Standard name
Human Ortholog
Description Homolog of mammalian ELMO (Engulfment and celL MOtility); upstream component for regulation through the small GTPase Rho5p; may form a complex with Dck1p that acts as a GEF for Rho5p; cytoplasmic protein that relocates to mitochondria under oxidative stress; implicated in mitophagy; not an essential protein
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.0 0.98 0.97 0.98 0.98 0.95 0.94 – 0.88 0.9 0.68 0.84 0.99 0.99 0.98 0.96 0.97 0.97 0.93 0.91 0.71 0.95 0.93 0.85
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.07 0.07 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.08 0 0 0 0 0.05 0.05 – 0.16 0.09 0.38 0.2 0 0 0 0 0 0 0 0 0.09 0 0 0.05
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 0 0 0 1 – 0 1 0 1 0 0 0 2 1 2 0 1 1 0 1 1
Bud 0 3 1 0 0 1 0 – 1 3 4 3 0 0 0 0 1 0 0 3 0 0 0 0
Bud Neck 0 1 0 0 1 0 4 – 3 4 1 1 0 1 0 0 1 2 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 1 0 0 – – – – – –
Cell Periphery 0 5 0 1 5 9 3 – 2 5 8 8 4 2 10 25 11 22 0 0 0 0 0 0
Cytoplasm 38 253 87 88 235 207 254 – 152 199 121 169 129 195 249 561 520 514 57 233 67 51 185 165
Endoplasmic Reticulum 0 1 1 0 2 0 2 – 6 5 0 2 0 1 0 40 35 30 0 1 1 0 0 2
Endosome 0 0 1 0 1 2 0 – 1 2 1 1 0 0 2 6 6 6 0 0 2 0 0 1
Golgi 0 0 1 0 0 1 0 – 0 0 0 0 0 0 0 4 1 4 0 1 0 0 0 1
Mitochondria 3 0 0 0 1 10 14 – 28 19 67 40 1 0 1 8 4 2 0 5 8 0 3 9
Nucleus 0 1 1 0 2 0 2 – 1 2 0 1 1 0 1 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0
Nucleolus 0 0 0 0 0 0 1 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 2 0 – 0 1 0 0 0 0 2 0 0 0 0 0 0 0 0 1
SpindlePole 0 0 0 1 1 3 0 – 1 2 1 1 0 0 0 8 6 7 0 0 0 0 1 2
Vac/Vac Membrane 0 2 0 1 2 0 1 – 0 0 3 0 1 0 0 4 4 3 1 2 6 0 0 4
Unique Cell Count 38 257 90 90 240 219 269 172 221 178 200 130 196 253 585 538 531 62 255 96 54 199 195
Labelled Cell Count 41 266 93 91 250 235 282 195 243 206 228 136 199 265 659 590 592 62 255 96 54 199 195


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.2 5.4 5.4 7.6 6.1 5.5 4.8 – 4.2 4.5 4.2 4.2 5.5 5.7 5.8 6.3 5.9 5.8 4.6 5.3 5.5
Std Deviation (1e-4) 0.4 0.7 1.4 6.2 2.3 3.2 1.4 – 0.8 1.1 2.0 1.5 0.9 0.9 1.2 1.1 1.0 1.0 0.3 1.0 1.6
Intensity Change (Log2) – – – 0.47 0.17 0.0 -0.19 – -0.38 -0.27 -0.36 -0.39 0.01 0.06 0.08 0.2 0.13 0.09 -0.25 -0.04 0.03

