Standard name | |
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Human Ortholog | |
Description | eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 1 | 4 | 13 | – | 15 | 8 | 7 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 1 | 0 | 3 | – | 0 | 1 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 1 | 13 | 4 | 6 | 9 | 6 | 9 | – | 15 | 10 | 12 | 22 | 3 | 6 | 12 | 18 | 24 | 27 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 119 | 340 | 121 | 170 | 222 | 205 | 240 | – | 183 | 187 | 133 | 144 | 131 | 313 | 315 | 227 | 230 | 195 | 118 | 326 | 120 | 133 | 298 | 297 |
Endoplasmic Reticulum | 2 | 8 | 1 | 6 | 16 | 18 | 43 | – | 41 | 38 | 15 | 35 | 2 | 3 | 4 | 7 | 6 | 4 | 3 | 5 | 4 | 0 | 5 | 4 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 1 | – | 2 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 1 | 1 |
Golgi | 0 | 0 | 0 | 0 | 0 | 2 | 5 | – | 3 | 2 | 0 | 10 | 0 | 0 | 1 | 3 | 0 | 2 | 1 | 1 | 0 | 0 | 0 | 1 |
Mitochondria | 1 | 1 | 0 | 1 | 1 | 7 | 18 | – | 41 | 33 | 77 | 66 | 0 | 0 | 0 | 2 | 1 | 3 | 0 | 1 | 2 | 2 | 3 | 3 |
Nucleus | 0 | 1 | 0 | 2 | 2 | 0 | 1 | – | 2 | 2 | 0 | 0 | 1 | 1 | 0 | 7 | 3 | 2 | 0 | 1 | 0 | 0 | 0 | 1 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Vac/Vac Membrane | 1 | 0 | 4 | 1 | 2 | 2 | 12 | – | 18 | 18 | 8 | 25 | 1 | 0 | 0 | 19 | 15 | 21 | 0 | 4 | 3 | 0 | 4 | 2 |
Unique Cell Count | 123 | 345 | 124 | 177 | 239 | 230 | 311 | 280 | 271 | 215 | 268 | 134 | 315 | 320 | 255 | 254 | 226 | 127 | 346 | 136 | 140 | 317 | 319 | |
Labelled Cell Count | 124 | 363 | 130 | 186 | 254 | 244 | 345 | 320 | 299 | 253 | 324 | 139 | 323 | 333 | 284 | 280 | 254 | 127 | 346 | 136 | 140 | 317 | 319 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 10.9 | 15.0 | 12.8 | 12.0 | 12.9 | 11.3 | 11.1 | – | 10.0 | 10.4 | 9.2 | 10.2 | 11.8 | 12.5 | 12.4 | 18.8 | 18.2 | 17.3 | 11.2 | 11.9 | 12.6 |
Std Deviation (1e-4) | 1.6 | 2.1 | 1.8 | 2.0 | 2.1 | 1.6 | 1.6 | – | 1.7 | 2.1 | 1.8 | 2.0 | 1.7 | 1.5 | 1.6 | 4.5 | 4.1 | 4.6 | 1.9 | 1.7 | 1.8 |
Intensity Change (Log2) | – | – | – | -0.09 | 0.02 | -0.18 | -0.21 | – | -0.36 | -0.3 | -0.48 | -0.32 | -0.11 | -0.03 | -0.04 | 0.55 | 0.51 | 0.44 | -0.19 | -0.1 | -0.02 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 3.0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | – | 0.9 | 0 | 1.0 | 1.8 | 0 | 0 | 0 | 1.5 | 2.2 | 2.7 |
