Standard name | |
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Human Ortholog | |
Description | ABC type transmembrane transporter of MRP/CFTR family; found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | – | – | 1 | 0 | 0 | 0 | 0 | 1 |
Bud | 0 | 1 | 0 | 0 | 0 | 4 | 3 | 7 | 7 | 2 | 8 | 10 | 0 | 0 | 1 | 0 | – | – | 2 | 2 | 1 | 0 | 5 | 5 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 1 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 2 | 2 | 1 | 2 | 3 | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 41 | 34 | 32 | 42 | 57 | 110 | 119 | 214 | 159 | 166 | 144 | 167 | 22 | 19 | 17 | 6 | – | – | 5 | 3 | 4 | 3 | 3 | 3 |
Endoplasmic Reticulum | 3 | 2 | 7 | 5 | 1 | 7 | 7 | 7 | 4 | 2 | 5 | 2 | 11 | 6 | 7 | 2 | – | – | 0 | 1 | 5 | 3 | 3 | 1 |
Endosome | 65 | 12 | 43 | 8 | 19 | 5 | 0 | 3 | 3 | 1 | 0 | 0 | 29 | 36 | 39 | 0 | – | – | 29 | 24 | 20 | 55 | 62 | 62 |
Golgi | 1 | 0 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | – | – | 6 | 0 | 3 | 1 | 2 | 3 |
Mitochondria | 11 | 13 | 26 | 60 | 42 | 177 | 226 | 242 | 176 | 230 | 156 | 189 | 0 | 0 | 0 | 2 | – | – | 9 | 4 | 6 | 9 | 10 | 7 |
Nucleus | 52 | 26 | 11 | 2 | 5 | 2 | 4 | 8 | 1 | 4 | 1 | 3 | 39 | 45 | 34 | 0 | – | – | 11 | 8 | 1 | 10 | 10 | 7 |
Nuclear Periphery | 11 | 24 | 21 | 5 | 0 | 3 | 5 | 2 | 3 | 3 | 1 | 3 | 6 | 17 | 4 | 0 | – | – | 22 | 10 | 35 | 23 | 24 | 21 |
Nucleolus | 9 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 5 | 0 | – | – | 2 | 1 | 0 | 3 | 1 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 1 | 0 | 1 | 0 | 0 | 2 | 0 | 1 | 0 | 1 | 1 | 0 | 2 | 2 | 4 | 0 | – | – | 1 | 0 | 0 | 0 | 3 | 1 |
Vac/Vac Membrane | 470 | 362 | 211 | 78 | 93 | 86 | 84 | 81 | 52 | 61 | 43 | 60 | 305 | 349 | 314 | 10 | – | – | 519 | 381 | 227 | 320 | 405 | 403 |
Unique Cell Count | 565 | 409 | 282 | 151 | 169 | 287 | 320 | 427 | 287 | 346 | 265 | 297 | 366 | 412 | 370 | 17 | 620 | 439 | 308 | 436 | 537 | 525 | ||
Labelled Cell Count | 664 | 474 | 354 | 202 | 219 | 397 | 452 | 568 | 407 | 471 | 361 | 437 | 418 | 476 | 430 | 20 | 620 | 439 | 308 | 436 | 537 | 525 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 7.3 | 7.4 | 5.7 | 5.3 | 5.2 | 4.4 | 4.3 | 4.4 | 4.1 | 4.0 | 4.0 | 4.1 | 7.7 | 7.8 | 8.1 | 7.3 | – | – | 7.6 | 8.0 | 8.5 |
Std Deviation (1e-4) | 1.3 | 1.1 | 1.0 | 1.1 | 1.1 | 1.2 | 1.5 | 1.2 | 0.9 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.1 | 1.4 | – | – | 1.4 | 1.6 | 1.8 |
Intensity Change (Log2) | – | – | – | -0.13 | -0.13 | -0.39 | -0.42 | -0.37 | -0.48 | -0.52 | -0.54 | -0.48 | 0.43 | 0.45 | 0.5 | 0.34 | – | – | 0.4 | 0.49 | 0.57 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – |
