Standard name
Human Ortholog
Description Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic60p is also involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; ortholog of mammalian mitofilin
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0.06 – 0 0 0 0 – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0.07 – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0
Cytoplasm 0.9 0.92 0.9 0.91 0.85 0.8 0.76 0.84 0.73 0.73 0.58 0.54 – 1.0 0.94 0.86 0.76 – 0.59 0.78 0.56 0.73 0.78 0.7
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0.12 – 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0.05 0.05 – 0.05 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0
Mitochondria 0.24 0.07 0.12 0.13 0.12 0.27 0.36 0.25 0.44 0.44 0.58 0.68 – 0 0.05 0.09 0 – 0.17 0.08 0.25 0.15 0.07 0.08
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0.08 – 0.05 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0.07 – 0.05 0 0 0 0 0.09
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 – 1 0 3 1 1 0
Bud 1 0 1 1 4 2 6 1 7 7 1 4 – 1 0 1 0 – 1 1 1 0 0 0
Bud Neck 0 0 0 1 0 0 5 2 1 4 0 0 – 0 0 3 4 – 0 1 2 0 0 0
Bud Site 0 0 0 0 0 0 1 0 0 1 0 0 – 0 0 0 0 – – – – – – –
Cell Periphery 0 0 0 0 0 0 1 1 0 1 0 1 – 0 1 0 0 – 0 1 0 0 0 0
Cytoplasm 77 164 178 118 141 146 205 221 143 195 32 37 – 67 101 102 45 – 61 142 109 24 62 44
Endoplasmic Reticulum 0 0 2 0 1 0 0 0 2 0 0 0 – 0 1 4 7 – 1 0 1 0 0 0
Endosome 0 3 0 1 3 3 0 1 0 1 0 0 – 0 1 6 3 – 5 4 7 0 2 0
Golgi 0 0 0 0 0 0 0 1 0 0 0 0 – 0 0 0 0 – 0 1 2 0 1 2
Mitochondria 21 13 23 17 20 50 97 66 87 118 32 46 – 1 5 11 0 – 17 13 48 4 5 4
Nucleus 0 1 0 0 1 0 1 0 1 0 0 0 – 0 1 0 0 – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 1 0 0 0 0 0 0 0 0 – 0 0 1 0 – 0 0 0 0 0 0
Nucleolus 0 0 0 0 2 0 0 1 0 0 1 0 – 0 1 0 0 – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 1 3 0 1 2 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0
SpindlePole 0 0 2 1 6 6 9 8 5 7 1 1 – 0 0 3 5 – 4 3 5 0 0 0
Vac/Vac Membrane 2 3 0 0 2 0 1 3 0 3 0 0 – 0 0 3 4 – 4 7 4 0 3 5
Unique Cell Count 86 178 197 129 165 182 271 264 197 268 55 68 67 108 119 59 103 184 196 33 80 64
Labelled Cell Count 101 184 206 140 181 210 326 306 248 337 67 89 69 111 134 68 103 184 196 33 80 64


Ambiguous, Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.2 3.5 3.5 3.1 3.6 2.9 2.3 3.0 2.5 2.3 2.5 2.4 – 4.0 4.2 5.3 5.2 – – 3.9 4.8
Std Deviation (1e-4) 1.3 0.7 1.8 1.0 2.1 1.3 0.8 1.9 1.3 1.1 0.6 1.3 – 1.9 2.0 2.5 1.4 – – 1.5 2.1
Intensity Change (Log2) – – – -0.19 0.03 -0.26 -0.59 -0.25 -0.47 -0.59 -0.52 -0.58 – 0.19 0.27 0.58 0.55 – – 0.16 0.44

