Standard name
Human Ortholog
Description hEST1A/B (SMG5/6)-like protein; contributes to environment-sensing adaptive gene expression responses; Esl2p and Esl1p contain a 14-3-3-like domain and a putative PilT N-terminus ribonuclease domain; interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; ESL2 has a paralog, ESL1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0.05 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.63 0.69 0.74 0.34 0.21 0.4 0.48 0.42 0.47 0.46 0.38 0.41 0.54 0.63 0.67 0.72 0.74 0.78 0.5 0.48 0.59 0.45 0.41 0.44
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.1 0.05 0 0 0.09 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.11 0.2 0.51 0.3 0.48 0.47 0.51 0.62 0.61 0.66 0.68 0 0 0.12 0 0 0 0 0 0.06 0 0 0
Nucleus 0.15 0 0 0.22 0.38 0.15 0.1 0.11 0.1 0.11 0.08 0.08 0 0 0 0 0 0 0.26 0.26 0.07 0.21 0.22 0.13
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.38 0.33 0.12 0.08 0.25 0.14 0.12 0.15 0.07 0.05 0.1 0.08 0.44 0.35 0.25 0.27 0.36 0.24 0.14 0.16 0.16 0.2 0.21 0.2
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 2
Bud 0 0 3 3 2 8 8 10 7 9 12 10 0 0 18 0 0 2 5 0 0 4 8 12
Bud Neck 0 0 1 0 0 0 1 0 0 1 1 0 0 0 0 0 0 0 4 0 3 2 2 7
Bud Site 0 0 0 0 2 1 1 12 4 6 6 4 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 1 0 0 0 0 0 0 3 0 0 1 1 1 1 0 0 0 0 0 0
Cytoplasm 244 31 125 58 66 112 235 257 149 202 145 176 96 177 201 138 55 117 233 40 143 64 72 138
Endoplasmic Reticulum 1 1 1 0 1 2 2 2 0 0 1 1 0 0 0 6 4 8 1 0 2 0 0 4
Endosome 1 1 0 0 4 4 3 1 0 0 1 0 16 29 15 8 2 14 8 2 1 0 2 7
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 3
Mitochondria 0 5 34 87 93 135 230 311 196 264 251 291 2 4 35 8 1 2 4 2 13 1 3 7
Nucleus 60 1 2 37 119 43 48 69 31 50 29 35 3 6 2 1 0 0 121 21 16 29 39 42
Nuclear Periphery 0 0 0 0 0 1 0 1 0 1 0 0 0 0 1 0 0 0 2 0 0 0 0 1
Nucleolus 0 0 0 0 1 0 1 3 1 0 0 0 0 1 3 0 0 0 1 0 0 0 1 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 1 0 1
SpindlePole 0 0 0 0 0 0 0 5 1 3 2 1 0 0 0 0 0 0 9 0 10 4 2 12
Vac/Vac Membrane 147 15 21 13 76 39 56 92 23 22 37 35 78 97 76 52 27 36 67 13 39 28 36 64
Unique Cell Count 390 45 170 170 310 279 485 606 314 436 382 430 177 279 302 191 74 150 468 84 243 142 177 316
Labelled Cell Count 453 54 187 198 365 345 585 763 412 558 485 556 195 314 352 216 90 180 468 84 243 142 177 316


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.4 5.1 3.8 4.0 4.3 4.0 3.8 3.8 3.3 3.4 3.4 3.1 5.5 5.7 4.9 16.9 24.0 26.5 5.3 5.4 6.1
Std Deviation (1e-4) 0.6 1.5 0.5 1.0 1.1 1.0 1.2 0.9 1.0 1.0 1.1 0.8 1.6 1.7 1.8 32.9 44.9 48.8 0.9 1.4 1.9
Intensity Change (Log2) – – – 0.07 0.2 0.07 0.0 -0.0 -0.19 -0.15 -0.15 -0.29 0.56 0.59 0.39 2.17 2.68 2.82 0.49 0.51 0.69

