Standard name
Human Ortholog
Description Widely-conserved NADHX dehydratase; converts (S)-NADHX to NADH in ATP-dependent manner; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; downstream intergenic region drives antisense expression and mediates coordinated regulation of YKL151C and GPM1 phosphoglycerate mutase; protein abundance increases in response to DNA replication stress; homolog of Carkd in mammals and C-terminus of YjeF in E.coli
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0
Cytoplasm 0.97 0.98 0.97 0.97 0.96 0.9 0.8 0.78 0.65 0.66 0.61 0.6 0.99 0.98 0.98 0.95 0.97 0.98 0.93 0.95 0.93 0.94 0.91 0.9
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.14 0.23 0.18 0.36 0.27 0.45 0.31 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.07 0.11 0.12 0.14 0.09 0.15 0 0 0 0.05 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 2 1 0 0 1 0 0 0 0 0 0 3 0 0 1 1 2
Bud 1 0 1 1 0 1 2 3 5 0 11 5 1 0 0 0 0 0 2 0 1 0 5 5
Bud Neck 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 1 4 0 4 6 4 3 1 3 5 0 0 3 4 3 6 0 0 0 0 0 0
Cytoplasm 283 129 153 252 376 269 284 307 147 101 167 141 225 277 330 95 76 94 275 124 158 143 265 293
Endoplasmic Reticulum 3 1 3 0 0 1 0 6 3 1 1 1 1 1 1 3 1 2 1 0 0 0 1 2
Endosome 0 0 0 0 0 0 0 1 0 0 1 2 1 0 0 0 0 0 1 0 1 0 2 4
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 1 0
Mitochondria 10 0 0 10 11 41 80 72 81 42 123 72 0 1 1 1 0 1 2 0 3 1 2 2
Nucleus 0 0 0 0 2 3 7 5 8 6 4 9 0 0 0 0 0 0 1 0 0 0 2 0
Nuclear Periphery 0 0 0 1 0 0 3 1 1 2 3 0 0 0 0 0 1 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 1 0 1 0 0 0 1 0 0 0 0 0 0 0 0 1
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0
SpindlePole 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 0 1 2
Vac/Vac Membrane 2 1 1 5 12 12 24 43 27 21 25 36 3 8 3 5 2 1 1 1 0 0 2 2
Unique Cell Count 292 131 157 259 390 299 354 396 226 153 273 236 228 284 336 100 78 96 296 132 170 153 292 328
Labelled Cell Count 299 131 159 274 401 332 406 444 277 174 339 273 231 287 339 108 83 104 296 132 170 153 292 328


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.4 6.9 6.0 5.9 6.1 5.4 5.4 6.2 5.6 5.6 5.2 5.9 6.0 7.6 8.3 14.5 15.6 14.2 5.6 5.8 6.8
Std Deviation (1e-4) 0.7 1.5 1.8 2.2 1.7 1.2 1.3 1.5 2.5 1.5 1.4 1.6 1.6 1.9 2.5 2.9 3.6 2.5 1.3 1.8 1.6
Intensity Change (Log2) – – – -0.01 0.05 -0.14 -0.14 0.06 -0.09 -0.1 -0.2 -0.01 0.02 0.36 0.48 1.28 1.39 1.26 -0.09 -0.04 0.19

