Standard name
Human Ortholog
Description Subunit of Nup84p subcomplex of nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis; is involved in establishment of a normal nucleocytoplasmic concentration gradient of GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at nuclear periphery, including double-strand break repair, transcription and chromatin silencing; relocalizes to cytosol in response to hypoxia; homolog of human NUP133
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 – 0 0 0 0 0 0.05 0.06 0.1 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0.07 0.05 – 0.08 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.07
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.06 0.11 0.11 0.12 0.13 0.26 – 0.23 0.4 0.38 0.48 0.41 0 0 0 0.06 0.14 0 0 0 0 0.09 0.13 0.18
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0.07 0 0.05 0.11 0.07 0.06 0 0 0 0 0 0
Nuclear Periphery 0.83 0.79 0.79 0.82 0.7 0.66 – 0.6 0.6 0.62 0.56 0.64 0.81 0.79 0.7 0.65 0.71 0.75 0.88 0.84 0.88 0.8 0.65 0.57
Nucleolus 0.14 0.12 0.19 0.25 0.25 0.27 – 0.29 0.35 0.35 0.28 0.37 0.06 0.07 0.05 0.13 0.17 0.18 0 0.05 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.31 0.25 0.19 0.12 0.12 0.09 – 0.1 0.06 0.05 0.06 0.05 0.18 0.2 0.28 0.27 0.29 0.3 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 – 2 0 0 0 1 0 1 0 2 0 0 1 0 2 0 7 5
Bud 0 0 0 0 0 0 – 4 1 3 2 3 0 0 0 0 0 0 3 1 3 0 4 1
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 1 1 4 1 0 1 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 1 – 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 4 3 8 15 12 14 – 27 12 7 6 6 6 12 21 9 2 4 0 0 0 0 0 0
Endoplasmic Reticulum 2 0 1 2 2 3 – 4 1 0 0 2 0 0 0 6 2 1 0 0 0 1 2 1
Endosome 4 0 20 11 35 36 – 69 26 34 17 30 1 3 2 5 0 5 3 3 11 4 21 24
Golgi 1 0 0 1 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 5 1 11 8
Mitochondria 16 22 61 50 66 192 – 199 274 301 330 296 0 0 0 12 8 7 6 5 12 13 55 65
Nucleus 4 8 10 8 23 18 – 37 7 19 26 20 9 6 10 23 4 10 5 4 3 1 0 0
Nuclear Periphery 231 160 429 341 368 490 – 524 412 497 382 466 107 163 145 138 42 122 268 183 536 128 270 205
Nucleolus 40 25 104 104 133 203 – 252 237 281 189 271 8 14 11 28 10 29 4 10 9 1 5 8
Peroxisomes 2 0 1 0 1 12 – 10 5 8 4 2 0 0 0 0 0 0 0 0 3 1 16 17
SpindlePole 0 0 2 0 5 6 – 4 2 6 3 2 3 6 5 2 0 0 1 0 4 0 5 4
Vac/Vac Membrane 86 50 103 49 64 69 – 86 39 39 44 33 24 41 58 58 17 49 8 8 8 4 11 13
Unique Cell Count 278 202 546 418 525 740 879 683 799 686 728 132 207 208 212 59 162 304 218 606 162 417 363
Labelled Cell Count 390 268 739 581 709 1045 1218 1017 1196 1007 1134 158 247 252 283 85 227 304 218 606 162 417 363


Nuclear Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 16.7 15.2 12.6 12.6 10.9 9.7 – 9.7 9.0 8.7 8.6 8.9 12.4 12.9 12.4 11.4 10.9 15.3 14.3 14.8 15.0
Std Deviation (1e-4) 4.1 3.5 2.9 3.1 2.7 2.4 – 2.5 2.3 2.3 2.2 2.4 2.6 3.5 3.3 5.2 3.5 5.3 2.8 3.0 3.2
Intensity Change (Log2) – – – -0.01 -0.22 -0.37 – -0.38 -0.49 -0.53 -0.55 -0.51 -0.02 0.04 -0.02 -0.14 -0.22 0.28 0.18 0.23 0.25

