Standard name
Human Ortholog
Description Aquaglyceroporin, plasma membrane channel; involved in efflux of glycerol and xylitol, and in uptake of acetic acid, arsenite, and antimonite; key factor in maintaining redox balance by mediating passive diffusion of glycerol; phosphorylated by Hog1p MAPK under acetate stress; deletion improves xylose fermentation; regulated by Rgc1p and Ask10p, which are regulated by Hog1p phosphorylation under osmotic stress; phosphorylation by Ypk1p required to maintain an open state
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.55 0.48 0.64 0.64 0.64 0.5 0.48 0.38 – 0.33 0.37 0.3 0.44 0.42 0.37 0.46 0.41 0.46 0.15 0.19 0.19 0.18 0.17 0.14
Bud 0.15 0.14 0.13 0.15 0.19 0.18 0.19 0.14 – 0.17 0.21 0.17 0.08 0.08 0.05 0.07 0.06 0.08 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.45 0.6 0.47 0.43 0.41 0.32 0.25 0.23 – 0.19 0.2 0.21 0.46 0.44 0.52 0.35 0.34 0.53 0.64 0.63 0.62 0.67 0.66 0.73
Cytoplasm 0.13 0.14 0.13 0.18 0.2 0.26 0.27 0.38 – 0.34 0.36 0.39 0.26 0.26 0.29 0.24 0.27 0.25 0 0 0 0 0 0
Endoplasmic Reticulum 0.1 0.06 0.08 0.07 0.05 0.08 0.05 0 – 0 0 0.06 0.05 0.07 0 0.07 0.06 0.06 0.11 0.08 0.08 0.05 0.07 0.07
Endosome 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.05 0.05 0.12 0.07 0.17 0.16 0.19 – 0.32 0.27 0.26 0 0 0 0.09 0.09 0.12 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0.13 0.07 0.08 0.08 0.1 – 0.05 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0.06 0.05 0.05 0.06 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 77 106 159 138 183 124 140 128 – 91 82 101 63 102 85 88 83 52 24 49 56 38 63 62
Bud 21 31 33 33 55 45 55 48 – 48 46 57 11 20 11 13 12 9 0 0 0 0 0 1
Bud Neck 0 0 1 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 1 4 7 5 8 8
Bud Site 0 1 0 1 4 2 2 1 – 5 2 2 1 0 0 0 0 0 – – – – – –
Cell Periphery 63 133 116 93 117 79 72 76 – 53 43 71 66 107 119 66 69 59 107 164 180 139 239 336
Cytoplasm 18 32 33 38 56 64 80 125 – 94 79 134 37 63 65 46 55 28 0 3 2 2 3 4
Endoplasmic Reticulum 14 14 20 14 13 19 15 14 – 7 8 19 7 18 9 14 12 7 18 21 24 11 26 32
Endosome 0 0 0 0 0 1 0 0 – 0 0 0 0 0 0 1 1 0 0 1 3 0 1 1
Golgi 1 1 0 1 0 0 0 0 – 0 0 0 0 0 0 0 0 0 2 3 1 2 3 1
Mitochondria 2 12 12 25 19 43 48 63 – 89 60 90 0 0 1 18 18 14 7 5 8 6 7 10
Nucleus 1 0 0 1 0 1 0 3 – 1 1 2 2 0 1 1 1 1 0 0 0 0 0 0
Nuclear Periphery 0 0 1 0 0 0 0 0 – 1 0 1 0 0 0 0 0 0 1 0 0 0 0 0
Nucleolus 0 1 0 0 0 0 0 0 – 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0
Peroxisomes 2 1 8 27 19 20 22 32 – 13 7 19 4 0 5 0 5 3 0 0 0 1 1 0
SpindlePole 6 1 1 2 8 3 6 6 – 4 2 5 9 11 11 11 9 5 0 0 0 0 0 0
Vac/Vac Membrane 1 0 0 0 1 0 0 0 – 2 1 0 2 0 0 0 1 0 3 5 2 0 4 2
