Standard name
Human Ortholog
Description Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes; YEH1 has a paralog, YEH2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0.12 0.06 0.18 0.16 0.25 0.18 0.09 0.1 0 0 0 0 0.17 0.21 0.3 0.35 0.31 0.39 0.21 0.18 0.27 0.25 0.22 0.15
Golgi 0 0 0.2 0 0.14 0 0 0 0 0 0 0 0 0 0 0.08 0.16 0.07 0.08 0.19 0.1 0.14 0.15 0.16
Mitochondria 0.64 0.77 0.36 0.48 0.41 0.71 0.7 0.62 0.78 0.7 0.82 0.79 0.28 0.16 0.11 0.14 0.2 0.14 0.06 0.14 0.05 0.12 0.08 0.06
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0.07 0.11 0.08 0 0 0 0.08 0.05 0.1 0.09 0.09 0.08 0 0 0 0.11 0.05 0.05 0 0 0 0 0 0
Nucleolus 0.21 0.13 0.12 0.14 0.06 0.09 0.13 0.19 0.22 0.22 0.25 0.23 0.24 0.21 0.33 0.3 0.18 0.28 0 0 0 0 0 0
Peroxisomes 0.41 0.21 0.25 0.45 0.19 0.15 0.11 0.09 0.05 0 0 0 0.49 0.42 0.43 0.16 0.16 0.28 0.54 0.35 0.49 0.35 0.4 0.49
SpindlePole 0.09 0.05 0.18 0.18 0.18 0.05 0.05 0.07 0 0 0 0 0.21 0.24 0.27 0.16 0.2 0.24 0.06 0 0 0 0 0.06
Vac/Vac Membrane 0 0 0.05 0 0 0 0 0.05 0 0.06 0 0 0 0 0 0.09 0.12 0.08 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 4 5 9 9 15 3 5 8 2 1 0 1 4 2 0 3 0 1 8 16 9 5 9 12
Bud 1 2 3 7 3 6 6 6 3 1 1 2 0 1 0 1 0 0 0 1 0 0 1 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0
Bud Site 0 2 1 0 0 1 2 0 0 0 0 3 0 0 2 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Cytoplasm 0 4 2 4 12 10 13 13 5 6 1 3 4 8 11 10 12 6 0 0 0 0 4 0
Endoplasmic Reticulum 1 0 1 0 0 0 0 2 1 1 2 0 0 1 0 5 6 1 0 0 0 1 0 0
Endosome 47 16 42 43 63 69 43 42 15 13 4 12 42 54 105 92 76 107 87 50 86 38 54 46
Golgi 1 3 45 4 34 4 6 7 2 4 0 1 4 4 3 22 40 19 32 55 33 21 35 47
Mitochondria 246 198 82 130 101 271 324 268 284 230 261 270 72 43 39 36 50 37 25 40 16 17 19 18
Nucleus 1 1 0 2 3 2 7 7 2 3 4 5 0 0 4 3 2 1 0 0 0 0 0 0
Nuclear Periphery 26 29 19 8 7 14 38 20 35 30 29 28 8 9 13 30 13 15 2 4 1 1 0 4
Nucleolus 82 33 27 39 14 34 62 80 80 73 80 77 61 56 115 78 43 76 3 3 2 0 2 2
Peroxisomes 157 54 58 124 46 58 50 39 19 11 6 10 123 110 150 42 39 77 223 100 157 54 97 148
SpindlePole 34 12 41 49 44 19 21 30 11 13 7 6 53 62 92 43 50 66 26 10 9 6 5 17
Vac/Vac Membrane 0 4 12 0 3 12 11 22 10 18 8 15 3 2 8 23 29 21 0 2 1 1 6 1
Unique Cell Count 387 258 229 273 248 380 461 431 366 327 319 341 253 261 346 261 245 274 414 287 321 155 245 305
Labelled Cell Count 600 363 342 419 345 503 589 545 469 404 403 433 374 353 542 389 361 427 414 287 321 155 245 305


