Standard name
Human Ortholog
Description O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0 0 0 0 0 0 0.06
Bud 0 0 0 0 0 0 0.08 0.06 0.05 0.06 0.09 0.09 0 0 0 0 0 0 0.11 0.11 0.05 0.07 0.07 0.05
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.19 0.18 0.19 0 0 0 0 0 0
Cytoplasm 0.77 0.88 0.87 0.93 0.96 0.9 0.9 0.84 0.84 0.8 0.78 0.77 0.87 0.94 0.96 0.94 0.93 0.93 0.41 0.57 0.6 0.72 0.72 0.62
Endoplasmic Reticulum 0.2 0.1 0.08 0 0 0 0 0 0 0 0 0 0.11 0 0 0.05 0 0 0.31 0.15 0.15 0.07 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0.06 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0.08 0.08 0.12 0.1 0.15 0.11 0.13 0 0 0 0 0.05 0 0.06 0.05 0.06 0 0 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 1 3 0 0 2 4 3 7 9 11 10 0 1 2 2 1 1 5 8 6 9 14 26
Bud 1 1 2 2 1 9 21 19 12 18 21 18 0 1 2 4 7 4 18 31 10 17 33 19
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 9 4 8 13 19
Bud Site 0 0 0 0 0 0 2 2 3 2 6 2 1 0 0 0 0 0 – – – – – –
Cell Periphery 1 2 8 3 3 6 6 4 3 4 4 6 1 3 2 60 37 43 0 1 1 0 3 3
Cytoplasm 118 237 155 122 179 207 236 260 204 235 182 161 184 383 425 299 196 213 69 159 115 191 327 262
Endoplasmic Reticulum 30 27 15 5 3 2 1 1 2 5 6 8 23 3 12 16 4 7 52 40 28 19 9 10
Endosome 0 0 0 0 0 0 1 4 3 2 1 1 0 3 1 1 0 0 1 5 4 3 12 28
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 3 2 0 0 0 2 3
Mitochondria 3 1 0 0 0 1 3 5 5 7 15 10 1 0 0 1 2 2 2 2 1 1 3 12
Nucleus 0 1 1 2 1 1 4 4 3 6 2 4 0 1 2 0 0 0 0 1 1 0 1 1
Nuclear Periphery 0 1 0 0 0 0 1 1 0 1 2 0 0 0 0 0 0 0 0 0 1 0 1 1
Nucleolus 0 0 0 0 0 0 0 3 1 0 1 0 0 0 0 0 1 1 0 0 0 0 1 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 1 0 0 0 2 2 2 1 0 1 0 0 0 1 0 3 10
Vac/Vac Membrane 2 9 3 4 6 18 21 38 25 44 25 27 8 16 2 6 11 3 10 12 12 8 18 20
Unique Cell Count 153 270 178 131 187 229 262 308 243 293 233 210 212 407 443 317 210 229 170 280 191 265 457 426
Labelled Cell Count 156 280 187 138 193 246 300 345 268 333 276 249 220 414 449 391 260 277 170 280 191 265 457 426


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.3 13.6 9.1 8.8 9.6 7.8 6.9 7.1 6.6 6.3 6.0 6.7 13.0 10.4 9.1 23.6 24.9 27.7 10.6 9.6 8.8
Std Deviation (1e-4) 4.0 7.2 3.1 3.7 3.4 2.1 2.3 1.9 2.0 2.1 2.2 2.5 7.7 4.6 3.7 15.1 16.9 20.7 3.2 2.7 2.3
Intensity Change (Log2) – – – -0.04 0.08 -0.21 -0.39 -0.35 -0.46 -0.51 -0.59 -0.43 0.52 0.19 0.0 1.38 1.45 1.61 0.22 0.09 -0.05


