Standard name
Human Ortholog
Description Non-essential small GTPase; member of the Rho/Rac subfamily of Ras-like proteins; likely to be involved in the establishment of cell polarity; has long N-terminal extension that plays an important role in Rho4p function and is shared with Rho4 homologs in other yeasts and filamentous fungi
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.05 0 0 0.07 0.05 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.19 0.46 0.65 0.48 0.31 0.3 0.23 0.2 – 0.19 0.21 0.24 0.63 0.72 0.92 0.28 0.22 0.3 0.23 0.4 0.57 0.37 0.49 0.57
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0.06 0 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.42 0 0.31 0.42 0.4 0.49 0.74 0.69 – 0.74 0.76 0.66 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.51 0.11 0.09 0.21 0.25 0.34 0.27 0.33 – 0.28 0.23 0.29 0 0.06 0.07 0.51 0.4 0.27 0.53 0.36 0.18 0.15 0.15 0.07
Nuclear Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.12 0.55 0.08 0.15 0.26 0.09 0.1 0.08 – 0.09 0.08 0.06 0.35 0.3 0.08 0.37 0.41 0.54 0.07 0.11 0.13 0.31 0.18 0.21
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0
Bud 0 0 0 0 1 4 2 11 – 8 1 3 1 0 0 0 1 0 7 5 2 3 4 2
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 1 2 0 0 1 3
Bud Site 0 0 0 0 0 0 1 2 – 5 2 3 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
Cytoplasm 22 81 89 53 44 50 72 66 – 62 42 81 45 48 69 48 38 63 33 79 95 15 38 78
Endoplasmic Reticulum 0 1 1 1 0 0 0 0 – 0 0 2 1 2 0 11 6 11 1 0 0 0 0 1
Endosome 0 0 0 0 1 0 0 0 – 0 0 2 2 1 0 0 4 11 2 5 1 0 0 1
Golgi 0 2 0 0 0 0 0 0 – 0 0 0 0 0 0 0 1 2 0 1 0 0 0 0
Mitochondria 48 7 43 46 57 81 228 223 – 237 149 228 0 0 0 4 1 4 2 3 4 0 2 3
Nucleus 58 20 13 23 35 56 83 107 – 90 45 101 3 4 5 88 68 57 76 71 30 6 12 9
Nuclear Periphery 1 1 0 0 0 0 0 1 – 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 1 0 0 0 0 0 0 1 – 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 1 – 2 0 0 0 0 0 0 0 0 4 4 3 1 0 3
Vac/Vac Membrane 14 98 11 17 37 15 31 26 – 28 15 21 25 20 6 64 70 114 10 21 21 12 13 28
Unique Cell Count 113 177 137 110 142 165 309 322 319 196 343 71 67 75 174 169 211 146 200 168 41 78 138
Labelled Cell Count 144 210 157 140 175 206 417 438 433 255 441 77 75 80 215 190 262 146 200 168 41 78 138


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.4 5.4 3.7 3.7 3.9 3.9 3.3 3.5 – 3.3 3.2 3.4 6.4 5.4 5.5 7.5 7.9 8.2 – 6.8 6.8
Std Deviation (1e-4) 1.2 1.0 0.6 0.9 1.1 1.3 0.8 1.2 – 1.0 0.9 0.9 2.3 1.5 1.3 1.0 1.2 1.4 – 2.0 2.6
Intensity Change (Log2) – – – 0.01 0.1 0.1 -0.15 -0.08 – -0.13 -0.19 -0.1 0.8 0.57 0.6 1.03 1.11 1.15 – 0.89 0.89

