Standard name
Human Ortholog
Description Metalloendopeptidase of the mitochondrial inner membrane; important for adaptive responses to various homeostatic insults, preservation of normal mitochondrial function under damage-eliciting conditions, and stability of respiratory supercomplexes; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; zebrafish ortholog has a role in organ development and mouse ortholog is also required for respiratory supercomplex stability
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.05 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0.05 0 0.05 0.06 0.07 0 0 0 0 0 0 0.08 0 0 0 0 0 0
Bud Neck 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.12 0.05 0 0 0 0 0 0
Cytoplasm 0.55 0.49 0.89 0.82 0.79 0.52 0.36 0.45 0.35 0.34 0.25 0.31 0.91 0.94 0.96 0.4 0.37 0.32 0.15 0.15 0.19 0.28 0.23 0.27
Endoplasmic Reticulum 0 0.1 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.06 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.18 0.12 0.16 0.07 0.07 0 0.05 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.56 0.43 0 0.14 0.1 0.4 0.67 0.54 0.69 0.71 0.82 0.72 0 0 0 0.15 0.11 0.13 0.61 0.6 0.67 0.44 0.52 0.45
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0.05 0 0 0 0 0 0
SpindlePole 0 0 0 0.07 0.07 0.07 0.09 0.12 0.05 0.06 0 0 0 0 0 0.15 0.17 0.12 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.12 0.15 0.13 0 0.08 0 0.06 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 2 1 0 1 0 0 0 0 0 0 0 4 0 1 2 7 4 4 0 2 5 12 15
Bud 1 2 1 3 4 2 18 14 15 14 9 4 1 1 1 1 2 6 0 0 0 0 4 8
Bud Neck 0 0 6 5 4 9 5 13 3 6 0 2 11 4 5 1 2 0 1 0 0 0 7 12
Bud Site 1 0 0 0 0 2 2 3 5 2 1 2 0 0 0 1 1 1 – – – – – –
Cell Periphery 0 0 4 3 5 0 1 1 1 1 1 0 0 2 1 7 10 4 1 0 2 0 4 7
Cytoplasm 103 40 79 124 158 119 123 142 104 79 33 32 225 335 417 56 30 24 31 16 27 39 83 104
Endoplasmic Reticulum 1 8 1 0 0 1 0 0 0 1 0 0 3 2 0 9 5 3 2 2 0 1 2 3
Endosome 0 0 0 0 7 3 3 0 0 0 0 0 1 2 8 26 10 12 13 8 4 6 13 10
Golgi 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 2 2 2 0 1 0 1 1 1
Mitochondria 106 35 2 22 19 91 226 171 203 164 108 75 4 3 0 21 9 10 125 65 95 60 194 176
Nucleus 0 0 1 1 3 1 4 11 3 7 5 2 0 0 1 1 1 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 1 0 0 1 1 0 0 0 0 0 0 0 1 0 0 0 1 1
Nucleolus 0 0 0 0 1 0 0 0 0 0 0 0 0 1 1 1 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 1 2 2 1 1 0 0 0 1 3 0 10 3 4 2 0 1 2 2 1
SpindlePole 7 0 1 11 13 17 30 37 15 13 5 3 5 3 6 21 14 9 4 0 0 4 15 17
Vac/Vac Membrane 1 0 0 0 5 9 1 6 3 1 1 2 2 9 2 17 12 10 9 8 2 8 13 17
Unique Cell Count 188 81 89 152 200 227 338 319 293 231 132 104 247 358 434 141 82 76 207 109 142 138 371 391