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP70005101520WT3HU80HU120HU16005101520WT3rpd3Δ_1rpd3Δ_2rpd3Δ_305101520WT1AF100AF140AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2.1 1.0 0.6 – 1.9 0.4 -1.0 -1.0 -1.1 0 3.3 5.5 0 0 0
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Endosome -0.9 2.2 1.0 – 3.2 0.1 0.5 -1.2 0.4 0 -1.6 -2.0 -0.9 0 -0.3
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.4 0.7 6.6 – 5.4 11.3 10.8 13.8 11.6 -4.0 -5.0 -5.0 -2.3 0.5 -2.6
Nucleus 0.1 2.4 0.7 – 2.4 -1.2 0.7 2.0 1.1 0 0 2.3 5.5 0 0
Nuclear Periphery 1.2 -3.2 -4.8 – -7.4 -6.8 -6.4 -8.4 -5.6 0.6 0.1 -2.6 -3.8 -1.3 -0.9
Nucleolus 2.2 2.5 3.5 – 4.1 6.1 6.4 3.5 7.0 -3.6 -4.1 -4.7 -1.9 -0.4 -0.3
Peroxisomes 0 0 2.5 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole -3.0 -3.0 -5.0 – -4.9 -7.2 -8.2 -6.7 -8.2 -0.2 0.3 2.7 2.6 1.8 3.1

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 10.512 11.0784 9.7992 9.9761 9.0001 10.4068 10.7494 12.5794 11.1763 11.4742 10.1891 10.7287 6.9765 13.401 12.9459 11.7646 10.5651 11.1985
Actin 0.0102 0.0001 0.0239 0.0159 0.024 0.0001 0.0072 0.0003 0.0234 0.0015 0.0003 0 0.0919 0.0005 0.002 0.0008 0.0004 0.0003
Bud 0.0002 0 0.0001 0.0002 0.0002 0 0.0002 0 0.0004 0.0001 0 0 0.0009 0 0.0001 0 0 0
Bud Neck 0.0014 0 0.0002 0.0009 0.0018 0 0.0001 0 0.0002 0 0.0001 0 0.0009 0 0 0 0 0
Bud Periphery 0.0002 0.0001 0.0003 0.0007 0.0004 0 0.0003 0.0002 0.0006 0.0004 0.0001 0 0.0018 0.0001 0.0004 0.0003 0 0.0001
Bud Site 0.002 0 0.0008 0.0015 0.0031 0 0.0006 0 0.0012 0 0.0001 0 0.0032 0 0 0 0 0
Cell Periphery 0.0001 0 0.0001 0.0002 0.0001 0 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0011 0 0.0001 0.0001 0 0
Cytoplasm 0.0074 0 0.0013 0.0001 0.0002 0 0.015 0 0.001 0 0.0001 0 0.0059 0.0001 0 0 0 0
Cytoplasmic Foci 0.01 0 0.006 0.0211 0.0033 0 0.0248 0 0.006 0.0001 0.0149 0 0.0591 0 0.0001 0.0001 0 0.0007
Eisosomes 0.0001 0 0.0002 0.0003 0.0002 0 0.0001 0.0001 0.0001 0.0001 0 0 0.0009 0 0.0001 0.0001 0 0
Endoplasmic Reticulum 0.005 0.0005 0.0011 0.0017 0.0013 0.0002 0.0063 0.0007 0.0015 0.0014 0.0005 0.0001 0.0228 0.0013 0.0031 0.0013 0.0004 0.0003
Endosome 0.0153 0.0001 0.008 0.0039 0.0034 0.0001 0.0286 0.0002 0.0073 0.0005 0.0043 0.0001 0.1205 0.0003 0.0006 0.0004 0.0002 0.0083
Golgi 0.0114 0.0001 0.004 0.0075 0.0032 0.0002 0.0083 0.0001 0.0053 0.0005 0.005 0.0001 0.0384 0.0001 0.0006 0.0004 0.0003 0.0144
Lipid Particles 0.0195 0.0006 0.0088 0.0085 0.0288 0.0017 0.0401 0.0028 0.0171 0.0035 0.2022 0.0014 0.1457 0.0004 0.0074 0.0019 0.0047 0.0015
Mitochondria 0.0032 0.0009 0.0057 0.0112 0.017 0.008 0.005 0.0268 0.0056 0.0054 0.0083 0.0003 0.0298 0.003 0.0045 0.0077 0.001 0.0016
None 0.0112 0.0001 0.0011 0.0005 0.0005 0.0001 0.0115 0.0001 0.0011 0.0006 0.0002 0 0.0193 0.0002 0.0004 0.0004 0.0001 0.0001
Nuclear Periphery 0.8514 0.9285 0.8821 0.8454 0.8591 0.9734 0.783 0.9115 0.8593 0.9198 0.7154 0.9774 0.2722 0.9031 0.9082 0.9237 0.9603 0.9478
Nucleolus 0.0033 0.0006 0.0014 0.0008 0.0013 0.0001 0.0016 0.0002 0.0006 0.0009 0.0031 0.0006 0.0042 0.0002 0.0009 0.0006 0.0004 0.0004
Nucleus 0.0083 0.0207 0.0051 0.0041 0.0024 0.0009 0.0047 0.0025 0.003 0.0038 0.0027 0.0014 0.0095 0.0242 0.0065 0.0034 0.0016 0.0031
Peroxisomes 0.0059 0 0.0038 0.0219 0.0036 0 0.0021 0 0.0056 0.0002 0.0027 0 0.0406 0 0.0001 0.0001 0 0.0001
Punctate Nuclear 0.0042 0.0023 0.0022 0.0012 0.0016 0.0002 0.0259 0.0003 0.0038 0.001 0.003 0.0004 0.0279 0.0003 0.0011 0.001 0.0006 0.0004
Vacuole 0.0009 0.0004 0.0012 0.0009 0.002 0.0001 0.0016 0.0006 0.0009 0.0007 0.0019 0.0001 0.0239 0.0008 0.0007 0.0006 0.0001 0.0003
Vacuole Periphery 0.0289 0.0449 0.0426 0.0515 0.0425 0.0148 0.033 0.0534 0.0557 0.0594 0.0351 0.0181 0.0795 0.0653 0.0632 0.0572 0.0298 0.0208