Cytoplasm | -0.7 | -1.9 | -2.8 | -5.1 | – | -6.9 | -6.4 | -7.3 | -8.6 | 0.1 | 1.6 | 0.6 | -2.9 | -2.5 | -3.4 |
Endoplasmic Reticulum | 0 | 2.5 | 2.8 | 4.1 | – | 4.2 | 4.1 | 2.6 | 3.9 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 2.7 | – | 4.5 | 4.1 | 7.6 | 6.1 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | – | 1.3 | 1.4 | 0 | 2.1 | 0 | 0 | 0 | 1.6 | 1.1 | 2.1 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 4.951 | 6.8147 | 6.2255 | 4.9251 | 4.9961 | 6.5595 | 6.3352 | 8.5145 | 7.1434 | 7.3146 | 6.5221 | 7.4828 | 5.8483 | 7.9144 | 6.749 | 6.9345 | 5.498 | 6.8393 |
Actin | 0.0175 | 0.0007 | 0.0144 | 0.0128 | 0.0027 | 0.0036 | 0.0033 | 0.0004 | 0.0029 | 0.0025 | 0.0011 | 0.0008 | 0.0609 | 0.0004 | 0.0258 | 0.001 | 0.0127 | 0.0065 |
Bud | 0.0006 | 0.0006 | 0.0051 | 0.0006 | 0.0024 | 0.0012 | 0.0004 | 0.0004 | 0.0007 | 0.0008 | 0.0006 | 0.0007 | 0.0008 | 0.0021 | 0.0017 | 0.0007 | 0.0004 | 0.0006 |
Bud Neck | 0.0021 | 0.0046 | 0.0033 | 0.0007 | 0.0016 | 0.0012 | 0.0003 | 0.0002 | 0.0052 | 0.01 | 0.0119 | 0.0007 | 0.0033 | 0.0001 | 0.0014 | 0.0009 | 0.0008 | 0.0009 |
Bud Periphery | 0.0005 | 0.0004 | 0.0013 | 0.0003 | 0.0031 | 0.0014 | 0.0003 | 0.0002 | 0.0004 | 0.0004 | 0.0003 | 0.0004 | 0.0007 | 0.0005 | 0.0023 | 0.0003 | 0.0003 | 0.0004 |
Bud Site | 0.0041 | 0.0067 | 0.0117 | 0.0012 | 0.0028 | 0.0007 | 0.0008 | 0.001 | 0.0019 | 0.0016 | 0.0164 | 0.0001 | 0.0106 | 0.0013 | 0.0044 | 0.0013 | 0.0021 | 0.0002 |
Cell Periphery | 0.0006 | 0.0006 | 0.0003 | 0.0003 | 0.0004 | 0.0008 | 0.0003 | 0.0002 | 0.0002 | 0.0003 | 0.001 | 0.0001 | 0.0005 | 0.0002 | 0.0003 | 0.0001 | 0.0001 | 0.0001 |
Cytoplasm | 0.7167 | 0.9283 | 0.851 | 0.6962 | 0.7028 | 0.7929 | 0.7843 | 0.9384 | 0.8057 | 0.7935 | 0.7921 | 0.831 | 0.6838 | 0.9509 | 0.8248 | 0.8001 | 0.7397 | 0.7872 |
Cytoplasmic Foci | 0.0392 | 0.0112 | 0.0221 | 0.0368 | 0.0275 | 0.0211 | 0.0255 | 0.0097 | 0.0207 | 0.0236 | 0.0265 | 0.022 | 0.0356 | 0.0113 | 0.0329 | 0.0602 | 0.0449 | 0.0233 |
Eisosomes | 0.0004 | 0 | 0.0001 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0.0007 | 0 | 0.0001 | 0 | 0.0002 | 0 |
Endoplasmic Reticulum | 0.0481 | 0.0078 | 0.0131 | 0.0314 | 0.0145 | 0.0408 | 0.0446 | 0.0234 | 0.019 | 0.0187 | 0.0131 | 0.0366 | 0.0585 | 0.0071 | 0.0198 | 0.0047 | 0.0075 | 0.0382 |
Endosome | 0.0943 | 0.0251 | 0.0386 | 0.1446 | 0.0516 | 0.0886 | 0.0819 | 0.0151 | 0.0758 | 0.0989 | 0.0997 | 0.0697 | 0.0714 | 0.0158 | 0.0381 | 0.0742 | 0.068 | 0.0921 |
