Standard name
Human Ortholog
Description Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.7 0.62 – 0.88 0.71 0.75 0.71 0.61 0.61 0.67 0.74 0.67 0.89 0.96 0.99 0.31 0.41 0.34 0.2 0.13 0.29 0.23 0.27 0.31
Endoplasmic Reticulum 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0
Endosome 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0.11 0 0 0 0
Golgi 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.2 0 – 0 0 0 0.07 0 0.1 0.06 0.17 0.09 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 – 0 0.05 0.09 0.09 0.13 0.08 0.08 0.06 0.06 0 0 0 0.2 0.16 0.11 0 0 0 0 0 0
Nuclear Periphery 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.23 0.41 – 0.16 0.37 0.38 0.3 0.35 0.42 0.33 0.26 0.33 0.12 0 0 0.61 0.52 0.69 0.67 0.64 0.56 0.6 0.59 0.55
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 – 0 0 0 0 0 0 1 0 1 1 0 0 0 0 0 0 0 0 0 2 2
Bud 1 0 – 0 0 0 1 3 6 6 10 7 0 0 0 0 0 0 0 4 1 8 10 8
Bud Neck 0 0 – 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 1 1
Bud Site 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 – 1 0 0 0 1 0 1 0 0 1 0 1 0 0 0 0 0 0 0 1 0
Cytoplasm 128 69 – 154 215 213 295 249 228 270 215 259 391 551 584 67 53 66 41 16 19 45 135 142
Endoplasmic Reticulum 1 2 – 0 0 0 3 0 0 1 0 0 2 1 1 9 7 10 1 0 0 1 2 4
Endosome 1 0 – 2 8 0 0 0 0 2 0 2 9 0 0 9 9 4 8 13 2 8 12 9
Golgi 0 0 – 0 0 0 0 0 0 0 0 0 1 1 0 2 1 4 0 2 0 0 1 1
Mitochondria 36 5 – 3 0 6 30 17 38 25 49 35 1 0 1 4 4 6 5 4 2 5 11 15
Nucleus 2 2 – 0 15 25 37 51 30 31 16 24 0 1 1 44 20 21 1 0 0 0 2 0
Nuclear Periphery 1 0 – 0 0 1 4 5 3 3 5 1 0 1 0 0 0 0 0 0 0 0 1 2
Nucleolus 0 2 – 1 0 0 0 0 0 0 0 0 0 0 0 2 1 0 0 0 0 0 1 0
Peroxisomes 0 0 – 0 0 0 0 0 0 0 0 0 1 1 1 0 0 1 0 0 0 0 0 1
SpindlePole 0 0 – 4 2 0 1 1 1 1 1 2 3 1 0 1 1 1 4 1 0 3 8 6
Vac/Vac Membrane 43 46 – 28 111 107 126 141 157 133 76 129 51 20 9 133 66 136 138 82 36 117 300 253
Unique Cell Count 183 112 176 304 285 418 405 371 404 290 389 437 573 590 218 128 197 207 129 66 196 506 459
Labelled Cell Count 213 126 193 351 352 498 468 463 474 372 460 462 577 598 271 162 249 207 129 66 196 506 459


Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.5 4.7 – 4.5 5.7 4.7 4.5 5.2 4.7 4.8 4.3 4.9 4.9 4.9 4.7 7.1 7.2 7.3 4.8 4.8 5.1
Std Deviation (1e-4) 0.7 1.1 – 1.4 1.7 1.3 1.4 1.8 1.8 1.5 1.5 1.6 1.0 1.0 1.4 2.8 2.5 2.9 1.3 1.3 1.6
Intensity Change (Log2) – – – – – – – – – – – – – – – – – – – – –

RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510HU80HU120HU1600510rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.702 0.1857 -0.2052 -0.3568 -0.2022 -0.1887 -0.9312 -0.0185 -0.1771 -0.1786 -0.2702 -0.1234 -1.5431 -0.5908 -1.0169 -0.3912 -0.815 -1.1521
Actin 0.0114 0.0002 0.003 0.0005 0.019 0.0004 0.005 0.0004 0.0002 0.0001 0.0208 0.0034 0.0469 0.0001 0.0047 0.009 0.0018 0.0012
Bud 0.0017 0.0062 0.0028 0.0008 0.002 0.0037 0.0026 0.005 0.0024 0.001 0.0017 0.0006 0.0013 0.0006 0.0016 0.0011 0.0025 0.001
Bud Neck 0.0026 0.0033 0.0116 0.0014 0.0039 0.0048 0.0022 0.0086 0.004 0.0069 0.0019 0.005 0.0044 0.001 0.0013 0.0019 0.0037 0.0012
Bud Periphery 0.0062 0.0053 0.0044 0.0017 0.0056 0.0057 0.004 0.0079 0.0023 0.0019 0.0022 0.0014 0.0019 0.0009 0.0047 0.0017 0.0032 0.0026
Bud Site 0.0019 0.0235 0.0187 0.0011 0.0052 0.0013 0.0169 0.009 0.0036 0.0039 0.0019 0.0011 0.0164 0.0028 0.0034 0.004 0.0107 0.0005
Cell Periphery 0.0012 0.0019 0.0014 0.0009 0.0012 0.0011 0.001 0.0017 0.0011 0.0013 0.0006 0.0008 0.0009 0.0015 0.0015 0.0008 0.0006 0.001
Cytoplasm 0.093 0.0797 0.0591 0.0398 0.0443 0.1042 0.0809 0.107 0.0787 0.0832 0.0669 0.1215 0.0861 0.0834 0.0572 0.025 0.1354 0.1057
Cytoplasmic Foci 0.0683 0.0669 0.071 0.0775 0.0685 0.0784 0.0776 0.0562 0.0682 0.0464 0.0638 0.0478 0.0485 0.0489 0.043 0.0588 0.0798 0.0378
Eisosomes 0.0004 0.0001 0.0002 0.0004 0.0002 0.0001 0.0005 0.0001 0.0001 0.0002 0.0002 0.0001 0.0007 0 0.0001 0.0001 0 0
Endoplasmic Reticulum 0.0088 0.0061 0.0044 0.0023 0.0037 0.0041 0.0078 0.007 0.0025 0.0022 0.0031 0.0037 0.0074 0.003 0.0057 0.0015 0.0066 0.0029
Endosome 0.1822 0.1534 0.1592 0.2433 0.2196 0.182 0.1344 0.1233 0.2151 0.1982 0.1992 0.1612 0.1609 0.1938 0.2206 0.1895 0.1972 0.1754
Golgi 0.0069 0.0029 0.0049 0.0066 0.011 0.0027 0.0088 0.0022 0.0062 0.003 0.0158 0.0027 0.0107 0.0043 0.0052 0.0095 0.013 0.0039
Lipid Particles 0.0152 0.0146 0.0241 0.0338 0.0433 0.0218 0.0283 0.0072 0.0159 0.0157 0.0285 0.0213 0.0236 0.0148 0.0115 0.0149 0.0085 0.0081
Mitochondria 0.0197 0.0218 0.0128 0.0269 0.0215 0.0083 0.0205 0.0074 0.0189 0.007 0.0076 0.0042 0.0183 0.0148 0.036 0.0108 0.0438 0.0069
None 0.3032 0.209 0.2915 0.1921 0.1278 0.2089 0.4402 0.3302 0.2045 0.1438 0.2699 0.1918 0.2396 0.1826 0.1165 0.1562 0.1251 0.1374
Nuclear Periphery 0.0129 0.0117 0.0056 0.004 0.0327 0.0089 0.0069 0.0098 0.0037 0.0034 0.0036 0.0139 0.0135 0.0032 0.0094 0.004 0.0167 0.0038
Nucleolus 0.0044 0.0071 0.0115 0.0139 0.0098 0.0064 0.0027 0.0042 0.0066 0.018 0.0052 0.0027 0.0038 0.004 0.0027 0.0021 0.0041 0.0014
Nucleus 0.0125 0.0226 0.0135 0.0299 0.0136 0.0204 0.0053 0.0133 0.0212 0.0129 0.012 0.0112 0.0046 0.0052 0.0055 0.0034 0.0386 0.0057
Peroxisomes 0.0079 0.0043 0.0052 0.0077 0.0164 0.004 0.0298 0.0036 0.0089 0.0034 0.0149 0.0105 0.0244 0.0014 0.0042 0.0053 0.0058 0.0012
Punctate Nuclear 0.0094 0.0035 0.0075 0.0076 0.005 0.0094 0.0092 0.0018 0.004 0.0026 0.0033 0.0044 0.0073 0.001 0.0019 0.0324 0.005 0.0009
Vacuole 0.2001 0.3268 0.2637 0.2716 0.3071 0.2913 0.1008 0.2751 0.2966 0.3989 0.2585 0.358 0.234 0.3975 0.3992 0.3994 0.2645 0.4533
Vacuole Periphery 0.0303 0.0293 0.0239 0.0361 0.0388 0.0319 0.0146 0.0191 0.0353 0.0459 0.0184 0.0328 0.0449 0.0352 0.064 0.0688 0.0332 0.0483