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 42.7196 42.8736 25.9148 37.0386 29.0323 29.2047 39.115 40.3023 29.3311 40.6112
Translational Efficiency 0.7926 0.7566 1.0473 0.626 0.7606 0.8005 0.8266 0.5181 0.6949 0.6342

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1457 879 254 1111 1289 1071 1882 1857 2746 1950 2136 2968

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1369.26 1258.37 1517.42 1742.33 1006.71 1240.55 1516.43 1575.16 1199.08 1248.58 1516.55 1637.74
Standard Deviation 224.32 244.49 219.00 342.05 194.76 212.34 251.41 315.97 277.93 227.57 247.78 335.87
Intensity Change Log 2 — -0.121840 0.148224 0.347621 — 0.301332 0.591031 0.645850 — 0.072788 0.352633 0.481575

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000344 0.000404 0.000243 0.000376 0.000918 0.000370 0.000348 0.000244 0.000613 0.000386 0.000335 0.000294
Bud Neck 0.000636 0.000567 0.000669 0.003261 0.000804 0.000510 0.000775 0.000878 0.000715 0.000535 0.000763 0.001770
Bud Site 0.000225 0.000084 0.000033 0.001060 0.000408 0.000117 0.000046 0.000105 0.000311 0.000102 0.000045 0.000462
Cell Periphery 0.000043 0.000036 0.000011 0.000110 0.000111 0.000043 0.000017 0.000035 0.000075 0.000040 0.000016 0.000063
Cytoplasm 0.000198 0.000434 0.000027 0.000490 0.002713 0.000165 0.000087 0.000191 0.001379 0.000287 0.000080 0.000303
Cytoplasmic Foci 0.001567 0.001875 0.000458 0.003315 0.001662 0.001539 0.000362 0.000640 0.001612 0.001691 0.000373 0.001642
Eisosomes 0.000006 0.000011 0.000004 0.000010 0.000025 0.000009 0.000005 0.000005 0.000015 0.000010 0.000005 0.000007
Endoplasmic Reticulum 0.001241 0.002488 0.000991 0.001074 0.004443 0.002728 0.000512 0.000662 0.002744 0.002620 0.000569 0.000816
Endosome 0.002016 0.000565 0.000142 0.002518 0.001599 0.000866 0.000094 0.000413 0.001820 0.000730 0.000100 0.001201
Golgi 0.001108 0.000853 0.000181 0.003911 0.000537 0.000518 0.000130 0.001014 0.000840 0.000669 0.000136 0.002098
Lipid Particles 0.000963 0.004113 0.000151 0.005748 0.007305 0.003460 0.000210 0.001441 0.003940 0.003754 0.000203 0.003054
Mitochondria 0.004309 0.003964 0.001242 0.006070 0.012159 0.006892 0.002284 0.004464 0.007994 0.005572 0.002160 0.005065
Mitotic Spindle 0.004806 0.003299 0.004703 0.029394 0.002903 0.002515 0.002501 0.005962 0.003913 0.002868 0.002763 0.014733
None 0.000362 0.000902 0.000086 0.001045 0.004125 0.000557 0.000224 0.000327 0.002128 0.000712 0.000207 0.000596
Nuclear Periphery 0.771915 0.645111 0.752823 0.630316 0.609074 0.692656 0.788955 0.689874 0.695476 0.671224 0.784659 0.667580
Nuclear Periphery Foci 0.161853 0.278229 0.193423 0.240901 0.271836 0.240043 0.144376 0.231692 0.213480 0.257256 0.150209 0.235139
Nucleolus 0.013479 0.021784 0.025852 0.011778 0.031187 0.014916 0.021805 0.010170 0.021791 0.018012 0.022286 0.010772
Nucleus 0.008654 0.014904 0.012363 0.005438 0.025822 0.008931 0.013676 0.006679 0.016713 0.011623 0.013520 0.006215
Peroxisomes 0.000359 0.000625 0.000503 0.000410 0.001082 0.000478 0.000394 0.000226 0.000699 0.000544 0.000407 0.000295
Vacuole 0.005452 0.004722 0.000969 0.010569 0.006617 0.005979 0.002325 0.006578 0.005999 0.005412 0.002164 0.008072
Vacuole Periphery 0.020465 0.015030 0.005126 0.042205 0.014669 0.016709 0.020874 0.038401 0.017744 0.015952 0.019002 0.039825

