Standard name | |
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Human Ortholog | |
Description | Subunit C of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) has eight subunits |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 1 | 0 | 10 | 24 | 53 | – | 32 | 30 | 30 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 1 | 1 | 4 | 4 | – | 8 | 2 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 6 | 2 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 1 | 4 | 7 | 13 | 56 | 62 | – | 78 | 68 | 60 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 13 | 6 | 12 | 17 | 25 | 72 | 77 | 71 | – | 81 | 99 | 72 | 10 | 8 | 8 | 17 | 16 | 15 | 1 | 0 | 1 | 3 | 2 | 1 |
Endoplasmic Reticulum | 0 | 1 | 1 | 2 | 3 | 24 | 31 | 73 | – | 45 | 41 | 54 | 1 | 1 | 3 | 4 | 5 | 9 | 0 | 0 | 0 | 0 | 5 | 1 |
Endosome | 0 | 0 | 1 | 1 | 2 | 0 | 1 | 1 | – | 3 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 4 | 1 | 2 | 3 |
Golgi | 16 | 4 | 9 | 29 | 53 | 51 | 82 | 102 | – | 74 | 59 | 58 | 8 | 10 | 14 | 36 | 39 | 32 | 1 | 0 | 1 | 2 | 4 | 3 |
Mitochondria | 4 | 0 | 21 | 23 | 55 | 131 | 117 | 136 | – | 110 | 163 | 193 | 0 | 0 | 0 | 4 | 3 | 6 | 2 | 1 | 11 | 5 | 7 | 3 |
Nucleus | 36 | 7 | 14 | 6 | 15 | 40 | 27 | 22 | – | 21 | 17 | 12 | 11 | 3 | 3 | 5 | 5 | 10 | 23 | 7 | 7 | 14 | 36 | 23 |
Nuclear Periphery | 8 | 2 | 68 | 105 | 21 | 101 | 163 | 156 | – | 79 | 70 | 125 | 7 | 30 | 41 | 11 | 8 | 10 | 9 | 0 | 52 | 6 | 19 | 15 |
Nucleolus | 12 | 5 | 26 | 23 | 10 | 22 | 18 | 34 | – | 9 | 8 | 11 | 4 | 2 | 3 | 6 | 6 | 9 | 13 | 3 | 4 | 5 | 11 | 10 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Vac/Vac Membrane | 310 | 123 | 356 | 453 | 487 | 596 | 731 | 698 | – | 606 | 457 | 399 | 184 | 182 | 207 | 151 | 191 | 198 | 328 | 130 | 374 | 141 | 298 | 282 |
Unique Cell Count | 356 | 134 | 419 | 512 | 567 | 893 | 1079 | 1167 | 927 | 834 | 816 | 201 | 199 | 228 | 177 | 214 | 230 | 383 | 148 | 462 | 184 | 402 | 352 | |
Labelled Cell Count | 399 | 148 | 509 | 664 | 679 | 1061 | 1331 | 1413 | 1146 | 1015 | 1017 | 226 | 236 | 282 | 236 | 274 | 290 | 383 | 148 | 462 | 184 | 402 | 352 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 36.8 | 34.5 | 24.4 | 25.3 | 23.4 | 21.3 | 20.9 | 20.3 | – | 19.2 | 21.1 | 19.4 | 29.2 | 31.9 | 28.6 | 36.2 | 36.9 | 37.6 | 33.0 | 33.5 | 36.1 |
Std Deviation (1e-4) | 9.7 | 10.6 | 7.6 | 7.2 | 6.8 | 7.0 | 6.6 | 6.1 | – | 5.9 | 5.9 | 4.9 | 9.2 | 10.7 | 7.9 | 12.4 | 13.3 | 12.7 | 12.1 | 13.0 | 12.2 |
