| Standard name | |
|---|---|
| Human Ortholog | |
| Description | Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 |
Micrographs
Sub-cellular Localization
Yeast GFP Assignment
Protein Abundance
Localization Change
External localization resources
| ensLOC | DeepLoc | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
| Cortical Patches | 4 | 2 | 1 | 1 | 0 | 0 | – | 0 | 1 | 3 | 0 | 0 | 1 | 2 | 0 | 9 | 5 | 7 | 8 | 6 | 3 | 1 | 2 | 5 |
| Bud | 7 | 0 | 3 | 6 | 4 | 8 | – | 13 | 18 | 7 | 5 | 13 | 0 | 1 | 0 | 0 | 1 | 1 | 5 | 2 | 1 | 1 | 2 | 3 |
| Bud Neck | 0 | 0 | 1 | 0 | 1 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 11 | 1 | 1 | 0 | 0 | 2 |
| Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 0 | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
| Cell Periphery | 0 | 2 | 1 | 8 | 5 | 12 | – | 5 | 6 | 7 | 9 | 4 | 1 | 6 | 17 | 6 | 16 | 19 | 6 | 1 | 2 | 0 | 0 | 2 |
| Cytoplasm | 316 | 39 | 122 | 128 | 144 | 165 | – | 231 | 150 | 137 | 95 | 136 | 84 | 125 | 184 | 61 | 79 | 83 | 146 | 16 | 58 | 26 | 38 | 52 |
| Endoplasmic Reticulum | 111 | 10 | 2 | 23 | 11 | 32 | – | 23 | 18 | 18 | 20 | 38 | 60 | 51 | 41 | 5 | 8 | 4 | 311 | 56 | 44 | 61 | 119 | 150 |
| Endosome | 7 | 0 | 0 | 2 | 18 | 6 | – | 6 | 3 | 7 | 0 | 6 | 2 | 1 | 4 | 1 | 1 | 1 | 6 | 2 | 1 | 1 | 2 | 7 |
| Golgi | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 3 |
| Mitochondria | 25 | 12 | 29 | 93 | 58 | 176 | – | 329 | 236 | 232 | 155 | 213 | 1 | 0 | 0 | 4 | 7 | 6 | 84 | 21 | 35 | 21 | 24 | 28 |
| Nucleus | 1 | 0 | 0 | 1 | 2 | 4 | – | 5 | 2 | 5 | 0 | 3 | 1 | 0 | 0 | 1 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 1 |
| Nuclear Periphery | 0 | 1 | 0 | 0 | 0 | 1 | – | 2 | 6 | 1 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 |
| Nucleolus | 0 | 0 | 0 | 0 | 1 | 0 | – | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Peroxisomes | 0 | 0 | 0 | 0 | 1 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| SpindlePole | 0 | 0 | 2 | 1 | 2 | 0 | – | 2 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 0 | 1 | 0 | 0 | 1 |
| Vac/Vac Membrane | 49 | 11 | 2 | 5 | 32 | 47 | – | 72 | 44 | 42 | 16 | 30 | 7 | 4 | 9 | 9 | 8 | 11 | 39 | 9 | 11 | 6 | 12 | 33 |
| Unique Cell Count | 482 | 69 | 146 | 214 | 240 | 361 | 574 | 381 | 381 | 252 | 363 | 147 | 172 | 231 | 85 | 113 | 117 | 634 | 121 | 168 | 124 | 209 | 298 | |
| Labelled Cell Count | 520 | 77 | 163 | 268 | 279 | 451 | 689 | 484 | 464 | 304 | 450 | 157 | 190 | 255 | 97 | 128 | 135 | 634 | 121 | 168 | 124 | 209 | 298 | |
Yeast GFP Assignment
Protein Abundance
| Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean Cell GFP Intensity (1e-4) | 4.9 | 5.4 | 3.7 | 4.2 | 5.3 | 4.5 | – | 4.3 | 4.1 | 4.1 | 4.1 | 4.1 | 5.9 | 6.3 | 5.9 | 7.6 | 7.6 | 7.8 | 5.4 | 6.4 | 6.5 |
| Std Deviation (1e-4) | 0.8 | 1.3 | 0.9 | 1.4 | 1.9 | 1.5 | – | 0.8 | 1.3 | 1.0 | 1.3 | 0.9 | 0.9 | 1.2 | 0.8 | 1.6 | 1.4 | 1.8 | 0.9 | 1.5 | 1.4 |
| Intensity Change (Log2) | – | – | – | 0.18 | 0.52 | 0.27 | – | 0.23 | 0.14 | 0.15 | 0.13 | 0.15 | 0.67 | 0.77 | 0.67 | 1.03 | 1.03 | 1.07 | 0.55 | 0.78 | 0.8 |
Localization Change
| Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cortical Patches | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bud | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bud Neck | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bud Site | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cell Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.0 | 0 | 4.3 | 4.7 |
| Cytoplasm | -4.8 | -4.9 | -7.8 | – | -9.3 | -9.1 | -9.8 | -8.9 | -9.4 | -4.9 | -2.3 | -0.9 | -2.1 | -2.6 | -2.5 |
| Endoplasmic Reticulum | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 8.3 | 6.7 | 4.9 | 0 | 0 | 0 |
| Endosome | 0 | 3.4 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Golgi | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Mitochondria | 0 | 1.0 | 0 | – | 0 | 0 | 0 | 0 | 0 | -5.4 | -6.1 | -7.1 | -3.2 | -3.2 | -3.5 |
| Nucleus | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nuclear Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nucleolus | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Peroxisomes | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| SpindlePole | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Vacuole | 0 | 4.0 | 4.0 | – | 4.0 | 3.7 | 3.6 | 2.3 | 2.9 | 0 | 0 | 0 | 0 | 0 | 3.0 |
External localization resources
Images
Protein Concentration and Protein Localization Data
| R1 | R2 | R3 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Concentration | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cytoplasmic Foci | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Eisosomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Lipid Particles | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| None | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Punctate Nuclear | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vacuole Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Sequencing Data
| R1 | R2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Gene Expression | 91.1068 | 42.2302 | 96.2482 | 70.6347 | 34.9997 | 84.3114 | 90.7351 | 78.2226 | 54.263 | 85.0337 |
| Translational Efficiency | 1.0629 | 2.3213 | 0.8415 | 0.8366 | 2.368 | 1.6489 | 1.3161 | 1.0527 | 1.8153 | 1.59 |
Hit Data
| Dataset | Hit |
|---|---|
| Protein Concentration | – |
| Protein Localization | – |
| Gene Expression | ✘ |
| Translational Efficiency | ✘ |
Micrographs
Cell Count
| R1 | R2 | R1 & R2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 |
| 1939 | 1350 | 276 | 134 | 1550 | 936 | 2101 | 1652 | 3489 | 2286 | 2377 | 1786 |
Protein Abundance
| R1 | R2 | R1 & R2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | |
| Mean | 705.16 | 799.11 | 985.51 | 956.45 | 766.11 | 805.18 | 906.34 | 994.47 | 732.24 | 801.60 | 915.53 | 991.62 |
| Standard Deviation | 80.75 | 105.12 | 110.62 | 112.15 | 96.00 | 103.92 | 138.19 | 168.38 | 92.93 | 104.67 | 137.64 | 165.13 |
| Intensity Change Log 2 | — | 0.180443 | 0.482920 | 0.439739 | — | 0.071760 | 0.242501 | 0.376376 | — | 0.124873 | 0.362736 | 0.407093 |
Localization Score (DeepLoc)
| R1 | R2 | R1 & R2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | |
| Actin | 0.000200 | 0.000701 | 0.000574 | 0.000490 | 0.000244 | 0.000275 | 0.003747 | 0.003144 | 0.000220 | 0.000526 | 0.003379 | 0.002945 |
| Bud Neck | 0.007691 | 0.017857 | 0.004993 | 0.001992 | 0.004709 | 0.013848 | 0.002693 | 0.005996 | 0.006367 | 0.016215 | 0.002960 | 0.005696 |