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -0.1 -0.6 -2.9 -5.1 -5.6 -7.6 -7.2 -8.3 -8.4 0.9 0.1 0.6 -1.0 0 0.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 4.9 6.5 5.7 8.4 7.1 10.0 7.7 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 3.0 4.0 4.2 4.5 3.6 4.9 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.7453 3.9937 3.1652 2.8083 3.1766 3.3752 1.4499 2.0381 1.7655 2.0605 1.7103 1.7959 3.0006 3.7662 3.0731 3.5213 3.6628 3.603
Actin 0.0037 0.0003 0.0041 0.0012 0.001 0.0017 0.0132 0.0005 0.0026 0.0007 0.0113 0.0023 0.0359 0.0015 0.0143 0.0631 0.0992 0.0043
Bud 0.0022 0.0006 0.0036 0.0038 0.0002 0.0069 0.0013 0.0044 0.0004 0.0003 0.0005 0.0009 0.0006 0.0039 0.001 0.0036 0.0013 0.0004
Bud Neck 0.0003 0.0003 0.0097 0.0006 0.0006 0.0014 0.0053 0.0002 0.0004 0.0006 0.0011 0.0012 0.0183 0.0002 0.0039 0.0281 0.002 0.0029
Bud Periphery 0.0009 0.0002 0.0013 0.0006 0.0001 0.0027 0.0018 0.0012 0.0004 0.0002 0.0004 0.0007 0.0006 0.0022 0.0008 0.0023 0.0021 0.0002
Bud Site 0.0032 0.0044 0.005 0.0038 0.0002 0.0006 0.0104 0.01 0.0049 0.0002 0.0015 0.0003 0.004 0.0089 0.0028 0.0106 0.0019 0.0004
Cell Periphery 0.0002 0.0001 0.0002 0.0001 0 0.0002 0.0003 0.0003 0.0001 0.0001 0.0001 0 0.0002 0.0001 0.0001 0.0002 0.0002 0
Cytoplasm 0.8159 0.9213 0.8261 0.8393 0.9122 0.8664 0.6219 0.8392 0.7681 0.8092 0.7015 0.7389 0.7837 0.9257 0.8913 0.72 0.6802 0.9308
Cytoplasmic Foci 0.0122 0.0082 0.0122 0.0134 0.0113 0.0207 0.0372 0.0071 0.0125 0.0102 0.0346 0.0201 0.0243 0.0082 0.0099 0.047 0.0239 0.013
Eisosomes 0.0001 0 0 0 0 0 0.0001 0 0 0 0.0002 0 0.0003 0 0.0002 0.0004 0.0003 0
Endoplasmic Reticulum 0.0071 0.0031 0.0025 0.0042 0.0047 0.0035 0.0056 0.0019 0.0031 0.0017 0.0012 0.0044 0.0042 0.0022 0.0039 0.0069 0.0104 0.0023
Endosome 0.0199 0.0079 0.0056 0.0142 0.0075 0.0114 0.0372 0.003 0.0123 0.0028 0.0661 0.0153 0.0165 0.0039 0.0132 0.0451 0.0584 0.0065
Golgi 0.003 0.0005 0.0004 0.0012 0.0007 0.0011 0.0074 0.0002 0.0022 0.0002 0.0256 0.0023 0.0074 0.0004 0.0041 0.0125 0.0156 0.0011
Lipid Particles 0.004 0.0001 0.0001 0.0005 0 0.0006 0.0085 0.0001 0.0032 0 0.0466 0.0065 0.0073 0.0001 0.0073 0.0045 0.0155 0.0016
Mitochondria 0.0019 0.0005 0.0005 0.0362 0.0004 0.0012 0.0038 0.0002 0.0015 0.0003 0.0292 0.0044 0.0019 0.0006 0.0075 0.0067 0.0105 0.0019
None 0.1085 0.0405 0.1056 0.0542 0.051 0.0558 0.2016 0.125 0.176 0.1663 0.034 0.1821 0.0663 0.0347 0.0195 0.0075 0.0069 0.0217
Nuclear Periphery 0.0041 0.0021 0.0029 0.0023 0.0017 0.0026 0.0137 0.0007 0.0024 0.0011 0.0009 0.0027 0.0028 0.0008 0.0057 0.0097 0.0372 0.0019
Nucleolus 0.0002 0.0001 0.0009 0.0006 0 0.0004 0.0008 0.0001 0.0006 0 0.0002 0.0002 0.0029 0.0001 0.0003 0.0004 0.0011 0.0001
Nucleus 0.0047 0.0062 0.0104 0.0085 0.0054 0.0092 0.0103 0.0027 0.0032 0.0038 0.003 0.0031 0.006 0.0035 0.0038 0.0085 0.0127 0.0058
Peroxisomes 0.0038 0.0001 0.0002 0.0011 0.0009 0.0043 0.0083 0 0.0026 0.0002 0.0357 0.0072 0.0097 0.001 0.0037 0.0128 0.0026 0.0011
Punctate Nuclear 0.0015 0.0013 0.0065 0.0115 0.0006 0.0069 0.0057 0.0007 0.0014 0.0006 0.0016 0.006 0.004 0.0006 0.0042 0.0052 0.0097 0.0027
Vacuole 0.0018 0.002 0.0017 0.0022 0.0013 0.0018 0.0041 0.0021 0.0014 0.0011 0.0034 0.001 0.0025 0.0012 0.0014 0.0029 0.005 0.001
Vacuole Periphery 0.0008 0.0003 0.0003 0.0007 0.0003 0.0005 0.0016 0.0002 0.0004 0.0002 0.0014 0.0004 0.0005 0.0002 0.001 0.0017 0.0034 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 20.6752 18.4824 17.3239 27.6179 19.0466 39.1524 24.343 29.2086 33.2655 27.7114
Translational Efficiency 2.0597 1.5772 1.7458 1.7921 1.6074 1.3183 1.6375 1.6047 1.7052 1.4557