Cytoplasm | 4.3 | 5.8 | 7.4 | 7.3 | 10.6 | 11.1 | 9.8 | 10.8 | 11.4 | -2.4 | -3.3 | -3.2 | 0 | – | – |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.4 | -1.0 | -0.5 | 0 | – | – |
Endosome | -3.1 | -1.2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2.9 | -2.7 | -1.8 | 0 | – | – |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – |
Mitochondria | 7.6 | 4.5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -5.9 | -6.3 | -6.0 | 0 | – | – |
Nucleus | 0 | -0.5 | -2.6 | -2.1 | -1.6 | -2.9 | -2.2 | -2.8 | -2.3 | 3.2 | 3.3 | 2.6 | 0 | – | – |
Nuclear Periphery | -1.7 | -3.6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -3.7 | -1.9 | -4.2 | 0 | – | – |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – |
Vacuole | -4.9 | -4.3 | -10.7 | -11.9 | -14.8 | -13.6 | -14.4 | -13.7 | -13.2 | 2.7 | 3.2 | 3.2 | -1.5 | – | – |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 2.7807 | 2.9744 | 2.8221 | 2.5562 | 2.2054 | 2.7639 | 4.9632 | 5.2664 | 5.0536 | 5.0952 | 4.1319 | 5.0288 | 5.5688 | 6.5583 | 5.0549 | 5.2796 | 4.4363 | 4.6762 |
Actin | 0.0245 | 0 | 0.0077 | 0.0468 | 0.0157 | 0.0027 | 0.0244 | 0 | 0.0027 | 0 | 0 | 0.0005 | 0.1184 | 0 | 0.018 | 0.0001 | 0 | 0 |
Bud | 0.0008 | 0.0004 | 0.0006 | 0.0008 | 0.0017 | 0.0003 | 0.0006 | 0.0004 | 0.0082 | 0.0003 | 0.0001 | 0.0021 | 0.0025 | 0.0002 | 0.0021 | 0.0005 | 0.0003 | 0.001 |
Bud Neck | 0.0027 | 0.0002 | 0.002 | 0.0024 | 0.0012 | 0.0003 | 0.0037 | 0.0002 | 0.0005 | 0.0002 | 0.0001 | 0.0011 | 0.0012 | 0.0002 | 0.0014 | 0.0006 | 0.0002 | 0.0006 |
Bud Periphery | 0.0009 | 0.0008 | 0.0008 | 0.0022 | 0.0022 | 0.0004 | 0.001 | 0.0008 | 0.0041 | 0.0008 | 0.0002 | 0.0015 | 0.0036 | 0.0003 | 0.0024 | 0.0008 | 0.0004 | 0.0017 |
Bud Site | 0.0029 | 0.0006 | 0.0021 | 0.002 | 0.0194 | 0.0003 | 0.0009 | 0.002 | 0.0033 | 0.0002 | 0.0001 | 0.0009 | 0.003 | 0.0007 | 0.0318 | 0.0014 | 0.0007 | 0.0005 |
Cell Periphery | 0.0006 | 0.0005 | 0.0004 | 0.0003 | 0.0003 | 0.0002 | 0.0006 | 0.0005 | 0.0007 | 0.0002 | 0.0002 | 0.0004 | 0.0012 | 0.0006 | 0.0023 | 0.0006 | 0.0003 | 0.0009 |
Cytoplasm | 0.013 | 0.0171 | 0.0214 | 0.0046 | 0.0031 | 0.0109 | 0.0149 | 0.0092 | 0.028 | 0.0074 | 0.001 | 0.0178 | 0.0108 | 0.0179 | 0.0294 | 0.0043 | 0.0162 | 0.0094 |
Cytoplasmic Foci | 0.0147 | 0.0035 | 0.0092 | 0.0104 | 0.019 | 0.0046 | 0.0151 | 0.0054 | 0.0152 | 0.0054 | 0.0015 | 0.0151 | 0.0188 | 0.005 | 0.0165 | 0.008 | 0.0023 | 0.0064 |
Eisosomes | 0.0003 | 0 | 0 | 0.0007 | 0.0002 | 0 | 0.0005 | 0 | 0 | 0 | 0 | 0 | 0.0008 | 0 | 0.0003 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0064 | 0.0036 | 0.0058 | 0.0032 | 0.0013 | 0.0083 | 0.0057 | 0.0063 | 0.0044 | 0.0017 | 0.0008 | 0.0026 | 0.0307 | 0.0028 | 0.0067 | 0.0013 | 0.0011 | 0.0041 |