Labelled Cell Count 220 87 96 170 221 256 416 399 353 289 164 122 257 365 444 176 108 89 207 109 142 138 371 391


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 2.9 4.1 4.3 4.5 4.6 3.8 3.6 3.9 3.4 3.2 3.2 3.5 4.7 5.1 5.0 5.8 6.0 5.6 4.6 4.8 5.1
Std Deviation (1e-4) 0.3 0.7 0.7 1.4 1.4 1.3 1.8 1.4 1.8 1.0 1.1 0.9 0.8 1.0 1.2 1.5 1.9 1.5 1.3 1.2 1.1
Intensity Change (Log2) – – – 0.06 0.09 -0.19 -0.25 -0.13 -0.32 -0.42 -0.42 -0.31 0.13 0.25 0.22 0.43 0.48 0.38 0.1 0.17 0.24

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 –
Bud Neck – – – – – – – – – – – – 0 0 –
Bud Site – – – – – – – – – – – – 0 0 –
Cell Periphery – – – – – – – – – – – – 0 0 –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 –
Endosome – – – – – – – – – – – – 0 0 –
Golgi – – – – – – – – – – – – 0 0 –
Mitochondria – – – – – – – – – – – – 0 0 –
Nuclear Periphery – – – – – – – – – – – – 0 0 –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 –
Peroxisomes – – – – – – – – – – – – 0 0 –
SpindlePole – – – – – – – – – – – – 0 0 –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 –
Cytoplasm – – – – – – – – – – – – 0 0 –
Nucleus – – – – – – – – – – – – 0 0 –
Vacuole – – – – – – – – – – – – 3.4 3.7 –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.7336 -0.5384 -0.7542 -0.8958 -0.8797 -0.5412 -0.349 -0.298 -0.094 -0.2154 -0.0158 -0.0198 -0.7764 -0.7024 -0.7561 -0.6725 -0.9836 -0.7829
Actin 0.028 0.0097 0.0079 0.0132 0.0131 0.009 0.03 0.0037 0.0145 0.0049 0.0351 0.0127 0.0239 0.0072 0.024 0.0063 0.0242 0.0143
Bud 0.0034 0.0086 0.0055 0.0016 0.0036 0.0038 0.0016 0.0022 0.0049 0.0038 0.0027 0.0012 0.0034 0.01 0.0088 0.0041 0.0023 0.0053
Bud Neck 0.0044 0.0013 0.0026 0.0315 0.001 0.0069 0.0086 0.0036 0.0086 0.0011 0.0007 0.0123 0.0046 0.0023 0.0073 0.0015 0.0014 0.007
Bud Periphery 0.0035 0.0082 0.0078 0.0042 0.0209 0.0039 0.0047 0.0047 0.0094 0.0076 0.0125 0.0053 0.0071 0.0079 0.0125 0.018 0.0072 0.0096
Bud Site 0.0114 0.0244 0.0107 0.0039 0.0026 0.0021 0.0148 0.0409 0.019 0.0074 0.0016 0.0014 0.0143 0.0476 0.0275 0.0079 0.0025 0.0016
Cell Periphery 0.0023 0.0011 0.003 0.0006 0.001 0.0005 0.0022 0.0037 0.0024 0.0008 0.001 0.002 0.0017 0.0023 0.0024 0.0033 0.0011 0.0013
Cytoplasm 0.0435 0.0623 0.053 0.0595 0.0422 0.0587 0.0824 0.1014 0.0615 0.0754 0.0529 0.0988 0.0562 0.0834 0.052 0.0804 0.0902 0.0634
Cytoplasmic Foci 0.1349 0.142 0.1215 0.0822 0.1389 0.1321 0.1567 0.1674 0.1359 0.1111 0.1424 0.1769 0.1311 0.1547 0.1296 0.128 0.1005 0.1221
Eisosomes 0.0016 0.0008 0.003 0.0004 0.0003 0.0006 0.0009 0.0015 0.001 0.0002 0.0006 0.0004 0.001 0.0008 0.0011 0.002 0.0015 0.0005