Intensity Change (Log2) | – | – | – | 0.05 | -0.06 | -0.2 | -0.22 | -0.27 | – | -0.35 | -0.21 | -0.34 | 0.26 | 0.38 | 0.23 | 0.57 | 0.6 | 0.62 | 0.44 | 0.46 | 0.56 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 3.1 | 4.4 | – | 3.8 | 3.9 | 4.0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 4.5 | 4.6 | – | 5.9 | 5.8 | 5.5 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.4 | 1.3 | 3.6 | 3.1 | 2.5 | – | 3.9 | 5.3 | 3.9 | 1.3 | 0.8 | 0.5 | 3.5 | 2.7 | 2.2 |
Endoplasmic Reticulum | 0 | 0 | 3.0 | 3.2 | 5.0 | – | 4.3 | 4.3 | 5.1 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 2.7 | 4.6 | 2.9 | 4.0 | 4.5 | – | 4.1 | 3.6 | 3.6 | 1.3 | 1.9 | 2.6 | 7.7 | 7.2 | 5.9 |
Mitochondria | -0.4 | 2.7 | 5.1 | 3.5 | 3.9 | – | 3.9 | 6.9 | 8.2 | -3.2 | -3.2 | -3.4 | -1.5 | -2.2 | -1.5 |
Nucleus | -2.3 | -0.6 | 1.0 | -0.9 | -1.7 | – | -1.1 | -1.4 | -2.2 | 1.3 | -1.3 | -1.5 | -0.3 | -0.7 | 0.6 |
Nuclear Periphery | 1.7 | -6.8 | -2.5 | -0.5 | -1.4 | – | -4.2 | -4.2 | -0.4 | -4.6 | -0.4 | 0.6 | -3.3 | -4.6 | -4.5 |
Nucleolus | -1.2 | -3.7 | -3.4 | -4.7 | -3.0 | – | -5.6 | -5.4 | -4.7 | -2.3 | -2.9 | -2.9 | -1.4 | -1.8 | -1.2 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 1.6 | 0.4 | -6.9 | -6.7 | -9.4 | – | -7.4 | -10.6 | -12.3 | 2.3 | 2.2 | 2.1 | 0.1 | 1.5 | 0.4 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 18.5265 | 27.8845 | 25.0397 | 23.6462 | 19.5937 | 25.4284 | 25.2756 | 33.1729 | 30.2104 | 27.284 | 24.2355 | 30.6466 | 26.9054 | 34.9446 | 31.8723 | 29.4898 | 28.0148 | 31.3896 |
Actin | 0.0049 | 0 | 0.0004 | 0 | 0.0001 | 0 | 0.0103 | 0 | 0.0026 | 0.0132 | 0.0002 | 0 | 0.0017 | 0 | 0 | 0 | 0 | 0 |
Bud | 0.0005 | 0.0001 | 0.0009 | 0.0001 | 0.0005 | 0 | 0.0002 | 0 | 0.0001 | 0.0001 | 0.0009 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0.0002 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0011 | 0 | 0.0002 | 0.0001 | 0.0002 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Periphery | 0.0008 | 0.0005 | 0.0028 | 0.0004 | 0.0011 | 0.0002 | 0.0004 | 0 | 0.0001 | 0.0001 | 0.003 | 0.0004 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0 |
Bud Site | 0.0007 | 0 | 0.0002 | 0 | 0.0001 | 0 | 0.0016 | 0 | 0.0004 | 0.0001 | 0.0028 | 0 | 0.0002 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0.003 | 0.0017 | 0.0024 | 0.0018 | 0.0039 | 0.0016 | 0.0018 | 0.0008 | 0.002 | 0.0004 | 0.0019 | 0.0009 | 0.0013 | 0.0012 | 0.0015 | 0.0006 | 0.0013 | 0.0011 |
Cytoplasm | 0.0016 | 0.0001 | 0.0004 | 0.0005 | 0.0043 | 0.0001 | 0.0022 | 0.0001 | 0.0015 | 0.0018 | 0.0021 | 0 | 0.0002 | 0 | 0 | 0 | 0 | 0 |
Cytoplasmic Foci | 0.0034 | 0 | 0.0001 | 0.0002 | 0.0009 | 0.0001 | 0.0067 | 0 | 0.0027 | 0.0003 | 0.0004 | 0.0001 | 0.0012 | 0 | 0.0001 | 0 | 0 | 0 |