Lipid Particles

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 9.5 11.8 11.3 10.0 9.8 8.8 9.1 10.5 9.8 10.7 10.0 10.6 12.0 11.9 10.5 11.3 13.3 11.2 10.2 10.9 11.3
Std Deviation (1e-4) 2.2 3.0 2.0 2.1 1.9 2.0 2.0 2.5 2.7 2.8 2.8 2.7 2.5 2.6 2.1 2.9 11.6 3.5 2.3 2.3 2.7
Intensity Change (Log2) – – – -0.17 -0.19 -0.36 -0.3 -0.1 -0.2 -0.07 -0.17 -0.09 0.09 0.08 -0.1 0.01 0.24 -0.0 -0.14 -0.05 0.0

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70005101520WT3HU80HU120HU16005101520WT3rpd3Δ_1rpd3Δ_2rpd3Δ_305101520WT1AF100AF140AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.4 1.1 0 0 -1.6 0 0 0 0 -1.6 -2.4 0 -2.0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 2.6 0 0 1.8 0 0 0 0 0 0 1.8 2.1 2.6 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome -0.8 1.9 -0.1 -3.4 -3.2 -5.7 -5.6 -7.1 -5.9 -0.5 0.7 3.2 4.2 3.2 5.1
Golgi -6.8 -1.7 -8.2 -8.7 -8.2 -8.4 -7.5 -8.3 -8.3 -6.6 -6.7 -8.0 -3.6 -0.9 -4.3
Mitochondria 2.7 1.1 8.6 8.7 6.5 10.2 8.1 11.0 10.4 -1.7 -4.9 -7.1 -5.7 -3.7 -5.9
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery -2.7 -2.6 -2.4 0 -1.9 0.5 0.4 0.3 0 -2.4 -2.3 -2.3 1.2 -1.3 -1.3
Nucleolus 0.8 -2.4 -1.1 0.6 2.2 3.1 3.2 3.9 3.3 3.5 2.8 5.8 4.9 1.8 4.4
Peroxisomes 4.7 -1.8 -3.1 -4.9 -5.6 -7.1 -7.7 -8.4 -8.1 5.3 3.9 4.4 -2.5 -2.5 0.7
SpindlePole 0 0 -5.2 -5.8 -4.3 -6.3 -5.5 -6.4 -6.9 0.8 1.6 2.4 -0.4 0.7 1.7
Vacuole -3.8 -2.5 -1.3 -2.0 -0.1 -1.6 0.1 -1.7 -0.5 -2.6 -3.0 -1.9 1.5 2.6 1.1