WT3RAP60RAP140RAP220RAP300RAP380RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cytoplasm -2.7 -5.7 -6.0 -8.5 -9.2 – -9.5 -8.0 -8.6 -0.2 1.0 4.3 -6.6 -7.5 -6.5
Endoplasmic Reticulum 0 0 0 0 0 – 0 0 0 0 0 0 2.5 0 0
Endosome 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 – 0 0 0 -5.3 -5.2 -5.4 -7.1 -7.6 -7.9
Nucleus 2.5 3.4 5.0 4.1 5.3 – 4.4 3.2 4.6 -1.4 -0.9 -0.7 7.7 6.1 4.0
Nuclear Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Vacuole 1.8 4.0 0.3 0.7 0 – 0.3 -0.1 -0.8 4.9 4.1 0 5.9 6.6 8.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.055 0.4349 0.1448 -0.2504 0.3917 0.2686 2.1053 2.6972 2.3527 2.4702 2.1208 2.5586 -0.842 -0.3357 -0.6944 -0.2633 -0.6584 -0.4451
Actin 0.019 0.0004 0.0056 0.0006 0.0032 0.001 0.0053 0.0001 0.0019 0.0011 0.0027 0.0032 0.0018 0.0001 0.0003 0.0002 0.0016 0.0004
Bud 0.0012 0.0006 0.0013 0.0035 0.0002 0.0003 0.0005 0.0002 0.0003 0.0001 0.0001 0.0008 0.0002 0 0.0001 0 0.0001 0.0002
Bud Neck 0.0018 0.0005 0.0005 0.0007 0.0006 0.0019 0.0072 0.0006 0.001 0.0007 0.0008 0.0034 0.0007 0.0003 0.0004 0.0006 0.001 0.0024
Bud Periphery 0.0005 0.0006 0.0003 0.0014 0.0004 0.0002 0.0004 0.0001 0.0004 0.0001 0.0001 0.0017 0.0001 0 0 0 0 0.0002
Bud Site 0.0126 0.0028 0.0024 0.0009 0.0005 0.0022 0.0044 0.0012 0.0017 0.0004 0.0003 0.0005 0.0005 0.0007 0.0003 0.0001 0.0002 0.0003
Cell Periphery 0.0003 0.0001 0.0001 0 0.0001 0 0.0002 0.0001 0.0001 0 0 0 0.0001 0 0 0 0 0
Cytoplasm 0.2741 0.2689 0.2032 0.2195 0.1014 0.2097 0.2337 0.2121 0.2018 0.2295 0.2003 0.18 0.2518 0.18 0.1883 0.1565 0.2005 0.182
Cytoplasmic Foci 0.0234 0.005 0.0078 0.0021 0.0243 0.0066 0.01 0.0025 0.0054 0.0038 0.0075 0.0086 0.0067 0.0026 0.0035 0.0029 0.0068 0.0036
Eisosomes 0.0003 0 0.0001 0 0.0003 0.0001 0.0004 0 0.0001 0.0001 0.0001 0 0.0002 0 0.0001 0 0.0001 0
Endoplasmic Reticulum 0.0063 0.0033 0.0039 0.0014 0.0018 0.0019 0.0041 0.0027 0.0028 0.0036 0.0027 0.0025 0.0043 0.0018 0.0024 0.0014 0.0026 0.002
Endosome 0.0192 0.0035 0.0071 0.0016 0.021 0.0043 0.0042 0.003 0.0043 0.0032 0.0107 0.0061 0.0066 0.0011 0.0022 0.0017 0.0041 0.0022
Golgi 0.0034 0.0002 0.0015 0.0001 0.0082 0.0007 0.0006 0.0001 0.0005 0.0001 0.0047 0.0007 0.0007 0 0.0001 0 0.0003 0.0001
Lipid Particles 0.0085 0.0002 0.0015 0.0001 0.0214 0.0016 0.0014 0.0001 0.0013 0.0004 0.0051 0.0004 0.0023 0.0001 0.0002 0.0001 0.0017 0.0002
Mitochondria 0.0036 0.0011 0.0037 0.0005 0.013 0.0029 0.0008 0.0005 0.001 0.001 0.0102 0.0016 0.001 0.0002 0.0006 0.0005 0.0006 0.0003
None 0.2357 0.2816 0.3024 0.2691 0.3214 0.2144 0.3545 0.1696 0.297 0.3261 0.2064 0.2055 0.3033 0.1283 0.269 0.1842 0.2294 0.1614
Nuclear Periphery 0.0221 0.0131 0.0184 0.0129 0.0173 0.0115 0.0107 0.008 0.0116 0.0276 0.0099 0.0084 0.0121 0.0068 0.0129 0.0104 0.0128 0.0108
Nucleolus 0.0035 0.0025 0.003 0.0027 0.0033 0.0038 0.0026 0.0016 0.003 0.0027 0.0026 0.0034 0.0025 0.0015 0.0018 0.0029 0.0036 0.003
Nucleus 0.3221 0.3882 0.3912 0.426 0.4083 0.4854 0.3353 0.5801 0.4296 0.3719 0.4794 0.5336 0.3807 0.6662 0.4948 0.6 0.4891 0.6005
Peroxisomes 0.0119 0.0004 0.0054 0.0001 0.0154 0.0018 0.003 0.0001 0.0022 0.0003 0.0163 0.0007 0.0014 0 0.0001 0.0001 0.001 0.0001
Punctate Nuclear 0.0262 0.0239 0.0378 0.056 0.0343 0.0484 0.0175 0.0153 0.0319 0.0253 0.0376 0.037 0.0198 0.0091 0.0218 0.0375 0.0433 0.0293
Vacuole 0.0034 0.0027 0.002 0.0006 0.0025 0.001 0.0029 0.0018 0.0017 0.0015 0.0017 0.0015 0.0028 0.0009 0.001 0.0006 0.0009 0.0009
Vacuole Periphery 0.0008 0.0004 0.0005 0.0002 0.0012 0.0003 0.0004 0.0002 0.0003 0.0006 0.0006 0.0003 0.0005 0.0001 0.0002 0.0001 0.0002 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 7.5576 12.386 5.0132 9.9584 6.5325 3.7767 11.1004 9.6051 10.2281 10.1119
Translational Efficiency 3.233 1.7427 3.7639 2.2195 2.7589 5.1221 2.3684 2.3554 2.0724 2.2595