Endoplasmic Reticulum 0.0038 0.0033 0.0043 0.0012 0.0024 0.0018 0.005 0.0038 0.0035 0.0047 0.0059 0.0023 0.0051 0.0023 0.0023 0.003 0.0031 0.0024
Endosome 0.1114 0.1329 0.0775 0.0498 0.0839 0.0769 0.1684 0.0975 0.1192 0.186 0.104 0.0857 0.1666 0.146 0.1038 0.1199 0.0906 0.1148
Golgi 0.0328 0.0378 0.023 0.0294 0.0243 0.0211 0.0433 0.0357 0.0311 0.0255 0.0353 0.0391 0.0585 0.0645 0.0636 0.0636 0.0878 0.062
Lipid Particles 0.0713 0.0219 0.0266 0.0144 0.053 0.0303 0.0456 0.0189 0.0249 0.0546 0.0385 0.0329 0.0365 0.0181 0.0184 0.0108 0.041 0.015
Mitochondria 0.1708 0.2152 0.25 0.3312 0.3678 0.2158 0.1154 0.1488 0.228 0.2476 0.2481 0.2029 0.2336 0.2323 0.3177 0.2678 0.3512 0.3562
None 0.2694 0.2495 0.3142 0.2254 0.0952 0.3379 0.2532 0.2984 0.2448 0.1544 0.187 0.2232 0.1609 0.1558 0.1297 0.1977 0.0775 0.136
Nuclear Periphery 0.0069 0.0019 0.0021 0.0011 0.0172 0.0015 0.0036 0.0017 0.0051 0.0032 0.0024 0.0031 0.0041 0.001 0.0009 0.0019 0.0068 0.0011
Nucleolus 0.0026 0.0019 0.0046 0.0014 0.0023 0.0017 0.0031 0.0018 0.0017 0.0013 0.0008 0.0014 0.0018 0.0027 0.002 0.0025 0.0005 0.0011
Nucleus 0.0049 0.003 0.0047 0.0018 0.0173 0.005 0.0044 0.0027 0.0026 0.0025 0.0013 0.0016 0.0024 0.0045 0.0039 0.0023 0.0011 0.002
Peroxisomes 0.0765 0.0538 0.0624 0.1372 0.0959 0.0738 0.0317 0.0467 0.0591 0.0754 0.1039 0.0814 0.0612 0.0408 0.0773 0.0587 0.1004 0.0704
Punctate Nuclear 0.0051 0.0061 0.0058 0.0034 0.0035 0.0077 0.0109 0.0017 0.008 0.0015 0.0027 0.0053 0.0061 0.0052 0.0043 0.0011 0.0021 0.0047
Vacuole 0.0083 0.0109 0.0067 0.0043 0.0093 0.006 0.0111 0.0105 0.0115 0.0223 0.0149 0.0071 0.0144 0.0083 0.008 0.0106 0.0039 0.0057
Vacuole Periphery 0.0033 0.0036 0.0029 0.0022 0.0044 0.0028 0.0025 0.0026 0.0035 0.0087 0.0058 0.0029 0.0057 0.0025 0.0028 0.0087 0.0031 0.0032

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 17.0082 5.7016 9.1668 22.8727 19.9845 21.2484 16.8142 20.4272 19.2947 22.606
Translational Efficiency 1.2581 2.7727 1.9622 0.6599 0.9089 1.19 1.2147 0.8198 0.9755 0.7473

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
392 220 2207 835 1114 1578 205 1013 1506 1798 2412 1848

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 637.84 755.27 820.57 786.15 641.88 698.30 918.83 846.12 640.83 705.27 828.92 819.02
Standard Deviation 63.32 112.75 95.56 95.61 69.78 86.31 98.68 108.18 68.18 91.88 99.67 106.94
Intensity Change Log 2 — 0.243798 0.363432 0.301610 — 0.121543 0.517494 0.398559 — 0.183772 0.442762 0.351052

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000347 0.002244 0.000550 0.006371 0.000271 0.001206 0.000808 0.004230 0.000291 0.001333 0.000572 0.005198