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000204060WT3HU80HU120HU1600204060WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30204060WT1AF100AF140AF1800204060
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 2.1 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -7.3 -11.2 -6.9 -5.7 -7.2 -5.5 -6.0 -7.7 -7.2 -3.7 -2.2 -1.6 -0.3 0.1 0.9
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 4.0 4.3 3.0 0 0 4.1
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 -5.8 -6.9 -2.5 -4.7 -3.8 -5.3
Nucleus 6.0 9.0 4.9 3.7 4.1 3.6 4.1 3.0 3.2 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -1.4 3.2 0.5 -0.3 0.9 -1.8 -3.1 -0.9 -1.6 6.5 5.2 3.3 3.5 4.4 2.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.661 2.9079 2.805 2.2069 2.2825 2.9467 2.2394 3.0068 2.7438 2.615 2.8991 2.5873 2.6526 2.1134 2.104 1.8964 2.2478 2.1425
Actin 0.0005 0.0008 0.0006 0.0004 0.0007 0.001 0.0152 0.001 0.0206 0.0263 0.0023 0.0082 0.001 0.0003 0.0051 0.0023 0.001 0.0006
Bud 0.0001 0.0001 0.0002 0.0002 0.0003 0.0002 0.0006 0.0003 0.0019 0.001 0.0016 0.0004 0.0002 0.0001 0.0011 0.0001 0.0001 0.0001
Bud Neck 0.0009 0.0019 0.0013 0.0017 0.0033 0.0085 0.0008 0.0006 0.0012 0.0014 0.0028 0.004 0.0017 0.0003 0.01 0.0009 0.0003 0.003
Bud Periphery 0.0001 0.0001 0.0001 0.0001 0.0003 0.0002 0.0005 0.0002 0.0013 0.0016 0.0017 0.0004 0.0001 0 0.0034 0 0 0.0001
Bud Site 0.0005 0.0025 0.0015 0.0008 0.0006 0.0006 0.0073 0.0016 0.0038 0.0018 0.0098 0.0005 0.0007 0.0011 0.0057 0.0002 0.0003 0.0002
Cell Periphery 0.0002 0.0004 0.0001 0.0002 0.0001 0.0001 0.0003 0.0001 0.0001 0.0001 0.0003 0.0001 0.0002 0.0001 0.0042 0 0.0001 0
Cytoplasm 0.5528 0.4921 0.4596 0.3626 0.4904 0.426 0.5694 0.6187 0.5606 0.4739 0.3178 0.5429 0.3761 0.7433 0.4844 0.5359 0.541 0.5638
Cytoplasmic Foci 0.0028 0.0043 0.0022 0.0096 0.0041 0.0023 0.0294 0.0042 0.0128 0.019 0.0388 0.0091 0.1496 0.0031 0.0107 0.0114 0.006 0.0032
Eisosomes 0.0001 0.0001 0 0.0001 0 0 0.0001 0 0.0001 0.0002 0 0 0 0 0.001 0 0 0
Endoplasmic Reticulum 0.0153 0.0151 0.0062 0.0082 0.0086 0.0048 0.0109 0.0077 0.0044 0.0046 0.0054 0.0109 0.0203 0.0057 0.0109 0.004 0.0127 0.0039
Endosome 0.0043 0.0054 0.0033 0.0192 0.0114 0.0033 0.0346 0.0032 0.0157 0.0116 0.0922 0.0128 0.1652 0.0017 0.0078 0.0043 0.0048 0.0021
Golgi 0.0001 0.0002 0.0001 0.0004 0.0002 0.0001 0.0078 0.0003 0.0049 0.0121 0.031 0.0035 0.0025 0.0001 0.0018 0.0004 0.0002 0.0001
Lipid Particles 0.0004 0.0009 0.0001 0.0017 0.0003 0.0001 0.0186 0.0002 0.002 0.0044 0.0079 0.0028 0.0048 0.0001 0.0054 0.0003 0.0004 0.0001
Mitochondria 0.0004 0.0003 0.0004 0.0007 0.0004 0.0005 0.0041 0.0005 0.0053 0.0311 0.0064 0.0057 0.0013 0.0002 0.0026 0.0005 0.0004 0.0003
None 0.0924 0.1288 0.0726 0.1641 0.1449 0.0564 0.0739 0.1055 0.08 0.0171 0.0775 0.0513 0.2113 0.0897 0.1221 0.1324 0.3282 0.2234
Nuclear Periphery 0.0249 0.0134 0.0151 0.0128 0.0163 0.0151 0.016 0.0077 0.0102 0.012 0.0318 0.0105 0.0144 0.0063 0.0139 0.0088 0.0089 0.0056
Nucleolus 0.002 0.0017 0.0012 0.0024 0.0023 0.0026 0.003 0.0004 0.001 0.0006 0.0018 0.0007 0.0007 0.0002 0.007 0.0004 0.0004 0.0005
Nucleus 0.2883 0.3188 0.4247 0.3844 0.3028 0.4528 0.1741 0.2406 0.2611 0.3459 0.3386 0.3138 0.0056 0.1429 0.2619 0.2828 0.0895 0.1856
Peroxisomes 0 0.0001 0.0001 0.0001 0.0001 0.0001 0.0136 0.0004 0.0019 0.0188 0.0077 0.0084 0.0102 0.0001 0.001 0.0009 0.0001 0.0001
Punctate Nuclear 0.0103 0.0089 0.0074 0.0204 0.0094 0.0233 0.0077 0.0053 0.0081 0.0143 0.0064 0.0117 0.0138 0.0035 0.0291 0.013 0.0043 0.006
Vacuole 0.0034 0.0037 0.0028 0.0088 0.0032 0.0017 0.0108 0.0013 0.0022 0.0015 0.0142 0.0016 0.0172 0.0011 0.0099 0.0011 0.001 0.0012
Vacuole Periphery 0.0003 0.0003 0.0003 0.0008 0.0003 0.0003 0.0011 0.0002 0.0007 0.0006 0.0038 0.0005 0.0031 0.0001 0.0009 0.0002 0.0003 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 15.0688 13.4706 11.6277 18.442 14.1546 13.5237 19.3183 20.8241 19.145 23.1347
Translational Efficiency 0.5909 0.7387 0.777 0.4877 0.5885 0.8034 0.5728 0.5238 0.6092 0.4655

