Standard name
Human Ortholog
Description Co-chaperone that binds and regulates Hsp90 family chaperones; plays a role in determining prion variants; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.98 0.98 1.0 0.93 0.96 0.91 0.84 0.8 0.75 0.81 0.84 0.81 0.99 1.0 0.99 0.98 0.97 0.98 0.97 0.96 0.95 0.97 0.93 0.89
Endoplasmic Reticulum 0 0 0 0 0 0.07 0.1 0.08 0.15 0.1 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.06 0.1 0 0.06 0.05 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 1 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 1 0 0 3 12
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 2 5 1 4 1 4 8 1 5 0 3 0 3 0 0 1 0 0 0 0 0 0 0
Cytoplasm 162 286 177 113 151 52 129 148 39 54 53 77 327 430 405 44 161 150 151 274 172 317 345 420
Endoplasmic Reticulum 2 3 0 3 3 4 16 15 8 7 1 7 1 2 2 2 3 4 0 0 1 0 5 2
Endosome 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0
Golgi 0 1 0 1 0 0 1 1 0 0 2 4 0 0 0 0 1 1 0 0 0 0 0 0
Mitochondria 1 0 0 0 0 1 0 1 0 0 4 0 1 0 0 0 0 1 0 0 0 0 1 1
Nucleus 1 0 0 0 0 2 0 2 0 1 0 1 1 0 0 0 0 1 0 3 1 2 2 14
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1
Nucleolus 0 0 0 0 0 0 1 1 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 1 1 0 4 3 1 6 12 5 3 4 5 0 2 4 0 6 2 0 1 0 1 5 10
Unique Cell Count 165 291 177 121 157 57 153 186 52 67 63 95 330 432 409 45 166 153 157 286 181 326 372 474
Labelled Cell Count 168 294 182 122 161 61 157 190 53 72 65 98 330 437 411 46 173 160 157 286 181 326 372 474


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 57.3 59.0 54.9 49.7 56.8 35.3 49.0 45.6 40.7 39.7 33.1 37.2 56.9 67.0 69.8 60.8 66.6 69.8 44.9 50.6 55.6
Std Deviation (1e-4) 14.7 13.3 9.8 12.2 14.2 13.8 15.8 13.1 12.0 15.5 14.6 12.9 12.6 17.8 19.4 29.8 28.0 25.2 11.1 14.2 16.8
Intensity Change (Log2) – – – -0.14 0.05 -0.64 -0.16 -0.27 -0.43 -0.47 -0.73 -0.56 0.05 0.29 0.35 0.15 0.28 0.35 -0.29 -0.12 0.02