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 1.7 1.7 0 0 0 0 0 0
Bud 0 0 0 3.2 2.6 2.2 2.6 3.4 3.3 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 -1.6 -1.0 -1.3 0 0 0 -1.7 -0.9 0 0 0 4.5 4.0 4.3
Cytoplasm 1.7 3.0 1.1 1.0 -0.8 -0.9 -1.9 -2.3 -2.6 -0.1 2.9 4.0 2.8 2.1 2.0
Endoplasmic Reticulum -1.6 -3.0 -3.8 -4.4 -4.8 -3.9 -3.5 -2.7 -1.9 0.8 -5.0 -3.2 -1.5 -3.0 -2.4
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 3.4 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 2.8 2.9 4.1 3.5 4.7 3.6 4.1 1.2 1.4 0 0 1.9 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 10.2065 9.91 6.2144 4.8737 4.7575 9.7417 9.6111 8.944 7.1441 5.4848 4.2277 10.3868 13.6131 13.1957 9.5827 6.137 5.7417 12.8705
Actin 0.0188 0.0056 0.0108 0.0046 0.0055 0.0047 0.0339 0.0039 0.0132 0.0018 0.0032 0.008 0.0184 0.0054 0.0215 0.0059 0.0524 0.0024
Bud 0.0017 0.0086 0.0079 0.0222 0.0046 0.0038 0.0014 0.0015 0.0055 0.0221 0.0053 0.0019 0.0011 0.0033 0.0043 0.0072 0.023 0.0012
Bud Neck 0.0014 0.0011 0.0016 0.0017 0.0021 0.0051 0.014 0.0006 0.0016 0.0006 0.0006 0.0039 0.0011 0.0008 0.0042 0.0008 0.0027 0.0036
Bud Periphery 0.0025 0.0051 0.0086 0.0162 0.0014 0.0007 0.001 0.0007 0.0036 0.0238 0.008 0.0017 0.0022 0.0025 0.0034 0.0112 0.0203 0.0012
Bud Site 0.0028 0.0149 0.0084 0.0019 0.0023 0.0004 0.004 0.0051 0.0071 0.001 0.0011 0.0003 0.0017 0.0087 0.0031 0.0024 0.0041 0.0002
Cell Periphery 0.0004 0.0006 0.0005 0.0002 0.0002 0.0002 0.0004 0.0002 0.0004 0.0001 0.0001 0.0002 0.0005 0.0013 0.0003 0.0005 0.0005 0.0001
Cytoplasm 0.6822 0.8237 0.7574 0.797 0.7335 0.7529 0.7449 0.8724 0.7988 0.8152 0.6563 0.7376 0.7585 0.8728 0.85 0.8109 0.7058 0.8369
Cytoplasmic Foci 0.0262 0.0073 0.0198 0.0299 0.0441 0.023 0.0148 0.0068 0.0109 0.0067 0.0295 0.0077 0.0102 0.0045 0.0172 0.0099 0.0146 0.0051
Eisosomes 0.0003 0 0.0001 0 0 0 0.0002 0 0.0002 0 0 0.0001 0.0001 0 0.0002 0 0.0003 0
Endoplasmic Reticulum 0.0871 0.0375 0.0151 0.0173 0.0176 0.1142 0.0559 0.048 0.0293 0.0046 0.0028 0.1429 0.0846 0.0496 0.0117 0.0165 0.0201 0.0928
Endosome 0.0249 0.0048 0.0197 0.0194 0.0255 0.0088 0.025 0.0034 0.0095 0.0043 0.008 0.01 0.0231 0.0029 0.0212 0.0096 0.0139 0.0066
Golgi 0.005 0.0006 0.0018 0.001 0.0064 0.0008 0.0059 0.0004 0.0028 0.0002 0.002 0.0012 0.0053 0.0004 0.004 0.0005 0.0122 0.0007
Lipid Particles 0.008 0.0012 0.0021 0.0008 0.0015 0.0006 0.0061 0.0003 0.0051 0 0.0073 0.0042 0.0069 0.0012 0.0033 0.0002 0.0115 0.0001
Mitochondria 0.0064 0.0009 0.0014 0.0012 0.0022 0.0006 0.0021 0.0003 0.0019 0.0012 0.0017 0.005 0.0116 0.0018 0.0094 0.0013 0.0042 0.0008
None 0.032 0.0197 0.0779 0.0317 0.0906 0.0102 0.0115 0.0337 0.0682 0.1016 0.1927 0.007 0.0065 0.0141 0.0049 0.0781 0.0569 0.0027
Nuclear Periphery 0.0342 0.0243 0.0158 0.0137 0.0204 0.032 0.0295 0.0085 0.0142 0.0029 0.0025 0.027 0.0319 0.0095 0.0111 0.0123 0.0086 0.019
Nucleolus 0.0022 0.0004 0.0006 0.0003 0.0008 0.0003 0.0006 0.0001 0.0007 0.0001 0.0002 0.0003 0.0003 0.0003 0.0002 0.0003 0.0003 0
Nucleus 0.0387 0.0299 0.0305 0.0221 0.0168 0.0292 0.0324 0.0095 0.0142 0.0085 0.006 0.0309 0.0197 0.0131 0.0197 0.0213 0.0124 0.0226
Peroxisomes 0.0095 0.0006 0.001 0.0015 0.0044 0.0005 0.0038 0.0004 0.003 0.0006 0.0641 0.0044 0.0021 0.0002 0.0029 0.0003 0.0272 0.0001
Punctate Nuclear 0.0088 0.005 0.0117 0.0103 0.0151 0.0073 0.0078 0.0015 0.0054 0.0009 0.0035 0.0023 0.0035 0.0015 0.003 0.0029 0.003 0.0013
Vacuole 0.0057 0.0074 0.0059 0.0057 0.0045 0.0039 0.0036 0.0026 0.0037 0.0031 0.004 0.0023 0.0086 0.0056 0.0033 0.0068 0.005 0.0019
Vacuole Periphery 0.0014 0.0008 0.0013 0.0011 0.0008 0.0007 0.0011 0.0002 0.0009 0.0006 0.001 0.0011 0.0021 0.0006 0.0011 0.0012 0.001 0.0006