Unique Cell Count 139 222 248 214 287 246 291 333 280 219 341 142 242 228 190 201 112 168 262 292 208 362 463
Labelled Cell Count 206 333 384 373 475 401 440 496 408 332 501 202 321 307 259 266 178 168 262 292 208 362 463


Cell Periphery, Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.4 8.7 6.8 6.9 6.3 5.9 5.5 5.7 – 4.8 5.1 4.9 8.9 8.0 8.9 5.9 6.8 8.2 9.3 10.1 10.3
Std Deviation (1e-4) 1.0 1.4 1.0 1.3 1.1 1.2 1.0 1.2 – 1.2 1.0 1.2 1.2 1.0 1.1 1.4 1.2 1.6 1.2 1.7 1.4
Intensity Change (Log2) – – – 0.03 -0.1 -0.19 -0.3 -0.23 – -0.49 -0.41 -0.45 0.4 0.25 0.4 -0.19 0.02 0.29 0.45 0.58 0.61

WT3RAP60RAP140RAP220RAP300RAP380RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0.1 -0.1 -3.1 -3.7 -6.1 – 0 -5.8 -8.3 -3.8 -4.9 -5.9 -3.7 -4.8 -3.2
Bud 0.6 1.8 1.5 1.8 0.4 – 0 2.2 1.1 -1.7 -1.8 -3.2 -2.2 -2.6 -1.4
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cell Periphery -0.7 -1.4 -3.3 -5.3 -6.1 – 0 -6.2 -6.7 -0.1 -0.6 1.2 -2.5 -2.7 1.0
Cytoplasm 1.3 1.9 3.6 4.0 6.5 – 5.4 5.8 6.9 3.2 3.5 4.1 2.9 3.7 2.7
Endoplasmic Reticulum -0.6 -1.7 -0.1 -1.4 -2.0 – 0 -2.0 -1.2 -1.2 -0.3 -1.9 -0.3 -0.9 -0.6
Endosome 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Mitochondria 2.7 0.9 4.5 4.3 5.0 – 0 6.7 6.8 0 -3.5 -2.9 1.9 1.7 2.6
Nucleus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Peroxisomes 3.8 1.8 2.4 2.2 3.0 – 0 0 1.3 0 0 -0.7 0 -0.5 0
SpindlePole 0 0 0 0 0 – 0 0 0 0 3.0 3.1 3.4 0 0
Vacuole 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.2485 4.3403 3.7925 3.8111 3.3204 3.8115 2.8081 4.7487 3.8736 3.2291 3.6269 3.8132 2.5144 4.4032 3.6542 3.5952 2.8281 3.6327
Actin 0.1285 0.055 0.1026 0.108 0.0936 0.0898 0.07 0.0632 0.062 0.1808 0.1448 0.0541 0.2197 0.0502 0.1188 0.1333 0.172 0.094
Bud 0.0027 0.0005 0.0024 0.0113 0.0011 0.0011 0.0004 0.0005 0.0008 0.0021 0.0012 0.001 0.0006 0.0005 0.0007 0.001 0.0025 0.0008
Bud Neck 0.0096 0.008 0.0236 0.0179 0.0712 0.0412 0.0126 0.0078 0.0184 0.0226 0.0314 0.0386 0.0134 0.0187 0.0389 0.0848 0.0303 0.0526
Bud Periphery 0.0044 0.0022 0.0071 0.0248 0.0102 0.0116 0.0028 0.0034 0.0065 0.0135 0.0193 0.0168 0.003 0.0023 0.0055 0.0104 0.0262 0.0115
Bud Site 0.0276 0.0695 0.0342 0.0091 0.0101 0.0055 0.0186 0.0307 0.0405 0.0088 0.0054 0.0044 0.0299 0.1084 0.0523 0.0095 0.0084 0.0039
Cell Periphery 0.3706 0.2955 0.3288 0.2883 0.3247 0.3137 0.4207 0.4476 0.4468 0.3507 0.4106 0.5476 0.1913 0.3416 0.3553 0.28 0.4255 0.4133
Cytoplasm 0.2163 0.3609 0.2839 0.3287 0.2838 0.3436 0.1922 0.2307 0.2307 0.1335 0.1479 0.1677 0.1644 0.2413 0.189 0.2105 0.1381 0.1823
Cytoplasmic Foci 0.0121 0.0177 0.0122 0.0089 0.0125 0.0156 0.0117 0.0058 0.007 0.0157 0.0274 0.0054 0.0192 0.0084 0.0082 0.0083 0.0263 0.0121