| Bud Site | 0.001387 | 0.011922 | 0.006610 | 0.002093 | 0.002775 | 0.004425 | 0.009293 | 0.013025 | 0.002003 | 0.008852 | 0.008981 | 0.012205 |
| Cell Periphery | 0.000559 | 0.000785 | 0.000649 | 0.000684 | 0.000710 | 0.000617 | 0.001083 | 0.001527 | 0.000626 | 0.000716 | 0.001032 | 0.001464 |
| Cytoplasm | 0.337763* | 0.250176* | 0.193142* | 0.200963* | 0.371455* | 0.312070* | 0.165283* | 0.190775* | 0.352730* | 0.275518* | 0.168518* | 0.191540* |
| Cytoplasmic Foci | 0.178865 | 0.182918* | 0.056608 | 0.084072 | 0.149565 | 0.172528 | 0.025743 | 0.039320 | 0.165848 | 0.178664 | 0.029327 | 0.042677 |
| Eisosomes | 0.000900 | 0.000654 | 0.000191 | 0.000253 | 0.000949 | 0.000710 | 0.000536 | 0.000615 | 0.000922 | 0.000677 | 0.000496 | 0.000588 |
| Endoplasmic Reticulum | 0.105141* | 0.180232* | 0.264433* | 0.181418* | 0.144751* | 0.099283 | 0.655352* | 0.470906* | 0.122738* | 0.147087* | 0.609961* | 0.449186* |
| Endosome | 0.018118 | 0.036399 | 0.019751 | 0.019983 | 0.013791 | 0.026702 | 0.010151 | 0.018767 | 0.016196 | 0.032428 | 0.011265 | 0.018858 |
| Golgi | 0.016851 | 0.023939 | 0.000613 | 0.000721 | 0.012264 | 0.008548 | 0.008344 | 0.007881 | 0.014813 | 0.017637 | 0.007446 | 0.007344 |
| Lipid Particles | 0.146914* | 0.111686* | 0.035334 | 0.046408 | 0.132850* | 0.136853* | 0.029358 | 0.045009 | 0.140666* | 0.121991* | 0.030052 | 0.045114 |
| Mitochondria | 0.009724 | 0.022004 | 0.000540 | 0.000338 | 0.005929 | 0.008434 | 0.003514 | 0.003043 | 0.008038 | 0.016448 | 0.003168 | 0.002840 |
| Mitotic Spindle | 0.000175 | 0.001145 | 0.000527 | 0.000441 | 0.000895 | 0.000644 | 0.001286 | 0.005757 | 0.000495 | 0.000940 | 0.001198 | 0.005358 |
| None | 0.005225 | 0.004210 | 0.000457 | 0.000849 | 0.002341 | 0.002353 | 0.003411 | 0.001125 | 0.003944 | 0.003449 | 0.003068 | 0.001105 |
| Nuclear Periphery | 0.005903 | 0.005337 | 0.045296 | 0.035809 | 0.007973 | 0.017421 | 0.005080 | 0.011431 | 0.006822 | 0.010285 | 0.009750 | 0.013260 |
| Nuclear Periphery Foci | 0.003990 | 0.006583 | 0.134365 | 0.097554 | 0.006514 | 0.005323 | 0.021478 | 0.040260 | 0.005111 | 0.006067 | 0.034585 | 0.044559 |
| Nucleolus | 0.001222 | 0.002198 | 0.001219 | 0.001626 | 0.000533 | 0.001903 | 0.000353 | 0.000362 | 0.000916 | 0.002077 | 0.000454 | 0.000457 |
| Nucleus | 0.111093 | 0.054981 | 0.132985* | 0.170404* | 0.094058 | 0.099687 | 0.031915 | 0.070471 | 0.103525 | 0.073286 | 0.043650 | 0.077969 |
| Peroxisomes | 0.004851 | 0.008417 | 0.001335 | 0.001502 | 0.003811 | 0.006877 | 0.001876 | 0.001993 | 0.004389 | 0.007786 | 0.001813 | 0.001956 |
| Vacuole | 0.041383 | 0.070873 | 0.099953 | 0.151934 | 0.042563 | 0.078030 | 0.018759 | 0.066968 | 0.041907 | 0.073804 | 0.028187 | 0.073342 |
| Vacuole Periphery | 0.002047 | 0.006982 | 0.000428 | 0.000466 | 0.001319 | 0.003469 | 0.000745 | 0.001625 | 0.001724 | 0.005544 | 0.000708 | 0.001538 |
Localization Changes (T-score)
| R1 | R2 | R1 & R2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | |
| Actin | -5.05 | -4.65 | -2.09 | 0.95 | 0.48 | -0.22 | -5.77 | -4.71 | -4.61 | 0.71 | -3.79 | -5.91 | -4.81 | -4.25 | 0.56 |
| Bud Neck | -6.29 | 1.67 | 6.84 | 9.96 | 2.07 | -4.58 | 2.90 | -1.83 | 3.77 | -4.66 | -7.85 | 5.79 | 0.61 | 7.81 | -4.12 |