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 39.2537 32.6869 289.6346 999.0893 367.4135 19.3473 25.7593 63.6387 689.2058 550.8899
Translational Efficiency 0.9827 1.2488 1.9546 1.4686 2.3735 1.1958 2.1848 1.6336 2.3117 2.5243

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
766 1379 1737 1690 1785 2545 197 1195 2551 3924 1934 2885

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 853.65 1062.86 992.26 1683.20 952.29 1104.59 1307.35 1573.07 922.67 1089.92 1024.36 1637.58
Standard Deviation 236.26 320.90 373.78 986.57 262.02 311.76 352.83 780.98 258.55 315.63 383.73 908.70
Intensity Change Log 2 — 0.316235 0.217074 0.979490 — 0.214038 0.457173 0.724110 — 0.263249 0.348639 0.850470

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.004666 0.002306 0.000711 0.005326 0.003965 0.001984 0.001312 0.002301 0.004175 0.002097 0.000772 0.004073
Bud Neck 0.061530 0.013156 0.007626 0.021802 0.031012 0.010028 0.006459 0.017612 0.040176 0.011127 0.007507 0.020067
Bud Site 0.179484* 0.074347 0.018822 0.065131 0.139682* 0.034742 0.006720 0.048466 0.151633* 0.048660 0.017590 0.058228
Cell Periphery 0.012118 0.002601 0.000933 0.015205 0.006295 0.001033 0.001870 0.002372 0.008044 0.001584 0.001028 0.009889
Cytoplasm 0.339882* 0.503050* 0.576192* 0.344157* 0.477440* 0.522030* 0.353310* 0.392657* 0.436135* 0.515360* 0.553489* 0.364246*
Cytoplasmic Foci 0.112009 0.089915 0.013963 0.022694 0.063863 0.061162 0.023487 0.036124 0.078320 0.071267 0.014933 0.028257
Eisosomes 0.000964 0.000111 0.000025 0.000089 0.000395 0.000080 0.000101 0.000040 0.000566 0.000091 0.000033 0.000069
Endoplasmic Reticulum 0.120998* 0.115427* 0.039186 0.102494* 0.114901* 0.152718* 0.064441 0.047123 0.116732* 0.139613* 0.041759 0.079559
Endosome 0.025133 0.019406 0.005463 0.012253 0.008958 0.015490 0.016049 0.024041 0.013815 0.016866 0.006542 0.017136
Golgi 0.006078 0.004912 0.000794 0.005293 0.002058 0.003204 0.000976 0.007035 0.003265 0.003804 0.000813 0.006015
Lipid Particles 0.011783 0.013549 0.006278 0.072432 0.006946 0.009756 0.019881 0.038590 0.008398 0.011089 0.007664 0.058414
Mitochondria 0.001936 0.001695 0.000876 0.001144 0.001937 0.002310 0.000465 0.002998 0.001937 0.002094 0.000834 0.001912
Mitotic Spindle 0.000496 0.003493 0.009869 0.034901 0.001615 0.009043 0.008693 0.085609 0.001279 0.007093 0.009749 0.055905
None 0.003829 0.005683 0.018076 0.004191 0.006688 0.003494 0.003880 0.007156 0.005829 0.004263 0.016630 0.005419
Nuclear Periphery 0.000219 0.000812 0.005468 0.003063 0.000643 0.004098 0.018914 0.008696 0.000516 0.002943 0.006838 0.005396
Nuclear Periphery Foci 0.003282 0.016324 0.032486 0.057437 0.008491 0.014467 0.068841 0.054083 0.006927 0.015120 0.036190 0.056048
Nucleolus 0.000316 0.000548 0.000643 0.000255 0.000384 0.000387 0.000470 0.000366 0.000364 0.000443 0.000625 0.000301
Nucleus 0.017249 0.024176 0.189347* 0.052780 0.042430 0.040246 0.181036* 0.046631 0.034869 0.034598 0.188500* 0.050233
Peroxisomes 0.004969 0.002581 0.000238 0.001464 0.001613 0.001778 0.000295 0.005267 0.002620 0.002060 0.000244 0.003039
Vacuole 0.090498 0.103705 0.072326 0.176260 0.078924 0.110159 0.222366* 0.166979 0.082399 0.107891 0.087609 0.172416
Vacuole Periphery 0.002563 0.002201 0.000678 0.001629 0.001760 0.001792 0.000434 0.005856 0.002001 0.001936 0.000653 0.003380