Eisosomes 0.0975 0.0815 0.0523 0.0327 0.0653 0.0343 0.1158 0.0816 0.0822 0.1143 0.0289 0.0655 0.1443 0.0654 0.087 0.1186 0.0823 0.0951
Endoplasmic Reticulum 0.0578 0.0534 0.0702 0.1033 0.0447 0.0609 0.0647 0.0633 0.0421 0.0717 0.0611 0.0549 0.0912 0.106 0.0858 0.0388 0.0272 0.0464
Endosome 0.0031 0.007 0.0034 0.0057 0.0152 0.0034 0.0055 0.0009 0.0084 0.012 0.0101 0.001 0.0094 0.0013 0.0017 0.001 0.0037 0.0016
Golgi 0.0178 0.0156 0.0244 0.0249 0.021 0.0163 0.0118 0.0064 0.0175 0.0316 0.0269 0.0069 0.0208 0.0066 0.0154 0.0153 0.0181 0.0117
Lipid Particles 0.0286 0.0192 0.0275 0.0149 0.0287 0.0285 0.0227 0.0324 0.0183 0.0191 0.0544 0.023 0.0643 0.0389 0.0279 0.0354 0.0273 0.0566
Mitochondria 0.0007 0.0004 0.0012 0.0013 0.0005 0.0006 0.0005 0.0005 0.0046 0.0097 0.0015 0.0003 0.0014 0.0001 0.005 0.0001 0.0015 0.0002
None 0.0121 0.008 0.0181 0.0053 0.0071 0.0258 0.0416 0.0122 0.0039 0.0047 0.0017 0.0042 0.0102 0.0034 0.0022 0.0494 0.0026 0.012
Nuclear Periphery 0.0014 0.001 0.0012 0.0017 0.0012 0.0007 0.0018 0.0021 0.0016 0.0015 0.0015 0.0008 0.0039 0.002 0.0017 0.0012 0.0017 0.001
Nucleolus 0.0003 0.0002 0.0009 0.0005 0.0002 0.0003 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0007 0.0002 0.0002 0.0001 0.0002 0.0002
Nucleus 0.0004 0.0003 0.0008 0.0011 0.0004 0.0004 0.0003 0.0003 0.0003 0.0004 0.0003 0.0002 0.0015 0.0004 0.0003 0.0002 0.0005 0.0003
Peroxisomes 0.0008 0.0004 0.0005 0.0003 0.0003 0.0006 0.0022 0.0004 0.0047 0.0016 0.0155 0.0003 0.0037 0.0003 0.0008 0.0003 0.002 0.0006
Punctate Nuclear 0.0004 0.0003 0.0008 0.0014 0.0006 0.0005 0.0008 0.0002 0.0003 0.0007 0.0008 0.0001 0.0025 0.0003 0.0003 0.0003 0.0007 0.0003
Vacuole 0.0072 0.0034 0.0039 0.0094 0.0075 0.0057 0.0028 0.0095 0.0033 0.0042 0.0089 0.007 0.0043 0.0036 0.0028 0.0016 0.0026 0.0036
Vacuole Periphery 0.0002 0.0001 0.0002 0.0005 0.0003 0.0002 0.0001 0.0001 0.0002 0.0004 0.0003 0.0001 0.0003 0.0001 0.0002 0.0001 0.0002 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 31.0161 39.2588 35.6863 35.9535 32.7404 25.7867 42.2994 44.3728 42.3038 39.7212
Translational Efficiency 0.9329 0.8932 0.8761 0.8471 0.8832 1.2195 0.8433 0.7761 0.6854 0.6803

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
239 1039 1328 1272 1637 1048 2200 1417 1876 2087 3528 2689

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1091.83 898.45 1019.96 1097.46 881.10 891.15 1068.50 1137.62 907.95 894.78 1050.23 1118.62
Standard Deviation 137.96 171.78 148.68 210.75 127.66 123.46 124.57 156.78 146.91 149.52 136.20 185.38
Intensity Change Log 2 — -0.281238 -0.098236 0.007420 — 0.016363 0.278209 0.368641 — -0.140703 0.082100 0.179987

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.152683 0.065007 0.163127 0.103407 0.026027 0.029602 0.048379 0.088846 0.042163 0.047228 0.091572 0.095734