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 363.9006 110.5937 39.9237 60.5801 416.9006 256.2046 87.6436 48.9546 50.398 332.1837
Translational Efficiency 1.8819 1.6332 0.9631 1.1217 1.6133 2.6042 1.6486 1.5725 1.2992 1.7766

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1762 1291 2790 164 1727 1979 311 1463 3489 3270 3101 1627

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 730.62 736.27 752.98 911.62 663.59 746.99 866.83 912.54 697.44 742.76 764.40 912.45
Standard Deviation 83.77 105.36 109.84 140.76 111.65 90.00 89.09 300.60 104.10 96.50 113.23 288.53
Intensity Change Log 2 — 0.011114 0.043490 0.319311 — 0.170797 0.385457 0.459596 — 0.089324 0.216377 0.387784

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000078 0.000296 0.000243 0.001419 0.000382 0.000494 0.000138 0.002594 0.000228 0.000416 0.000232 0.002475
Bud Neck 0.043350 0.038007 0.021175 0.014848 0.033262 0.041846 0.003819 0.017109 0.038357 0.040330 0.019435 0.016881
Bud Site 0.016082 0.032278 0.018677 0.033008 0.009576 0.021339 0.004772 0.049374 0.012862 0.025658 0.017283 0.047724
Cell Periphery 0.000094 0.000411 0.000192 0.000925 0.001319 0.000295 0.000232 0.006453 0.000700 0.000341 0.000196 0.005896
Cytoplasm 0.321767 0.159267 0.546379 0.224169 0.412907 0.198118 0.269980 0.339870 0.366880 0.182779 0.518659 0.328207
Cytoplasmic Foci 0.108684 0.108453 0.018109 0.051374 0.121151 0.091785 0.057441 0.051569 0.114855 0.098366 0.022054 0.051549
Eisosomes 0.000058 0.000080 0.000022 0.000147 0.000072 0.000077 0.000134 0.000124 0.000065 0.000078 0.000033 0.000126
Endoplasmic Reticulum 0.000518 0.001418 0.001384 0.009020 0.000805 0.001381 0.001865 0.006193 0.000660 0.001395 0.001432 0.006478
Endosome 0.088853 0.115780 0.007044 0.042847 0.036078 0.081864 0.013846 0.048830 0.062730 0.095254 0.007726 0.048227
Golgi 0.001816 0.005270 0.000251 0.000459 0.001009 0.004756 0.002290 0.002585 0.001416 0.004959 0.000455 0.002371
Lipid Particles 0.003160 0.004586 0.001078 0.025924 0.004098 0.003806 0.004094 0.015061 0.003625 0.004114 0.001381 0.016156
Mitochondria 0.003373 0.006311 0.001398 0.000162 0.002281 0.006533 0.000473 0.003954 0.002832 0.006445 0.001305 0.003572
Mitotic Spindle 0.004415 0.002218 0.010294 0.011087 0.002517 0.006208 0.000803 0.028782 0.003476 0.004632 0.009342 0.026999
None 0.000882 0.000595 0.006341 0.008042 0.001868 0.001082 0.005247 0.004148 0.001370 0.000890 0.006232 0.004540
Nuclear Periphery 0.000270 0.000213 0.001938 0.001258 0.000383 0.000419 0.001116 0.001003 0.000326 0.000338 0.001855 0.001029
Nuclear Periphery Foci 0.000170 0.000260 0.000911 0.008728 0.000290 0.000187 0.001982 0.003753 0.000230 0.000216 0.001018 0.004254
Nucleolus 0.001209 0.001151 0.001564 0.000993 0.001291 0.001361 0.002372 0.001118 0.001250 0.001278 0.001645 0.001106
Nucleus 0.047604 0.026205 0.281892 0.055967 0.091577 0.049899 0.494064 0.074247 0.069370 0.040545 0.303170 0.072405
Peroxisomes 0.005694 0.009138 0.002203 0.002303 0.003229 0.007636 0.000978 0.007229 0.004474 0.008229 0.002080 0.006733
Vacuole 0.347780 0.474402 0.078558 0.506677 0.273353 0.471484 0.133859 0.331535 0.310939 0.472636 0.084104 0.349189
Vacuole Periphery 0.004146 0.013660 0.000348 0.000642 0.002550 0.009432 0.000495 0.004468 0.003356 0.011101 0.000363 0.004082