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2224 1793 111 1341 1825 1018 212 1995 4049 2811 323 3336

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 706.81 780.96 908.00 966.11 711.76 718.71 966.82 977.45 709.04 758.42 946.61 972.89
Standard Deviation 78.66 123.07 114.49 141.24 85.31 92.21 117.16 131.61 81.76 116.77 119.56 135.68
Intensity Change Log 2 — 0.143926 0.361370 0.450865 — 0.014019 0.441856 0.457632 — 0.080208 0.402315 0.454264

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000034 0.000147 0.001043 0.001264 0.000057 0.000203 0.001084 0.002379 0.000044 0.000168 0.001070 0.001930
Bud Neck 0.004801 0.003699 0.002109 0.021780 0.005463 0.010532 0.003684 0.015523 0.005100 0.006174 0.003143 0.018038
Bud Site 0.002371 0.002426 0.001690 0.053472 0.001253 0.004450 0.005236 0.020152 0.001867 0.003159 0.004017 0.033546
Cell Periphery 0.000108 0.000105 0.000196 0.000245 0.000120 0.000166 0.000150 0.000156 0.000113 0.000127 0.000166 0.000192
Cytoplasm 0.328896 0.376609 0.072338 0.221093 0.377700 0.317521 0.042271 0.270478 0.350893 0.355210 0.052604 0.250626
Cytoplasmic Foci 0.053550 0.044245 0.003395 0.006549 0.084852 0.100935 0.001419 0.005353 0.067659 0.064775 0.002098 0.005834
Eisosomes 0.000039 0.000034 0.000070 0.000032 0.000061 0.000078 0.000045 0.000025 0.000049 0.000050 0.000054 0.000028
Endoplasmic Reticulum 0.000576 0.001211 0.011334 0.005442 0.000643 0.001232 0.009569 0.003300 0.000606 0.001218 0.010176 0.004161
Endosome 0.001363 0.002451 0.001934 0.008988 0.002728 0.006382 0.002775 0.005759 0.001978 0.003874 0.002486 0.007057
Golgi 0.000217 0.000551 0.000116 0.012601 0.000823 0.004003 0.000308 0.001467 0.000490 0.001801 0.000242 0.005943
Lipid Particles 0.002919 0.002607 0.002218 0.000747 0.005108 0.006317 0.000886 0.000665 0.003906 0.003950 0.001344 0.000698
Mitochondria 0.001947 0.002239 0.000574 0.010947 0.004291 0.011346 0.001679 0.005049 0.003004 0.005537 0.001299 0.007420
Mitotic Spindle 0.002275 0.002003 0.000506 0.054618 0.001239 0.004739 0.004211 0.043026 0.001808 0.002994 0.002938 0.047686
None 0.004179 0.009238 0.003148 0.014486 0.006590 0.010105 0.004234 0.009595 0.005266 0.009552 0.003861 0.011561
Nuclear Periphery 0.000974 0.000875 0.001313 0.002908 0.000763 0.000917 0.001538 0.002461 0.000879 0.000890 0.001461 0.002641
Nuclear Periphery Foci 0.000216 0.000509 0.002211 0.002135 0.000465 0.000650 0.000731 0.000508 0.000328 0.000560 0.001240 0.001162
Nucleolus 0.001159 0.001540 0.001920 0.000849 0.001750 0.003317 0.001064 0.001205 0.001426 0.002184 0.001358 0.001062
Nucleus 0.583559 0.532623 0.865853 0.528742 0.490837 0.488939 0.893290 0.574476 0.541767 0.516803 0.883861 0.556092
Peroxisomes 0.001228 0.001832 0.000356 0.000536 0.002391 0.008466 0.000276 0.001948 0.001752 0.004235 0.000303 0.001380
Vacuole 0.009274 0.014634 0.027473 0.047486 0.012577 0.018345 0.025097 0.034911 0.010763 0.015978 0.025914 0.039966
Vacuole Periphery 0.000313 0.000421 0.000200 0.005081 0.000289 0.001359 0.000453 0.001564 0.000302 0.000761 0.000366 0.002978