Bud Neck 0.054234 0.059367 0.014508 0.016328 0.036592 0.059147 0.006601 0.014310 0.041184 0.059174 0.013836 0.015222
Bud Site 0.007687 0.040814 0.016266 0.043825 0.007731 0.032501 0.013731 0.044365 0.007719 0.033519 0.016051 0.044121
Cell Periphery 0.000382 0.001253 0.000132 0.000293 0.000285 0.000230 0.000299 0.000264 0.000311 0.000355 0.000146 0.000277
Cytoplasm 0.210174 0.074232 0.368164 0.311684 0.265572 0.186710 0.297915 0.377543 0.251153 0.172947 0.362193 0.347785
Cytoplasmic Foci 0.396860 0.293509 0.026872 0.149525 0.380930 0.309884 0.059925 0.114618 0.385076 0.307881 0.029681 0.130390
Eisosomes 0.000567 0.000287 0.000038 0.000216 0.000383 0.000259 0.000131 0.000126 0.000431 0.000263 0.000046 0.000167
Endoplasmic Reticulum 0.000727 0.000889 0.004779 0.005566 0.001593 0.000914 0.007258 0.003317 0.001367 0.000911 0.004990 0.004333
Endosome 0.047770 0.086263 0.003082 0.015505 0.031658 0.052365 0.010830 0.012566 0.035852 0.056513 0.003741 0.013894
Golgi 0.011066 0.060150 0.000220 0.002576 0.017924 0.030203 0.000372 0.003028 0.016139 0.033868 0.000233 0.002824
Lipid Particles 0.035347 0.009467 0.001985 0.005588 0.027536 0.011540 0.005508 0.003970 0.029569 0.011286 0.002284 0.004701
Mitochondria 0.053565 0.125429 0.002639 0.003312 0.053840 0.102768 0.000838 0.002109 0.053769 0.105540 0.002486 0.002653
Mitotic Spindle 0.000858 0.017500 0.008120 0.015453 0.001391 0.011440 0.005207 0.021876 0.001252 0.012182 0.007873 0.018974
None 0.001005 0.001088 0.002840 0.001163 0.002809 0.002024 0.003180 0.002588 0.002340 0.001909 0.002869 0.001944
Nuclear Periphery 0.000605 0.000287 0.003142 0.000933 0.000635 0.000283 0.002457 0.001419 0.000627 0.000284 0.003084 0.001199
Nuclear Periphery Foci 0.000218 0.000316 0.001134 0.002227 0.000368 0.000317 0.004722 0.002048 0.000329 0.000317 0.001439 0.002129
Nucleolus 0.002155 0.002456 0.001089 0.000849 0.001865 0.002313 0.003914 0.000965 0.001940 0.002330 0.001329 0.000913
Nucleus 0.085955 0.034440 0.491220 0.175398 0.099742 0.059754 0.432646 0.178314 0.096154 0.056656 0.486242 0.176996
Peroxisomes 0.053580 0.133394 0.003059 0.043911 0.029538 0.071811 0.002513 0.015200 0.035796 0.079347 0.003012 0.028173
Vacuole 0.034172 0.050455 0.049682 0.198291 0.035194 0.057840 0.140436 0.194874 0.034928 0.056936 0.057395 0.196418
Vacuole Periphery 0.002728 0.006162 0.000480 0.000987 0.004141 0.006491 0.000710 0.002269 0.003773 0.006451 0.000499 0.001690

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.38 -2.80 -5.94 -3.31 -5.55 -6.50 -6.02 -2.53 -1.58 -1.87 -7.78 -4.90 -5.45 -3.79 -4.83
Bud Neck -0.44 6.74 6.51 4.52 -0.72 -5.87 11.21 8.98 14.74 -3.91 -4.87 10.73 10.91 15.27 -0.21