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000246WT3HU120HU1600246WT3rpd3Δ_1rpd3Δ_20246WT1AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin – – – – – – 0.0731 0 0.0342 0.0002 0.0011 0.0002 0.1149 0 0.0512 0.0002 0.001 0.0046
Bud – – – – – – 0.0023 0 0.0026 0.0038 0 0.0003 0.0011 0 0.0008 0 0.0016 0.0007
Bud Neck – – – – – – 0.0014 0 0.0077 0.0003 0 0.0001 0.0105 0 0.0047 0 0.0003 0.0055
Bud Periphery – – – – – – 0.006 0 0.0013 0.0071 0 0.0004 0.0024 0 0.0012 0 0.0011 0.0015
Bud Site – – – – – – 0.0066 0 0.0197 0.004 0.0001 0.0001 0.0145 0 0.0098 0 0.0048 0.0015
Cell Periphery – – – – – – 0.001 0 0.0004 0.0006 0.0002 0 0.0011 0 0.0013 0 0.0002 0.0002
Cytoplasm – – – – – – 0.022 0.0112 0.011 0.0154 0.0213 0.0373 0.0198 0.0034 0.0115 0.0176 0.0362 0.0327
Cytoplasmic Foci – – – – – – 0.0558 0.0007 0.0634 0.0131 0.0197 0.0147 0.0986 0.0004 0.0218 0.0012 0.0074 0.0089
Eisosomes – – – – – – 0.0011 0.0002 0.0005 0.0002 0.0007 0.0001 0.0021 0.0001 0.0018 0.0003 0 0.0002
Endoplasmic Reticulum – – – – – – 0.02 0.0001 0.0004 0.0008 0.0141 0.0004 0.0054 0 0.0015 0.0006 0.0061 0.0003
Endosome – – – – – – 0.0471 0 0.0175 0.0123 0.0421 0.005 0.0622 0 0.0269 0.0002 0.0629 0.0005
Golgi – – – – – – 0.0136 0 0.0107 0.0019 0.0058 0.0005 0.0141 0 0.0088 0 0.0045 0.0005
Lipid Particles – – – – – – 0.0275 0.0001 0.0252 0.0777 0.0421 0.0012 0.0843 0 0.0221 0.0002 0.0007 0.001
Mitochondria – – – – – – 0.0115 0.0001 0.0326 0.002 0.0008 0.0006 0.013 0 0.0234 0.0003 0.0076 0.002
None – – – – – – 0.5977 0.9872 0.736 0.8103 0.846 0.9359 0.348 0.9959 0.7579 0.9781 0.8279 0.9343
Nuclear Periphery – – – – – – 0.0129 0.0001 0.0006 0.0025 0.0021 0.0002 0.0425 0 0.0009 0.0002 0.0077 0.0001
Nucleolus – – – – – – 0.0015 0 0.0038 0.0163 0.0001 0.0001 0.0161 0 0.0007 0.0001 0.0004 0.0002
Nucleus – – – – – – 0.0046 0 0.0006 0.0069 0.0001 0.0002 0.0513 0 0.0007 0.0003 0.0082 0.0001
Peroxisomes – – – – – – 0.0472 0 0.0251 0.0032 0.0011 0.0011 0.0355 0 0.0217 0.0001 0.0003 0.0048
Punctate Nuclear – – – – – – 0.0229 0.0001 0.0041 0.0094 0.0005 0.0004 0.016 0 0.0022 0.0002 0.0007 0.0002
Vacuole – – – – – – 0.0207 0 0.0015 0.0088 0.0014 0.001 0.02 0 0.0275 0.0001 0.0152 0.0002
Vacuole Periphery – – – – – – 0.0035 0 0.001 0.0032 0.0006 0.0003 0.0268 0 0.0015 0 0.0049 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 22.4352 10.9395 24.3527 29.5011 20.7143 26.4997 23.5044 26.3361 24.7883 24.1084
Translational Efficiency 0.899 1.7844 0.9627 1.0553 1.1375 0.7754 0.8669 0.9283 1.0865 0.9497

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
856 627 108 1374 1806 1561 1516 943 2662 2188 1624 2317