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.54 -6.29 -10.41 -8.42 1.70 -5.08 -6.12 -3.37 -2.86 0.46 -5.37 -8.39 -5.22 -4.50 1.04
Bud Neck 1.53 2.13 -6.91 -7.85 -8.01 -2.90 0.06 -6.53 -0.98 -6.01 -1.42 0.75 -9.63 -7.26 -9.53
Bud Site 0.01 -0.35 -7.38 -7.44 -7.26 -4.14 -2.44 -8.04 -4.67 -3.33 -2.44 -2.16 -10.41 -9.24 -7.05
Cell Periphery 0.27 -3.42 -5.11 -6.08 1.26 -4.48 -1.43 0.67 4.91 1.69 -1.91 -3.47 -3.65 -1.92 1.85
Cytoplasm -5.24 22.23 25.11 27.47 -6.42 5.95 41.49 22.07 11.57 -22.64 -0.29 46.52 31.58 27.29 -20.77
Cytoplasmic Foci 2.94 20.83 22.75 17.16 1.35 -2.79 26.26 25.67 19.82 -3.73 0.96 34.00 34.00 25.59 -1.48
Eisosomes 1.76 -4.59 -5.68 -7.20 3.29 -3.49 -0.21 8.22 10.29 4.79 -0.79 -4.00 3.81 4.31 5.50
Endoplasmic Reticulum -7.76 -8.66 -22.92 -20.13 4.10 -4.10 -11.06 -18.16 -12.77 7.65 -8.34 -14.07 -28.86 -23.52 8.38
Endosome -3.49 -2.37 -3.39 -0.88 -0.49 -4.26 0.79 0.70 4.50 -0.28 -4.95 -0.51 -1.58 2.72 -0.49
Golgi -1.19 2.15 -2.56 -2.22 -2.68 -2.55 2.08 0.94 2.87 -1.57 -2.64 2.27 -2.11 0.52 -3.01
Lipid Particles 1.04 0.80 7.10 6.72 3.24 -1.57 8.00 9.02 8.58 2.24 -0.10 7.26 11.59 11.00 3.78
Mitochondria -0.50 3.49 -2.10 -1.80 -3.62 -2.84 2.56 1.16 3.68 -2.93 -2.52 3.23 -0.61 2.18 -4.47
Mitotic Spindle 0.28 0.25 -8.15 -8.22 -7.75 -2.72 -0.67 -9.45 -7.80 -7.98 -1.58 -0.33 -12.39 -11.69 -10.94
None -6.06 1.94 -5.52 -0.10 -6.45 -2.01 3.89 -3.10 0.55 -7.45 -5.10 3.82 -6.67 0.33 -9.70
Nuclear Periphery 0.99 -4.51 -19.79 -21.31 -11.38 -1.82 -9.10 -13.69 -11.30 -4.73 -0.77 -9.69 -21.42 -20.89 -9.69
Nuclear Periphery Foci -3.48 -3.14 -5.80 -4.20 0.99 -1.22 -2.90 -0.80 0.81 2.73 -2.95 -4.44 -5.87 -3.18 1.92
Nucleolus -0.12 -0.32 2.30 5.33 1.89 -3.04 2.75 2.31 4.64 -0.33 -2.15 1.56 2.95 5.73 1.17
Nucleus 5.06 -14.25 -5.89 -9.85 10.42 0.22 -28.38 -17.02 -13.81 16.58 3.11 -30.03 -15.52 -16.72 19.54
Peroxisomes -1.23 5.00 6.06 4.84 2.64 -4.98 7.07 4.72 6.58 -2.45 -4.69 8.83 6.36 7.60 -1.90
Vacuole -5.62 -4.37 -20.25 -18.68 -5.74 -4.14 -5.24 -17.78 -14.24 -2.41 -6.62 -6.96 -26.95 -23.80 -5.78
Vacuole Periphery -0.92 1.15 -1.97 -1.74 -2.17 -3.90 -0.23 -1.93 2.43 -1.37 -3.76 0.17 -2.59 -0.42 -2.52
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Non-essential small GTPase; member of the Rho/Rac subfamily of Ras-like proteins; likely to be involved in the establishment of cell polarity; has long N-terminal extension that plays an important role in Rho4p function and is shared with Rho4 homologs in other yeasts and filamentous fungi
Localization
Cell Percentages nucleus (23%), cytoplasm (11%), mixed (53%)
Cell Cycle Regulation Yes
cytoplasm - MA (0.00091)
Subcompartmental Group N/A

Rho4

Rho4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rho4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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Images are not yet available