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.5 0.7 -0.8 -0.8 – -2.3 -1.9 -5.3 -3.0 1.4 1.9 1.0 -0.3 0 0.1
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 2.1 2.0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -1.0989 -0.4637 -0.826 -1.0459 -0.961 -0.6306 -0.387 0.2512 0.1342 -0.384 0.2907 -0.222 -0.5866 -0.2024 -0.232 -0.2486 -0.396 -0.3104
Actin 0.0113 0.0053 0.0053 0.0003 0.0121 0.0049 0.016 0.002 0.0177 0.0018 0.0505 0.0064 0.0074 0.0004 0.0451 0.0014 0.0168 0.0083
Bud 0.0006 0.0005 0.0005 0 0.0005 0.0003 0.0023 0.0001 0.0016 0.0084 0.0021 0.0003 0.0003 0.0002 0.003 0.0004 0.0005 0.0003
Bud Neck 0.0031 0.0003 0.0009 0.0002 0.0021 0.0023 0.0013 0.0004 0.0018 0.0004 0.0015 0.002 0.0015 0.0002 0.0003 0.0007 0.0009 0.0019
Bud Periphery 0.0006 0.0004 0.0008 0 0.0006 0.0006 0.0013 0.0001 0.0017 0.0044 0.0016 0.0006 0.0005 0.0002 0.0043 0.001 0.0005 0.0004
Bud Site 0.0081 0.0038 0.0025 0 0.0025 0.0012 0.0069 0.0017 0.0094 0.0025 0.0209 0.0002 0.0047 0.0048 0.0043 0.0014 0.0111 0.0011
Cell Periphery 0.0006 0.0008 0.0005 0.0001 0.0005 0.0004 0.0007 0.0006 0.0005 0.0007 0.0002 0.0002 0.0003 0.0005 0.0003 0.0001 0.0002 0.0001
Cytoplasm 0.2674 0.4192 0.3708 0.6043 0.2674 0.4136 0.2449 0.3712 0.333 0.4078 0.4198 0.4269 0.3361 0.5498 0.4224 0.3858 0.4853 0.5856
Cytoplasmic Foci 0.035 0.0096 0.0241 0.0041 0.0512 0.0127 0.0231 0.0052 0.0164 0.0156 0.0318 0.01 0.0247 0.0089 0.0234 0.0639 0.021 0.0229
Eisosomes 0.001 0.0002 0.0003 0 0.0026 0.0003 0.0006 0.0003 0.0004 0.0003 0.0001 0.0001 0.0002 0.0001 0.0003 0.0001 0.0002 0.0001
Endoplasmic Reticulum 0.0049 0.0023 0.0042 0.0019 0.0021 0.0021 0.0032 0.0015 0.0049 0.0025 0.0023 0.0018 0.0046 0.003 0.0029 0.0069 0.003 0.0021
Endosome 0.0261 0.0006 0.0181 0.0044 0.0939 0.0138 0.0153 0.0007 0.0117 0.0075 0.0431 0.0038 0.0147 0.0043 0.0094 0.0092 0.012 0.0044
Golgi 0.0089 0.0004 0.0113 0.0001 0.0709 0.0047 0.0046 0.0003 0.0027 0.0005 0.0215 0.0015 0.0076 0.0006 0.0043 0.0025 0.0052 0.008
Lipid Particles 0.022 0.0003 0.0174 0 0.0348 0.0225 0.015 0.0002 0.0036 0.0005 0.0383 0.0025 0.0096 0.0003 0.0041 0.0172 0.0144 0.0034
Mitochondria 0.0035 0.0001 0.0108 0.0001 0.0187 0.0008 0.0069 0.0001 0.0015 0.0261 0.0034 0.0014 0.0061 0.0003 0.0114 0.0578 0.0038 0.0099
None 0.5805 0.5543 0.5208 0.3815 0.3873 0.5045 0.6353 0.6133 0.5714 0.4977 0.3306 0.5306 0.5582 0.4231 0.4414 0.4195 0.398 0.3432
Nuclear Periphery 0.0013 0.0002 0.0008 0.0005 0.0018 0.0042 0.0022 0.0002 0.0035 0.001 0.0025 0.0004 0.0056 0.0006 0.0006 0.0009 0.0006 0.0004
Nucleolus 0.0018 0.0001 0.0005 0 0.0005 0.0008 0.0018 0.0001 0.0005 0.006 0.0006 0.0001 0.0006 0.0001 0.0003 0.0008 0.0001 0.0001
Nucleus 0.0014 0.0005 0.0008 0.0008 0.0008 0.0011 0.0027 0.0006 0.002 0.0049 0.0015 0.0005 0.0022 0.001 0.001 0.0009 0.0005 0.0007
Peroxisomes 0.0148 0.0002 0.0053 0 0.0118 0.0028 0.0087 0.0001 0.0038 0.0008 0.0121 0.0086 0.0073 0.0001 0.0184 0.0107 0.023 0.0054
Punctate Nuclear 0.0044 0.0003 0.0014 0.0002 0.0182 0.0046 0.0032 0.0003 0.0101 0.005 0.0091 0.0008 0.0033 0.0005 0.0011 0.0173 0.0006 0.0013
Vacuole 0.0024 0.0005 0.0022 0.0013 0.0152 0.0012 0.0031 0.0007 0.0014 0.0045 0.0054 0.001 0.0027 0.0011 0.0014 0.0013 0.002 0.0004
Vacuole Periphery 0.0006 0 0.0006 0.0002 0.0043 0.0006 0.0007 0 0.0005 0.0012 0.001 0.0002 0.0017 0.0001 0.0003 0.0003 0.0003 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 5.7987 8.3926 5.8613 6.2515 6.8022 4.9675 6.6139 6.9065 6.3309 7.7218
Translational Efficiency 0.6103 0.5372 0.7515 0.5492 0.6267 1.0006 0.8313 0.7432 0.7909 0.795