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.41 -4.71 -2.96 -2.08 -2.46 -0.33 0.58 -2.64 -2.50 -3.49 -0.99 0.05 -3.47 -2.95 -3.68
Bud Neck 1.53 6.18 10.52 8.65 5.90 -2.84 12.48 8.43 11.86 -6.99 -0.95 6.90 13.82 14.58 6.13
Bud Site -6.44 0.64 -1.01 1.98 -1.21 -6.81 2.10 -9.65 -5.18 -9.41 -8.82 -0.63 -8.80 -3.59 -7.87
Cell Periphery -3.72 -1.74 -1.41 -0.08 -1.15 1.48 1.57 -1.87 -3.20 -3.26 1.04 1.58 -2.63 -3.17 -3.36
Cytoplasm 17.57 -17.85 5.81 -2.83 14.42 23.54 10.68 7.28 -14.61 -5.36 28.11 -12.56 5.00 -17.03 15.26
Cytoplasmic Foci -0.09 23.79 13.04 11.59 -4.12 6.01 10.28 19.04 13.21 2.05 4.42 32.29 23.50 17.77 -7.56
Eisosomes -2.72 11.00 -2.64 -1.51 -4.11 -1.08 -7.69 -2.04 -1.49 3.49 -3.09 9.86 -3.24 -1.70 -6.11
Endoplasmic Reticulum -4.68 -15.38 -2.37 -2.00 -1.84 -5.05 -7.23 -3.68 -3.05 -1.17 -7.34 -15.19 -4.35 -3.49 -2.85
Endosome -4.71 20.53 9.94 13.25 -3.02 -12.44 7.50 1.77 12.96 -5.05 -9.67 23.21 10.09 18.69 -8.68
Golgi -4.58 11.37 9.28 6.63 -0.63 -5.73 -0.40 -1.39 4.74 0.08 -7.17 5.94 0.25 6.61 -3.37
Lipid Particles -2.68 7.50 -2.23 -1.92 -2.57 0.52 -0.39 -3.37 -3.56 -3.27 -1.51 8.11 -4.21 -3.84 -5.46
Mitochondria -3.28 3.46 5.54 8.53 8.43 -6.37 5.49 -0.16 4.23 -2.54 -6.51 4.53 0.82 5.12 -1.31
Mitotic Spindle 1.34 -4.42 -2.27 -2.88 -0.11 -2.62 1.82 -7.26 -5.77 -8.05 -1.19 -5.46 -7.24 -6.74 -4.02
None 1.63 -8.28 -1.49 -1.63 0.33 2.52 -3.36 -1.73 -2.84 1.59 2.51 -8.06 -2.77 -3.52 2.43
Nuclear Periphery 1.91 -22.23 -4.74 -4.88 1.63 -0.43 -11.68 -9.04 -8.93 0.15 -0.16 -22.38 -11.15 -11.05 9.20
Nuclear Periphery Foci -2.98 -9.28 -4.80 -4.75 -4.14 1.25 -4.88 -6.47 -6.81 0.20 0.27 -9.73 -8.05 -8.11 -4.75
Nucleolus 0.42 -4.65 1.02 0.76 5.17 -0.33 -1.34 1.40 2.13 1.96 0.01 -5.08 1.76 2.10 6.04
Nucleus 7.24 -48.38 -3.30 -5.19 17.69 10.82 -21.20 -2.18 -10.65 20.20 11.56 -48.54 -7.04 -13.64 34.26
Peroxisomes -3.76 6.00 8.15 8.57 1.31 -4.96 5.16 -2.12 2.47 -5.45 -5.83 5.15 -0.27 4.13 -3.49
Vacuole -10.67 30.82 -8.34 -3.11 -18.36 -18.84 6.36 -9.43 8.88 -12.80 -20.67 31.97 -8.93 8.32 -32.87
Vacuole Periphery -9.02 11.75 11.36 13.06 -1.23 -11.21 8.65 0.05 8.41 -3.49 -13.75 15.67 1.82 11.76 -3.76
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication
Localization
Cell Percentages vacuole (61%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Pry2

Pry2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pry2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available