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.464 6.3976 5.8851 4.9949 4.698 5.7141 2.931 5.1286 4.946 4.2507 3.3249 4.5668 5.5625 8.638 7.6296 7.2868 6.6097 7.4444
Actin 0.0082 0.0009 0.0038 0.0197 0.0049 0.0005 0.0063 0.001 0.007 0.0109 0.0239 0.0048 0.0032 0.0004 0.0028 0.004 0.0014 0.0008
Bud 0.0002 0.0001 0.0001 0.0002 0.0009 0 0.0001 0.0003 0.0002 0.0004 0.0003 0.0001 0.0001 0 0.0001 0 0.0001 0
Bud Neck 0.0009 0.0005 0.0003 0.0019 0.0008 0.0003 0.0003 0.0002 0.0003 0.0002 0.0005 0.0003 0.0002 0.0003 0.0002 0.0001 0.0001 0.0001
Bud Periphery 0.0003 0.0004 0.0002 0.0002 0.0034 0.0001 0.0002 0.0004 0.0003 0.0004 0.0006 0.0001 0.0001 0 0.0002 0 0.0001 0.0001
Bud Site 0.0032 0.0009 0.0005 0.0007 0.0041 0.0001 0.0014 0.0022 0.0014 0.0008 0.0013 0.0003 0.0006 0.0001 0.0009 0.0001 0.0002 0.0001
Cell Periphery 0.0003 0.0004 0.0001 0.0001 0.0005 0.0002 0.0001 0.0004 0.0002 0.0001 0.0002 0.0001 0.0001 0.0001 0.0002 0 0.0001 0.0001
Cytoplasm 0.0008 0.0003 0.0005 0.0003 0.0009 0.0001 0.001 0.0001 0.0012 0.0005 0.001 0.0036 0.0004 0.0001 0.0001 0.0001 0.0001 0.0003
Cytoplasmic Foci 0.0603 0.1007 0.0688 0.0606 0.0562 0.0489 0.0595 0.0674 0.0549 0.0802 0.0461 0.0383 0.0733 0.063 0.067 0.0905 0.0652 0.042
Eisosomes 0.0001 0 0 0.0001 0.0003 0 0.0001 0 0.0002 0.0001 0.0003 0.0001 0 0 0.0002 0 0 0
Endoplasmic Reticulum 0.0013 0.0002 0.001 0.0005 0.0013 0.0003 0.0007 0.0001 0.0015 0.0002 0.0032 0.0005 0.0005 0.0001 0.0002 0.0001 0.0001 0.0013
Endosome 0.0549 0.0564 0.0354 0.0333 0.0805 0.024 0.0379 0.0254 0.0265 0.0176 0.0413 0.014 0.0207 0.0193 0.0129 0.0165 0.0273 0.0083
Golgi 0.0544 0.0609 0.0631 0.053 0.0659 0.0382 0.0331 0.0264 0.0368 0.0497 0.0585 0.0299 0.0485 0.0446 0.0397 0.0795 0.0517 0.0252
Lipid Particles 0.677 0.648 0.7214 0.6906 0.5837 0.7646 0.7506 0.7833 0.7608 0.7478 0.5921 0.8313 0.726 0.7892 0.7276 0.6527 0.6863 0.8436
Mitochondria 0.0112 0.0108 0.0228 0.0287 0.0552 0.0183 0.0104 0.0073 0.0236 0.0069 0.0441 0.019 0.0134 0.0069 0.0154 0.0063 0.0422 0.0073
None 0.0006 0.0001 0.0005 0.0002 0.0006 0.0001 0.0015 0.0001 0.0043 0.0003 0.0007 0.0003 0.0002 0 0.0001 0.0001 0.0001 0.0001
Nuclear Periphery 0.0044 0.0036 0.0039 0.002 0.0039 0.0073 0.01 0.0019 0.0032 0.0005 0.0036 0.0015 0.0007 0.0003 0.0037 0.0001 0.0007 0.0017
Nucleolus 0.0139 0.0278 0.002 0.0006 0.0184 0.0147 0.0103 0.0166 0.0215 0.0015 0.0032 0.0066 0.003 0.0045 0.0069 0.0001 0.0018 0.0022
Nucleus 0.0011 0.0046 0.0042 0.0002 0.0083 0.0016 0.001 0.0009 0.0012 0.0001 0.0006 0.0007 0.0002 0.0002 0.0003 0 0.0003 0.0003
Peroxisomes 0.0833 0.0603 0.0604 0.1022 0.0993 0.0597 0.05 0.0332 0.0443 0.0769 0.17 0.039 0.1005 0.0636 0.1169 0.1483 0.1047 0.061
Punctate Nuclear 0.0127 0.0038 0.0048 0.0026 0.0022 0.0027 0.0156 0.009 0.0046 0.0033 0.003 0.004 0.0046 0.0006 0.0017 0.0007 0.0104 0.001
Vacuole 0.0065 0.0113 0.0027 0.0008 0.0044 0.0098 0.002 0.0149 0.0025 0.0005 0.0023 0.0014 0.0013 0.0021 0.001 0.0002 0.0027 0.0014
Vacuole Periphery 0.0045 0.0079 0.0036 0.0015 0.0044 0.0084 0.008 0.0086 0.0035 0.0011 0.0032 0.0039 0.0024 0.0044 0.0017 0.0004 0.0043 0.0032

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 36.2035 33.2229 22.9526 16.2052 26.5851 28.1782 20.9948 18.7631 18.1601 24.4938
Translational Efficiency 0.7171 0.6037 0.5115 0.6603 0.5894 0.7299 0.643 0.3852 0.4701 0.5664

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
415 521 1274 701 1713 1898 156 124 2128 2419 1430 825