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2382 703 1561 111 2292 2032 447 1560 4674 2735 2008 1671

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 765.61 868.36 827.35 1164.09 743.73 812.54 1042.98 1108.90 754.88 826.89 875.35 1112.57
Standard Deviation 91.42 111.15 179.85 179.14 95.30 100.08 120.04 191.46 93.98 105.88 190.79 191.16
Intensity Change Log 2 — 0.181684 0.111888 0.604521 — 0.127660 0.487861 0.576278 — 0.155316 0.309375 0.590674

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000162 0.000285 0.000292 0.002660 0.000159 0.000297 0.000218 0.000478 0.000161 0.000294 0.000276 0.000623
Bud Neck 0.016021 0.017711 0.003602 0.002495 0.009061 0.021060 0.002415 0.004068 0.012608 0.020199 0.003338 0.003963
Bud Site 0.005830 0.014189 0.008491 0.028969 0.004758 0.015754 0.007184 0.019550 0.005305 0.015352 0.008200 0.020175
Cell Periphery 0.000098 0.000114 0.000128 0.000225 0.000076 0.000091 0.000213 0.000081 0.000087 0.000097 0.000147 0.000091
Cytoplasm 0.556987 0.502936 0.610565 0.521840 0.627772 0.546740 0.474136 0.655034 0.591698 0.535480 0.580194 0.646186
Cytoplasmic Foci 0.202171 0.228811 0.008363 0.045215 0.158442 0.180290 0.041592 0.026155 0.180728 0.192762 0.015760 0.027421
Eisosomes 0.000129 0.000082 0.000018 0.000055 0.000058 0.000073 0.000107 0.000020 0.000094 0.000076 0.000038 0.000022
Endoplasmic Reticulum 0.000888 0.000764 0.001914 0.002895 0.000950 0.000607 0.002319 0.000945 0.000919 0.000648 0.002004 0.001075
Endosome 0.012263 0.025755 0.001359 0.008385 0.006386 0.018763 0.006980 0.009493 0.009381 0.020560 0.002610 0.009419
Golgi 0.002944 0.004045 0.000143 0.000533 0.001578 0.004738 0.000118 0.009138 0.002274 0.004560 0.000137 0.008566
Lipid Particles 0.005175 0.003560 0.000601 0.002598 0.002791 0.002511 0.003009 0.000872 0.004006 0.002780 0.001137 0.000987
Mitochondria 0.003004 0.003220 0.000381 0.000213 0.001401 0.005633 0.000248 0.003508 0.002218 0.005013 0.000352 0.003289
Mitotic Spindle 0.002380 0.005706 0.006603 0.005492 0.001046 0.013186 0.000895 0.054192 0.001726 0.011263 0.005332 0.050957
None 0.002973 0.003265 0.017999 0.001043 0.003017 0.001471 0.006140 0.005890 0.002995 0.001932 0.015359 0.005568
Nuclear Periphery 0.000237 0.000319 0.000672 0.000655 0.000263 0.000327 0.001113 0.000917 0.000250 0.000325 0.000770 0.000900
Nuclear Periphery Foci 0.000421 0.000885 0.002011 0.014384 0.000425 0.000318 0.004086 0.002046 0.000423 0.000464 0.002473 0.002866
Nucleolus 0.000919 0.001334 0.000469 0.000136 0.000534 0.001144 0.000727 0.000570 0.000730 0.001193 0.000526 0.000541
Nucleus 0.118781 0.072204 0.297931 0.056207 0.131389 0.087962 0.236429 0.058350 0.124964 0.083911 0.284240 0.058207
Peroxisomes 0.003047 0.008747 0.000223 0.000733 0.001807 0.005755 0.000399 0.001357 0.002439 0.006524 0.000262 0.001316
Vacuole 0.064576 0.104392 0.037981 0.304765 0.047212 0.091069 0.211394 0.142325 0.056061 0.094494 0.076584 0.153116
Vacuole Periphery 0.000993 0.001674 0.000253 0.000503 0.000874 0.002213 0.000280 0.005012 0.000935 0.002074 0.000259 0.004712