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.10 1.76 -0.83 0.18 -2.35 4.35 6.49 7.69 1.55 2.33 3.17 5.34 6.15 1.64 0.88
Bud Neck 0.57 -0.80 -6.06 -6.28 -5.51 2.11 -0.05 -0.83 -2.78 -0.50 1.91 -0.50 -5.83 -6.82 -4.11
Bud Site 2.00 1.19 -2.36 -2.74 -2.65 1.59 1.92 1.59 -0.00 -2.30 2.13 2.59 -0.90 -2.72 -3.06
Cell Periphery 0.65 3.71 -3.13 -3.53 -4.83 4.10 7.05 5.42 0.59 -4.63 3.57 7.48 0.87 -2.47 -5.84
Cytoplasm -0.92 3.28 -1.81 -0.12 -2.62 2.79 2.89 2.77 -0.44 -3.57 2.27 3.02 2.38 -0.03 -3.19
Cytoplasmic Foci -0.58 2.88 -2.26 -1.89 -4.24 0.33 4.49 3.92 2.53 -1.62 -0.20 4.66 -0.02 0.17 -4.38
Eisosomes -3.54 1.28 -2.39 0.56 -3.17 6.15 8.89 8.61 2.97 0.18 3.11 8.31 5.77 2.76 -2.18
Endoplasmic Reticulum -4.78 1.40 0.74 5.37 -0.58 3.72 11.44 10.76 6.73 -1.89 0.44 11.77 9.80 8.82 -3.17
Endosome 2.80 3.62 -0.64 -3.24 -3.94 1.75 3.98 3.03 2.12 -4.18 3.19 5.30 1.54 -1.89 -4.83
Golgi 0.48 3.13 -3.31 -3.37 -4.71 0.04 2.90 -1.31 -1.33 -2.71 0.60 4.14 -3.13 -3.37 -5.43
Lipid Particles -3.47 4.47 -3.91 -1.09 -4.60 3.34 7.24 5.76 3.10 -4.57 0.25 7.88 1.28 0.98 -5.87
Mitochondria 0.40 3.83 -1.56 -2.00 -4.70 2.85 6.88 4.76 1.57 -2.48 2.33 6.95 2.88 0.40 -4.11
Mitotic Spindle 0.84 -0.76 -6.83 -7.10 -4.79 0.35 0.32 -2.14 -2.44 -2.42 1.00 0.73 -6.63 -7.18 -6.98
None -1.35 3.39 -1.11 -0.21 -1.57 4.41 4.87 4.73 2.01 -2.40 3.35 5.04 3.43 0.37 -1.69
Nuclear Periphery 13.30 1.69 15.43 1.65 8.87 -8.61 -21.79 -9.20 0.35 14.79 3.47 -14.51 4.56 0.75 19.93
Nuclear Periphery Foci -16.37 -3.70 -12.63 4.76 -5.06 4.35 21.85 6.05 1.33 -18.31 -8.60 15.59 -4.69 4.47 -21.16
Nucleolus -2.78 -2.20 0.61 3.17 2.44 5.33 3.12 7.88 2.06 5.28 1.80 -0.26 6.29 3.83 5.71
Nucleus -2.60 -1.11 1.63 3.86 1.96 5.78 4.12 7.00 1.30 3.89 2.79 1.68 6.63 3.67 4.54
Peroxisomes -2.69 -1.46 -0.46 1.51 0.62 4.77 6.98 7.79 2.91 2.82 1.90 4.84 5.16 3.36 1.83
Vacuole 0.63 5.51 -4.01 -4.57 -9.32 0.52 4.50 -0.10 -0.66 -5.48 0.69 5.92 -2.56 -3.20 -9.16
Vacuole Periphery 2.28 8.76 -6.52 -8.10 -12.64 -1.01 -3.46 -10.60 -8.35 -7.26 1.12 -0.77 -11.48 -11.73 -10.10
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of Nup84p subcomplex of nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis; is involved in establishment of a normal nucleocytoplasmic concentration gradient of GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at nuclear periphery, including double-strand break repair, transcription and chromatin silencing; relocalizes to cytosol in response to hypoxia; homolog of human NUP133
Localization
Cell Percentages nuclear periphery (92%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Nup133

Nup133


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nup133-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available