Golgi | 0.0213 | 0.003 | 0.0077 | 0.0192 | 0.0131 | 0.0176 | 0.0121 | 0.0019 | 0.0139 | 0.0096 | 0.0109 | 0.011 | 0.028 | 0.0011 | 0.0129 | 0.0125 | 0.019 | 0.0094 |
Lipid Particles | 0.0072 | 0.0002 | 0.0058 | 0.0196 | 0.0475 | 0.0001 | 0.0034 | 0.0001 | 0.0023 | 0.0015 | 0.0099 | 0.0039 | 0.0046 | 0.0001 | 0.0112 | 0.0083 | 0.0077 | 0.0043 |
Mitochondria | 0.0113 | 0.0016 | 0.0042 | 0.0062 | 0.0193 | 0.0153 | 0.0058 | 0.0013 | 0.0258 | 0.0032 | 0.0018 | 0.0108 | 0.0065 | 0.0008 | 0.0037 | 0.003 | 0.0043 | 0.0069 |
None | 0.0075 | 0.0008 | 0.003 | 0.002 | 0.0027 | 0.0008 | 0.0092 | 0.0011 | 0.0013 | 0.0015 | 0.001 | 0.0011 | 0.0048 | 0.0035 | 0.0033 | 0.0006 | 0.0159 | 0.0039 |
Nuclear Periphery | 0.0054 | 0.0006 | 0.0016 | 0.0031 | 0.0019 | 0.0016 | 0.0054 | 0.0011 | 0.0025 | 0.0024 | 0.0023 | 0.001 | 0.0056 | 0.0006 | 0.0017 | 0.0009 | 0.037 | 0.0092 |
Nucleolus | 0.0005 | 0.0003 | 0.0003 | 0.0001 | 0.0239 | 0 | 0.0001 | 0 | 0.0001 | 0.0002 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0015 | 0.0003 | 0.0006 | 0.0002 |
Nucleus | 0.0029 | 0.0006 | 0.0013 | 0.0013 | 0.0248 | 0.0009 | 0.0022 | 0.0008 | 0.001 | 0.0023 | 0.0014 | 0.0008 | 0.0015 | 0.0006 | 0.0016 | 0.001 | 0.004 | 0.0021 |
Peroxisomes | 0.0032 | 0.0014 | 0.0067 | 0.0088 | 0.0056 | 0.0001 | 0.0018 | 0 | 0.0038 | 0.0003 | 0.0012 | 0.002 | 0.0102 | 0.0001 | 0.004 | 0.0104 | 0.0175 | 0.0021 |
Punctate Nuclear | 0.0045 | 0.0001 | 0.0011 | 0.0009 | 0.0325 | 0.0001 | 0.0012 | 0.0001 | 0.0002 | 0.0013 | 0.0002 | 0.0001 | 0.0018 | 0.0001 | 0.0011 | 0.0017 | 0.0066 | 0.0062 |
Vacuole | 0.0091 | 0.0044 | 0.0058 | 0.0099 | 0.0144 | 0.0072 | 0.0139 | 0.0039 | 0.0129 | 0.0215 | 0.0063 | 0.0047 | 0.008 | 0.0025 | 0.0055 | 0.0138 | 0.007 | 0.0035 |
Vacuole Periphery | 0.0032 | 0.0011 | 0.0014 | 0.0037 | 0.0046 | 0.0038 | 0.0028 | 0.0007 | 0.0038 | 0.006 | 0.0022 | 0.0024 | 0.002 | 0.0007 | 0.0017 | 0.004 | 0.0036 | 0.0026 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 17.4313 | 23.3738 | 24.6676 | 37.4809 | 32.0174 | 20.906 | 32.2988 | 34.383 | 34.6001 | 31.7562 |
Translational Efficiency | 2.962 | 2.8886 | 2.5288 | 1.5318 | 1.9022 | 2.8067 | 1.9468 | 1.7105 | 2.0348 | 2.018 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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