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.40 -4.40 -1.55 -1.41 -1.30 -1.92 -2.11 -1.83 -0.06 0.11 -3.18 -4.25 -2.79 -1.15 -0.24
Bud Neck -0.79 11.00 13.13 8.34 1.41 -8.02 7.78 9.04 13.63 -0.11 -6.08 12.11 15.90 15.81 1.40
Bud Site -5.75 -1.65 -2.10 -0.94 -1.76 -7.94 -0.97 -5.61 2.52 -2.17 -9.22 -2.19 -5.71 2.12 -2.74
Cell Periphery -1.39 -3.79 -4.38 -3.10 -1.76 -2.64 -10.50 3.45 4.79 11.48 -1.67 -8.18 4.61 5.05 10.36
Cytoplasm 4.77 -0.04 5.72 3.32 5.65 10.00 14.88 5.58 -3.44 -10.65 8.71 8.77 3.15 -3.75 -4.18
Cytoplasmic Foci -2.57 46.67 33.34 23.01 -5.31 -3.67 29.03 36.42 37.04 5.49 -2.22 57.84 55.16 44.34 -4.74
Eisosomes 5.89 16.60 10.60 4.93 -6.02 -3.89 -6.95 19.12 15.96 13.88 4.34 13.99 21.48 18.88 10.24
Endoplasmic Reticulum 0.74 -9.50 -4.51 -5.01 1.65 2.59 -9.71 2.45 -0.52 11.84 2.70 -12.51 1.73 -1.17 14.22
Endosome -5.84 15.38 7.94 9.33 -4.84 -11.01 0.38 5.16 13.54 4.31 -10.66 16.01 10.36 16.41 -2.34
Golgi -1.16 13.21 12.35 4.68 -2.38 -4.87 7.84 -1.24 2.07 -3.14 -4.26 15.09 -0.20 2.28 -3.14
Lipid Particles 3.32 13.66 6.90 2.43 -5.71 1.37 -0.16 11.56 9.00 9.28 5.28 14.47 16.21 10.33 3.21
Mitochondria -0.14 5.44 5.73 3.59 1.75 -5.35 8.90 0.64 5.03 -1.99 -4.12 7.33 2.43 5.30 -1.69
Mitotic Spindle -1.53 -2.61 -1.57 -0.02 0.12 -6.28 -0.83 -9.70 -4.65 -9.54 -6.10 -3.23 -9.50 -5.31 -7.93
None -0.20 -6.92 2.12 1.29 7.66 4.60 -1.16 -2.11 -5.40 0.06 2.63 -7.07 -2.02 -3.83 5.94
Nuclear Periphery -3.81 -17.69 -7.36 -5.96 0.17 -1.77 -16.36 -9.06 -7.19 6.30 -2.90 -22.89 -10.07 -7.98 2.31
Nuclear Periphery Foci -3.16 -11.43 -6.74 -6.38 -5.31 1.58 -10.30 -7.77 -8.72 6.93 -0.88 -15.10 -10.02 -9.69 2.67
Nucleolus -1.45 4.39 7.03 4.08 4.31 -3.08 0.29 2.63 4.09 2.08 -2.82 4.19 4.64 5.12 1.63
Nucleus 9.68 -29.17 7.10 1.02 26.83 11.06 -9.49 12.01 0.60 14.01 13.81 -29.99 13.29 -0.06 35.92
Peroxisomes -5.37 13.31 10.36 7.99 -1.28 -7.51 6.44 5.18 11.28 -1.12 -8.82 13.83 9.93 13.61 -1.96
Vacuole -8.24 -1.26 -13.62 -11.74 -13.38 -13.58 -18.86 -30.61 -22.38 1.78 -14.56 -13.55 -31.90 -24.14 -19.48
Vacuole Periphery -3.22 9.34 8.20 7.15 -0.27 -4.35 5.05 -1.41 1.43 -3.05 -4.99 8.97 -1.18 1.48 -3.06
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Widely-conserved NADHX dehydratase; converts (S)-NADHX to NADH in ATP-dependent manner; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; downstream intergenic region drives antisense expression and mediates coordinated regulation of YKL151C and GPM1 phosphoglycerate mutase; protein abundance increases in response to DNA replication stress; homolog of Carkd in mammals and C-terminus of YjeF in E.coli
Localization
Cell Percentages cytoplasm (80%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Nnr2

Nnr2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nnr2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available