Endosome | 0.2178 | 0.1084 | 0.2208 | 0.1231 | 0.1603 | 0.167 | 0.2373 | 0.1565 | 0.2167 | 0.262 | 0.1455 | 0.2265 | 0.2528 | 0.1431 | 0.195 | 0.2199 | 0.1093 | 0.1252 |
Golgi | 0.0101 | 0.0013 | 0.0061 | 0.0083 | 0.0079 | 0.0036 | 0.0148 | 0.0016 | 0.0044 | 0.0028 | 0.0012 | 0.0031 | 0.1063 | 0.0047 | 0.0173 | 0.0062 | 0.0009 | 0.0019 |
Lipid Particles | 0.0129 | 0.0005 | 0.0046 | 0.0105 | 0.0115 | 0.0034 | 0.0119 | 0.0014 | 0.0035 | 0.0005 | 0.0005 | 0.0035 | 0.0149 | 0.0014 | 0.0033 | 0.0018 | 0.0005 | 0.0043 |
Mitochondria | 0.0087 | 0.0066 | 0.0105 | 0.0185 | 0.0067 | 0.0066 | 0.0149 | 0.0052 | 0.009 | 0.0316 | 0.0011 | 0.0063 | 0.0261 | 0.0012 | 0.0511 | 0.0019 | 0.0006 | 0.0066 |
None | 0.0074 | 0.001 | 0.003 | 0.008 | 0.0069 | 0.0003 | 0.0208 | 0.0099 | 0.0126 | 0.0002 | 0.0001 | 0.0049 | 0.004 | 0.0026 | 0.0032 | 0.0002 | 0.0001 | 0.0172 |
Nuclear Periphery | 0.0341 | 0.0252 | 0.0191 | 0.0098 | 0.0071 | 0.03 | 0.0169 | 0.0397 | 0.0068 | 0.0047 | 0.0063 | 0.0146 | 0.0472 | 0.0089 | 0.0057 | 0.0019 | 0.0079 | 0.0483 |
Nucleolus | 0.0025 | 0.0011 | 0.0016 | 0.0011 | 0.0019 | 0.0005 | 0.0044 | 0.0009 | 0.0019 | 0.0002 | 0.0003 | 0.0017 | 0.0006 | 0.0008 | 0.0037 | 0.0008 | 0.0007 | 0.002 |
Nucleus | 0.0162 | 0.0188 | 0.0049 | 0.0028 | 0.0022 | 0.0064 | 0.0174 | 0.0038 | 0.0054 | 0.0009 | 0.0007 | 0.0049 | 0.0083 | 0.0034 | 0.0038 | 0.0013 | 0.0032 | 0.0031 |
Peroxisomes | 0.0052 | 0.0001 | 0.006 | 0.005 | 0.0158 | 0.0018 | 0.0073 | 0.0002 | 0.0014 | 0.0001 | 0.0001 | 0.0007 | 0.0022 | 0.0001 | 0.0022 | 0.0005 | 0.0001 | 0.001 |
Punctate Nuclear | 0.0033 | 0.0001 | 0.0006 | 0.0094 | 0.0162 | 0.0013 | 0.0041 | 0.0001 | 0.0039 | 0 | 0 | 0.0007 | 0.002 | 0.0002 | 0.0004 | 0.0001 | 0 | 0.0001 |
Vacuole | 0.3745 | 0.4702 | 0.4111 | 0.4238 | 0.3604 | 0.3687 | 0.3893 | 0.4947 | 0.4371 | 0.3619 | 0.4157 | 0.4091 | 0.2649 | 0.586 | 0.473 | 0.5555 | 0.4556 | 0.4579 |
Vacuole Periphery | 0.2406 | 0.3402 | 0.2616 | 0.3062 | 0.3391 | 0.3824 | 0.1934 | 0.2612 | 0.2301 | 0.319 | 0.4246 | 0.2821 | 0.0796 | 0.2198 | 0.1304 | 0.1922 | 0.3996 | 0.308 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 22.0445 | 13.0674 | 16.4216 | 21.2031 | 19.2582 | 20.265 | 16.7286 | 19.8486 | 22.2607 | 24.0667 |
Translational Efficiency | 0.525 | 0.6152 | 0.6177 | 0.5099 | 0.4267 | 0.6578 | 0.5139 | 0.4392 | 0.4896 | 0.4421 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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