| Bud Site | -8.82 | -2.42 | -1.94 | 7.20 | 1.85 | -1.22 | -4.99 | -5.98 | -4.83 | -2.10 | -7.60 | -6.94 | -7.06 | -2.23 | -1.99 |
| Cell Periphery | -1.98 | -1.05 | -1.78 | 0.66 | -0.37 | 0.95 | -3.45 | -5.06 | -5.59 | -2.56 | -1.13 | -4.80 | -5.95 | -4.94 | -2.72 |
| Cytoplasm | 11.45 | 10.69 | 7.49 | 2.65 | -0.23 | 6.17 | 27.55 | 22.03 | 12.59 | -3.86 | 12.78 | 32.20 | 24.55 | 11.50 | -3.64 |
| Cytoplasmic Foci | -0.75 | 19.63 | 10.04 | 10.05 | -2.95 | -3.51 | 29.89 | 25.32 | 23.03 | -6.00 | -2.95 | 44.20 | 36.76 | 33.34 | -6.00 |
| Eisosomes | 2.33 | 6.79 | 6.28 | 9.04 | -1.81 | 1.31 | 2.96 | 2.20 | 0.54 | -0.64 | 2.51 | 4.24 | 2.86 | 0.80 | -0.82 |
| Endoplasmic Reticulum | -8.97 | -8.53 | -3.03 | 0.33 | 2.95 | 5.30 | -53.91* | -27.72 | -31.07 | 16.13 | -3.89 | -59.75 | -31.72 | -27.48 | 14.51 |
| Endosome | -8.82 | -0.87 | -1.37 | 6.34 | -0.37 | -6.34 | 4.11 | -3.90 | 3.41 | -6.68 | -10.98 | 6.08 | -2.39 | 7.61 | -6.35 |
| Golgi | -4.57 | 21.42 | 21.02 | 17.15 | -0.68 | 3.12 | 3.90 | 3.39 | 0.61 | 0.54 | -2.68 | 9.53 | 6.63 | 7.74 | 0.26 |
| Lipid Particles | 6.37 | 22.48 | 18.68 | 11.97 | -2.25 | -0.57 | 23.99 | 19.19 | 15.97 | -6.18 | 4.42 | 35.44 | 27.83 | 20.29 | -6.42 |
| Mitochondria | -6.71 | 13.38 | 13.76 | 12.78 | 2.22 | -1.60 | 2.10 | 2.38 | 4.16 | 0.69 | -6.63 | 6.75 | 6.20 | 10.82 | 0.54 |
| Mitotic Spindle | -3.38 | -2.22 | -0.99 | 0.33 | -0.46 | 0.51 | -0.59 | -3.98 | -4.32 | -3.55 | -1.71 | -1.41 | -4.49 | -4.08 | -3.62 |
| None | 0.97 | 6.81 | 6.21 | 4.13 | -1.19 | -0.03 | -1.50 | 2.36 | 2.66 | 4.34 | 0.73 | 1.45 | 6.11 | 4.47 | 4.21 |
| Nuclear Periphery | 0.66 | -7.51 | -4.11 | -4.19 | 1.15 | -5.06 | 3.66 | -2.81 | 2.97 | -5.51 | -3.75 | -3.16 | -5.34 | -2.04 | -2.61 |
| Nuclear Periphery Foci | -4.35 | -13.25 | -8.32 | -8.08 | 2.36 | 1.59 | -11.68 | -14.76 | -15.15 | -7.55 | -2.08 | -17.02 | -17.31 | -16.75 | -3.84 |
| Nucleolus | -2.31 | 0.02 | -0.94 | 1.06 | -0.51 | -4.43 | 1.35 | 0.63 | 4.39 | -0.47 | -4.10 | 3.09 | 2.75 | 5.08 | -0.41 |
| Nucleus | 15.62 | -2.56 | -3.39 | -6.60 | -1.60 | -1.27 | 19.28 | 5.23 | 5.51 | -11.06 | 10.30 | 20.72 | 6.25 | -1.56 | -9.05 |
| Peroxisomes | -6.48 | 6.92 | 8.52 | 12.59 | -0.51 | -3.84 | 6.67 | 5.61 | 6.15 | -0.55 | -7.40 | 10.52 | 8.75 | 12.49 | -0.72 |
| Vacuole | -8.58 | -8.24 | -9.06 | -6.68 | -3.50 | -8.26 | 10.89 | -8.10 | 1.05 | -15.53 | -11.88 | 6.50 | -10.93 | -1.35 | -14.12 |
| Vacuole Periphery | -8.47 | 12.64 | 12.56 | 11.40 | -0.67 | -6.61 | 3.95 | -0.56 | 3.36 | -1.77 | -10.31 | 8.73 | 0.50 | 7.17 | -1.81 |
| Standard name | |
|---|---|
| Human Ortholog | |
| Description | Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 |
| Localization | |
| Cell Percentages | ER (70%) |
| Cell Cycle Regulation | No |
| Subcompartmental Group | ER-3 |
Emc6
Emc6
Nearest neighbours ( genes)
correlation threshold
0.80
Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)
Endocytosis
| Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
|---|---|---|---|---|
| 37℃ | ||||
| RT |
Cell Cycle Omics
CYCLoPs (Emc6-GFP)
| Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
|---|
| Gene | Images |
|---|
| Gene | Images |
|---|
Images are not yet available
Images are not yet available