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 980.73 964.72 1036.80 1163.51 1038.54 1014.15 1280.52 1209.00 1027.27 1003.50 1063.39 1170.35
Standard Deviation 146.69 222.57 188.15 227.01 179.74 184.55 196.35 204.63 175.29 194.44 203.76 224.38
Intensity Change Log 2 — -0.023746 0.080210 0.246556 — -0.034286 0.302173 0.219257 — -0.029157 0.198623 0.232580

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.023568 0.023179 0.099970 0.045252 0.015230 0.003659 0.018823 0.018025 0.016856 0.007863 0.091117 0.041160
Bud Neck 0.000698 0.001405 0.010713 0.003915 0.000242 0.001255 0.008954 0.004858 0.000331 0.001287 0.010521 0.004056
Bud Site 0.000306 0.000826 0.031088 0.003913 0.000077 0.000478 0.002229 0.006583 0.000121 0.000553 0.027940 0.004315
Cell Periphery 0.000053 0.000100 0.001041 0.000174 0.000024 0.000060 0.000123 0.000127 0.000029 0.000069 0.000941 0.000167
Cytoplasm 0.000642 0.000936 0.022347 0.001654 0.000534 0.000678 0.000837 0.000807 0.000555 0.000733 0.020001 0.001527
Cytoplasmic Foci 0.060433 0.074737 0.180736 0.183706 0.062112 0.096001 0.203183 0.216567 0.061785 0.091421 0.183185 0.188645
Eisosomes 0.002419 0.002327 0.000394 0.000550 0.002272 0.000498 0.000313 0.000178 0.002301 0.000892 0.000385 0.000494
Endoplasmic Reticulum 0.000740 0.001202 0.043764 0.001128 0.000362 0.000465 0.001808 0.001360 0.000436 0.000624 0.039187 0.001163
Endosome 0.003958 0.008829 0.095004 0.068307 0.002552 0.021201 0.040810 0.125778 0.002826 0.018536 0.089092 0.076945
Golgi 0.218679 0.156811 0.024329 0.272309 0.230727 0.126002 0.100708 0.258404 0.228377 0.132638 0.032661 0.270219
Lipid Particles 0.627288 0.635620 0.334703 0.281556 0.649335 0.655050 0.441733 0.214065 0.645036 0.650865 0.346379 0.271412
Mitochondria 0.015558 0.017962 0.000616 0.049877 0.013091 0.033831 0.008355 0.025463 0.013572 0.030413 0.001461 0.046207
Mitotic Spindle 0.002693 0.004007 0.035020 0.025291 0.000956 0.006928 0.102586 0.043820 0.001295 0.006299 0.042391 0.028076
None 0.000541 0.001093 0.000174 0.000318 0.000501 0.000260 0.000136 0.000184 0.000509 0.000439 0.000169 0.000298
Nuclear Periphery 0.000287 0.000584 0.000603 0.002908 0.000376 0.001347 0.008541 0.006863 0.000359 0.001182 0.001469 0.003502
Nuclear Periphery Foci 0.001405 0.007091 0.035698 0.005502 0.000865 0.008336 0.018732 0.006080 0.000970 0.008068 0.033847 0.005589
Nucleolus 0.001170 0.005811 0.000314 0.000429 0.000557 0.001520 0.002152 0.000326 0.000676 0.002444 0.000514 0.000413
Nucleus 0.000302 0.001437 0.001974 0.000176 0.000081 0.000917 0.001294 0.000086 0.000124 0.001029 0.001900 0.000162
Peroxisomes 0.037778 0.052362 0.066595 0.030617 0.019039 0.037900 0.028857 0.024250 0.022694 0.041015 0.062478 0.029660
Vacuole 0.000903 0.002544 0.014508 0.015784 0.000531 0.002675 0.007310 0.027346 0.000603 0.002647 0.013722 0.017522
Vacuole Periphery 0.000580 0.001138 0.000409 0.006634 0.000539 0.000940 0.002517 0.018831 0.000547 0.000982 0.000639 0.008467