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2012 11 2566 1272 734 992 186 74 2746 1003 2752 1346

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 687.95 322.23 1057.04 878.49 694.65 790.44 1013.23 943.75 689.74 785.31 1054.08 882.08
Standard Deviation 78.32 3.26 133.04 117.99 86.16 105.06 106.28 114.86 80.55 115.30 131.87 118.76
Intensity Change Log 2 — -1.094213 0.619654 0.352722 — 0.186370 0.544604 0.442118 — -0.313358 0.582435 0.398329

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000032 0.000039 0.000157 0.001017 0.000128 0.000790 0.000602 0.000407 0.000058 0.000782 0.000187 0.000983
Bud Neck 0.002368 0.000010 0.005443 0.011851 0.004471 0.017590 0.001897 0.002671 0.002930 0.017397 0.005203 0.011346
Bud Site 0.001011 0.000029 0.008825 0.040579 0.001620 0.016222 0.002307 0.005258 0.001174 0.016044 0.008384 0.038638
Cell Periphery 0.000125 0.000054 0.000061 0.000281 0.000189 0.000230 0.000252 0.000177 0.000142 0.000228 0.000074 0.000276
Cytoplasm 0.441561 0.000040 0.438601 0.459076 0.437984 0.378369 0.162589 0.461356 0.440605 0.374220 0.419946 0.459202
Cytoplasmic Foci 0.039796 0.000013 0.001678 0.022422 0.142654 0.119855 0.016477 0.055205 0.067290 0.118540 0.002678 0.024224
Eisosomes 0.000032 0.000059 0.000007 0.000051 0.000097 0.000094 0.000118 0.000070 0.000050 0.000094 0.000014 0.000052
Endoplasmic Reticulum 0.000331 0.000001 0.001149 0.002456 0.001396 0.002237 0.010127 0.006320 0.000616 0.002213 0.001756 0.002669
Endosome 0.001176 0.000002 0.000263 0.011022 0.004629 0.010472 0.007042 0.001990 0.002099 0.010357 0.000721 0.010525
Golgi 0.000237 0.000004 0.000054 0.007915 0.000597 0.002841 0.000788 0.000160 0.000333 0.002809 0.000104 0.007488
Lipid Particles 0.001610 0.000024 0.000181 0.001867 0.007093 0.004904 0.003323 0.002307 0.003075 0.004850 0.000393 0.001891
Mitochondria 0.001247 0.000010 0.000465 0.012186 0.002597 0.006100 0.000388 0.000251 0.001608 0.006033 0.000459 0.011529
Mitotic Spindle 0.000872 0.000285 0.002238 0.067410 0.000882 0.023145 0.003233 0.010810 0.000875 0.022895 0.002305 0.064298
None 0.010739 0.999258 0.006016 0.007119 0.007157 0.003421 0.003037 0.002160 0.009782 0.014343 0.005814 0.006846
Nuclear Periphery 0.000475 0.000000 0.000921 0.001673 0.000763 0.001130 0.001972 0.001488 0.000552 0.001118 0.000992 0.001663
Nuclear Periphery Foci 0.000223 0.000039 0.000409 0.001651 0.001399 0.001309 0.002469 0.002727 0.000537 0.001295 0.000548 0.001710
Nucleolus 0.000985 0.000042 0.000128 0.001109 0.001915 0.002834 0.000581 0.000283 0.001234 0.002804 0.000159 0.001064
Nucleus 0.489258 0.000010 0.517397 0.192429 0.354099 0.342149 0.670671 0.290223 0.453130 0.338397 0.527756 0.197806
Peroxisomes 0.000766 0.000079 0.000039 0.002309 0.004100 0.011213 0.000480 0.000403 0.001657 0.011091 0.000069 0.002204
Vacuole 0.006953 0.000002 0.015764 0.146222 0.025829 0.052606 0.111357 0.155615 0.011998 0.052030 0.022225 0.146738
Vacuole Periphery 0.000202 0.000000 0.000207 0.009355 0.000402 0.002488 0.000291 0.000119 0.000255 0.002461 0.000212 0.008848