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1469 1275 1764 1569 1856 2278 180 83 3325 3553 1944 1652

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 614.44 618.12 910.16 892.82 725.09 692.89 984.89 966.39 676.20 666.06 917.08 896.52
Standard Deviation 62.16 109.21 96.17 121.55 79.06 86.61 97.84 95.22 90.64 101.86 98.73 121.44
Intensity Change Log 2 — 0.008615 0.566848 0.539097 — -0.065534 0.441803 0.414445 — -0.031048 0.500509 0.472963

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000034 0.000722 0.000398 0.002332 0.000102 0.000455 0.000359 0.005366 0.000072 0.000551 0.000394 0.002485
Bud Neck 0.003870 0.005969 0.003662 0.014187 0.006849 0.025480 0.006949 0.021016 0.005533 0.018479 0.003966 0.014530
Bud Site 0.001237 0.007502 0.008948 0.081152 0.003901 0.013989 0.017322 0.080226 0.002724 0.011661 0.009723 0.081105
Cell Periphery 0.000152 0.000187 0.000147 0.000230 0.000113 0.000129 0.000287 0.000308 0.000130 0.000150 0.000160 0.000234
Cytoplasm 0.590192 0.533357 0.486583 0.405624 0.593209 0.502366 0.459407 0.217765 0.591876 0.513487 0.484066 0.396186
Cytoplasmic Foci 0.122881 0.149455 0.016665 0.079361 0.138912 0.214794 0.043089 0.099934 0.131829 0.191347 0.019111 0.080394
Eisosomes 0.000116 0.000091 0.000035 0.000066 0.000098 0.000151 0.000101 0.000122 0.000106 0.000130 0.000041 0.000069
Endoplasmic Reticulum 0.000652 0.001507 0.003597 0.002209 0.000769 0.000848 0.003867 0.003032 0.000718 0.001085 0.003622 0.002250
Endosome 0.003450 0.011050 0.002484 0.014783 0.003625 0.014807 0.015226 0.050149 0.003547 0.013459 0.003664 0.016560
Golgi 0.001034 0.002327 0.000090 0.004423 0.001124 0.004399 0.000168 0.012654 0.001084 0.003655 0.000097 0.004837
Lipid Particles 0.003692 0.013792 0.001436 0.002889 0.004315 0.007898 0.004402 0.009446 0.004040 0.010013 0.001710 0.003218
Mitochondria 0.002304 0.002967 0.000597 0.001346 0.002154 0.011332 0.000481 0.018769 0.002220 0.008330 0.000586 0.002221
Mitotic Spindle 0.000193 0.000822 0.004392 0.165889 0.002054 0.003228 0.005919 0.220641 0.001232 0.002365 0.004534 0.168640
None 0.005106 0.022164 0.002516 0.002011 0.002274 0.001292 0.002180 0.000975 0.003526 0.008782 0.002485 0.001959
Nuclear Periphery 0.000336 0.001190 0.002053 0.000809 0.000318 0.000382 0.001410 0.000680 0.000326 0.000672 0.001994 0.000802
Nuclear Periphery Foci 0.000182 0.001905 0.001686 0.005987 0.000214 0.000410 0.007281 0.013086 0.000200 0.000946 0.002204 0.006343
Nucleolus 0.000654 0.003986 0.000260 0.000924 0.000474 0.000879 0.000531 0.000780 0.000554 0.001994 0.000285 0.000917
Nucleus 0.244755 0.191785 0.398425 0.066001 0.207620 0.124616 0.169751 0.039806 0.224027 0.148720 0.377252 0.064685
Peroxisomes 0.001548 0.002860 0.000231 0.025258 0.002342 0.007515 0.000964 0.039668 0.001991 0.005845 0.000299 0.025982
Vacuole 0.017184 0.044825 0.065611 0.122618 0.029033 0.063391 0.259934 0.156464 0.023798 0.056728 0.083604 0.124318
Vacuole Periphery 0.000428 0.001537 0.000185 0.001902 0.000499 0.001637 0.000373 0.009113 0.000468 0.001601 0.000203 0.002264