Bud Neck 0.027351 0.010428 0.023107 0.027706 0.007151 0.010157 0.021007 0.021579 0.009724 0.010292 0.021798 0.024477
Bud Site 0.075281 0.029761 0.087976 0.090880 0.013163 0.017548 0.024951 0.053805 0.021077 0.023628 0.048674 0.071343
Cell Periphery 0.230548 0.524125 0.102471 0.469208 0.668732 0.652246 0.328679 0.518633 0.612908 0.588462 0.243530 0.495253
Cytoplasm 0.100510 0.057940 0.111396 0.064072 0.056331 0.082654 0.112636 0.060163 0.061960 0.070350 0.112169 0.062012
Cytoplasmic Foci 0.019750 0.019290 0.012862 0.007435 0.007741 0.007361 0.002720 0.004307 0.009271 0.013299 0.006537 0.005787
Eisosomes 0.152263 0.056132 0.081605 0.084014 0.069984 0.063868 0.138047 0.112227 0.080466 0.060016 0.116802 0.098881
Endoplasmic Reticulum 0.052545 0.027698 0.302683 0.062508 0.013243 0.018182 0.143566 0.049626 0.018250 0.022919 0.203460 0.055720
Endosome 0.013321 0.013528 0.005003 0.005598 0.003210 0.005702 0.002949 0.005827 0.004498 0.009598 0.003722 0.005719
Golgi 0.022400 0.026234 0.010331 0.007083 0.010081 0.008258 0.004545 0.006975 0.011651 0.017207 0.006723 0.007026
Lipid Particles 0.019323 0.036291 0.043114 0.035528 0.011494 0.007180 0.063133 0.029041 0.012491 0.021673 0.055597 0.032110
Mitochondria 0.004047 0.008956 0.001150 0.002001 0.004680 0.008157 0.001720 0.003472 0.004599 0.008555 0.001505 0.002776
Mitotic Spindle 0.000856 0.000572 0.000252 0.000821 0.000471 0.000389 0.000748 0.001055 0.000521 0.000480 0.000561 0.000944
None 0.000037 0.000318 0.000605 0.000298 0.000163 0.000093 0.001003 0.000164 0.000147 0.000205 0.000853 0.000228
Nuclear Periphery 0.000129 0.000273 0.000245 0.000520 0.000313 0.000296 0.000975 0.000652 0.000289 0.000285 0.000701 0.000590
Nuclear Periphery Foci 0.002612 0.000285 0.004013 0.001088 0.000131 0.000308 0.001040 0.000790 0.000447 0.000297 0.002159 0.000931
Nucleolus 0.000013 0.000066 0.000041 0.000025 0.000017 0.000024 0.000043 0.000064 0.000016 0.000045 0.000042 0.000045
Nucleus 0.006958 0.001124 0.016355 0.002879 0.000697 0.000892 0.004552 0.002194 0.001494 0.001007 0.008995 0.002518
Peroxisomes 0.005317 0.119312 0.009511 0.014105 0.105067 0.082382 0.086315 0.022804 0.092359 0.100767 0.057404 0.018689
Vacuole 0.112432 0.001623 0.024027 0.020407 0.000990 0.003368 0.012852 0.015852 0.015187 0.002499 0.017058 0.018007
Vacuole Periphery 0.001624 0.001037 0.000128 0.000418 0.000313 0.001334 0.000141 0.001926 0.000480 0.001186 0.000136 0.001213

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 6.20 -0.74 3.42 -5.59 7.49 -1.01 -6.58 -11.99 -10.58 -7.35 -1.35 -12.38 -12.20 -10.92 -0.95
Bud Neck 4.01 0.95 -0.14 -8.80 -2.19 -2.77 -10.41 -9.87 -7.30 -0.33 -0.59 -10.39 -11.11 -11.41 -1.97