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin NaN NaN NaN NaN NaN -4.68 -8.02 -5.91 0.58 1.04 -5.25 -6.57 -7.22 1.10 -4.46
Bud Neck NaN NaN NaN NaN NaN -7.09 1.32 -0.45 6.24 -1.47 -8.41 -3.36 -5.96 5.06 -2.83
Bud Site NaN NaN NaN NaN NaN -7.07 -3.56 -4.86 4.25 -3.17 -7.29 -6.00 -7.94 -0.66 -4.26
Cell Periphery NaN NaN NaN NaN NaN -0.85 -3.36 -0.88 0.19 1.98 -2.22 6.79 -1.21 1.61 -5.88
Cytoplasm NaN NaN NaN NaN NaN 4.89 18.68 4.00 2.16 -4.73 7.30 9.40 12.05 3.19 5.01
Cytoplasmic Foci NaN NaN NaN NaN NaN 2.96 20.02 11.30 9.62 -0.88 -9.12 28.84 22.23 20.30 -11.33
Eisosomes NaN NaN NaN NaN NaN 0.48 -4.12 -0.62 -0.91 2.76 -8.52 13.80 -6.72 5.10 -22.58
Endoplasmic Reticulum NaN NaN NaN NaN NaN -3.18 -9.37 -5.98 -5.24 2.53 -7.88 -13.09 -18.87 -7.15 -7.69
Endosome NaN NaN NaN NaN NaN -4.43 -0.81 4.20 6.62 2.49 -6.94 7.02 -3.75 4.65 -6.54
Golgi NaN NaN NaN NaN NaN -3.72 0.68 3.47 4.71 0.93 -4.27 3.19 -2.08 0.66 -2.42
Lipid Particles NaN NaN NaN NaN NaN 2.95 4.87 5.50 2.18 1.25 -2.72 13.60 5.10 4.82 -8.49
Mitochondria NaN NaN NaN NaN NaN -2.15 1.93 1.99 5.31 0.77 -3.82 2.71 -1.93 1.39 -3.11
Mitotic Spindle NaN NaN NaN NaN NaN -5.76 -0.46 -1.94 0.92 -1.84 -5.87 -1.59 -9.41 -2.12 -8.99
None NaN NaN NaN NaN NaN 2.77 3.25 2.97 0.92 -0.49 -1.31 5.13 5.23 2.93 1.57
Nuclear Periphery NaN NaN NaN NaN NaN -3.28 -11.91 -5.26 -4.14 -0.40 -5.81 -18.05 -20.98 -12.86 -14.26
Nuclear Periphery Foci NaN NaN NaN NaN NaN 0.50 -3.74 -3.05 -3.33 -0.47 -3.55 -2.47 -7.03 -2.10 -5.83
Nucleolus NaN NaN NaN NaN NaN -1.39 4.54 4.99 5.20 1.72 -3.20 9.50 3.03 4.36 -2.82
Nucleus NaN NaN NaN NaN NaN 0.82 -11.30 1.89 1.52 9.25 10.95 -14.43 19.27 4.57 32.11
Peroxisomes NaN NaN NaN NaN NaN -4.44 3.98 4.15 8.69 1.75 -7.29 5.25 2.68 8.22 -3.55
Vacuole NaN NaN NaN NaN NaN -8.41 -9.61 -9.28 -8.25 -3.83 -14.16 -13.53 -35.66 -27.06 -31.26
Vacuole Periphery NaN NaN NaN NaN NaN -2.55 1.75 3.60 2.95 2.28 -2.76 0.90 -3.39 -0.19 -3.51
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description hEST1A/B (SMG5/6)-like protein; contributes to environment-sensing adaptive gene expression responses; Esl2p and Esl1p contain a 14-3-3-like domain and a putative PilT N-terminus ribonuclease domain; interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; ESL2 has a paralog, ESL1, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (21%), nucleus (10%), mixed (56%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Esl2

Esl2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Esl2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available