Eisosomes | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0.0002 | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0017 | 0.0001 | 0.0034 | 0.0001 | 0.0022 | 0.0001 | 0.0009 | 0.0001 | 0.0017 | 0.0146 | 0.0005 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0001 |
Endosome | 0.0156 | 0.0012 | 0.0037 | 0.0069 | 0.0524 | 0.003 | 0.0044 | 0.0008 | 0.0042 | 0.0082 | 0.0026 | 0.0009 | 0.0016 | 0.0006 | 0.0019 | 0.0006 | 0.0008 | 0.0004 |
Golgi | 0.0027 | 0 | 0.0002 | 0.0002 | 0.0012 | 0.0001 | 0.0009 | 0 | 0.0018 | 0.0015 | 0.0002 | 0.0001 | 0.0002 | 0 | 0.0002 | 0 | 0 | 0 |
Lipid Particles | 0.0046 | 0.0001 | 0.0003 | 0.0003 | 0.0002 | 0.0003 | 0.0082 | 0.0002 | 0.0037 | 0.0003 | 0.0013 | 0.0018 | 0.0016 | 0.0002 | 0.0006 | 0.0001 | 0.0005 | 0.0003 |
Mitochondria | 0.0099 | 0.0059 | 0.0108 | 0.0012 | 0.0024 | 0.0002 | 0.0125 | 0.0002 | 0.006 | 0.001 | 0.0075 | 0.0085 | 0.0037 | 0.0004 | 0.0086 | 0.0001 | 0.0002 | 0.0005 |
None | 0.0023 | 0 | 0.0001 | 0 | 0.0002 | 0 | 0.003 | 0 | 0.0003 | 0.0008 | 0.0035 | 0 | 0.0003 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0.01 | 0.0057 | 0.0036 | 0.0038 | 0.0083 | 0.0069 | 0.0064 | 0.018 | 0.0138 | 0.0149 | 0.0219 | 0.0166 | 0.0045 | 0.0072 | 0.005 | 0.0004 | 0.0023 | 0.0046 |
Nucleolus | 0.0066 | 0.001 | 0.001 | 0.0012 | 0.0013 | 0.0007 | 0.0024 | 0.0004 | 0.0089 | 0.0001 | 0.008 | 0.0045 | 0.0041 | 0.0008 | 0.0017 | 0.0001 | 0.0008 | 0.0003 |
Nucleus | 0.0046 | 0.0033 | 0.0021 | 0.0041 | 0.003 | 0.0007 | 0.0023 | 0.0004 | 0.003 | 0.0016 | 0.0316 | 0.0007 | 0.0012 | 0.0004 | 0.0009 | 0.0002 | 0.0006 | 0.0003 |
Peroxisomes | 0.0013 | 0 | 0 | 0 | 0 | 0 | 0.0005 | 0 | 0.0029 | 0 | 0.0002 | 0 | 0.001 | 0 | 0 | 0 | 0 | 0 |
Punctate Nuclear | 0.0031 | 0 | 0 | 0 | 0.0001 | 0 | 0.0036 | 0 | 0.0008 | 0.0004 | 0.0033 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0.2843 | 0.3018 | 0.2974 | 0.3311 | 0.3659 | 0.2327 | 0.2047 | 0.1658 | 0.182 | 0.157 | 0.1481 | 0.1113 | 0.1925 | 0.1945 | 0.2158 | 0.2475 | 0.1815 | 0.0992 |
Vacuole Periphery | 0.6382 | 0.6783 | 0.6703 | 0.648 | 0.552 | 0.7533 | 0.7258 | 0.8132 | 0.7615 | 0.7833 | 0.7596 | 0.854 | 0.7842 | 0.7946 | 0.7633 | 0.7502 | 0.8118 | 0.8931 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 254.0919 | 235.0905 | 233.4241 | 253.4613 | 209.9202 | 268.4493 | 230.5096 | 220.0935 | 215.469 | 247.1387 |
Translational Efficiency | 1.0159 | 1.0562 | 1.0285 | 0.8528 | 1.0637 | 0.9309 | 1.0968 | 0.9529 | 1.0969 | 0.9858 |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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