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 639.37 720.84 846.52 781.30 680.22 708.32 760.48 778.20 667.08 711.91 766.20 780.04
Standard Deviation 69.36 92.45 90.07 105.31 76.05 85.79 102.58 111.41 76.38 87.93 104.03 107.84
Intensity Change Log 2 — 0.173028 0.404893 0.289226 — 0.058400 0.160909 0.194140 — 0.115078 0.284280 0.240994

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000628 0.000552 0.000549 0.003985 0.000086 0.000317 0.000443 0.000973 0.000260 0.000384 0.000450 0.002759
Bud Neck 0.026441 0.045481 0.004318 0.012878 0.030564 0.053326 0.004900 0.011325 0.029238 0.051078 0.004861 0.012246
Bud Site 0.014360 0.023958 0.010519 0.034834 0.004350 0.017238 0.013506 0.045327 0.007569 0.019164 0.013308 0.039105
Cell Periphery 0.000347 0.000227 0.000263 0.000319 0.000149 0.000142 0.000190 0.000466 0.000213 0.000166 0.000195 0.000379
Cytoplasm 0.420583 0.273438 0.132778 0.430115 0.418224 0.330469 0.454536 0.439125 0.418983 0.314126 0.433138 0.433782
Cytoplasmic Foci 0.206086 0.274218 0.021964 0.024729 0.219235 0.273501 0.019835 0.032975 0.215007 0.273706 0.019977 0.028085
Eisosomes 0.000230 0.000185 0.000123 0.000056 0.000202 0.000165 0.000045 0.000077 0.000211 0.000171 0.000050 0.000065
Endoplasmic Reticulum 0.000659 0.001066 0.008227 0.002498 0.000615 0.000652 0.001987 0.001623 0.000629 0.000770 0.002402 0.002142
Endosome 0.039387 0.048930 0.007574 0.014224 0.016879 0.040865 0.004335 0.009616 0.024117 0.043176 0.004550 0.012349
Golgi 0.018169 0.010125 0.000493 0.007363 0.001922 0.009524 0.001454 0.003015 0.007146 0.009696 0.001390 0.005593
Lipid Particles 0.017452 0.010626 0.006038 0.001416 0.011631 0.009128 0.001293 0.001978 0.013503 0.009558 0.001609 0.001645
Mitochondria 0.032791 0.031175 0.003150 0.003818 0.005741 0.026752 0.001096 0.002932 0.014440 0.028019 0.001232 0.003457
Mitotic Spindle 0.002147 0.012523 0.006457 0.051851 0.001508 0.011179 0.008086 0.026699 0.001714 0.011564 0.007978 0.041614
None 0.005166 0.002986 0.004574 0.006949 0.002485 0.002792 0.008128 0.016432 0.003347 0.002848 0.007892 0.010809
Nuclear Periphery 0.000671 0.000587 0.001964 0.001801 0.000584 0.000614 0.001097 0.001047 0.000612 0.000607 0.001155 0.001495
Nuclear Periphery Foci 0.000999 0.000459 0.001580 0.000912 0.000243 0.000287 0.000502 0.000835 0.000486 0.000337 0.000574 0.000881
Nucleolus 0.002057 0.003867 0.002477 0.000916 0.001562 0.002413 0.000878 0.001262 0.001721 0.002830 0.000985 0.001057
Nucleus 0.139968 0.128948 0.710179 0.294945 0.218091 0.105647 0.423568 0.283321 0.192969 0.112324 0.442629 0.290214
Peroxisomes 0.023209 0.032366 0.001186 0.001344 0.007525 0.029915 0.000687 0.003446 0.012568 0.030617 0.000721 0.002199
Vacuole 0.045326 0.092893 0.072229 0.102447 0.057344 0.081794 0.052772 0.114243 0.053479 0.084974 0.054066 0.107248
Vacuole Periphery 0.003322 0.005390 0.003358 0.002599 0.001060 0.003280 0.000662 0.003282 0.001788 0.003885 0.000841 0.002877