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.08 -11.23 -3.72 -3.82 7.43 7.48 -0.56 -0.49 -2.62 0.09 5.51 -13.86 -5.79 -8.24 7.60
Bud Neck -1.48 -10.48 -7.04 -4.14 6.57 -7.24 -4.25 -5.00 -3.85 1.85 -6.41 -11.75 -9.59 -6.73 6.81
Bud Site -1.30 -13.86 -3.65 -2.95 11.17 -5.02 -5.21 -2.98 -2.79 -1.95 -4.09 -13.98 -4.67 -4.16 10.79
Cell Periphery -2.29 -4.22 -2.67 -1.49 3.63 -6.35 -7.61 -7.65 -4.57 -0.21 -6.21 -4.37 -3.61 -2.54 3.65
Cytoplasm -2.43 -8.32 -3.00 -2.17 7.80 -3.34 -1.91 -3.37 -1.39 0.24 -4.19 -8.35 -3.35 -2.79 7.80
Cytoplasmic Foci -2.61 -18.14 -17.25 -14.49 -0.16 -11.58 -9.97 -8.78 -6.82 -0.64 -11.44 -22.30 -20.86 -15.61 -0.53
Eisosomes 0.25 6.71 6.20 8.10 -2.11 8.55 9.22 10.11 7.21 2.08 7.69 10.57 10.04 5.71 -1.68
Endoplasmic Reticulum -1.82 -9.57 -1.94 0.36 9.48 -1.74 -5.65 -3.00 -2.67 1.08 -2.66 -9.65 -6.55 -4.67 9.46
Endosome -4.28 -26.24 -16.43 -14.84 5.04 -13.27 -7.11 -9.70 -8.19 -6.18 -13.85 -27.40 -19.11 -14.50 2.31
Golgi 5.05 19.35 -3.92 -9.93 -27.06 16.81 11.65 -1.12 -5.55 -6.18 17.22 40.37 -4.28 -15.12 -27.47
Lipid Particles -0.41 18.22 20.82 22.59 3.69 -0.57 8.35 18.09 18.27 6.67 -0.64 29.28 35.01 35.49 5.70
Mitochondria -0.50 4.78 -5.63 -5.07 -9.43 -7.38 1.70 -1.77 1.15 -2.35 -6.94 9.24 -6.88 -3.14 -9.78
Mitotic Spindle -0.71 -9.23 -5.65 -5.46 1.92 -5.23 -5.65 -3.10 -2.65 2.56 -5.13 -11.79 -7.06 -5.58 2.71
None -2.24 4.74 3.71 3.11 -2.14 6.76 9.70 7.87 2.13 -1.19 0.91 5.97 5.78 2.33 -2.14
Nuclear Periphery -2.66 -3.50 -6.62 -5.72 -5.67 -7.20 -3.07 -3.14 -2.67 0.50 -7.58 -3.69 -6.87 -4.95 -3.67
Nuclear Periphery Foci -2.80 -11.42 -3.15 0.76 9.64 -7.00 -2.84 -3.27 1.26 2.08 -7.51 -12.08 -4.52 1.84 9.87
Nucleolus -2.46 1.27 1.19 3.01 -0.31 -2.35 -1.68 0.72 3.34 1.94 -3.41 0.32 0.96 4.31 0.87
Nucleus -2.15 -4.01 0.58 2.36 4.29 -1.80 -1.80 -0.10 1.80 1.79 -2.38 -4.75 -1.05 2.17 4.56
Peroxisomes -1.82 -4.25 1.13 3.11 6.81 -6.51 -1.60 -0.82 2.06 0.53 -6.44 -9.79 -2.12 3.03 6.87
Vacuole -1.92 -10.96 -6.71 -5.68 -0.33 -5.90 -5.16 -4.22 -3.87 -3.08 -6.04 -11.98 -8.04 -7.00 -1.41
Vacuole Periphery -1.20 1.02 -7.87 -6.33 -8.24 -3.38 -3.24 -2.65 -2.59 -2.36 -3.19 -0.84 -6.45 -6.08 -6.38
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes; YEH1 has a paralog, YEH2, that arose from the whole genome duplication
Localization
Cell Percentages —
Cell Cycle Regulation No
Subcompartmental Group N/A

Yeh1

Yeh1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Yeh1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available