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700020406080WT3HU80HU120HU160020406080WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3020406080WT1AF100AF140AF180020406080
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0.8 0 0 0 0 0 0 0 0 0 0
Cytoplasm -3.5 -2.6 -4.0 -5.5 -6.4 -6.8 -6.0 -5.4 -6.0 -1.3 -0.9 -1.3 -2.0 -2.3 -1.9
Endoplasmic Reticulum 0 0 0 4.4 3.9 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 3.4 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 40.6082 66.1 55.4646 49.5094 49.6573 53.8977 50.064 70.4631 62.1676 60.0146 49.6612 63.1005 66.3155 81.0152 73.8168 70.6415 59.9685 73.1771
Actin 0.0207 0.0059 0.0134 0.0144 0.0013 0.0008 0.0173 0.0001 0.0052 0.0007 0.0008 0.0002 0.0071 0.0001 0.0003 0.0001 0.0213 0.0002
Bud 0.0029 0.0001 0.0008 0.0017 0.0006 0.0002 0.0012 0 0.0005 0.0001 0.0016 0.0001 0.0006 0 0.0001 0.0002 0.0003 0.0001
Bud Neck 0.0035 0.0007 0.0003 0.0019 0.0004 0.0009 0.0008 0.0001 0.0003 0.0002 0.0008 0.0005 0.0002 0.0001 0.0001 0.0001 0.0005 0.0003
Bud Periphery 0.0018 0 0.0006 0.0018 0.0004 0.0001 0.0008 0 0.0003 0 0.0008 0.0001 0.0005 0 0 0.0002 0.0005 0
Bud Site 0.0149 0.0002 0.0007 0.0087 0.0014 0 0.0073 0.0001 0.0004 0.0001 0.0005 0 0.001 0 0.0001 0.0001 0.0007 0
Cell Periphery 0.0005 0 0.0003 0.0005 0.0008 0.0001 0.0007 0.002 0.0001 0.0001 0.0006 0.0001 0.0005 0 0.0001 0.0003 0.0003 0
Cytoplasm 0.7741 0.9816 0.9205 0.8777 0.8607 0.9622 0.8183 0.9756 0.9194 0.9308 0.8324 0.9136 0.8795 0.9901 0.9591 0.9415 0.8203 0.9551
Cytoplasmic Foci 0.0211 0.0002 0.0066 0.0035 0.0122 0.0024 0.0138 0.0001 0.011 0.006 0.0174 0.0034 0.0169 0.0001 0.0028 0.0005 0.0062 0.0002
Eisosomes 0.0004 0.0001 0.0002 0.0002 0.0003 0 0.0002 0 0.0001 0.0003 0.0002 0 0.0006 0 0 0 0.0002 0
Endoplasmic Reticulum 0.0064 0.0002 0.0006 0.0013 0.0018 0.0016 0.0042 0.0003 0.0007 0.0004 0.0037 0.0006 0.0032 0.0001 0.0005 0.0002 0.0085 0.0002
Endosome 0.0338 0.0007 0.0033 0.0068 0.0265 0.0007 0.007 0 0.0034 0.0004 0.0265 0.0031 0.0048 0 0.0004 0.001 0.0263 0.0001
Golgi 0.0056 0.0007 0.0051 0.0023 0.0093 0.0001 0.002 0 0.0012 0.0003 0.0049 0.0043 0.0013 0 0.0001 0 0.0109 0
Lipid Particles 0.0083 0.0001 0.0025 0.0009 0.0115 0.0002 0.0078 0.0002 0.0058 0.0065 0.0091 0.0005 0.0092 0 0.0008 0.0003 0.006 0
Mitochondria 0.0068 0.0002 0.0164 0.0047 0.01 0.0003 0.0066 0 0.0039 0.0046 0.0057 0.0006 0.0081 0 0.0064 0.0006 0.0074 0.0001
None 0.0088 0.0001 0.0033 0.0008 0.009 0.0011 0.0042 0.0001 0.0032 0.0034 0.0162 0.0003 0.0085 0.0001 0.002 0.0006 0.0044 0.0001
Nuclear Periphery 0.0171 0.001 0.0034 0.0073 0.0055 0.0035 0.0145 0.0019 0.0037 0.0027 0.0119 0.0056 0.0062 0.0007 0.0023 0.003 0.0206 0.0049
Nucleolus 0.0017 0 0.0023 0.0006 0.0104 0 0.0023 0.0001 0.001 0.0009 0.007 0.0008 0.0052 0 0.0005 0.0015 0.003 0
Nucleus 0.0276 0.0078 0.014 0.0526 0.0189 0.0229 0.0703 0.0183 0.0303 0.0402 0.0396 0.0587 0.0269 0.0088 0.0211 0.0316 0.0306 0.0378
Peroxisomes 0.0122 0.0001 0.0012 0.0005 0.0012 0 0.0057 0 0.0035 0.0008 0.001 0.0001 0.0091 0 0.0001 0 0.0006 0
Punctate Nuclear 0.0175 0.0002 0.0016 0.0006 0.0045 0.0003 0.0048 0.0001 0.0015 0.0005 0.0044 0.0004 0.0054 0 0.0013 0.0001 0.0043 0.0005
Vacuole 0.0102 0.0001 0.0018 0.0086 0.0079 0.0021 0.0075 0.0012 0.0028 0.0004 0.0095 0.0057 0.0032 0 0.0007 0.0111 0.0079 0.0002
Vacuole Periphery 0.0039 0 0.0012 0.0024 0.0056 0.0004 0.0026 0 0.0017 0.0005 0.0055 0.0014 0.0021 0 0.0013 0.0068 0.0194 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 151.6969 171.2143 200.1293 243.3358 224.1512 201.5859 208.7333 259.5311 282.2806 209.8693
Translational Efficiency 6.5399 5.624 4.6306 4.9884 4.0475 4.68 4.4728 3.9577 3.2488 3.6672