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 3.73 6.59 0.73 -3.12 -6.29 3.63 4.24 3.19 -0.81 -1.74 4.92 8.79 1.66 -3.27 -7.41
Bud Neck 10.72 11.82 8.78 -6.51 -12.12 9.81 9.93 5.75 -6.02 -6.22 14.25 15.40 9.56 -10.27 -13.00
Bud Site 10.52 17.08 11.97 2.00 -13.74 18.27* 23.20* 16.02* -2.84 -11.48 20.33 27.21 18.85 -2.55 -15.35
Cell Periphery 5.91 7.08 2.33 -7.07 -10.19 8.75 6.93 7.30 -2.50 -0.88 9.99 11.10 3.43 -8.64 -10.33
Cytoplasm -12.13 -16.00 -0.28 14.22 19.80 -4.38 8.09 9.72 14.08 -2.27 -9.64 -8.41 10.21 21.32 18.82
Cytoplasmic Foci 3.17 16.59 12.81 13.22 -8.55 0.53 11.61 9.17 9.68 -4.17 1.98 23.11 15.16 15.80 -11.11
Eisosomes 7.23 7.94 7.56 3.08 -7.88 7.71 7.19 8.97 3.90 4.88 10.38 11.67 11.16 3.69 -5.77
Endoplasmic Reticulum 0.85 8.75 7.12 8.30 -3.25 -3.91 7.66 14.02 19.90 1.50 -2.63 14.52 14.08 19.52 -1.01
Endosome 2.87 10.77 8.88 8.69 -5.36 -7.93 -2.10 -3.62 1.19 -0.88 -3.28 10.61 3.57 7.29 -6.87
Golgi 1.37 6.95 3.87 2.75 -3.56 -1.72 3.36 -1.17 0.20 -3.35 -0.77 7.19 1.09 1.78 -4.90
Lipid Particles -0.93 2.45 -13.61 -13.60 -16.58 -3.03 -2.74 -10.72 -9.45 -4.33 -3.04 0.05 -18.70 -17.28 -18.46
Mitochondria 0.58 4.63 4.34 1.57 -0.04 -0.73 3.70 1.14 2.36 -3.01 -0.30 3.93 2.77 3.64 -1.77
Mitotic Spindle -4.93 -7.08 -12.87 -11.89 -10.01 -5.99 -1.98 -14.85 -13.44 -10.95 -6.96 -6.62 -19.38 -17.29 -16.07
None -1.03 -5.53 0.64 2.06 7.40 4.27 3.71 2.26 -0.66 -0.72 2.30 -5.00 3.04 1.06 7.03
Nuclear Periphery -4.17 -7.45 -12.20 -7.42 3.56 -6.87 -2.74 -4.97 -1.05 1.47 -7.35 -7.34 -7.96 -1.44 2.42
Nuclear Periphery Foci -8.62 -13.17 -17.74 -10.19 -4.47 -4.65 -5.31 -9.84 -7.75 0.91 -8.22 -12.46 -18.49 -13.42 -3.68
Nucleolus -1.48 -3.24 -0.83 1.02 2.73 -0.22 -0.66 -0.80 -0.54 0.11 -1.16 -3.44 -0.88 0.50 2.91
Nucleus -4.39 -37.48 -20.20 -17.43 24.82 0.84 -10.41 -4.28 -5.14 9.41 -0.25 -35.69 -14.26 -15.13 28.36
Peroxisomes 3.45 7.26 5.62 3.95 -3.04 -0.65 8.18 -1.52 -1.26 -3.32 2.04 10.21 2.15 0.79 -4.37
Vacuole -3.22 -2.65 -20.34 -18.45 -19.28 -8.40 -11.77 -22.08 -17.33 2.70 -8.82 -9.10 -31.76 -25.44 -19.01
Vacuole Periphery 1.14 6.18 4.99 5.47 -2.03 0.02 4.33 -0.89 -0.99 -3.40 0.41 5.68 1.44 1.41 -3.53
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
Localization
Cell Percentages ER (32%), cytoplasm (28%), mixed (31%)
Cell Cycle Regulation Yes
cytoplasm - MA (0.00031)
Subcompartmental Group N/A

Pir1

Pir1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pir1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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