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.25 -0.13 -1.77 -2.06 -1.84 -4.96 -1.62 -3.59 -2.20 -1.52 -1.30 -0.65 -2.94 -2.66 -2.49
Bud Neck -3.70 6.52 5.31 8.44 -2.86 -6.28 11.50 8.59 14.26 -3.62 -7.36 13.32 10.26 16.79 -5.36
Bud Site -2.69 0.71 -1.94 0.84 -1.68 -8.92 -3.53 -6.77 -3.21 -4.67 -7.83 -1.64 -7.63 -2.33 -5.30
Cell Periphery 1.56 0.91 1.82 0.72 1.68 0.67 -0.89 -2.97 -3.15 -2.47 1.80 1.28 -0.54 -2.29 -1.78
Cytoplasm 10.71 17.42 6.53 -5.61 -13.62 9.48 1.00 5.59 -2.18 4.40 13.62 3.30 9.19 -4.18 4.52
Cytoplasmic Foci -6.42 27.05 30.25 29.38 0.57 -7.11 40.85 37.80 40.67 -3.67 -9.46 49.84 49.22 51.10 -1.86
Eisosomes 1.80 3.02 7.20 10.57 5.96 2.34 9.86 7.74 11.44 -7.48 3.01 12.02 10.80 16.50 -5.12
Endoplasmic Reticulum -3.33 -4.42 -9.79 -8.17 3.07 -0.39 -2.72 -11.51 -10.89 -0.76 -1.92 -3.63 -14.04 -12.89 -0.57
Endosome -1.76 7.85 8.79 10.92 0.44 -9.14 9.05 7.56 14.93 -2.02 -7.74 12.56 11.13 18.10 -2.25
Golgi 2.99 7.25 5.94 4.50 -2.58 -7.77 1.58 0.61 6.85 -0.55 -2.11 6.47 4.86 7.59 -1.65
Lipid Particles 2.72 4.66 7.00 8.13 6.04 2.47 12.46 11.68 9.87 -2.59 3.73 12.82 12.81 12.93 -0.25
Mitochondria 0.46 7.20 7.49 7.80 0.19 -9.12 5.68 4.36 11.53 -2.05 -5.60 9.21 8.46 13.89 -2.88
Mitotic Spindle -3.42 -1.25 -8.38 -4.15 -3.23 -5.14 -3.92 -6.08 -2.60 -3.53 -6.18 -4.09 -10.36 -5.36 -6.48
None 2.17 1.28 0.03 -2.47 -1.38 -0.73 -6.13 -3.69 -3.37 -1.44 0.79 -4.62 -3.86 -4.20 -0.49
Nuclear Periphery 0.42 -7.84 -11.03 -14.02 -2.61 -0.31 -12.07 -11.35 -8.44 -2.29 -0.07 -12.53 -16.13 -14.62 -7.43
Nuclear Periphery Foci 1.15 -2.00 -0.16 -4.36 2.81 -1.03 -6.82 -6.85 -6.31 -3.38 0.92 -1.58 -3.34 -7.64 -3.26
Nucleolus -2.21 -0.20 1.94 3.26 2.56 -2.77 3.52 2.57 5.08 -0.76 -3.36 3.81 2.85 5.33 -0.43
Nucleus 0.85 -18.47 -22.91 -20.69 10.72 18.10 -24.91 -9.16 -20.58 10.89 15.38 -31.46 -20.71 -32.51 12.78
Peroxisomes -2.18 7.40 7.50 10.32 1.14 -11.49 10.13 6.46 14.69 -2.52 -9.54 11.11 10.33 18.51 -2.49
Vacuole -8.15 -4.71 -21.30 -12.13 -3.37 -7.06 -6.78 -18.10 -14.75 -13.76 -10.53 -8.81 -27.53 -20.28 -17.67
Vacuole Periphery -2.12 0.55 3.42 5.27 0.80 -6.86 2.22 -0.74 1.93 -1.42 -5.68 3.72 1.18 5.26 -1.51
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic60p is also involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; ortholog of mammalian mitofilin
Localization
Cell Percentages —
Cell Cycle Regulation No
Subcompartmental Group N/A

Mic60

Mic60


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mic60-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available