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
337 1592 216 868 1205 1834 173 2019 1542 3426 389 2887

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 4561.28 3767.51 5643.38 6618.43 2991.33 3619.87 6352.48 6841.00 3334.44 3688.48 5958.74 6774.08
Standard Deviation 1270.77 747.30 1021.53 1386.30 706.56 721.10 1033.97 1573.87 1078.88 737.07 1085.84 1523.34
Intensity Change Log 2 — -0.275827 0.307121 0.537050 — 0.275151 1.086533 1.193420 — -0.031913 0.667489 0.833570

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000494 0.000063 0.000216 0.000114 0.000458 0.000066 0.000116 0.000113 0.000466 0.000065 0.000172 0.000113
Bud Neck 0.006017 0.000446 0.003670 0.001067 0.000934 0.000311 0.002058 0.000859 0.002045 0.000374 0.002953 0.000921
Bud Site 0.008859 0.000722 0.001344 0.000757 0.001990 0.001095 0.000734 0.001685 0.003491 0.000922 0.001073 0.001406
Cell Periphery 0.002895 0.000305 0.006009 0.000490 0.000244 0.000098 0.001122 0.000199 0.000823 0.000194 0.003836 0.000287
Cytoplasm 0.370889 0.679182 0.527419 0.372183 0.653890 0.720517 0.403094 0.568879 0.592041 0.701310 0.472128 0.509741
Cytoplasmic Foci 0.016521 0.003454 0.031986 0.004844 0.004918 0.002688 0.020987 0.002755 0.007454 0.003044 0.027094 0.003383
Eisosomes 0.000006 0.000001 0.000006 0.000002 0.000002 0.000000 0.000003 0.000001 0.000003 0.000001 0.000005 0.000001
Endoplasmic Reticulum 0.000272 0.000030 0.000039 0.001267 0.000132 0.000035 0.000025 0.000018 0.000162 0.000033 0.000033 0.000393
Endosome 0.000233 0.000034 0.000122 0.000116 0.000334 0.000084 0.000038 0.000110 0.000312 0.000061 0.000084 0.000112
Golgi 0.002253 0.000410 0.002269 0.000125 0.001898 0.000379 0.000345 0.000163 0.001976 0.000393 0.001414 0.000151
Lipid Particles 0.001818 0.000241 0.005226 0.000272 0.000415 0.000123 0.000775 0.000134 0.000722 0.000178 0.003246 0.000175
Mitochondria 0.001513 0.000150 0.000259 0.000318 0.000272 0.000117 0.000251 0.000252 0.000543 0.000133 0.000255 0.000272
Mitotic Spindle 0.001980 0.000514 0.000262 0.000351 0.002198 0.001427 0.000281 0.003749 0.002150 0.001003 0.000270 0.002727
None 0.009292 0.024283 0.006011 0.013118 0.011103 0.023418 0.006706 0.021097 0.010708 0.023820 0.006320 0.018698
Nuclear Periphery 0.000444 0.000086 0.001066 0.000317 0.000248 0.000054 0.000590 0.000136 0.000291 0.000069 0.000855 0.000190
Nuclear Periphery Foci 0.001990 0.000763 0.003084 0.001461 0.002003 0.000512 0.000831 0.000195 0.002000 0.000629 0.002082 0.000575
Nucleolus 0.000341 0.000451 0.000121 0.000109 0.000173 0.000076 0.000081 0.000082 0.000210 0.000250 0.000104 0.000090
Nucleus 0.565228 0.286910 0.381679 0.598617 0.312208 0.246788 0.547434 0.396678 0.367505 0.265432 0.455395 0.457393
Peroxisomes 0.000024 0.000010 0.000008 0.000005 0.000207 0.000021 0.000007 0.000019 0.000167 0.000016 0.000007 0.000015
Vacuole 0.006860 0.001801 0.028513 0.004302 0.005223 0.001925 0.014443 0.002829 0.005581 0.001867 0.022255 0.003272
Vacuole Periphery 0.002071 0.000142 0.000692 0.000165 0.001151 0.000265 0.000079 0.000048 0.001352 0.000208 0.000419 0.000083