Bud Site -5.55 -3.66 -7.80 0.86 -5.62 -11.05 -0.92 -6.91 0.22 -3.79 -12.44 -4.37 -10.34 0.06 -6.74
Cell Periphery -0.91 4.10 1.95 1.04 -7.15 1.37 -0.27 1.78 0.88 2.52 -0.35 4.92 2.26 1.05 -5.30
Cytoplasm 9.02 -11.45 -5.66 -16.15 6.11 8.48 0.47 -6.60 -15.07 -4.59 9.61 -11.11 -7.51 -17.84 3.25
Cytoplasmic Foci 5.98 33.55 22.79 11.70 -17.06 7.81 35.06 35.97 31.05 -5.03 9.71 59.39 41.83 32.75 -20.67
Eisosomes 3.85 8.27 5.75 2.45 -13.02 3.29 6.62 7.73 8.04 2.14 4.99 12.60 9.05 6.63 -15.96
Endoplasmic Reticulum -0.91 -16.51 -12.50 -12.34 -0.64 2.74 -9.56 -6.62 -10.79 6.94 2.31 -15.65 -12.19 -15.92 3.82
Endosome -3.84 8.54 6.64 8.74 -8.90 -6.85 9.84 11.37 17.62 0.50 -6.77 16.42 12.40 19.10 -11.42
Golgi -6.10 6.78 5.74 7.43 -5.26 -5.08 11.66 9.93 14.88 -2.29 -7.87 13.32 11.54 16.88 -4.16
Lipid Particles 6.31 8.88 7.99 2.47 -10.38 8.97 13.10 15.03 9.14 3.38 10.75 17.84 16.44 8.80 -9.47
Mitochondria -4.46 7.39 7.40 8.53 0.13 -7.88 13.97 13.74 21.05 -3.36 -9.05 15.37 15.51 22.63 1.20
Mitotic Spindle -3.29 -6.95 -5.70 0.60 -1.96 -6.72 -1.85 -6.24 -2.28 -2.97 -7.56 -6.92 -8.32 -1.90 -3.57
None -0.27 -5.28 -0.73 -0.07 6.01 1.13 -0.08 0.67 -0.60 0.82 0.75 -0.71 1.09 0.06 2.82
Nuclear Periphery 2.24 -14.76 -4.95 -9.32 12.19 2.99 -8.38 -4.80 -6.41 2.67 3.63 -16.61 -6.18 -9.10 8.54
Nuclear Periphery Foci -1.80 -9.25 -11.61 -10.84 -5.22 0.48 -7.95 -8.07 -8.55 5.19 0.13 -9.91 -12.93 -13.05 -3.06
Nucleolus -0.14 2.27 2.66 1.84 1.12 -0.83 -0.89 3.50 3.58 1.96 -0.72 2.73 4.42 3.99 2.08
Nucleus 5.43 -46.28 -10.32 -15.07 33.30 7.19 -15.76 -11.77 -18.42 10.91 8.31 -55.71 -15.25 -23.67 39.22
Peroxisomes -5.57 9.89 3.65 7.45 -7.81 -10.91 13.05 7.87 17.55 -5.84 -11.11 15.63 6.02 15.89 -9.04
Vacuole -2.79 -8.87 -26.56 -21.09 -22.95 -7.66 -10.82 -29.34 -25.86 -4.45 -8.33 -13.92 -39.71 -34.45 -30.13
Vacuole Periphery -3.67 7.45 6.05 6.11 -1.88 -3.51 9.68 4.70 6.92 -1.54 -4.64 12.19 7.09 9.39 -2.18
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Metalloendopeptidase of the mitochondrial inner membrane; important for adaptive responses to various homeostatic insults, preservation of normal mitochondrial function under damage-eliciting conditions, and stability of respiratory supercomplexes; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; zebrafish ortholog has a role in organ development and mouse ortholog is also required for respiratory supercomplex stability
Localization
Cell Percentages mitochondrion (27%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Oma1

Oma1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Oma1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available