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.37 -2.95 -7.59 -1.75 -4.70 -2.11 -5.16 -1.90 -1.66 -1.69 -2.29 -2.92 -7.61 -3.94 -5.06
Bud Neck -2.51 -0.74 -11.50 -8.95 -12.04 -12.32 0.88 -1.27 2.73 -1.51 -12.76 1.93 -10.26 2.76 -11.95
Bud Site -4.65 -5.35 -17.55 -14.59 -14.22 -6.86 -2.38 -4.13 -3.17 -3.05 -8.53 -4.82 -17.55 -14.12 -14.50
Cell Periphery -1.72 -0.84 -2.87 0.07 -2.26 -2.08 -5.01 -2.81 -2.48 0.33 -2.15 -4.67 -5.79 -3.20 -1.76
Cytoplasm 6.20 18.10 26.59 18.09 9.73 11.82 9.65 12.04 8.85 4.07 13.26 22.40 31.33 21.12 10.16
Cytoplasmic Foci -4.71 30.35 7.43 10.96 -19.33 -13.42 17.64 4.27 9.53 -2.79 -14.42 41.99 10.67 22.29 -19.17
Eisosomes 3.52 14.84 7.94 3.12 -9.09 -4.40 -1.39 -1.89 0.45 -1.26 -3.01 15.51 6.71 6.36 -7.98
Endoplasmic Reticulum -1.81 -9.42 -3.89 -3.45 9.63 -0.62 -8.86 -4.25 -4.08 1.77 -1.70 -15.46 -6.97 -7.18 9.90
Endosome -7.42 0.97 -10.29 -2.72 -13.07 -13.50 -2.68 -3.61 -1.66 -1.90 -15.01 -0.37 -12.25 -1.28 -11.95
Golgi -2.09 2.81 -1.80 0.23 -4.11 -6.79 5.31 -1.20 0.17 -1.61 -6.67 5.48 -2.19 2.37 -4.37
Lipid Particles -7.82 6.49 -2.28 7.21 -10.52 -5.35 -0.29 -1.82 0.13 -1.71 -9.59 6.85 -1.80 8.68 -9.96
Mitochondria -0.73 1.99 1.61 4.76 -2.07 -6.87 3.21 -0.84 1.68 -1.36 -6.59 3.33 2.01 8.64 -2.41
Mitotic Spindle -2.12 -4.13 -22.90 -22.81 -22.21 -1.11 -2.14 -4.81 -4.77 -4.60 -1.73 -3.24 -23.23 -23.06 -22.66
None -7.21 3.50 2.90 8.64 -2.05 3.95 -0.39 0.61 -1.08 0.76 -5.85 2.97 1.91 7.20 -1.83
Nuclear Periphery -5.10 -24.94 -15.27 -3.01 8.17 -1.89 -10.41 -6.12 -5.62 1.47 -5.27 -31.05 -18.75 -10.95 8.14
Nuclear Periphery Foci -3.98 -13.46 -11.92 -9.70 -10.01 -1.76 -2.67 -3.15 -3.12 -1.05 -4.35 -6.99 -12.32 -11.51 -9.10
Nucleolus -6.19 3.81 -5.32 1.15 -6.17 -3.69 -0.66 -1.57 -0.44 -1.05 -6.97 3.46 -5.64 -2.20 -6.18
Nucleus 6.60 -20.85 28.18 17.41 47.23 16.13 3.54 13.54 6.09 6.08 17.07 -24.05 33.71 17.49 45.79
Peroxisomes -2.72 3.29 -9.23 -8.43 -10.39 -5.82 2.67 -2.47 -1.73 -2.70 -6.66 4.77 -9.33 -6.70 -10.72
Vacuole -11.19 -21.54 -28.48 -22.09 -12.67 -15.88 -15.00 -9.17 -8.01 0.98 -20.16 -23.00 -28.75 -22.59 -10.06
Vacuole Periphery -4.90 2.08 -1.48 2.17 -2.56 -7.90 2.63 -1.06 -0.48 -1.18 -9.10 4.24 -1.71 2.43 -2.80
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Homolog of mammalian ELMO (Engulfment and celL MOtility); upstream component for regulation through the small GTPase Rho5p; may form a complex with Dck1p that acts as a GEF for Rho5p; cytoplasmic protein that relocates to mitochondria under oxidative stress; implicated in mitophagy; not an essential protein
Localization
Cell Percentages cytoplasm (46%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Lmo1

Lmo1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Lmo1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available