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 5.19 2.04 4.04 -6.84 4.92 1.61 0.96 1.53 -0.56 3.64 2.14 0.97 1.90 -1.92 6.07
Bud Neck 6.91 0.89 5.35 -7.63 5.10 6.84 -5.94 -0.47 -6.02 5.63 8.77 -5.05 3.68 -8.33 7.41
Bud Site 3.84 3.15 3.56 -3.02 3.02 1.66 0.56 0.79 -1.73 0.54 3.55 2.15 2.54 -2.58 1.23
Cell Periphery 6.02 -4.71 4.95 -7.17 8.56 5.57 -8.62 0.73 -6.18 8.87 6.39 -8.54 4.33 -7.34 9.85
Cytoplasm -23.04 -4.99 -0.01 36.16 5.97 -10.37 17.42 11.27 26.16 -12.00 -16.74 13.23 11.18 38.12 -6.63
Cytoplasmic Foci 7.48 -6.79 4.01 -6.26 9.02 3.90 -7.46 1.97 -2.96 7.76 6.93 -11.46 3.23 -5.75 12.31
Eisosomes 7.53 -2.06 2.40 -7.55 4.49 3.27 -5.91 0.32 -5.87 6.57 6.65 -7.43 0.94 -9.46 8.58
Endoplasmic Reticulum 5.40 4.93 -0.49 -1.04 -0.99 5.04 4.56 5.78 1.62 3.67 7.17 6.36 0.08 -0.98 -0.86
Endosome 3.47 0.95 2.89 -0.42 2.73 2.70 2.79 2.80 0.33 0.34 3.44 2.47 3.32 -0.10 2.29
Golgi 3.45 -0.35 4.21 6.12 6.24 2.92 2.63 3.59 2.36 5.37 3.75 0.75 4.62 4.45 6.91
Lipid Particles 2.20 -2.42 1.71 -5.26 4.48 5.03 -4.77 1.61 -4.19 5.61 3.51 -4.48 2.06 -5.59 5.38
Mitochondria 7.81 6.90 6.78 -8.95 -0.92 5.66 -0.23 0.84 -5.37 1.18 9.07 5.17 5.60 -7.52 0.84
Mitotic Spindle 1.23 2.26 1.20 -0.11 -1.87 1.45 3.58 -1.62 -2.94 -4.73 2.16 4.15 -1.11 -3.22 -5.03
None -5.95 1.26 -1.05 7.76 -4.95 -9.56 5.19 -7.19 3.30 -12.58 -11.97 5.40 -6.13 6.72 -14.13
Nuclear Periphery 7.77 -5.94 0.26 -10.52 6.15 9.29 -8.86 -0.88 -13.09 8.68 11.19 -9.55 -1.07 -16.10 9.35
Nuclear Periphery Foci 1.94 -1.53 1.62 -0.15 4.04 4.85 2.30 6.11 1.34 5.69 5.12 -0.90 5.53 1.13 6.39
Nucleolus -0.31 2.25 2.82 0.96 2.25 4.23 2.03 2.24 -3.37 0.42 -0.25 2.88 3.71 0.79 1.77
Nucleus 18.99 9.07 -1.15 -32.69 -12.82 9.37 -11.16 -10.53 -23.79 6.47 14.96 -6.35 -11.01 -34.88 -0.68
Peroxisomes 1.67 2.23 4.06 0.86 4.29 1.15 1.20 1.23 1.00 0.70 1.21 1.24 1.27 1.00 1.02
Vacuole 4.92 -6.74 -4.36 -10.54 4.82 6.59 -7.08 -3.47 -10.53 6.08 8.29 -9.84 -5.48 -14.85 8.02
Vacuole Periphery 3.62 2.30 3.75 0.84 4.32 1.48 1.81 2.00 1.29 5.59 2.44 1.83 2.87 1.59 5.01
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Co-chaperone that binds and regulates Hsp90 family chaperones; plays a role in determining prion variants; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Sba1

Sba1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sba1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available