8.41 6.13 11.47 -0.54
Vacuole 6.97 17.54 -5.02 -8.77 -14.32 3.53 31.11 -2.68 -3.60 -10.28 8.25 38.03 -6.49 -9.79 -21.03
Vacuole Periphery 2.01 13.59 14.95 5.15 5.20 -13.83 14.21 13.56 23.29 -0.08 -8.21 18.72 19.61 23.76 4.53
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Molecular chaperone of the endoplasmic reticulum lumen; involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway
Localization
Cell Percentages vacuole (87%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Lhs1

Lhs1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Lhs1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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