Bud Site 5.21 -1.26 -1.55 -12.05 -0.53 -1.91 -5.88 -11.68 -9.62 -8.00 -1.05 -11.30 -16.01 -15.15 -7.01
Cell Periphery -15.02 7.72 -13.04 3.71 -35.74 1.27 34.46 12.74 10.15 -18.61 2.13 40.32 11.43 9.28 -32.96
Cytoplasm 4.53 -1.15 3.89 -1.41 9.29 -5.49 -14.19 -1.08 4.68 13.19 -2.31 -14.38 -0.03 2.52 15.94
Cytoplasmic Foci 0.15 1.76 3.15 5.92 3.70 0.30 5.70 3.25 2.58 -2.33 -3.00 2.76 3.28 6.48 1.04
Eisosomes 7.94 5.76 5.53 -6.41 -0.57 1.54 -16.29 -9.07 -9.79 5.05 5.93 -9.89 -4.90 -11.70 4.97
Endoplasmic Reticulum 3.21 -22.83 -1.21 -7.30 26.29 -2.11 -26.47 -10.62 -8.42 16.43 -2.14 -39.33 -12.74 -10.91 28.73
Endosome -0.08 2.69 2.44 5.38 -0.69 -2.65 0.70 -2.72 -0.10 -3.05 -5.63 1.49 -1.61 3.94 -3.15
Golgi -0.67 2.07 2.60 7.00 2.32 1.07 4.47 1.84 0.75 -1.97 -2.97 3.73 3.02 6.28 -0.36
Lipid Particles -3.91 -6.56 -4.15 0.14 2.17 2.72 -18.70 -6.83 -8.95 10.18 -4.47 -20.64 -9.50 -4.38 9.53
Mitochondria -1.86 1.21 0.84 5.44 -2.76 -2.14 5.12 1.20 2.70 -2.07 -3.48 5.31 2.47 5.32 -2.70
Mitotic Spindle 0.79 1.63 0.14 -3.09 -8.70 1.44 -4.35 -4.92 -5.60 -2.52 0.61 -0.57 -4.77 -6.31 -5.24
None -3.69 -4.53 -5.17 0.23 2.27 3.28 -4.77 -0.03 -1.74 4.67 -1.41 -5.88 -2.26 -0.44 5.08
Nuclear Periphery -4.22 -5.91 -10.47 -5.49 -7.77 0.56 -16.17 -6.64 -6.68 5.38 0.18 -14.24 -8.86 -8.62 2.94
Nuclear Periphery Foci 7.23 -2.95 4.57 -7.75 8.72 -4.22 -22.08 -9.35 -5.96 3.08 3.03 -12.72 -6.23 -9.80 8.81
Nucleolus -1.30 -7.28 -4.38 1.04 4.29 -2.03 -12.95 -1.29 -1.08 -0.58 -1.42 -13.82 -1.51 0.02 -0.17
Nucleus 4.11 -5.73 3.17 -2.59 12.65 -1.66 -19.07 -8.26 -7.21 9.57 1.33 -16.33 -4.38 -4.36 14.62
Peroxisomes -18.72 -4.19 -6.28 17.10 -3.45 3.39 3.46 17.13 11.37 18.10 -1.50 7.81 17.83 20.20 16.92
Vacuole 8.77 7.00 7.24 -13.57 1.71 -3.11 -25.96 -16.33 -10.63 -3.03 6.85 -0.74 -1.29 -17.35 -1.21
Vacuole Periphery 0.77 2.08 1.66 2.68 -2.90 -1.92 2.13 -2.48 -0.71 -2.76 -2.33 3.04 -2.04 -0.06 -3.12
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Aquaglyceroporin, plasma membrane channel; involved in efflux of glycerol and xylitol, and in uptake of acetic acid, arsenite, and antimonite; key factor in maintaining redox balance by mediating passive diffusion of glycerol; phosphorylated by Hog1p MAPK under acetate stress; deletion improves xylose fermentation; regulated by Rgc1p and Ask10p, which are regulated by Hog1p phosphorylation under osmotic stress; phosphorylation by Ypk1p required to maintain an open state
Localization
Cell Percentages cell periphery (86%)
Cell Cycle Regulation No
Subcompartmental Group cell periphery-2

Fps1

Fps1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Fps1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available